Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Licofelone inhibits interleukin-18-induced pro-inflammatory cytokine release and cellular proliferation in human mesangial cells.
Journal: Basic & clinical pharmacology & toxicology 20120901
Title: The decrease of cell membrane fluidity by the non-steroidal anti-inflammatory drug Licofelone inhibits epidermal growth factor receptor signalling and triggers apoptosis in HCA-7 colon cancer cells.
Journal: Cancer letters 20120828
Title: Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects.
Journal: Respiratory medicine 20120801
Title: Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
Journal: Bioorganic & medicinal chemistry letters 20120801
Title: Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
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Title: Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism.
Journal: PloS one 20120101
Title: Prostaglandins in cancer cell adhesion, migration, and invasion.
Journal: International journal of cell biology 20120101
Title: Anti-inflammatory drugs and prediction of new structures by comparative analysis.
Journal: Anti-inflammatory & anti-allergy agents in medicinal chemistry 20120101
Title: Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
Journal: Cancer prevention research (Philadelphia, Pa.) 20111201
Title: Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone.
Journal: British journal of pharmacology 20110901
Title: Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation.
Journal: Annals of the rheumatic diseases 20110801
Title: Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration.
Journal: Cancer prevention research (Philadelphia, Pa.) 20110801
Title: Licofelone-nitric oxide donors as anticancer agents.
Journal: Archiv der Pharmazie 20110801
Title: Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI.
Journal: Annals of the rheumatic diseases 20110601
Title: Antibody-mediated 'universal' osteoclast targeting platform using calcitonin as a model drug.
Journal: Pharmaceutical research 20110501
Title: Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.
Journal: Journal of medicinal chemistry 20110428
Title: Licofelone attenuates quinolinic acid induced Huntington like symptoms: possible behavioral, biochemical and cellular alterations.
Journal: Progress in neuro-psychopharmacology & biological psychiatry 20110330
Title: Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
Journal: European journal of medicinal chemistry 20110301
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Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20110101
Title: Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model.
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Title: The implications of relationships between human diseases and metabolic subpathways.
Journal: PloS one 20110101
Title: Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.
Journal: BMC musculoskeletal disorders 20110101
Title: Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis.
Journal: PloS one 20110101
Title: Quantitative cartilage imaging in knee osteoarthritis.
Journal: Arthritis 20110101
Title: Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis.
Journal: Annals of the rheumatic diseases 20101201
Title: Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI.
Journal: Annals of the rheumatic diseases 20101201
Title: Licofelone attenuates MPTP-induced neuronal toxicity: behavioral, biochemical and cellular evidence.
Journal: Inflammopharmacology 20101001
Title: Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice.
Journal: Atherosclerosis 20100901
Title: Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
Journal: European journal of medicinal chemistry 20100201
Title: Pharmacophore modeling and virtual screening for designing potential 5-lipoxygenase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20100201
Title: Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes.
Journal: Arthritis research & therapy 20100101
Title: High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes.
Journal: Arthritis research & therapy 20100101
Title: Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis.
Journal: Arthritis research & therapy 20100101
Title: Upregulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells.
Journal: BMC research notes 20100101
Title: Investigational pharmacology for low back pain.
Journal: Journal of pain research 20100101
Title: 5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis.
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Title: Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.
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Title: Systematic review of the management of canine osteoarthritis.
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Title: An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model.
Journal: BMC veterinary research 20090101
Title: Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes.
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Title: Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
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Title: In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.
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Title: The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands.
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Journal: Methods and findings in experimental and clinical pharmacology 20080301
Title: Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.
Journal: Carcinogenesis 20080201
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Journal: Methods and findings in experimental and clinical pharmacology 20080101
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Title: Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.
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Title: Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis.
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Title: Combination Therapy of PPARgamma Ligands and Inhibitors of Arachidonic Acid in Lung Cancer.
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Title: Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor.
Journal: The Journal of pharmacology and experimental therapeutics 20071201
Title: The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products.
Journal: British journal of pharmacology 20071001
Title: Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors and beyond.
Journal: Acta bio-medica : Atenei Parmensis 20070801
Title: Efficacy of licofelone in dogs with clinical osteoarthritis.
Journal: The Veterinary record 20070428
Title: Dynamic simulations on the arachidonic acid metabolic network.
Journal: PLoS computational biology 20070301
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Journal: Clinical interventions in aging 20070301
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Title: Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
Journal: The Journal of pharmacology and experimental therapeutics 20070101
Title: Licofelone--a novel analgesic and anti-inflammatory agent.
Journal: Current topics in medicinal chemistry 20070101
Title: Selection of reliable reference genes for qPCR studies on chondroprotective action.
Journal: BMC molecular biology 20070101
Title: Extracellular localization of galectin-3 has a deleterious role in joint tissues.
Journal: Arthritis research & therapy 20070101
Title: Anticancer effects of licofelone (ML-3000) in prostate cancer cells.
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Journal: Bulletin of the NYU hospital for joint diseases 20070101
Title: Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study.
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Title: Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity.
Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20061201
Title: The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit.
Journal: European journal of pharmacology 20060928
Title: Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.
Journal: The Journal of rheumatology 20060601
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Journal: Fundamental & clinical pharmacology 20060201
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Title: Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.
Journal: Biochemical pharmacology 20050701
Title: The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
Journal: Annals of the rheumatic diseases 20050601
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Title: Dual inhibition of cyclo-oxygenases and 5-lipoxygenase: a novel therapeutic approach to inflammation?
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Journal: The Journal of rheumatology 20050401
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Journal: Drugs & aging 20050101
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Title: The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
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Title: Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.
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Title: The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
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