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Title: δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.
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Title: δ-Opioid receptor agonist SNC80 induces central antinociception mediated by Ca2+ -activated Cl- channels.
Journal: The Journal of pharmacy and pharmacology 20120801
Title: Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain.
Journal: Neuroscience 20120726
Title: Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists.
Journal: Drug and alcohol dependence 20120401
Title: Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons.
Journal: Molecular pharmacology 20120201
Title: Peripheral antinociception induced by δ-opioid receptors activation, but not μ- or κ-, is mediated by Ca²⁺-activated Cl⁻ channels.
Journal: European journal of pharmacology 20120115
Title: Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.
Journal: Bioorganic & medicinal chemistry 20120115
Title: New insights into opioid regulatory pathways: influence of opioids on Wnt1 expression in zebrafish embryos.
Journal: Neuroscience 20120103
Title: Delta-opioid receptor activation promotes mesenchymal stem cell survival via PKC/STAT3 signaling pathway.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101
Title: The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions.
Journal: Behavioural brain research 20111001
Title: Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis.
Journal: Psychopharmacology 20110801
Title: Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.
Journal: Pain 20110601
Title: Effects of delta opioid receptors activation on a response inhibition task in rats.
Journal: Psychopharmacology 20110401
Title: Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208
Title: Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat.
Journal: Neuroscience 20101124
Title: Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Synthesis and in vivo brain distribution of carbon-11-labeled δ-opioid receptor agonists.
Journal: Nuclear medicine and biology 20101101
Title: Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety.
Journal: The Journal of pharmacology and experimental therapeutics 20101001
Title: Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.
Journal: Journal of anesthesia 20100401
Title: Modulation of delta opioid agonist-induced antinociception by repeated morphine pretreatment in rhesus monkeys.
Journal: Life sciences 20100313
Title: Cocaine withdrawal-induced anxiety in females: impact of circulating estrogen and potential use of delta-opioid receptor agonists for treatment.
Journal: Journal of neuroscience research 20100301
Title: Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.
Journal: Pain 20100101
Title: Synthesis and pharmacological evaluation of SNC80 analogues with a bridged piperazine ring.
Journal: ChemMedChem 20091201
Title: N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: the development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive activity in rodent models.
Journal: Bioorganic & medicinal chemistry letters 20091101
Title: Opiate-agonist induced taste aversion learning in the Fischer 344 and Lewis inbred rat strains: evidence for differential mu opioid receptor activation.
Journal: Pharmacology, biochemistry, and behavior 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.
Journal: Bioorganic & medicinal chemistry 20090901
Title: Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.
Journal: The Journal of biological chemistry 20090703
Title: Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.
Journal: Bioorganic & medicinal chemistry letters 20090515
Title: Syntheses of novel high affinity ligands for opioid receptors.
Journal: Bioorganic & medicinal chemistry letters 20090415
Title: Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.
Journal: American journal of physiology. Heart and circulatory physiology 20090401
Title: The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats.
Journal: European journal of pharmacology 20090214
Title: In vivo delta opioid receptor internalization controls behavioral effects of agonists.
Journal: PloS one 20090101
Title: Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.
Journal: Bioorganic & medicinal chemistry letters 20081215
Title: Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.
Journal: Journal of neurochemistry 20081201
Title: Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants.
Journal: Journal of pharmacological sciences 20081101
Title: Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Journal: Journal of medicinal chemistry 20081009
Title: The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum.
Journal: Neuropharmacology 20081001
Title: Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.
Journal: Brain research bulletin 20080905
Title: The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
Journal: British journal of pharmacology 20080701
Title: Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model.
Journal: Brain research 20080507
Title: Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.
Journal: Psychoneuroendocrinology 20080501
Title: Inflammatory pain is enhanced in delta opioid receptor-knockout mice.
Journal: The European journal of neuroscience 20080501
Title: Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.
Journal: Bioorganic & medicinal chemistry 20080415
Title: Opioid modulation of ferret vagal afferent mechanosensitivity.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20080401
Title: Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety.
Journal: Bioorganic & medicinal chemistry 20080315
Title: Blockade of NMDA receptors prevents analgesic tolerance to repeated transcutaneous electrical nerve stimulation (TENS) in rats.
Journal: The journal of pain : official journal of the American Pain Society 20080301
Title: Dopamine-independent psychostimulant activity of a delta-agonist.
Journal: Behavioural pharmacology 20080301
Title: The delta-opioid receptor agonist SNC80 [(+)-4-[alpha(R)-alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] synergistically enhances the locomotor-activating effects of some psychomotor stimulants, but not direct dopamine agonists, in rats.
Journal: The Journal of pharmacology and experimental therapeutics 20080201
Title: Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat.
