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1510-21-0,MFCD00037705
Catalog No.:AA001MXV

1510-21-0 | Cholest-5-en-3-ol (3β)-, 3-(hydrogen butanedioate)

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5g
95%
in stock  
$34.00   $24.00
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25g
95%
in stock  
$168.00   $117.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001MXV
Chemical Name:
Cholest-5-en-3-ol (3β)-, 3-(hydrogen butanedioate)
CAS Number:
1510-21-0
Molecular Formula:
C31H50O4
Molecular Weight:
486.7263
MDL Number:
MFCD00037705
SMILES:
CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)OC(=O)CCC(=O)O)C)C
Properties
Properties
 
BP:
586°C at 760 mmHg  
Form:
Solid  
MP:
178 °C  
Refractive Index:
-34 ° (C=2, CHCl3)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
815  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
8.5  

Literature

Title: Preparation and characterization of 5-fluorouracil pH-sensitive niosome and its tumor-targeted evaluation: in vitro and in vivo.

Journal: Drug development and industrial pharmacy 20120901

Title: The role of cholesterol on the activity and stability of neurotensin receptor 1.

Journal: Biochimica et biophysica acta 20120901

Title: Fusogenic activity of PEGylated pH-sensitive liposomes.

Journal: Journal of liposome research 20120601

Title: Recombinant cannabinoid type 2 receptor in liposome model activates g protein in response to anionic lipid constituents.

Journal: The Journal of biological chemistry 20120203

Title: pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system.

Journal: International journal of nanomedicine 20120101

Title: GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles.

Journal: Methods (San Diego, Calif.) 20111201

Title: Toward rational design of protein detergent complexes: determinants of mixed micelles that are critical for the in vitro stabilization of a G-protein coupled receptor.

Journal: Biophysical journal 20111019

Title: Activation of Toll-like receptor 9 and production of epitope specific antibody by liposome-encapsulated CpG-DNA.

Journal: BMB reports 20110901

Title: RNAi-based therapeutics targeting survivin and PLK1 for treatment of bladder cancer.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20110501

Title: Preparation, therapeutic efficacy and intratumoral localization of targeted daunorubicin liposomes conjugating folate-PEG-CHEMS.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110201

Title: The morphology and composition of cholesterol-rich micellar nanostructures determine transmembrane protein (GPCR) activity.

Journal: Biophysical journal 20110119

Title: Folate receptor-targeted fluorescent paramagnetic bimodal liposomes for tumor imaging.

Journal: International journal of nanomedicine 20110101

Title: Fusion-relevant changes in lipid shape of hydrated cholesterol hemisuccinate induced by pH and counterion species.

Journal: The journal of physical chemistry. B 20101125

Title: A purified C-terminally truncated human adenosine A(2A) receptor construct is functionally stable and degradation resistant.

Journal: Protein expression and purification 20101101

Title: Morphological effect of lipid carriers on permeation of lidocaine hydrochloride through lipid membranes.

Journal: International journal of pharmaceutics 20100330

Title: Alpha-tocopheryl succinate induces rapid and reversible phosphatidylserine externalization in histiocytic lymphoma through the caspase-independent pathway.

Journal: Molecular and cellular biochemistry 20100101

Title: Long-circulating, pH-sensitive liposomes.

Journal: Methods in molecular biology (Clifton, N.J.) 20100101

Title: Glycosaminoglycan-resistant and pH-sensitive lipid-coated DNA complexes produced by detergent removal method.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20081021

Title: Esterase-catalyzed dePEGylation of pH-sensitive vesicles modified with cleavable PEG-lipid derivatives.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20080924

Title: Anionic pH-sensitive pegylated lipoplexes to deliver DNA to tumors.

Journal: International journal of pharmaceutics 20080901

Title: LHRHa aided liposomes targeting to human ovarian tumor cells: preparation and cellular uptake.

Journal: Die Pharmazie 20080601

Title: Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes.

Journal: International journal of pharmaceutics 20080522

Title: Preparation and characterization of pH-sensitive vesicles made of cholesteryl hemisuccinate.

Journal: Drug development and industrial pharmacy 20080201

Title: Enhanced depigmenting effects of N-glycosylation inhibitors delivered by pH-sensitive liposomes into HM3KO melanoma cells.

Journal: Journal of cosmetic science 20080101

Title: Long-circulating, pH-sensitive liposomes sterically stabilized by copolymers bearing short blocks of lipid-mimetic units.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201

Title: Cholesterol hemisuccinate: a selective inhibitor of family X DNA polymerases.

Journal: Biochemical and biophysical research communications 20070309

Title: A reduction-triggered delivery by a liposomal carrier possessing membrane-permeable ligands and a detachable coating.

Journal: Colloids and surfaces. B, Biointerfaces 20060415

Title: Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.

Journal: International journal of pharmaceutics 20050826

Title: [Cholesteryl hemisuccinate as liposomal membrane stabilizer and its use in the preparation of saikosaponin-D liposomes].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050701

Title: Bile acid induces hydrophobicity-dependent membrane alterations.

Journal: Biochimica et biophysica acta 20050615

Title: Influence of membrane physical state on lysosomal potassium ion permeability.

Journal: Cell biology international 20050601

Title: Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20040811

Title: On the formulation of pH-sensitive liposomes with long circulation times.

Journal: Advanced drug delivery reviews 20040423

Title: Pharmaco attributes of dioleoylphosphatidylethanolamine/cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers.

Journal: Pharmacological research 20040201

Title: Targeted gene delivery into HepG2 cells using complexes containing DNA, cationized asialoorosomucoid and activated cationic liposomes.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20031030

Title: Cholesteryl-hemisuccinate-induced apoptosis of promyelocytic leukemia HL-60 cells through a cyclosporin A-insensitive mechanism.

Journal: Biochemical pharmacology 20030201

Title: Influence of the physical states of membrane surface area and center area on lysosomal proton permeability.

Journal: Archives of biochemistry and biophysics 20020815

Title: Application of a modified version of Habeeb's trinitrophenylation method for the characterization of hapten-protein conjugates in a reversed micellar medium.

Journal: Journal of immunological methods 20020501

Title: Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.

Journal: Toxicology letters 19970207

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Tags:1510-21-0 Molecular Formula|1510-21-0 MDL|1510-21-0 SMILES|1510-21-0 Cholest-5-en-3-ol (3β)-, 3-(hydrogen butanedioate)