Title: Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20180201
Title: Acidic conditions induce the suppression of CD86 and CD54 expression in THP-1 cells.
Journal: The Journal of toxicological sciences 20180101
Title: Oxidative stress parameters induced by exposure to either cadmium or 17β-estradiol on Mytilus galloprovincialis hemocytes. The role of signaling molecules.
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20140101
Title: Coordinated role of voltage-gated sodium channels and the Na+/H+ exchanger in sustaining microglial activation during inflammation.
Journal: Toxicology and applied pharmacology 20131201
Title: JAK2 mediates the acute response to decreased cell volume in mouse preimplantation embryos by activating NHE1.
Journal: Journal of cellular physiology 20130201
Title: Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Journal: Journal of medicinal chemistry 20120823
Title: Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis.
Journal: International journal of molecular medicine 20120601
Title: The Na+/H+ exchanger-1 inhibitor cariporide prevents glutamate-induced necrotic neuronal death by inhibiting mitochondrial Ca2+ overload.
Journal: Journal of neuroscience research 20120401
Title: NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts.
Journal: Pflugers Archiv : European journal of physiology 20120301
Title: Effect of thymoquinone on cytosolic pH and Na+/H+ exchanger activity in mouse dendritic cells.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Title: The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice.
Journal: Cardiovascular diabetology 20120101
Title: Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
Journal: American journal of physiology. Heart and circulatory physiology 20111201
Title: Hydrogen sulfide regulates Na+/H+ exchanger activity via stimulation of phosphoinositide 3-kinase/Akt and protein kinase G pathways.
Journal: The Journal of pharmacology and experimental therapeutics 20111101
Title: Chronic neurological deficits in mice after perinatal hypoxia and ischemia correlate with hemispheric tissue loss and white matter injury detected by MRI.
Journal: Developmental neuroscience 20111001
Title: Role of sodium/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains.
Journal: Journal of neurochemistry 20111001
Title: Reversal of Imatinib resistance in BCR-ABL-positive leukemia after inhibition of the Na+/H+ exchanger.
Journal: Cancer letters 20110901
Title: Disruption of chronic cariporide treatment abrogates myocardial ion homeostasis during acute ischemia reperfusion.
Journal: Journal of cardiovascular pharmacology 20110901
Title: Synthesis and Na+/H+ exchanger inhibitory activity of benzoylguanidine derivatives.
Journal: European journal of medicinal chemistry 20110901
Title: Evidence for NHE3-mediated Na transport in sheep and bovine forestomach.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20110801
Title: Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance.
Journal: American journal of physiology. Cell physiology 20110701
Title: Oxidative stress augments the secretion of atrial natriuretic peptide in isolated rat atria.
Journal: Peptides 20110601
Title: Mitochondrial KATP channels participate in the limitation of infarct size by cariporide.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110601
Title: Inhibition of Na+/H+ exchanger isoform 1 is neuroprotective in neonatal hypoxic ischemic brain injury.
Journal: Antioxidants & redox signaling 20110515
Title: A recombinant human neuregulin-1 peptide improves preservation of the rodent heart after prolonged hypothermic storage.
Journal: Transplantation 20110515
Title: Effect of glucose and insulin on oxidized low-density lipoprotein phagocytosis by human monocytes: a pilot study.
Journal: Angiology 20110201
Title: Inhibiting the Na+/H+ exchanger reduces reperfusion injury: a small animal MRI study.
Journal: Frontiers in bioscience (Elite edition) 20110101
Title: Myocardial reperfusion injury: reactive oxygen species vs. NHE-1 reactivation.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
Title: Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.
Journal: Brain research 20101202
Title: Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101110
Title: [Cariporide pretreatment attenuated warm ischemia/reperfusion injury in an isolated rat lung: a study on antioxidative mechanism].
Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20100201
Title: Effect of bacterial lipopolysaccharide on Na(+)/H(+) exchanger activity in dendritic cells.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20091101
Title: Synthesis and Na(+)/H(+) exchanger-1 inhibitory activity of substituted (quinolinecarbonyl)guanidine derivatives.