Journal: Neuropharmacology 20080201
Title: Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats.
Journal: Journal of anesthesia 20080101
Title: Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.
Journal: Journal of medicinal chemistry 20070809
Title: Use of Freund's Complete Adjuvant (FCA) in inflammatory pain models: consequences on the metabolism and pharmacokinetics of the non-peptidic delta receptor agonist SNC80 in the rat.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070801
Title: Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.
Journal: Journal of medicinal chemistry 20070419
Title: Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.
Journal: Brain : a journal of neurology 20070401
Title: Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability.
Journal: Journal of pharmacological and toxicological methods 20070101
Title: Differential effects of micro-opioid, delta-opioid and kappa-opioid receptor agonists on dopamine receptor agonist-induced climbing behavior in mice.
Journal: Behavioural pharmacology 20061201
Title: Changes in emotional behavior of mice in the hole-board test after olfactory bulbectomy.
Journal: Journal of pharmacological sciences 20061201
Title: Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys.
Journal: European journal of pharmacology 20061010
Title: Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats.
Journal: European journal of pharmacology 20061010
Title: Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys.
Journal: Pharmacology, biochemistry, and behavior 20061001
Title: Mu-delta opioid receptor functional interaction: Insight using receptor-G protein fusions.
Journal: The Journal of pharmacology and experimental therapeutics 20060801
Title: The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol.
Journal: The Journal of pharmacology and experimental therapeutics 20060601
Title: Role of delta-opioid receptor function in neurogenesis and neuroprotection.
Journal: Journal of neurochemistry 20060601
Title: Modulation of delta opioid-evoked hypothermia in rats by WAY 100635 and fluoxetine.
Journal: Neuroscience letters 20060508
Title: Nitric oxide synthase mediates delta opioid receptor-induced hypothermia in rats.
Journal: European journal of pharmacology 20060424
Title: Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401
Title: Delta opioid receptor ligands modulate anxiety-like behaviors in the rat.
Journal: British journal of pharmacology 20060401
Title: Dissociation between sex differences in the immunological, behavioral, and physiological effects of kappa- and delta-opioids in Fischer rats.
Journal: Psychopharmacology 20060301
Title: Effects of mu-, delta- and kappa-opioid receptor agonists on methamphetamine-induced self-injurious behavior in mice.
Journal: European journal of pharmacology 20060217
Title: Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects.
Journal: European journal of pharmacology 20060215
Title: Delta opioid agonists attenuate TAT(1-72)-induced oxidative stress in SK-N-SH cells.
Journal: Neurotoxicology 20060101
Title: delta-Opioid receptor agonist SNC80 elicits peripheral antinociception via delta(1) and delta(2) receptors and activation of the l-arginine/nitric oxide/cyclic GMP pathway.
Journal: Life sciences 20051119
Title: Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats.
Journal: Psychopharmacology 20051101
Title: Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats.
Journal: Psychopharmacology 20051101
Title: Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley rats.
Journal: The Journal of pharmacology and experimental therapeutics 20051001
Title: Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice.
Journal: The European journal of neuroscience 20051001
Title: 3D-QSAR comparative molecular field analysis on delta opioid receptor agonist SNC80 and its analogs.
Journal: Journal of molecular graphics & modelling 20050901
Title: Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats.
Journal: Brain research 20050705
Title: Interactions between delta and mu opioid agonists in assays of schedule-controlled responding, thermal nociception, drug self-administration, and drug versus food choice in rhesus monkeys: studies with SNC80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and heroin.
Journal: The Journal of pharmacology and experimental therapeutics 20050701
Title: The antinociceptive effect of zolpidem and zopiclone in mice.
Journal: Pharmacology, biochemistry, and behavior 20050701
Title: Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids.
Journal: International immunopharmacology 20050701
Title: A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80.
Journal: Basic & clinical pharmacology & toxicology 20050701
Title: Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats.
Journal: Psychopharmacology 20050601
Title: Molecular modeling directed synthesis of a bicyclic analogue of the delta opioid receptor agonist SNC 80.
Journal: Archiv der Pharmazie 20050601
Title: The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats.
Journal: Brain research 20050531
Title: Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels.
Journal: European journal of pharmacology 20050404
Title: Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20050401
Title: Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.
Journal: European journal of pharmacology 20050328
Title: In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323
Title: Reciprocal regulation of agonist and inverse agonist signaling efficacy upon short-term treatment of the human delta-opioid receptor with an inverse agonist.
Journal: Molecular pharmacology 20050101
Title: Enhanced striatal opioid receptor-mediated G-protein activation in L-DOPA-treated dyskinetic monkeys.
Journal: Neuroscience 20050101
Title: Increased survival of tumor-bearing mice by the delta opioid SNC 80.
