Home Iodos 160003-66-7
160003-66-7,MFCD11110639
Catalog No.:AA001RIZ

160003-66-7 | 4-Iodo-3-nitrobenzamide

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10mg
98%
in stock  
$6.00   $4.00
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25mg
98%
in stock  
$7.00   $5.00
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50mg
98%
in stock  
$9.00   $7.00
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100mg
98%
in stock  
$15.00   $11.00
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250mg
98%
in stock  
$22.00   $15.00
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1g
98%
in stock  
$61.00   $43.00
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5g
98%
in stock  
$171.00   $120.00
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25g
98%
in stock  
$580.00   $406.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001RIZ
Chemical Name:
4-Iodo-3-nitrobenzamide
CAS Number:
160003-66-7
Molecular Formula:
C7H5IN2O3
Molecular Weight:
292.0307
MDL Number:
MFCD11110639
SMILES:
[O-][N+](=O)c1cc(ccc1I)C(=O)N
Properties
Computed Properties
 
Complexity:
228  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.3  

Literature

Title: Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.

Journal: Cell metabolism 20140603

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Iniparib plus paclitaxel and carboplatin as initial treatment of advanced or recurrent uterine carcinosarcoma: a Gynecologic Oncology Group Study.

Journal: Gynecologic oncology 20120901

Title: Neoadjuvant treatments for triple-negative breast cancer (TNBC).

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20120801

Title: Current and emerging targeted therapies for metastatic breast cancer.

Journal: Cancer 20120615

Title: Dissecting the heterogeneity of triple-negative breast cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120520

Title: Re: potential pitfalls of crossover and thoughts on iniparib in triple-negative breast cancer.

Journal: Journal of the National Cancer Institute 20120502

Title: Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides.

Journal: Chemical communications (Cambridge, England) 20120425

Title: [PARP inhibitors and breast cancer: update and perspectives].

Journal: Bulletin du cancer 20120401

Title: Drug candidates derailed in case of mistaken identity.

Journal: Nature 20120328

Title: Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120315

Title: Present status and problems on molecular targeted therapy of cancer.

Journal: Cancer research and treatment : official journal of Korean Cancer Association 20120301

Title: Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120115

Title: Basal breast cancer: a complex and deadly molecular subtype.

Journal: Current molecular medicine 20120101

Title: Ovarian cancer: opportunity for targeted therapy.

Journal: Journal of oncology 20120101

Title: BRCAness profile of sporadic ovarian cancer predicts disease recurrence.

Journal: PloS one 20120101

Title: Molecular basis of triple negative breast cancer and implications for therapy.

Journal: International journal of breast cancer 20120101

Title: Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer.

Journal: International journal of breast cancer 20120101

Title: Major clinical research advances in gynecologic cancer in 2011.

Journal: Journal of gynecologic oncology 20120101

Title: Advances in using PARP inhibitors to treat cancer.

Journal: BMC medicine 20120101

Title: Optimizing molecular-targeted therapies in ovarian cancer: the renewed surge of interest in ovarian cancer biomarkers and cell signaling pathways.

Journal: Journal of oncology 20120101

Title: Metastasis of neuroendocrine tumors are characterized by increased cell proliferation and reduced expression of the ATM gene.

Journal: PloS one 20120101

Title: Advancements in the Treatment of Metastatic Breast Cancer (MBC): The Role of Ixabepilone.

Journal: Journal of oncology 20120101

Title: The first European interdisciplinary ewing sarcoma research summit.

Journal: Frontiers in oncology 20120101

Title: Potential pitfalls of crossover and thoughts on iniparib in triple-negative breast cancer.

Journal: Journal of the National Cancer Institute 20111207

Title: The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy.

Journal: Therapeutic advances in medical oncology 20111101

Title: Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition.

Journal: Cancer science 20111001

Title: PARP inhibitors--current status and the walk towards early breast cancer.

Journal: Breast (Edinburgh, Scotland) 20111001

Title: DNA-damaging therapies emerging as possible triple-negative breast cancer therapies.

Journal: Oncology (Williston Park, N.Y.) 20111001

Title: PARP inhibitors: its role in treatment of cancer.

Journal: Chinese journal of cancer 20110701

Title: Novel agents and future directions for refractory breast cancer.

Journal: Seminars in oncology 20110601

Title: Iniparib in metastatic triple-negative breast cancer.

Journal: The New England journal of medicine 20110505

Title: Few positives for triple-negative breast cancer.

Journal: Journal of the National Cancer Institute 20110406

Title: Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer.

Journal: Anticancer research 20110401

Title: Triple negative breast cancer: unmet medical needs.

Journal: Breast cancer research and treatment 20110201

Title: Iniparib plus chemotherapy in metastatic triple-negative breast cancer.

Journal: The New England journal of medicine 20110120

Title: PARP and cancer--if it's broke, don't fix it.

Journal: The New England journal of medicine 20110120

Title: PARP inhibitors in oncology: a new synthetic lethal approach to cancer therapy.

Journal: Acta clinica Belgica 20110101

Title: Promising molecular targeted therapies in breast cancer.

Journal: Indian journal of pharmacology 20110101

Title: Targeted treatment of recurrent platinum-resistant ovarian cancer: current and emerging therapies.

Journal: Cancer management and research 20110101

Title: Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells.

Journal: BMC pharmacology 20110101

Title: Drug therapy for hereditary cancers.

Journal: Hereditary cancer in clinical practice 20110101

Title: Management options in triple-negative breast cancer.

Journal: Breast cancer : basic and clinical research 20110101

Title: Poly(ADP-ribose) polymerase inhibition: a new direction for BRCA and triple-negative breast cancer?

Journal: Breast cancer research : BCR 20110101

Title: Tips and tricks in triple-negative breast cancer: how to manage patients in real-life practice?

Journal: Ecancermedicalscience 20110101

Title: Triple-negative breast cancer: adjuvant therapeutic options.

Journal: Chemotherapy research and practice 20110101

Title: [PARP inhibitors to treat triple negative breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20101201

Title: Iniparib, a PARP1 inhibitor for the potential treatment of cancer, including triple-negative breast cancer.

Journal: IDrugs : the investigational drugs journal 20100901

Title: Small-molecule PARP modulators--current status and future therapeutic potential.

Journal: Current opinion in drug discovery & development 20100901

Title: Beyond PARP inhibitors: agents in pipelines target DNA repair mechanisms.

Journal: Journal of the National Cancer Institute 20100804

Title: Treatment options for patients with triple-negative breast cancer.

Journal: Journal of hematology & oncology 20100101

Title: Directed therapy of subtypes of triple-negative breast cancer.

Journal: The oncologist 20100101

Title: Enzymatic mechanism of the tumoricidal action of 4-iodo-3-nitrobenzamide.

Journal: Molecular medicine reports 20090101

Title: Anti-cancer action of 4-iodo-3-nitrobenzamide in combination with buthionine sulfoximine: inactivation of poly(ADP-ribose) polymerase and tumor glycolysis and the appearance of a poly(ADP-ribose) polymerase protease.

Journal: Biochemical pharmacology 20020201

Title: Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture.

Journal: Biochemical pharmacology 19950825

Title: Liu X, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18(2):510-23.

Title: Yin S, et al. Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells. PLoS One. 2017 Aug 17;12(8):e0183578.

Title: Ma W, et al. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5.

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