Catalog No.:AA001PG5

157599-02-5 | 1,4,7,10-Tetrakis(aminocarbonylmethyl)-1,4,7,10-tetraazacyclododecane

Name: Name:1,4,7,10-Tetrakis(aminocarbonylmethyl)-1,4,7,10-tetraazacyclododecane
Brand: AABLOCKS
SKU: AA001PG5
Availability: InStock
Rating: 90 (10 reviews)

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100mg

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$7.00 $5.00

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250mg

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$16.00 $11.00

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$29.00 $21.00

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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
Request for Quotation
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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA001PG5

Chemical Name:

1,4,7,10-Tetrakis(aminocarbonylmethyl)-1,4,7,10-tetraazacyclododecane

CAS Number:

157599-02-5

Molecular Formula:

C16H32N8O4

Molecular Weight:

400.4765

MDL Number:

MFCD09263318

SMILES:

NC(=O)CN1CCN(CCN(CCN(CC1)CC(=O)N)CC(=O)N)CC(=O)N

Properties

BP:

767.4°C at 760 mmHg

Form:

Solid

MP:

>236°C (dec.)

Stability:

Hygroscopic

Storage:

Inert atmosphere;2-8℃;

Computed Properties

Complexity:

447

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

-4.1

Upstream Synthesis Route

683-57-8

294-90-6

157599-02-5

[1]Patent:WO2015/38943,2015,A1,.Locationinpatent:Page/Pagecolumn51;52

[2]AngewandteChemie,1994,vol.106,#7,p.824-826

[3]HelveticaChimicaActa,2005,vol.88,#5,p.923-935

294-90-6

79-07-2

157599-02-5

[1]JournaloftheAmericanChemicalSociety,1995,vol.117,#25,p.6698-6707

[2]JournaloftheChemicalSociety,ChemicalCommunications,1994,#8,p.1007-1008

Downstream Synthesis Route

683-57-8

294-90-6

157599-02-5

[1]Patent:WO2015/38943,2015,A1.Locationinpatent:Page/Pagecolumn51;52

[2]AngewandteChemie,1994,vol.106,p.824-826

[3]JournaloftheAmericanChemicalSociety,2020,vol.142,p.198-206

[4]HelveticaChimicaActa,2005,vol.88,p.923-935

[5]InorganicChemistry,2019,vol.58,p.8710-8719

294-90-6

79-07-2

157599-02-5

[1]Maumela,Hulisani;Hancock,RobertD.;Carlton,Laurence;Reibenspies,JosephH.;Wainwright,KevinP.[JournaloftheAmericanChemicalSociety,1995,vol.117,#25,p.6698-6707]

[2]Carlton,Laurence;Hancock,RobertD.;Maumela,Hulisani;Wainwright,KevinP.[JournaloftheChemicalSociety.Chemicalcommunications,1994,#8,p.1007-1008]

[3]Nielsen,LeaGundorff;Sørensen,ThomasJust[InorganicChemistry,2019]

157599-02-5

CASUnavailable

172798-73-1

[1]Amin,Shahid;Morrow,JanetR.;Lake,CharlesH.;Churchill,MelvynRowen[AngewandteChemie,1994,vol.106,#7,p.824-826]

157599-02-5

52093-25-1

{(1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane)Eu}trifluoromethanesulfonate

[1]AngewandteChemie-InternationalEdition,1997,vol.37,p.2673-2675

[2]AngewandteChemie,1994,vol.106,p.824-826

CASUnavailable

157599-02-5

CASUnavailable

[1]Wang;Choudhary;Vink;Secord;Morrow[ChemicalCommunications,2000,#24,p.2509-2510]

Literature

Title: Iron(II) complexes containing octadentate tetraazamacrocycles as paraCEST magnetic resonance imaging contrast agents.

Journal: Inorganic chemistry 20120716

Title: DOTAM-type ligands possessing arginine pendant groups for use in PARACEST MRI.

Journal: Contrast media & molecular imaging 20120101

Title: Gd(III) chelates as NMR probes of protein-protein interactions. Case study: rubredoxin and cytochrome c3.

Journal: Inorganic chemistry 20111107

Title: Contrast agents possessing high temperature sensitivity.

Journal: Chemical communications (Cambridge, England) 20110828

Title: NMR of insensitive nuclei enhanced by dynamic nuclear polarization.

Journal: Chimia 20110101

Title: Synthesis of MRI contrast agents derived from DOTAM-Gly-L-Phe-OH incorporating a disulfide bridge: conjugation to a cell penetrating peptide and preparation of a dimeric agent.

Journal: Bioorganic & medicinal chemistry letters 20100915

Title: Selective detection of phosphotyrosine in the presence of various phosphate-containing biomolecules with the aid of a terbium(III) complex.

Journal: Chembiochem : a European journal of chemical biology 20090720

Title: A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent.

Journal: Organic & biomolecular chemistry 20081007

Title: The thulium complex of 1,4,7,10-tetrakis{[N-(1H-imidazol-2-yl)carbamoyl]methyl}-1,4,7,10-tetraazacyclododecane (dotami) as a ParaCEST contrast agent.

Journal: Chemistry & biodiversity 20080801

Title: Analogs of Eu3+ DOTAM-Gly-Phe-OH and Tm3+ DOTAM-Gly-Lys-OH: synthesis and magnetic properties of potential PARACEST MRI contrast agents.

Journal: Bioorganic & medicinal chemistry 20080601

Title: On the sensitivity of f electrons to their chemical environment.

Journal: Journal of the American Chemical Society 20080220

Title: A sensitive PARACEST contrast agent for temperature MRI: Eu3+-DOTAM-glycine (Gly)-phenylalanine (Phe).

Journal: Magnetic resonance in medicine 20080201

Title: A robust and convergent synthesis of dipeptide-DOTAM conjugates as chelators for lanthanide ions: new PARACEST MRI agents.

Journal: Bioconjugate chemistry 20070101

Title: Non-cytotoxic, bifunctional EuIII and TbIII luminescent macrocyclic complexes for luminescence resonant energy-transfer experiments.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Title: Structural characterisation of a diprotonated ligand lanthanide complex--a key intermediate in lanthanide ion association and complex dissociation pathways.

Journal: Dalton transactions (Cambridge, England : 2003) 20060721

Title: Structural effects of the lone pair on lead(II), and parallels with the coordination geometry of mercury(II). Does the lone pair on lead(II) form H-bonds? Structures of the lead(II) and mercury(II) complexes of the pendant-donor macrocycle DOTAM (1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane).

Journal: Inorganic chemistry 20040503

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