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163706-36-3,MFCD14635359
Catalog No.:AA001U93

163706-36-3 | 5'-Adenylic acid, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P'-(dichloromethylene)bis[phosphonic acid], sodium salt (1:1:4)

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1mg
98%
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$22.00   $15.00
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5mg
98%
in stock  
$52.00   $36.00
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10mg
98%
in stock  
$76.00   $54.00
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25mg
98%
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$128.00   $89.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001U93
Chemical Name:
5'-Adenylic acid, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P'-(dichloromethylene)bis[phosphonic acid], sodium salt (1:1:4)
CAS Number:
163706-36-3
Molecular Formula:
C17H21Cl2F3N5Na4O12P3S2
Molecular Weight:
864.2865
MDL Number:
MFCD14635359
SMILES:
CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)([O-])[O-])(Cl)Cl)[O-])[O-].[Na+].[Na+].[Na+].[Na+]
Properties
Computed Properties
 
Complexity:
1110  
Covalently-Bonded Unit Count:
5  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
48  
Hydrogen Bond Acceptor Count:
21  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
14  

Literature

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Title: Overview of the 2014 Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee meeting regarding cangrelor.

Journal: The American journal of cardiology 20150415

Title: Cangrelor: an emerging therapeutic option for patients with coronary artery disease.

Journal: Current medical research and opinion 20140501

Title: Effects on platelet function of a direct acting antagonist of coagulation factor Xa.

Journal: Journal of thrombosis and thrombolysis 20121001

Title: Evaluation of ticagrelor pharmacodynamic interactions with reversibly binding or non-reversibly binding P2Y(12) antagonists in an ex-vivo canine model.

Journal: Thrombosis research 20121001

Title: Advances in antiplatelet therapy for acute coronary syndromes.

Journal: Postgraduate medical journal 20120701

Title: Synthesis of N6-alkyl(aryl)-2-alkyl(aryl)thioadenosines as antiplatelet agents.

Journal: European journal of medicinal chemistry 20120701

Title: Pharmacodynamic effects of cangrelor and clopidogrel: the platelet function substudy from the cangrelor versus standard therapy to achieve optimal management of platelet inhibition (CHAMPION) trials.

Journal: Journal of thrombosis and thrombolysis 20120701

Title: Short-acting P2Y12 blockade to reduce platelet dysfunction and coagulopathy during experimental extracorporeal circulation and hypothermia.

Journal: British journal of anaesthesia 20120601

Title: Rationale and design of the Cangrelor versus standard therapy to acHieve optimal Management of Platelet InhibitiON PHOENIX trial.

Journal: American heart journal 20120501

Title: Reduced immediate ischemic events with cangrelor in PCI: a pooled analysis of the CHAMPION trials using the universal definition of myocardial infarction.

Journal: American heart journal 20120201

Title: Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial.

Journal: JAMA 20120118

Title: Thienopyridines and other ADP-receptor antagonists.

Journal: Handbook of experimental pharmacology 20120101

Title: The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.

Journal: PloS one 20120101

Title: BF061, a novel antiplatelet and antithrombotic agent targeting P2Y₁₂ receptor and phosphodiesterase.

Journal: Thrombosis and haemostasis 20111201

Title: Nucleotides control the excitability of sensory neurons via two P2Y receptors and a bifurcated signaling cascade.

Journal: Pain 20110801

Title: Beyond aspirin and clopidogrel: is there a need for additional antiplatelet therapy in ACS?

Journal: Current cardiology reports 20110801

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Journal: Hamostaseologie 20110502

Title: High residual platelet reactivity on standard clopidogrel maintenance dose predicts increased responsiveness to the double-standard dose in an assay-dependent manner.

Journal: Thrombosis and haemostasis 20110501

Title: Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate.

Journal: Thrombosis and haemostasis 20110501

Title: Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors.

Journal: Thrombosis and haemostasis 20110501

Title: Comparison of the VASP assay and platelet aggregometry in the evaluation of platelet P2Y12 receptor blockade.

Journal: Polskie Archiwum Medycyny Wewnetrznej 20110401

Title: [Recent advances on the studies of the platelet's inhibition and aggregation. State of the art of new P2Y12 antagonists].

Journal: Recenti progressi in medicina 20110401

Title: Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110201

Title: The new INNOVANCE® PFA P2Y cartridge is sensitive to the detection of the P2Y₁₂ receptor inhibition.

Journal: Platelets 20110101

Title: Mode of action of P2Y(12 ) antagonists as inhibitors of platelet function.

