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161230-88-2,MFCD00935266
Catalog No.:AA001S6R

161230-88-2 | Mdl 105519

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5mg
99%
1 week  
$209.00   $147.00
- +
10mg
99%
1 week  
$320.00   $224.00
- +
25mg
99%
1 week  
$622.00   $435.00
- +
50mg
99%
1 week  
$1,019.00   $713.00
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100mg
99%
1 week  
$1,590.00   $1,113.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001S6R
Chemical Name:
Mdl 105519
CAS Number:
161230-88-2
Molecular Formula:
C18H11Cl2NO4
Molecular Weight:
376.1902
MDL Number:
MFCD00935266
SMILES:
Clc1cc(Cl)c2c(c1)[nH]c(c2/C=C(\c1ccccc1)/C(=O)O)C(=O)O
Properties
Computed Properties
 
Complexity:
561  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
4.8  

Literature

Title: Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation.

Journal: Synapse (New York, N.Y.) 20091001

Title: Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070901

Title: CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.

Journal: Journal of medicinal chemistry 20050224

Title: An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.

Journal: The Journal of pharmacology and experimental therapeutics 20050201

Title: Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands.

Journal: Journal of structural biology 20040301

Title: Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity.

Journal: European journal of medicinal chemistry 20031001

Title: Expression of a soluble glycine binding domain of the NMDA receptor in Escherichia coli.

Journal: Biochemical and biophysical research communications 20030606

Title: Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors.

Journal: Bioscience, biotechnology, and biochemistry 20021201

Title: Radioligand binding assays for the glycine site on N-methyl-D-aspartate receptors.

Journal: Current protocols in pharmacology 20020801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: 4-Hydroxy-6-oxo-6,7-dihydro-thieno[2,3-b] pyrimidine derivatives: synthesis and their biological evaluation for the glycine site acting on the N-methyl-D-aspartate (NMDA) receptor.

Journal: Archives of pharmacal research 20010801

Title: Ontogeny of ionotropic glutamate receptor expression in human fetal brain.

Journal: Brain research. Developmental brain research 20010430

Title: NMDA recepter-mediated neuroprotection by essential oils from the rhizomes of Acorus gramineus.

Journal: Life sciences 20010216

Title: Characterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonists.

Journal: British journal of pharmacology 20000501

Title: [3H]MDL 105,519 binds with equal high affinity to both assembled and unassembled NR1 subunits of the NMDA receptor.

Journal: European journal of pharmacology 19980717

Title: Baron BM, et al. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. Eur J Pharmacol. 1997 Apr 4;323(2-3):181-92.

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