Journal: Chemistry & biodiversity 20091001
Title: Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives.
Journal: European journal of medicinal chemistry 20090901
Title: Combining cariporide with glyceryl trinitrate optimizes cardiac preservation during porcine heart transplantation.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20090901
Title: Na+ currents in cardioprotection: better to be late.
Journal: Journal of medicinal chemistry 20090723
Title: Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090615
Title: Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL.
Journal: Journal of gastroenterology and hepatology 20090501
Title: Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20090401
Title: Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction.
Journal: American journal of physiology. Heart and circulatory physiology 20090401
Title: Insulin inhibits Na+/H+ exchange in vascular smooth muscle and endothelial cells in situ: involvement of H2O2 and tyrosine phosphatase SHP-2.
Journal: American journal of physiology. Heart and circulatory physiology 20090201
Title: Na+/H+ exchange inhibitor cariporide attenuates skeletal muscle infarction when administered before ischemia or reperfusion.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20090101
Title: Down-regulation of P-glycoprotein expression by sustained intracellular acidification in K562/Dox cells.
Journal: Biochemical and biophysical research communications 20081212
Title: Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20081201
Title: Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide in isolated perfused rabbit hearts.
Journal: Biological chemistry 20081201
Title: Na+/H+ exchanger is required for hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain.
Journal: Cardiovascular research 20081101
Title: Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils.
Journal: American journal of physiology. Cell physiology 20081101
Title: Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.
Journal: Circulation research 20081010
Title: Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart.
Journal: The Journal of experimental biology 20080801
Title: Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions.
Journal: Journal of neurochemistry 20080701
Title: Na+/H+ exchange inhibition with cariporide prevents alterations of coronary endothelial function in streptozotocin-induced diabetes.
Journal: Molecular and cellular biochemistry 20080301
Title: Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells.
Journal: Molecular and cellular biochemistry 20080301
Title: Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration.
Journal: Resuscitation 20080101
Title: Inhibition of the Na+/H+ exchanger protects the immature rabbit myocardium from ischemia and reperfusion injury.
Journal: Pediatric cardiology 20080101
Title: Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells.
Journal: American journal of physiology. Cell physiology 20080101
Title: Na+/H+ exchanger inhibitor cariporide attenuates the mitochondrial Ca2+ overload and PTP opening.
Journal: American journal of physiology. Heart and circulatory physiology 20071201
Title: Enhanced Na+/H+ exchange activity contributes to the pathogenesis of muscular dystrophy via involvement of P2 receptors.
Journal: The American journal of pathology 20071101
Title: Effects of SM-20550 against myocardial infarction-induced arrhythmias, late infarct expansion, and left ventricular dysfunction.
Journal: Journal of cardiovascular pharmacology 20071101
Title: The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury.
Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20071001
Title: [Cardioprotective effects of cariporide as an adjunct in different cardioplegic solutions: an experiment with rabbits].
Journal: Zhonghua yi xue za zhi 20070904
Title: Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells.
Journal: Cancer research 20070815
Title: Pharmacodynamic characteristics and cardioprotective effects of new NHE1 inhibitors.
Journal: European journal of pharmacology 20070712
Title: NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.
Journal: The Journal of biological chemistry 20070706
Title: Delay of acute intracellular pH recovery after acidosis decreases endothelial cell activation.
Journal: Journal of cellular physiology 20070501
Title: Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury.
Journal: Bioorganic & medicinal chemistry letters 20070501
Title: Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20070301
Title: 3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070301
Title: Sodium-hydrogen exchange inhibition and beta-blockade additively decrease infarct size.
Journal: The Annals of thoracic surgery 20070301
Title: Invited commentary.
Journal: The Annals of thoracic surgery 20070301
Title: Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070101
Title: Reoxygenation-induced Ca2+ rise is mediated via Ca2+ influx and Ca2+ release from the endoplasmic reticulum in cardiac endothelial cells.