Journal: Thrombosis and haemostasis 20110101

Title: P2Y₁₂ and EP3 antagonists promote the inhibitory effects of natural modulators of platelet aggregation that act via cAMP.

Journal: Platelets 20110101

Title: Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells.

Journal: PloS one 20110101

Title: Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn.

Journal: Glia 20101115

Title: SCH 602539, a protease-activated receptor-1 antagonist, inhibits thrombosis alone and in combination with cangrelor in a Folts model of arterial thrombosis in cynomolgus monkeys.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20101101

Title: Mutational analysis of residues important for ligand interaction with the human P2Y(12) receptor.

Journal: European journal of pharmacology 20101010

Title: State of the art of new P2Y12 antagonists.

Journal: Internal and emergency medicine 20101001

Title: Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism.

Journal: Thrombosis research 20101001

Title: BF0801, a novel adenine derivative, inhibits platelet activation via phosphodiesterase inhibition and P2Y12 antagonism.

Journal: Thrombosis and haemostasis 20101001

Title: P2Y13 receptor is critical for reverse cholesterol transport.

Journal: Hepatology (Baltimore, Md.) 20101001

Title: Update on the clinical development of cangrelor.

Journal: Expert review of cardiovascular therapy 20100801

Title: Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts.

Journal: Thrombosis and haemostasis 20100701

Title: [Novel agents in antiplatelet therapy].

Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20100701

Title: Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.

Journal: Journal of medicinal chemistry 20100513

Title: Two-pore potassium ion channels are inhibited by both G(q/11)- and G(i)-coupled P2Y receptors.

Journal: Molecular and cellular neurosciences 20100401

Title: Platelet inhibition with cangrelor.

Journal: The New England journal of medicine 20100318

Title: Platelet inhibition with cangrelor.

Journal: The New England journal of medicine 20100318

Title: Antiplatelet therapy: cangrelor for ACS-lessons from the CHAMPION trials.

Journal: Nature reviews. Cardiology 20100301

Title: Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases.

Journal: British journal of pharmacology 20100201

Title: The influence of variation in the P2Y12 receptor gene on in vitro platelet inhibition with the direct P2Y12 antagonist cangrelor.

Journal: Thrombosis and haemostasis 20100201

Title: Testing a new approach for rapid and reversible platelet inhibition during percutaneous coronary intervention among patients with acute coronary syndrome.

Journal: Hospital practice (1995) 20100201

Title: Emerging P2Y12 receptor antagonists: role in coronary artery disease.

Journal: Current vascular pharmacology 20100101

Title: Pharmacokinetics and pharmacodynamics of a bolus and infusion of cangrelor: a direct, parenteral P2Y12 receptor antagonist.

Journal: Journal of clinical pharmacology 20100101

Title: Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system.

Journal: Platelets 20100101

Title: Platelet inhibition with cangrelor in patients undergoing PCI.

Journal: The New England journal of medicine 20091210

Title: Intravenous platelet blockade with cangrelor during PCI.

Journal: The New England journal of medicine 20091210

Title: Cangrelor - a champion lost in translation?

Journal: The New England journal of medicine 20091210

Title: New antiplatelet agents: why they are needed.

Journal: European journal of internal medicine 20091201

Title: Ticagrelor--a new platelet aggregation inhibitor in patients with acute coronary syndromes. An improvement of other inhibitors?

Journal: Medical science monitor : international medical journal of experimental and clinical research 20091201

Title: Cangrelor: a review on its mechanism of action and clinical development.

Journal: Expert review of cardiovascular therapy 20091001

Title: Cangrelor: a novel P2Y12 receptor antagonist.

Journal: Expert opinion on investigational drugs 20090801

Title: New P2Y12 blockers.

Journal: Journal of thrombosis and haemostasis : JTH 20090701

Title: The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.

Journal: The Journal of biological chemistry 20090612

Title: Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin.

Journal: Platelets 20090601

Title: Mechanism of activation and functional role of protein kinase Ceta in human platelets.

Journal: The Journal of biological chemistry 20090515

Title: New antiplatelet drugs: beyond aspirin and clopidogrel.

Journal: International journal of clinical practice 20090501

Title: Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation.

Journal: Coronary artery disease 20090301

Title: Advances in antiplatelet therapy: agents in clinical development.

Journal: The American journal of cardiology 20090202

Title: Cangrelor attenuates coated-platelet formation.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20090101

Title: RhoA/ROCK I signalling downstream of the P2Y13 ADP-receptor controls HDL endocytosis in human hepatocytes.

Journal: Cellular signalling 20090101

Title: Current problems, new opportunities and future directions of anti-platelet therapy - increasing role of novel antiplatelet agents in cardiovascular diseases.

