154992-24-2,MFCD00925776
Catalog No.:AA001NFX

154992-24-2 | Ru 58841

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$6.00   $4.00
- +
10mg
98%
in stock  
$8.00   $6.00
- +
50mg
98%
in stock  
$13.00   $9.00
- +
100mg
98%
in stock  
$19.00   $14.00
- +
1g
98%
in stock  
$52.00   $36.00
- +
5g
98%
in stock  
$128.00   $89.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001NFX
Chemical Name:
Ru 58841
CAS Number:
154992-24-2
Molecular Formula:
C17H18F3N3O3
Molecular Weight:
369.3383
MDL Number:
MFCD00925776
SMILES:
OCCCCN1C(=O)N(C(=O)C1(C)C)c1ccc(c(c1)C(F)(F)F)C#N
Properties
Computed Properties
 
Complexity:
611  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.1  

Literature

Title: Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.

Journal: Bioorganic & medicinal chemistry letters 20090301

Title: Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.

Journal: Journal of medicinal chemistry 20081113

Title: Novel vesicular and particulate drug delivery systems for topical treatment of acne.

Journal: Expert opinion on drug delivery 20080601

Title: (1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.

Journal: Bioorganic & medicinal chemistry letters 20071101

Title: Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production.

Journal: Bioorganic & medicinal chemistry letters 20071015

Title: Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production.

Journal: Bioorganic & medicinal chemistry letters 20071015

Title: Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake.

Journal: Pharmaceutical research 20070501

Title: Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.

Journal: Journal of medicinal chemistry 20050224

Title: Synthesis and structure-activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands.

Journal: Bioorganic & medicinal chemistry letters 20041101

Title: Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands.

Journal: Bioorganic & medicinal chemistry letters 20010423

Title: A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice By De Brouwer, B.; Tetelin, C.; Leroy, T.; Bonfils, A.; Van Neste, D. .From British Journal of Dermatology (1997), 137(5), 699-702.

Title: Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Sch?fer-Korting M.RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia.Pharmazie. 2005 Jan;60(1):8-12.

Title: Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D.RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism.J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60.

Title: Blaschke T, Kankate L, Kramer KD.Structure and dynamics of drug-carrier systems as studied by parelectric spectroscopy.Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10. Epub 2007 May 3.

Title: Matias JR, Gaillard M.Local inhibition of sebaceous gland growth by topically applied RU 58841.Ann N Y Acad Sci. 1995 Jun 12;761:56-65.

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SDS
Related Products of 154992-24-2
Tags:154992-24-2 Molecular Formula|154992-24-2 MDL|154992-24-2 SMILES|154992-24-2 Ru 58841
Catalog No.: AA001NFX
154992-24-2,MFCD00925776
154992-24-2 | Ru 58841
Pack Size: 5mg
Purity: 98%
in stock
$6.00 $4.00
Pack Size: 10mg
Purity: 98%
in stock
$8.00 $6.00
Pack Size: 50mg
Purity: 98%
in stock
$13.00 $9.00
Pack Size: 100mg
Purity: 98%
in stock
$19.00 $14.00
Pack Size: 1g
Purity: 98%
in stock
$52.00 $36.00
Pack Size: 5g
Purity: 98%
in stock
$128.00 $89.00
Quantity
- +
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Technical Information
Catalog Number: AA001NFX
Chemical Name: Ru 58841
CAS Number: 154992-24-2
Molecular Formula: C17H18F3N3O3
Molecular Weight: 369.3383
MDL Number: MFCD00925776
SMILES: OCCCCN1C(=O)N(C(=O)C1(C)C)c1ccc(c(c1)C(F)(F)F)C#N
Properties
Complexity: 611  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.1  
Literature fold

Title: Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.

Journal: Bioorganic & medicinal chemistry letters20100101

Title: Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production.

Journal: Bioorganic & medicinal chemistry letters20090415

Title: 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.

Journal: Bioorganic & medicinal chemistry letters20090301

Title: Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.

Journal: Journal of medicinal chemistry20081113

Title: Novel vesicular and particulate drug delivery systems for topical treatment of acne.

Journal: Expert opinion on drug delivery20080601

Title: (1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.

Journal: Bioorganic & medicinal chemistry letters20071101

Title: Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production.

Journal: Bioorganic & medicinal chemistry letters20071015

Title: Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production.

Journal: Bioorganic & medicinal chemistry letters20071015

Title: Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake.

Journal: Pharmaceutical research20070501

Title: Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.

Journal: Journal of medicinal chemistry20050224

Title: Synthesis and structure-activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands.

Journal: Bioorganic & medicinal chemistry letters20041101

Title: Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands.

Journal: Bioorganic & medicinal chemistry letters20010423

Title: A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice By De Brouwer, B.; Tetelin, C.; Leroy, T.; Bonfils, A.; Van Neste, D. .From British Journal of Dermatology (1997), 137(5), 699-702.

Title: Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Sch?fer-Korting M.RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia.Pharmazie. 2005 Jan;60(1):8-12.

Title: Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D.RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism.J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60.

Title: Blaschke T, Kankate L, Kramer KD.Structure and dynamics of drug-carrier systems as studied by parelectric spectroscopy.Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10. Epub 2007 May 3.

Title: Matias JR, Gaillard M.Local inhibition of sebaceous gland growth by topically applied RU 58841.Ann N Y Acad Sci. 1995 Jun 12;761:56-65.

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