Journal: Cardiovascular research 20070101
Title: Preconditioning with Na+/H+ exchange inhibitor HOE642 reduces calcium overload and exhibits marked protection on immature rabbit hearts.
Journal: ASAIO journal (American Society for Artificial Internal Organs : 1992) 20070101
Title: Modification of intracellular calcium concentration in cardiomyocytes by inhibition of sarcolemmal Na+/H+ exchanger.
Journal: American journal of physiology. Heart and circulatory physiology 20061201
Title: Cariporide attenuates myocardial ischaemia, reperfusion injury and apoptosis in isolated rat hearts.
Journal: Acta cardiologica 20061201
Title: Ras triggers acidosis-induced activation of the extracellular-signal-regulated kinase pathway in cardiac myocytes.
Journal: The Biochemical journal 20061101
Title: Cariporide inhibits high glucose-mediated adhesion of monocyte-endothelial cell and expression of intercellular adhesion molecule-1.
Journal: Life sciences 20060829
Title: Signalling pathways involved in hypertonicity- and acidification-induced activation of Na+/H+ exchange in trout hepatocytes.
Journal: The Journal of experimental biology 20060801
Title: The case for sodium-hydrogen exchanger isoform-1 inhibition during cardiac resuscitation remains strong.
Journal: Critical care medicine 20060501
Title: Diastolic dysfunction in stunned myocardium: a state of abnormal excitation-contraction coupling that is limited by Na+-H+ exchange inhibition.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060401
Title: 17beta-estradiol increases volume, apical surface and elasticity of human endothelium mediated by Na+/H+ exchange.
Journal: Cardiovascular research 20060301
Title: Protection of endothelial-derived vasorelaxation with cariporide, a sodium-proton exchanger inhibitor, after prolonged hypoxia and hypoxia-reoxygenation: effect of age.
Journal: European journal of pharmacology 20060215
Title: Inhibition of Na+/H+ exchanger isoform 1 attenuates mitochondrial cytochrome C release in cortical neurons following in vitro ischemia.
Journal: Acta neurochirurgica. Supplement 20060101
Title: Na+/H+ exchanger inhibition at the onset of reperfusion decreases myocardial infarct size: role of reactive oxygen species.
Journal: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20060101
Title: Inhibition of the Na+-H+ exchanger isoform-1 and the extracellular signal-regulated kinase induces apoptosis: a time course of events.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101
Title: Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium--a mechanism for the slow force response.
Journal: Cardiovascular research 20051201
Title: Insulin-sensitizing and cardiovascular effects of the sodium-hydrogen exchange inhibitor, cariporide, in the JCR: LA-cp rat and db/db mouse.
Journal: Journal of cardiovascular pharmacology 20051201
Title: Effects of combined inhibition of the Na+-H+ exchanger and angiotensin-converting enzyme in rats with congestive heart failure after myocardial infarction.
Journal: British journal of pharmacology 20051101
Title: Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation.
Journal: Critical care medicine 20051101
Title: Cariporide in cardiac resuscitation--Does it really make a difference?
Journal: Critical care medicine 20051101
Title: Multiple treatment approach to limit cardiac ischemia-reperfusion injury.
Journal: The Annals of thoracic surgery 20051001
Title: Invited commentary.
Journal: The Annals of thoracic surgery 20051001
Title: Cariporide counteracts atherosclerosis-related functions in monocytes from obese and normal individuals.
Journal: Obesity research 20050901
Title: [Protection of HOE642 against cardiomyocyte injury caused by anoxia and reoxygenation].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050901
Title: Improved preservation of the rat heart with celsior solution supplemented with cariporide plus glyceryl trinitrate.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050801
Title: Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2.
Journal: Cellular and molecular life sciences : CMLS 20050701
Title: Endothelin isoforms and the response to myocardial stretch.