Journal: Recent patents on cardiovascular drug discovery 20090101

Title: Novel antiplatelet agents in development: prasugrel, ticagrelor, and cangrelor and beyond.

Journal: American journal of therapeutics 20090101

Title: Update on antiplatelet therapy in acute coronary syndromes: what do new drugs bring into clinical practice?

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

Title: Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future.

Journal: Nature clinical practice. Cardiovascular medicine 20081201

Title: DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease.

Journal: Platelets 20081201

Title: Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptor.

Journal: Biochemical pharmacology 20081115

Title: Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy.

Journal: Thrombosis and haemostasis 20081101

Title: Future prospects in anti-platelet therapy: a review of potential P2Y12 and thrombin receptor antagonists.

Journal: Recent patents on cardiovascular drug discovery 20081101

Title: Pharmacology of emerging novel platelet inhibitors.

Journal: American heart journal 20080801

Title: Clinical overview of promising nonthienopyridine antiplatelet agents.

Journal: American heart journal 20080801

Title: Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor.

Journal: Thrombosis and haemostasis 20080801

Title: The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function.

Journal: Journal of thrombosis and haemostasis : JTH 20080701

Title: Antiplatelet therapy in acute coronary syndromes.

Journal: Current cardiology reports 20080701

Title: Multiple electrode aggregometry and P2Y(12) antagonists.

Journal: Thrombosis and haemostasis 20080601

Title: Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia.

Journal: Journal of neuroscience research 20080515

Title: P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080507

Title: The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses.

Journal: Platelets 20080301

Title: Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents.

Journal: Platelets 20080301

Title: Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect.

Journal: Thrombosis research 20080101

Title: GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.

Journal: BMC bioinformatics 20080101

Title: Enhanced platelet aggregation and activation under conditions of hypothermia.

Journal: Thrombosis and haemostasis 20071201

Title: Preliminary experience with intravenous P2Y12 platelet receptor inhibition as an adjunct to reduced-dose alteplase during acute myocardial infarction: results of the Safety, Tolerability and Effect on Patency in Acute Myocardial Infarction (STEP-AMI) angiographic trial.

Journal: American heart journal 20071001

Title: Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents.

Journal: The American journal of cardiology 20070815

Title: New antiplatelet therapies for acute coronary syndromes.

Journal: Current cardiology reports 20070701

Title: Inhibition of the platelet P2Y12 receptor for adenosine diphosphate potentiates the antiplatelet effect of prostacyclin.

Journal: Journal of thrombosis and haemostasis : JTH 20070301

Title: Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques.

Journal: Thrombosis and haemostasis 20070301

Title: Platelet P2 receptors: old and new targets for antithrombotic drugs.

Journal: Expert review of cardiovascular therapy 20070101

Title: ADP receptor antagonism: what's in the pipeline?

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

Title: Comparison of VASP-phosphorylation assay to light-transmission aggregometry in assessing inhibition of the platelet ADP P2Y12 receptor.

Journal: Thrombosis and haemostasis 20061201

Title: Aspirin and clopidogrel resistance: consideration and management.

Journal: Journal of interventional cardiology 20061001

Title: Effects on blood compatibility in vitro by combining a direct P2Y12 receptor inhibitor and heparin coating of stents.

Journal: Platelets 20060801

Title: Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha(IIb)beta3 activation: association with Rap1B activation.

Journal: Journal of thrombosis and haemostasis : JTH 20060601

Title: Can the PFA-100 be modified to detect P2Y12 inhibition?

Journal: Journal of thrombosis and haemostasis : JTH 20060601

Title: Cangrelor for treatment of coronary thrombosis.

Journal: The Annals of pharmacotherapy 20060501

Title: P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation.

Journal: Journal of thrombosis and haemostasis : JTH 20060301

Title: Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial.

Journal: American heart journal 20060301

Title: Evaluation of platelet function, a method comparison.

Journal: Platelets 20060201

Title: Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling.

Journal: Journal of the American College of Cardiology 20060103

Title: The nucleotide receptor P2Y13 is a key regulator of hepatic high-density lipoprotein (HDL) endocytosis.

Journal: Cellular and molecular life sciences : CMLS 20051101

Title: Glycoprotein IIb/IIIa and P2Y12 receptor antagonists yield additive inhibition of platelet aggregation, granule secretion, soluble CD40L release and procoagulant responses.

Journal: Platelets 20051101

Title: Evidence that the purinergic receptor P2Y12 potentiates platelet shape change by a Rho kinase-dependent mechanism.

Journal: Platelets 20051101

Title: Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons.