Journal: Anticancer research 20050101
Title: Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons.
Journal: Neuropharmacology 20041201
Title: Different regulation of human delta-opioid receptors by SNC-80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and endogenous enkephalins.
Journal: The Journal of pharmacology and experimental therapeutics 20040801
Title: Delta-opioid agonist SNC80 can attenuate the development of dynorphin A-induced tactile allodynia in rats.
Journal: Anesthesiology 20040801
Title: Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.
Journal: Journal of pharmacological sciences 20040701
Title: The effects of the delta-opioid agonist SNC80 on hind-limb motor function and neuronal injury after spinal cord ischemia in rats.
Journal: Anesthesia and analgesia 20040701
Title: N,N-dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective delta opioid agonists.
Journal: Bioorganic & medicinal chemistry letters 20040503
Title: Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats.
Journal: The Journal of pharmacology and experimental therapeutics 20040401
Title: Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Journal: Journal of medicinal chemistry 20040311
Title: Functional interaction among opioid receptor types: up-regulation of mu- and delta-opioid receptor functions after repeated stimulation of kappa-opioid receptors.
Journal: Neuropharmacology 20040301
Title: Mutation S363A in the human delta-opioid receptor selectively reduces down-regulation by a peptide agonist.
Journal: European journal of pharmacology 20040206
Title: SNC 80 and related delta opioid agonists.
Journal: Current pharmaceutical design 20040101
Title: Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception.
Journal: The Journal of pharmacology and experimental therapeutics 20031201
Title: Delta-opioid agonist-stimulated inositol phosphate formation in isolated, rabbit iris-ciliary bodies: role of G(i/o) proteins and Gbetagamma-subunits.
Journal: Experimental eye research 20031201
Title: Effects of the delta-opioid receptor agonist SNC80 on learning relative to its antidepressant-like effects in rats.
Journal: Behavioural pharmacology 20031101
Title: Pharmacological characterization of a 7-benzylidenenaltrexone-preferring opioid receptor in porcine ileal submucosa.
Journal: British journal of pharmacology 20031001
Title: Pharmacological characterization of AR-M1000390 at human delta opioid receptors.
Journal: Life sciences 20030815
Title: Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment.
Journal: The Journal of pharmacology and experimental therapeutics 20030701
Title: SNC-80-induced preconditioning: selective activation of the mitochondrial adenosine triphosphate-gated potassium channel.
Journal: Journal of cardiovascular pharmacology 20030501
Title: Development of opioid tolerance with repeated transcutaneous electrical nerve stimulation administration.
Journal: Pain 20030301
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Journal: European journal of pharmacology 20030110
Title: The molecular mechanisms of cellular tolerance to delta-opioid agonists. A minireview.
Journal: Acta biologica Hungarica 20030101
Title: Chemotaxis of human and rat leukocytes by the delta-selective non-peptidic opioid SNC 80.
Journal: Revista latinoamericana de microbiologia 20030101
Title: Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain.
Journal: Pharmacology, biochemistry, and behavior 20021201
Title: Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20021101
Title: Delta opioid antagonist effects of buprenorphine in rhesus monkeys.
Journal: Behavioural pharmacology 20021101
Title: Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats.
Journal: Psychopharmacology 20021001
Title: Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
Journal: Psychopharmacology 20021001
Title: Antinociceptive effects of the selective delta opioid agonist SNC80 alone and in combination with mu opioids in the squirrel monkey titration procedure.
Journal: Psychopharmacology 20021001
Title: Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists.
Journal: The Journal of pharmacology and experimental therapeutics 20020901
Title: Behavioral effects of delta-opioid receptor agonists: potential antidepressants?
Journal: Japanese journal of pharmacology 20020901
Title: The role of nitric oxide in the proconvulsant effect of delta-opioid agonist SNC80 in mice.
Journal: Neuroscience letters 20020830
Title: Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020601
Title: Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
Journal: Brain research 20020524
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Journal: The Journal of pharmacology and experimental therapeutics 20020201
Title: Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells.
Journal: British journal of pharmacology 20020101
Title: Delta opioid discrimination learning in the rat: assessment with the selective delta agonist SNC80.
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Title: Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.
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Title: Studies of tolerance and dependence with the delta-opioid agonist SNC80 in rhesus monkeys responding under a schedule of food presentation.
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Title: Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.
Journal: Molecular pharmacology 20011101
Title: Antiparkinsonian action of a delta opioid agonist in rodent and primate models of Parkinson's disease.
Journal: Experimental neurology 20011101
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Title: Increased tumor necrosis factor-alpha and nitric oxide production by rat macrophages following in vitro stimulation and intravenous administration of the delta-opioid agonist SNC 80.
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