Journal: American journal of physiology. Heart and circulatory physiology 20050601
Title: Na+/H+ exchanger inhibitor prevented endothelial dysfunction induced by high glucose.
Journal: Journal of cardiovascular pharmacology 20050601
Title: Reduction of myocardial infarct size by SM-198110, a novel Na+/H+ exchange inhibitor, in rabbits.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050501
Title: Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury.
Journal: The Canadian journal of cardiology 20050501
Title: (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1.
Journal: Journal of medicinal chemistry 20050421
Title: Na+/H+ exchange inhibition and antioxidants lack additive protective effects after reperfusion injury in the working heterotopic rat heart isograft.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050401
Title: Cariporide potentiates the effects of epinephrine and vasopressin by nonvascular mechanisms during closed-chest resuscitation.
Journal: Chest 20050401
Title: Protective effects of cariporide on endothelial dysfunction induced by high glucose.
Journal: Acta pharmacologica Sinica 20050301
Title: Endothelin-1 stimulates the Na+/Ca2+ exchanger reverse mode through intracellular Na+ (Na+i)-dependent and Na+i-independent pathways.
Journal: Hypertension (Dallas, Tex. : 1979) 20050201
Title: Neurologic preservation by Na+-H+ exchange inhibition prior to 90 minutes of hypothermic circulatory arrest.
Journal: The Annals of thoracic surgery 20050201
Title: Na+/H+ exchange inhibition in hypertrophied myocardium subjected to cardioplegic arrest: an effective cardioprotective approach.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050101
Title: The preischemic combination of the sodium-hydrogen exchanger inhibitor cariporide and the adenosine agonist AMP579 acts additively to reduce porcine myocardial infarct size.
Journal: Journal of the American College of Surgeons 20041001
Title: Na+ / H+ exchanger-3 is involved in mouse blastocyst formation.
Journal: Journal of experimental zoology. Part A, Comparative experimental biology 20040901
Title: Activation of Na+-H+ exchange and stretch-activated channels underlies the slow inotropic response to stretch in myocytes and muscle from the rat heart.
Journal: The Journal of physiology 20040815
Title: Inhibition of Na+-H+ exchange by cariporide reduces inflammation and heart failure in rabbits with myocardial infarction.
Journal: British journal of pharmacology 20040801
Title: The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction.
Journal: International journal of molecular medicine 20040801
Title: Myocardial protection at a crossroads: the need for translation into clinical therapy.
Journal: Circulation research 20040723
Title: The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20040701
Title: Intracellular acidification by inhibition of the Na+/H+-exchanger leads to caspase-independent death of cerebellar granule neurons resembling paraptosis.
Journal: Cell death and differentiation 20040701
Title: Effects of acute and chronic treatment with the sodium hydrogen exchanger 1 (NHE-1) inhibitor cariporide on myocardial infarct mass in rabbits with hypercholesterolaemia.
Journal: Basic & clinical pharmacology & toxicology 20040701
Title: The many targets of aldosterone.
Journal: Hypertension (Dallas, Tex. : 1979) 20040501
Title: Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury.
Journal: Life sciences 20040430
Title: Emergency donor heart protection: application of the port access catheter technique using a pig heart transplantation model.
Journal: Transplantation 20040427
Title: Experimental studies on myocardial protection with intermittent cross-clamp fibrillation: additive effect of the sodium-hydrogen exchanger inhibitor, cariporide.
Journal: The Annals of thoracic surgery 20040401
Title: American Heart Association scientific sessions.
Journal: Expert opinion on investigational drugs 20040401
Title: Endothelin causes contraction of human esophageal muscularis mucosae through interaction with both ETA and ETB receptors.
Journal: Regulatory peptides 20040315
Title: Na+-H+ exchange activity in taste receptor cells.
Journal: Journal of neurophysiology 20040301
Title: Involvement of Na+/H+ exchanger in hypoxia/re-oxygenation-induced neonatal rat cardiomyocyte apoptosis.
Journal: European journal of pharmacology 20040220
Title: Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model.
