[1]Patent:US2017/73304,2017,A1.Locationinpatent:Paragraph0025
[2]Patent:WO2016/203410,2016,A1.Locationinpatent:Page/Pagecolumn16;17;18;19
[3]Chemicalandpharmaceuticalbulletin,2003,vol.51,p.313-314
[4]Patent:US5494911,1996,A
[5]Patent:US5504084,1996,A
[6]Patent:US5519042,1996,A
[7]ChemicalCommunications,2012,vol.48,p.11781-11783
[8]ChemicalPhysicsLetters,2014,vol.613,p.127-132
[9]GreenChemistry,2017,vol.19,p.2541-2545
[10]ChemCatChem,2019,vol.11,p.1425-1430
[1]CurrentPatentAssignee:ALEMBICPHARMACEUTICALSLIMITED-WO2010/13159,2010,A1Locationinpatent:Page/Pagecolumn7
[1]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-US2016/58730,2016,A1
Title: Mitochondrial dysfunction induced by leflunomide and its active metabolite.
Journal: Toxicology 20180301
Title: Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.
Journal: Archives of toxicology 20170101
Title: Long-term safety and efficacy of teriflunomide: Nine-year follow-up of the randomized TEMSO study.
Journal: Neurology 20160308
Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
Journal: Chemical research in toxicology 20150518
Title: Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives.
Journal: Journal of medicinal chemistry 20131024
Title: On dihydroorotate dehydrogenases and their inhibitors and uses.
Journal: Journal of medicinal chemistry 20130425
Title: Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.
Journal: Journal of medicinal chemistry 20121011
Title: New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.
Journal: European journal of medicinal chemistry 20120301
Title: Biaryl analogues of teriflunomide as potent DHODH inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20111215
Title: Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110801
Title: 1,2,5-Oxadiazole analogues of leflunomide and related compounds.
Journal: European journal of medicinal chemistry 20110101
Title: Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.
Journal: Journal of medicinal chemistry 20090514
Title: ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.
Journal: Bioorganic & medicinal chemistry 20090201
Title: Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells.
Journal: Molecular cancer therapeutics 20090201
Title: Spotlight on teriflunomide.
Journal: International MS journal 20080601
Title: The immunomodulatory drug Leflunomide inhibits cell cycle progression of B-CLL cells.
Journal: Leukemia 20080301
Title: Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.
Journal: Journal of medicinal chemistry 20070125
Title: A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses.
Journal: Neurology 20060328
Title: SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20051101
Title: [The active metabolite of leflunomide A771726 inhibits proliferation and collagen synthesis of hepatic stellate cell].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20041101
Title: A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools.
Journal: Molecular pharmacology 20020901
Title: Inhibition of HIV replication by A77 1726, the active metabolite of leflunomide, in combination with pyrimidine nucleoside reverse transcriptase inhibitors.
Journal: Journal of acquired immune deficiency syndromes (1999) 20011001
Title: Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects?
Journal: European journal of biochemistry 20010301
Title: New dermatological agents for the treatment of psoriasis.
Journal: Journal of medicinal chemistry 20010201
Title: Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression.
Journal: Journal of immunology (Baltimore, Md. : 1950) 19990215
Title: Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives.
Journal: Biochemical pharmacology 19981101
Title: Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria.
Journal: Biochemical pharmacology 19981015
Title: Differential modulation of pro- and anti-inflammatory cytokine receptors by N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxy-crotonic acid amide (A77 1726), the physiologically active metabolite of the novel immunomodulator leflunomide.
Journal: Biochemical pharmacology 19980501