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Title: Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450.
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Title: Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism.
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Title: Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.
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Title: Regulation of CYP3A genes by glucocorticoids in human lung cells.
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Title: Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen.
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Title: Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist.
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Title: Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine.
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Title: Vestibular toxicity of cis-2-pentenenitrile in the rat.
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Title: [Metabolic detoxification of bakuchiol is mediated by cytochrome P450 enzymes in human liver microsomes].
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Title: Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
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Title: Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.
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Title: Determination of metabolic profile of anti-malarial trioxane CDRI 99/411 in rat liver microsomes using HPLC.
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Title: Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats.
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Title: Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes.
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Title: The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo.
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Title: Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.
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Title: Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes.
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Title: Biotransformation enzyme-dependent formation of micronucleus and multinuclei in cell line V79-hCYP2E1-hSULT1A1 by 2-nitropropane and N-nitrosodimethylamine.
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Title: Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans.
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Title: 1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase.
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Title: The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.
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Title: Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4.
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Title: Postmenopausal hypertension: role of 20-HETE.
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Title: Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.
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Title: Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model.
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Title: Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice.
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Title: Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model.
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Title: Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
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Title: Dual effects of estrogen on vascular smooth muscle cells: receptor-mediated proliferative vs. metabolite-induced pro-senescent actions.
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Title: An oxygenase inhibitor study in Solanum lycopersicum combined with metabolite profiling analysis revealed a potent peroxygenase inactivator.
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Title: Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock.
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Title: Derivatization of the azole 1-aminobenzotriazole using laccase of Pycnoporus cinnabarinus and Myceliophthora thermophila: influence of methanol on the reaction and biological evaluation of the derivatives.
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Title: Differential oxidative metabolism and 5-ketoclomazone accumulation are involved in Echinochloa phyllopogon resistance to clomazone.
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Title: Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR.
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Title: 3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.
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Title: Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis.
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Title: Biotransformation of beta-myrcene to geraniol by a strain of Rhodococcus erythropolis isolated by selective enrichment from hop plants.
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Title: White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR.
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Title: Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion.
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Title: 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice.
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Title: Benzyne arylation of oxathiane glycosyl donors.
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Title: Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice.
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Title: Capsaicinoids, chloropicrin and sulfur mustard: possibilities for exposure biomarkers.
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Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
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Title: Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers.
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Title: Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla.
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Title: Dechlorination of 1,2,3- and 1,2,4-trichlorobenzene by the white-rot fungus Trametes versicolor.
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Title: Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice.
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Title: Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse.
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Title: Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of ibuprofen by Trametes versicolor.
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Title: Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?
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Title: Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes.
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Title: Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice.
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Title: Involvement of cytochrome P450-mediated metabolism in tienilic acid hepatotoxicity in rats.
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Title: Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites.
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Title: Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol.
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Title: Validation of the use of nonnaive surgically catheterized rats for pharmacokinetics studies.
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Title: Responses to clomazone and 5-ketoclomazone by Echinochloa phyllopogon resistant to multiple herbicides in Californian rice fields.
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Title: Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes.
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Title: Role of biotransformation in 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione-induced hepatotoxicity in Fischer 344 rats.
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Title: Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.
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Title: Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes.
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Title: Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.
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Title: Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726.
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Title: Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes.
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Title: Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model.
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Title: Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes.
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Title: Accelerated cytotoxic mechanism screening of hydralazine using an in vitro hepatocyte inflammatory cell peroxidase model.
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Title: The use of 1-aminobenzotriazole in differentiating the role of CYP-mediated first pass metabolism and absorption in limiting drug oral bioavailability: a case study.
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Title: Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.
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Title: 1-Phenyl-4-(triphenyl-phosphanyl-idene)pyrrolidine-2,3,5-trione.
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Title: Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats.
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Title: Mechanistics of trichloroethylene mineralization by the white-rot fungus Trametes versicolor.
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Title: In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers.
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Title: CYP3A4 and CYP3A5 catalyse the conversion of the N-methyl-D-aspartate (NMDA) antagonist CJ-036878 to two novel dimers.
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Title: Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: The cytochrome p450 inhibitor ketoconazole potentiates 5-hydroxytryptamine-induced contraction in rat aorta.
Journal: The Journal of pharmacology and experimental therapeutics 20071101
Title: Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101
Title: Degradation of 2,5-dimethylpyrazine by Rhodococcus erythropolis strain DP-45 isolated from a waste gas treatment plant of a fishmeal processing company.
Journal: Biodegradation 20071001
Title: Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
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Title: The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore.
Journal: The Journal of pharmacology and experimental therapeutics 20070901
Title: Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression.
Journal: Mutagenesis 20070501
Title: Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling.
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Title: Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.
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Title: Reactivity of dehydrometallophthalocyanines and -porphyrazines.
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Title: Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450.
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Title: Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats.
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Title: Novel aerobic perchloroethylene degradation by the white-rot fungus Trametes versicolor.
Journal: Environmental science & technology 20061215
Title: Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/-and wild-type mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201
Title: Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth.
Journal: Journal of lipid research 20061201
Title: CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].
Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201
Title: Effects of quercetin on beta-apo-8'-carotenal-induced DNA damage and cytochrome P1A2 expression in A549 cells.
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Title: Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101
Title: Acrylonitrile-induced oxidative DNA damage in rat astrocytes.
Journal: Environmental and molecular mutagenesis 20061001
Title: Nitric oxide/cytochrome P450 interactions in cyclosporin A-induced effects in the rat.
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Title: Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration.