Journal: European journal of pharmacology 20051003

Title: P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets.

Journal: Thrombosis and haemostasis 20050501

Title: Preclinical and clinical studies with selective reversible direct P2Y12 antagonists.

Journal: Seminars in thrombosis and hemostasis 20050401

Title: P2Y receptor antagonists in thrombosis.

Journal: Current opinion in investigational drugs (London, England : 2000) 20050301

Title: Inhibitory effects of P2Y12 receptor antagonists on TRAP-induced platelet aggregation, procoagulant activity, microparticle formation and intracellular calcium responses in patients with acute coronary syndromes.

Journal: Platelets 20050301

Title: P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetes.

Journal: The Journal of clinical endocrinology and metabolism 20050201

Title: Regulation of tissue factor-induced coagulation and platelet aggregation in flowing whole blood.

Journal: Thrombosis and haemostasis 20050101

Title: Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases.

Journal: Journal of thrombosis and haemostasis : JTH 20050101

Title: Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin.

Journal: Thrombosis research 20050101

Title: Investigation of the PADA as a method for monitoring GPIIb/IIIa inhibitors and other antiplatelet agents.

Journal: Seminars in thrombosis and hemostasis 20050101

Title: Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels.

Journal: The European journal of neuroscience 20041201

Title: P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B.

Journal: Journal of neurochemistry 20040401

Title: Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation.

Journal: FEBS letters 20040102

Title: Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1.

Journal: Cell calcium 20040101

Title: Pharmacodynamic profile of antiplatelet agents: marked differences between single versus costimulation with platelet activators.

Journal: Thrombosis research 20040101

Title: Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20031001

Title: Potential value of triple antiplatelet therapy for secondary stroke prevention.

Journal: Stroke 20031001

Title: Effects of inhibition of P2Y(1) and P2Y(12) on whole blood clotting, coagulum elasticity and fibrinolysis resistance studied with free oscillation rheometry.

Journal: Thrombosis research 20030315

Title: In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030301

Title: Advantages of fast-acting ADP receptor blockade in ischemic heart disease.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030201

Title: Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030201

Title: A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.

Journal: The Journal of biological chemistry 20030103

Title: The effects of GPIIb-IIIa antagonists and a combination of three other antiplatelet agents on platelet-leukocyte interactions.

Journal: Current medical research and opinion 20030101

Title: Effects of the NHE-1 inhibitor cariporide alone or together with the P2Y12 antagonist AR-C 69331 MX on CD62p expression and formation of platelet-leukocyte aggregates.

Journal: Thrombosis research 20030101

Title: Agonist concentration-dependent differential responsivity of a human platelet purinergic receptor: pharmacological and kinetic studies of aggregation, deaggregation and shape change responses mediated by the purinergic P2Y1 receptor in vitro.

Journal: Platelets 20030101

Title: Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease.

Journal: Platelets 20021101

Title: Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin.

Journal: Thrombosis and haemostasis 20020901

Title: Functional significance of adenosine 5'-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate.

Journal: Circulation 20020528

Title: Safety profile and tolerability of intravenous AR-C69931MX, a new antiplatelet drug, in unstable angina pectoris and non-Q-wave myocardial infarction.

Journal: Clinical therapeutics 20020501

Title: A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets.

Journal: The Journal of biological chemistry 20020405

Title: Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20020401

Title: Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.

Journal: Thrombosis and haemostasis 20020401

Title: Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.

Journal: The Journal of biological chemistry 20011221

Title: Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow.

Journal: Blood 20011201

Title: Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro.

Journal: British journal of pharmacology 20010901

Title: Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010315

Title: Activation of Gi-coupled receptors releases a tonic state of inhibited platelet aggregation.

Journal: Platelets 20010301

Title: Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes.

Journal: Thrombosis and haemostasis 20010301

Title: ADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF-1, MDC and TARC.

Journal: FEBS letters 20010209

Title: Cangrelor AstraZeneca.

Journal: Current opinion in investigational drugs (London, England : 2000) 20010201

Title: The medicinal chemistry of the P2 receptor family.

Journal: Progress in medicinal chemistry 20010101

Title: Bhattad VB, , et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408.

Title: Zhan T, Wei T, et al. Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Mol Immunol. 2020;120:83-92.

Title: Bekő K, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain. J Thromb Haemost. 2017;15(6):1223-1235.

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Tags:163706-36-3 Molecular Formula|163706-36-3 MDL|163706-36-3 SMILES|163706-36-3 5'-Adenylic acid, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P'-(dichloromethylene)bis[phosphonic acid], sodium salt (1:1:4)