Journal: Cardiovascular research 20040215
Title: Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040201
Title: Effects of cariporide (HOE642) on myocardial infarct size and ventricular arrhythmias in a rat ischemia/reperfusion model: comparison with other drugs.
Journal: Pharmacology 20040201
Title: Na+/H+ exchange inhibition attenuates left ventricular remodeling and preserves systolic function in pressure-overloaded hearts.
Journal: British journal of pharmacology 20040201
Title: Sodium-hydrogen exchange inhibition attenuates in vivo porcine myocardial stunning.
Journal: The Annals of thoracic surgery 20040201
Title: Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes.
Journal: Journal of molecular and cellular cardiology 20040101
Title: The role of the sodium hydrogen exchanger-1 in mediating diabetes-induced changes in the retina.
Journal: Diabetes/metabolism research and reviews 20040101
Title: Na /H+ exchange inhibitor cariporide: effects on respiratory dysfunction after cardiopulmonary bypass.
Journal: Perfusion 20040101
Title: The cardioprotective effects of Na+/H+ exchange inhibition and mitochondrial KATP channel activation are additive in the isolated rat heart.
Journal: Pflugers Archiv : European journal of physiology 20031201
Title: A low dose of angiotensin II increases inotropism through activation of reverse Na(+)/Ca(2+) exchange by endothelin release.
Journal: Cardiovascular research 20031201
Title: Sodium-hydrogen inhibitor cariporide (HOE 642) improves in situ protection of hearts from non-heart-beating donors.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20031201
Title: Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.
Journal: Annals of the New York Academy of Sciences 20031201
Title: Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway.
Journal: Circulation 20031104
Title: Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20031101
Title: Enhanced cardioprotection of the rat heart during hypothermic storage with combined Na+ - H+ exchange inhibition and ATP-dependent potassium channel activation.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20031101
Title: Na(+)-Ca(2+) exchanger overexpression predisposes to reactive oxygen species-induced injury.
Journal: Cardiovascular research 20031101
Title: A new role for cardioplegic buffering: should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts?
Journal: The Journal of thoracic and cardiovascular surgery 20031101
Title: Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability.
Journal: The Journal of thoracic and cardiovascular surgery 20031101
Title: Cariporide enhances lactate clearance upon reperfusion but does not alter lactate accumulation during global ischaemia.
Journal: Pflugers Archiv : European journal of physiology 20031001
Title: Role of the Na+-H+ exchanger (NHE1) in heart muscle function during transient acidosis. A study in papillary muscles from rat and guinea pig hearts.
Journal: Canadian journal of physiology and pharmacology 20031001
Title: [Effect of cariporide on immature rabbit heart].
Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20031001
Title: Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions.
Journal: American journal of physiology. Heart and circulatory physiology 20030901
Title: Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis.
Journal: Endocrinology 20030901
Title: Prognostic significance of elevated creatine kinase MB after coronary bypass surgery and after an acute coronary syndrome: results from the GUARDIAN trial.
Journal: The Journal of thoracic and cardiovascular surgery 20030901
Title: Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study.
Journal: The Journal of thoracic and cardiovascular surgery 20030801
Title: Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide.
Journal: Molecular and cellular biochemistry 20030801
Title: Myocardial protection during resuscitation from cardiac arrest.
Journal: Current opinion in critical care 20030601
Title: An overview of inhibitors of Na(+)/H(+) exchanger.
Journal: European journal of medicinal chemistry 20030601
Title: Signal transduction and Ca2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium.
Journal: Circulation research 20030516
Title: Is microvascular protection by cariporide and ischemic preconditioning causally linked to myocardial salvage?
Journal: American journal of physiology. Heart and circulatory physiology 20030401
Title: Pre-treatment with the Na+/H+ exchange inhibitor cariporide delays cell-to-cell electrical uncoupling during myocardial ischemia.
Journal: Cardiovascular research 20030401
Title: Blood cardioplegic protection in profoundly damaged hearts: role of Na+-H+ exchange inhibition during pretreatment or during controlled reperfusion supplementation.