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Title: Regioselective hydroxylation of adamantane by Streptomyces griseoplanus cells.
Journal: Applied microbiology and biotechnology 20060701
Title: Activation of T cells by carbamazepine and carbamazepine metabolites.
Journal: The Journal of allergy and clinical immunology 20060701
Title: In vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance.
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Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
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Title: Growth of Phanerochaete chrysosporium on diesel fuel hydrocarbons at neutral pH.
Journal: Chemosphere 20060401
Title: Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060401
Title: Flavonoids suppresses the enhancing effect of beta-carotene on DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A549 cells.
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Title: Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats.
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Title: Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus.
Journal: American journal of physiology. Renal physiology 20051201
Title: Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver.
Journal: Life sciences 20051021
Title: Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
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Title: In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.
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Title: Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery.
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Title: Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats.
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Title: Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice.
Journal: Toxicology and applied pharmacology 20050601
Title: Extrahepatic metabolism of carbamate and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050201
Title: Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver.
Journal: Hepatology (Baltimore, Md.) 20050201
Title: Preparation of tertiary alkyl carbinamines, propargylamines, and alpha-heteroarylamines by ketone-based aminoalkylation.
Journal: The Journal of organic chemistry 20050107
Title: A role for one or more p450 enzymes in the response to sepsis.
Journal: Critical care medicine 20050101
Title: The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens.
Journal: European journal of drug metabolism and pharmacokinetics 20050101
Title: Expression and activities of several drug-metabolizing enzymes in LLC-PK1 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20041201
Title: Subchronic acrylamide treatment induces a tissue-specific increase in DNA synthesis in the rat.
Journal: Toxicology letters 20041201
Title: Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20041001
Title: Endothelial cytochrome P450 contributes to the acetylcholine-induced cardiodepression in isolated rat hearts.
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Title: Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20040701
Title: The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040401
Title: Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20040301
Title: Cytochrome P450-catalyzed brassinosteroid pathway activation through synthesis of castasterone and brassinolide in Phaseolus vulgaris.
Journal: Phytochemistry 20040301
Title: Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
Journal: Chemical research in toxicology 20040301
Title: Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis.
Journal: Critical care medicine 20040201
Title: The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice.
Journal: Free radical biology & medicine 20031215
Title: Studies on the metabolism of the thiofurans furfuryl mercaptan and 2-methyl-3-furanthiol in rat liver.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20031201
Title: Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20031001
Title: Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030901
Title: Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats.
Journal: American journal of physiology. Renal physiology 20030801
Title: Effect of cytochrome P-450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female mice.
Journal: Archives of toxicology 20030801
Title: NO inhibits Na+-K+-2Cl- cotransport via a cytochrome P-450-dependent pathway in renal epithelial cells (MMDD1).
Journal: American journal of physiology. Renal physiology 20030601
Title: The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Journal: Free radical biology & medicine 20030601
Title: CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis.
Journal: American journal of physiology. Heart and circulatory physiology 20030501
Title: Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030501
Title: Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice.
Journal: The Journal of pharmacology and experimental therapeutics 20030501
Title: Biodegradation of chloronaphthalenes and polycyclic aromatic hydrocarbons by the white-rot fungus Phlebia lindtneri.
Journal: Applied microbiology and biotechnology 20030501
Title: Concurrent corticosteroid and phenanthrene transformation by filamentous fungus Cunninghamella elegans.
Journal: The Journal of steroid biochemistry and molecular biology 20030501
Title: [Effects of acrylamide on DNA damage in human keratinocytes].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20030401
Title: Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
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Title: 3-methylindole-induced toxicity to human bronchial epithelial cell lines.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030201
Title: In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.
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Title: Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021001
Title: Oxidation of dibenzo- p-dioxin, dibenzofuran, biphenyl, and diphenyl ether by the white-rot fungus Phlebia lindtneri.
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Title: Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung.
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Title: NTP Technical Report on the metabolism, toxicity and predicted carcinogenicity of diazoaminobenzene (CAS No. 136-35-6).
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Title: Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II.
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Title: Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile.
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Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
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Title: Methoxyestradiols mediate estradiol-induced antimitogenesis in human aortic SMCs.
Journal: Hypertension (Dallas, Tex. : 1979) 20020401
Title: Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020201
Title: Acrylamide-induced cellular transformation.
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Title: Renal damage, metabolism and covalent binding following administration of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) to male Fischer 344 rats.
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Title: Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.
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Title: Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide.
Journal: American journal of physiology. Renal physiology 20010901
Title: State-dependent block of rabbit vascular smooth muscle delayed rectifier and Kv1.5 channels by inhibitors of cytochrome P450-dependent enzymes.
Journal: The Journal of pharmacology and experimental therapeutics 20010801
Title: Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes).
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010601
Title: Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.
Journal: American journal of physiology. Heart and circulatory physiology 20010601
Title: An evaluation of the mutagenicity, metabolism, and DNA adduct formation of 5-nitrobenzo[b]naphtho[2,1-d]thiophene.
Journal: Chemical research in toxicology 20010601
Title: Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
Journal: Cancer gene therapy 20010601
Title: Inhibition of cytochrome P450 2E1 decreases, but does not eliminate, genotoxicity mediated by 1,3-butadiene.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20000601
Title: The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats.
Journal: Toxicology letters 19970919
Title: Benzoic acid 2-hydroxylase, a soluble oxygenase from tobacco, catalyzes salicylic acid biosynthesis.
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Title: Purification and properties of isoenzymes of cinnamyl-alcohol dehydrogenase from soybean-cell-suspension cultures.
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