Home Fluorides 1622-79-3
1622-79-3,MFCD00270922
Catalog No.:AA001ST5

1622-79-3 | 1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one hydrochloride

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5mg
≥98%
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$53.00   $37.00
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10mg
≥98%
in stock  
$93.00   $65.00
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25mg
≥98%
in stock  
$166.00   $116.00
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50mg
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$255.00   $178.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001ST5
Chemical Name:
1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one hydrochloride
CAS Number:
1622-79-3
Molecular Formula:
C16H23ClFNO
Molecular Weight:
299.8113
MDL Number:
MFCD00270922
SMILES:
CC1CCN(CC1)CCCC(=O)c1ccc(cc1)F.Cl
NSC Number:
760102
Properties
Computed Properties
 
Complexity:
279  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  

Downstream Synthesis Route
CASUnavailable 
  3874-54-2    1622-79-3 

[1]CurrentPatentAssignee:CRISTALIAPRODUTOSQUIMICOSFARMACEUTICOS,LTDA-EP2905278,2015,A1Locationinpatent:Paragraph0158

[1]Griffiths,RobertJ.;Burley,GlennA.;Talbot,EricP.A.[OrganicLetters,2017,vol.19,#4,p.870-873]

Literature

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Journal: Drug development and industrial pharmacy 20121101

Title: Melperone is ineffective in treating Parkinson's disease psychosis.

Journal: Movement disorders : official journal of the Movement Disorder Society 20120501

Title: Auditing clinical outcomes after introducing off-licence prescribing of atypical antipsychotic melperone for patients with treatment refractory schizophrenia.

Journal: TheScientificWorldJournal 20120101

Title: Changes in weight and body mass index during treatment with melperone, clozapine and typical neuroleptics.

Journal: Psychiatry research 20100430

Title: Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics.

Journal: Human psychopharmacology 20090701

Title: Diminished glucocorticoid negative feedback in polydipsic hyponatremic schizophrenic patients.

Journal: The Journal of clinical endocrinology and metabolism 20070201

Title: Cytochrome P450 2D6 dependent metabolization of risperidone is inhibited by melperone.

Journal: European journal of clinical pharmacology 20060401

Title: Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor.

Journal: European journal of medicinal chemistry 20050201

Title: P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6.

Journal: Journal of psychopharmacology (Oxford, England) 20041201

Title: Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms.

Journal: Pharmacology, biochemistry, and behavior 20040201

Title: [Treatment of behavioral disorders in dementia with risperidone in psychogeriatric out-patients].

Journal: MMW Fortschritte der Medizin 20031009

Title: A comparison of two doses of melperone, an atypical antipsychotic drug, in the treatment of schizophrenia.

Journal: Schizophrenia research 20030701

Title: The effect of melperone, an atypical antipsychotic drug, on cognitive function in schizophrenia.

Journal: Schizophrenia research 20030101

Title: Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.

Journal: Pharmacopsychiatry 20030101

Title: Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism.

Journal: Brain research 20021129

Title: [Atypical neuroleptics in dementia. Managing behavioral disorders early and efficiently].

Journal: MMW Fortschritte der Medizin 20020307

Title: Melperone in the treatment of neuroleptic-resistant schizophrenia.

Journal: Psychiatry research 20011231

Title: [Practical experiences in the therapy of postweaning edema disease in piglets].

Journal: Berliner und Munchener tierarztliche Wochenschrift 19961001

Title: Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications.

Journal: European journal of pharmacology 19930604

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SDS
Tags:1622-79-3 Molecular Formula|1622-79-3 MDL|1622-79-3 SMILES|1622-79-3 1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one hydrochloride