Journal: The Annals of thoracic surgery 20030401
Title: Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030401
Title: Increased Na+/H+-exchange activity is the cause of increased [Na+]i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model.
Journal: Cardiovascular research 20030315
Title: Effective protection by NHE-1 inhibition in ischemic and reperfused heart under preconditioning blockade.
Journal: American journal of physiology. Heart and circulatory physiology 20030301
Title: Cariporide (HOE642) limits S-100B release during cardiac surgery.
Journal: Journal of cardiovascular pharmacology 20030301
Title: Na/H exchange isoform 1 is involved in mineralocorticoid/salt-induced cardiac injury.
Journal: Hypertension (Dallas, Tex. : 1979) 20030301
Title: Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.
Journal: European journal of pharmacology 20030214
Title: Selective Na+/H+ exchange inhibition by cariporide reduces liver fibrosis in the rat.
Journal: Hepatology (Baltimore, Md.) 20030201
Title: Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells.
Journal: Gastroenterology 20030201
Title: Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection.
Journal: The Annals of thoracic surgery 20030201
Title: Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries.
Journal: European journal of pharmacology 20030101
Title: Blood cardioplegia supplementation with the sodium-hydrogen ion exchange inhibitor cariporide to attenuate infarct size and coronary artery endothelial dysfunction after severe regional ischemia in a canine model.
Journal: The Journal of thoracic and cardiovascular surgery 20030101
Title: A review of the GUARDIAN trial results: clinical implications and the significance of elevated perioperative CK-MB on 6-month survival.
Journal: Journal of cardiac surgery 20030101
Title: Effects of the NHE-1 inhibitor cariporide alone or together with the P2Y12 antagonist AR-C 69331 MX on CD62p expression and formation of platelet-leukocyte aggregates.
Journal: Thrombosis research 20030101
Title: Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes.
Journal: American journal of physiology. Endocrinology and metabolism 20021201
Title: Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na/H exchange.
Journal: The Journal of thoracic and cardiovascular surgery 20021201
Title: Upregulation of myocardial Na+/H+ exchanger induced by chronic treatment with a selective inhibitor.
Journal: Journal of molecular and cellular cardiology 20021101
Title: Protection from AMP 579 can be added to that from either cariporide or ischemic preconditioning in ischemic rabbit heart.
Journal: Journal of cardiovascular pharmacology 20021001
Title: Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.
Journal: European journal of pharmacology 20020906
Title: Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.
Journal: British journal of cancer 20020715
Title: Novel, non-acylguanidine-type Na(+)/H(+) exchanger inhibitors: synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives.
Journal: Journal of medicinal chemistry 20020704
Title: Blockade of the Na+-Ca2+ exchanger is more efficient than blockade of the Na+-H+ exchanger for protection of the myocardium from lethal reperfusion injury.
Journal: Cardiovascular drugs and therapy 20020701
Title: Angiotensin II increases L-type Ca2+ current in gramicidin D-perforated adult rabbit ventricular myocytes: comparison with conventional patch-clamp method.
Journal: Pflugers Archiv : European journal of physiology 20020501
Title: Effects of inhibiting Na(+)/H(+)-exchange or angiotensin converting enzyme on atrial tachycardia-induced remodeling.
Journal: Cardiovascular research 20020501
Title: Ammonia inhibits sodium and chloride absorption in rat distal colon.
Journal: Experimental physiology 20020501
Title: In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559.
Journal: British journal of pharmacology 20020401
Title: Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure.
Journal: Circulation 20020319
Title: Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification.
Journal: The Biochemical journal 20020301
Title: Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na(+)/H(+) exchanger.
Journal: Cardiovascular research 20020301
Title: [Protective effect of Na(+)-H+ exchanger inhibitor cariporide on the injury of vascular endothelial function induced by hypercholesterolemia].
Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20020227
Title: Role of the cardiac Na(+)/H(+)exchanger in [Ca(2+)](i)and [Na(+)](i)handling during intracellular acidosis. Effect of cariporide (Hoe 642).
Journal: Pharmacological research 20020101
Title: Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium.
Journal: Diabetes/metabolism research and reviews 20020101
Title: Cariporide (HOE 642) attenuates leukocyte activation in ischemia and reperfusion.
Journal: Anesthesia and analgesia 20011201
Title: Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs.
Journal: American journal of physiology. Renal physiology 20011001
Title: Na(+)/H(+) exchange subtype 1 inhibition reduces endothelial dysfunction in vessels from stunned myocardium.
Journal: American journal of physiology. Heart and circulatory physiology 20011001
Title: [Rapid acid extrusion response triggered by alpha-1a adrenoceptor in CHO cells].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011001
Title: Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.
Journal: Journal of medicinal chemistry 20010927
Title: Role of cellular acidosis in production of nitric oxide in canine ischemic myocardium.
Journal: Journal of molecular and cellular cardiology 20010901
Title: Rapid acid extrusion response triggered by alpha(1) adrenoceptor in CHO cells.
Journal: The Journal of physiology 20010815
Title: Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide.
Journal: The Journal of pharmacology and experimental therapeutics 20010801
Title: Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide.
Journal: Circulation 20010710
Title: NHE and ICAM-1 expression in hypoxic/reoxygenated coronary microvascular endothelial cells.
Journal: American journal of physiology. Heart and circulatory physiology 20010601
Title: Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559.
Journal: European journal of pharmacology 20010518
Title: Na(+)/H(+)-exchange inhibition and aprotinin administration: promising tools for myocardial protection during minimally invasive CABG.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010501
Title: Second-site revertants of a low-sodium-affinity mutant of the Na+/H+ exchanger reveal the participation of TM4 into a highly constrained sodium-binding site.
Journal: Biochemistry 20010424
Title: Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.
Journal: Bioorganic & medicinal chemistry letters 20010326
Title: Mitochondrial ATP-sensitive K+ channels play a role in cardioprotection by Na+-H+ exchange inhibition against ischemia/reperfusion injury.
Journal: Journal of the American College of Cardiology 20010301
Title: Inhibition of the Na(+)/H(+) exchanger delays the development of rapid pacing-induced atrial contractile dysfunction.
Journal: Circulation 20010206
Title: Na(+)/H(+) exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats.
Journal: American journal of physiology. Heart and circulatory physiology 20010201
Title: HOE-642 (cariporide) alters pH(i) and diastolic function after ischemia during reperfusion in pig hearts in situ.
Journal: American journal of physiology. Heart and circulatory physiology 20010201
Title: Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants?
Journal: The Journal of thoracic and cardiovascular surgery 20010101
Title: Verapamil prevents stretch-induced shortening of atrial effective refractory period in langendorff-perfused rabbit heart.
Journal: Journal of cardiovascular electrophysiology 20010101
Title: Hearts from non-heart-beating donors: sodium-hydrogen-inhibitor cariporide improves functional recovery.
Journal: Transplantation proceedings 20010101
Title: The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure.
Journal: Drugs 20010101
Title: [The Na+/Ca2+ exchanger as responsible for myocardial stunning].
Journal: Medicina 20010101
Title: Influence of ammonia on sodium absorption in rat proximal colon.
Journal: Pflugers Archiv : European journal of physiology 20000801
Title: Antiarrhythmic effects of HOE642, a novel Na(+)-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts.
Journal: European journal of pharmacology 19961219
Title: Teshima Y, et al. Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation. 2003 Nov 4;108(18):2275-81.
Title: Chang HB, et al. Na(+)/H(+) exchanger in the regulation of platelet activation and paradoxical effects of cariporide. Exp Neurol. 2015 Oct;272:11-6.
Title: O'Donnell ME, et al. Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. J Cereb Blood Flow Metab. 2013 Feb;33(2):225-34.
