1672-58-8,MFCD00085457
Catalog No.:AA001X4S

1672-58-8 | (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)formamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$170.00   $119.00
- +
5g
95%
in stock  
$482.00   $337.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001X4S
Chemical Name:
(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)formamide
CAS Number:
1672-58-8
Molecular Formula:
C12H13N3O2
Molecular Weight:
231.2505
MDL Number:
MFCD00085457
SMILES:
O=CNc1c(C)n(n(c1=O)c1ccccc1)C
NSC Number:
60565
Properties
Properties
 
BP:
400.1°C at 760 mmHg  
Form:
Solid  
MP:
189 - 192˚C  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
359  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0  

Literature

Title: High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies.

Journal: Journal of pharmaceutical and biomedical analysis 20121201

Title: N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)formamide.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Investigation of the microbial degradation of phenazone-type drugs and their metabolites by natural biofilms derived from river water using liquid chromatography/tandem mass spectrometry (LC-MS/MS).

Journal: Water research 20100801

Title: Hydrophilic anthropogenic markers for quantification of wastewater contamination in ground- and surface waters.

Journal: Environmental toxicology and chemistry 20091201

Title: Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products.

Journal: Water research 20080501

Title: Occurrence, fate and assessment of polar metamizole (dipyrone) residues in hospital and municipal wastewater.

Journal: Chemosphere 20080401

Title: Behaviour and redox sensitivity of pharmaceutical residues during bank filtration - Investigation of residues of phenazone-type analgesics.

Journal: Chemosphere 20080401

Title: Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.

Journal: Critical care (London, England) 20080101

Title: Investigation of the behavior and metabolism of pharmaceutical residues during purification of contaminated ground water used for drinking water supply.

Journal: Chemosphere 20071101

Title: [Analysis of three metabolite residues of dipyrone in bovine muscle and pork muscle using high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20071101

Title: Long-term comparison of trace organics removal performances between conventional and membrane activated sludge processes.

Journal: Water environment research : a research publication of the Water Environment Federation 20061201

Title: Simultaneous determination of residues of dipyrone and its major metabolites in milk, bovine muscle, and porcine muscle by liquid chromatography/mass spectrometry.

Journal: Journal of AOAC International 20050101

Title: Pharmaceuticals in the river Elbe and its tributaries.

Journal: Chemosphere 20041001

Title: Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.

Journal: Liver 20021201

Title: Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.

Journal: European journal of clinical pharmacology 20010901

Title: M Levy, et al. Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis B virus. Clin Pharmacol Ther

Title: A Noda, et al.Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II. Enzymatic demethylation and oxidation of aminopyrine and 4-monomethylaminoantipyrine. Chem Pharm Bull (Tokyo).1976 Dec;24(12):3229-31.

Title: David do C Malvar, et al. Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. Br J Pharmacol. 2014 Aug;171(15):3666-79.

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SDS
Tags:1672-58-8 Molecular Formula|1672-58-8 MDL|1672-58-8 SMILES|1672-58-8 (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)formamide
Catalog No.: AA001X4S
1672-58-8,MFCD00085457
1672-58-8 | (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)formamide
Pack Size: 1g
Purity: 95%
in stock
$170.00 $119.00
Pack Size: 5g
Purity: 95%
in stock
$482.00 $337.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001X4S
Chemical Name: (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)formamide
CAS Number: 1672-58-8
Molecular Formula: C12H13N3O2
Molecular Weight: 231.2505
MDL Number: MFCD00085457
SMILES: O=CNc1c(C)n(n(c1=O)c1ccccc1)C
NSC Number: 60565
Properties
BP: 400.1°C at 760 mmHg  
Form: Solid  
MP: 189 - 192˚C  
Storage: Inert atmosphere;-20 ℃;  
Complexity: 359  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0  
Literature fold

Title: High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies.

Journal: Journal of pharmaceutical and biomedical analysis20121201

Title: N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)formamide.

Journal: Acta crystallographica. Section E, Structure reports online20110601

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Investigation of the microbial degradation of phenazone-type drugs and their metabolites by natural biofilms derived from river water using liquid chromatography/tandem mass spectrometry (LC-MS/MS).

Journal: Water research20100801

Title: Hydrophilic anthropogenic markers for quantification of wastewater contamination in ground- and surface waters.

Journal: Environmental toxicology and chemistry20091201

Title: Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products.

Journal: Water research20080501

Title: Occurrence, fate and assessment of polar metamizole (dipyrone) residues in hospital and municipal wastewater.

Journal: Chemosphere20080401

Title: Behaviour and redox sensitivity of pharmaceutical residues during bank filtration - Investigation of residues of phenazone-type analgesics.

Journal: Chemosphere20080401

Title: Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.

Journal: Critical care (London, England)20080101

Title: Investigation of the behavior and metabolism of pharmaceutical residues during purification of contaminated ground water used for drinking water supply.

Journal: Chemosphere20071101

Title: [Analysis of three metabolite residues of dipyrone in bovine muscle and pork muscle using high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography20071101

Title: Long-term comparison of trace organics removal performances between conventional and membrane activated sludge processes.

Journal: Water environment research : a research publication of the Water Environment Federation20061201

Title: Simultaneous determination of residues of dipyrone and its major metabolites in milk, bovine muscle, and porcine muscle by liquid chromatography/mass spectrometry.

Journal: Journal of AOAC International20050101

Title: Pharmaceuticals in the river Elbe and its tributaries.

Journal: Chemosphere20041001

Title: Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.

Journal: Liver20021201

Title: Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.

Journal: European journal of clinical pharmacology20010901

Title: M Levy, et al. Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis B virus. Clin Pharmacol Ther

Title: A Noda, et al.Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II. Enzymatic demethylation and oxidation of aminopyrine and 4-monomethylaminoantipyrine. Chem Pharm Bull (Tokyo).1976 Dec;24(12):3229-31.

Title: David do C Malvar, et al. Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. Br J Pharmacol. 2014 Aug;171(15):3666-79.

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