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157341-41-8,MFCD00871548
Catalog No.:AA001PBD

157341-41-8 | 1-Azetidinecarboxamide, N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-, (2S)-

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Purity
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5mg
99%
1 week  
$368.00   $258.00
- +
10mg
99%
1 week  
$527.00   $369.00
- +
25mg
99%
1 week  
$860.00   $602.00
- +
50mg
99%
1 week  
$1,344.00   $941.00
- +
100mg
99%
1 week  
$2,193.00   $1,535.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001PBD
Chemical Name:
1-Azetidinecarboxamide, N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-, (2S)-
CAS Number:
157341-41-8
Molecular Formula:
C31H40N4O6
Molecular Weight:
564.6725
MDL Number:
MFCD00871548
SMILES:
CCC[C@H](c1ccc2c(c1)OCO2)NC(=O)N1C(=O)C([C@@H]1Oc1ccc(cc1)C(=O)N1CCN(CC1)C)(CC)CC
Properties
Computed Properties
 
Complexity:
928  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
4.9  

Downstream Synthesis Route
157341-41-8   
α-propyl-piperonylamine 
 
5-(1-chloro-butyl)-benzo1,3dioxole 
  6890-31-9    85858-94-2 

[1]Raghavan,KrishnaswamyS.;Gray,DavidB.;Scholz,ThomasH.;Nemeth,GregoryA.;Hussain,MunirA.[PharmaceuticalResearch,1996,vol.13,#12,p.1815-1820]

[1]JournalofOrganicChemistry,1996,vol.61,p.6575-6580

[2]JournalofOrganicChemistry,1996,vol.61,p.6575-6580

[3]JournalofOrganicChemistry,1996,vol.61,p.6575-6580

[4]JournalofOrganicChemistry,1996,vol.61,p.6575-6580

[1]Storace,Louis;Anzalone,Luigi;Confalone,PatN.;Davis,WayneP.;Fortunak,JosephM.;Giangiordano,Mark;HaleyJr.,JamesJ.;Kamholz,Kenneth;Li,Hui-Yin;Ma,Philip;Nugent,WilliamA.;ParsonsJr.,RodneyL.;Sheeran,PatrickJ.;Silverman,CharlotteE.;Waltermire,RobertE.;Wood,ChristopherC.[OrganicProcessResearchandDevelopment,2002,vol.6,#1,p.54-63]

Literature

Title: Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice.

Journal: Digestive diseases and sciences 20090801

Title: Altered gastric chief cell lineage differentiation in histamine-deficient mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090601

Title: Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.

Journal: The Journal of biological chemistry 20070720

Title: Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice.

Journal: Gastroenterology 20070501

Title: Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20060401

Title: Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777.

Journal: Digestive diseases and sciences 20060301

Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Journal: Current drug metabolism 20051001

Title: Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.

Journal: Bioorganic & medicinal chemistry letters 20010122

Title: Ogawa M, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci. 2006 Mar;51(3):431-9.

Title: Zagrobelny J, et al. Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching. J Pharm Biomed Anal. 1998 Sep 1;17(6-7

Title: Weis VG, et al. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 23:ajpgi.00326.2016

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Tags:157341-41-8 Molecular Formula|157341-41-8 MDL|157341-41-8 SMILES|157341-41-8 1-Azetidinecarboxamide, N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-, (2S)-