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16820-18-1,MFCD00145243
Catalog No.:AA001XUO

16820-18-1 | 2-Methyl-l-serine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
97%
in stock  
$42.00   $29.00
- +
250mg
97%
in stock  
$73.00   $51.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001XUO
Chemical Name:
2-Methyl-l-serine
CAS Number:
16820-18-1
Molecular Formula:
C4H9NO3
Molecular Weight:
119.1192
MDL Number:
MFCD00145243
SMILES:
OC[C@@](C(=O)O)(N)C
Properties
Properties
 
BP:
345.8°C at 760 mmHg  
Form:
Solid  
MP:
286-288 °C  
Refractive Index:
1.4183 (estimate)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
104  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-3.9  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2007,vol.50,p.6718-6721

[2]PolishJournalofChemistry,1991,vol.65,p.1427-1431

[3]Tetrahedron,1998,vol.54,p.14963-14974

[4]Chemistry-AEuropeanJournal,2008,vol.14,p.7042-7058

[5]TetrahedronLetters,2010,vol.51,p.2493-2496

[6]JournalofMedicinalChemistry,2010,vol.53,p.876-886

16820-18-1    1818317-50-8   
CASUnavailable 

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2015/291549,2015,A1Locationinpatent:Paragraph0950-0954

3398-40-1   
5-5-3-3-(3-bromopropoxy)-2-methylphenyl-2-methylphenylmethoxy-4-chloro-2-formylphenoxymethylpyridine-3-carbonitrile 
  498-95-3   
(3R)-1-(3-(3'-((4-(((S)-2-carboxy-1-hydroxypropan-2-ylamino)methyl)-2-chloro-5-((5-cyanopyridin-3-yl)methoxy)phenoxy)methyl)-2,2'-dimethylbiphenyl-3-yloxy)propyl)piperidine-3-carboxylicacid 

[1]Patent:US2017/107202,2017,A1.Locationinpatent:Paragraph1523;1524

16820-18-1    2095231-77-7   
CASUnavailable 

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2017/107202,2017,A1Locationinpatent:Paragraph1972;1973;1974;1975

16820-18-1    2095236-47-6   
CASUnavailable 

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2017/107202,2017,A1Locationinpatent:Paragraph2210;2211;2212;2213

Literature

Title: 4-Methylpseudoproline derived from α-methylserine - synthesis and conformational studies.

Journal: Organic & biomolecular chemistry 20120907

Title: Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.

Journal: PloS one 20120101

Title: Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids.

Journal: Organic & biomolecular chemistry 20111007

Title: Rational design of a Tn antigen mimic.

Journal: Chemical communications (Cambridge, England) 20110514

Title: Molecular recognition of β-O-GlcNAc glycopeptides by a lectin-like receptor: binding modulation by the underlying Ser or Thr amino acids.

Journal: Chembiochem : a European journal of chemical biology 20110103

Title: Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures.

Journal: The Journal of biological chemistry 20090911

Title: Cloning of the gene encoding alpha-methylserine hydroxymethyltransferase from Aminobacter sp. AJ110403 and Ensifer sp. AJ110404 and characterization of the recombinant enzyme.

Journal: Bioscience, biotechnology, and biochemistry 20081101

Title: Gene cloning of alpha-methylserine aldolase from Variovorax paradoxus and purification and characterization of the recombinant enzyme.

Journal: Bioscience, biotechnology, and biochemistry 20081001

Title: Piperazimycins: cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus Streptomyces.

Journal: The Journal of organic chemistry 20070119

Title: Synthesis and biological evaluation of two chemically modified peptide epitopes for the class I MHC protein HLA-B*2705.

Journal: Organic & biomolecular chemistry 20061021

Title: Synthesis of (+)-conagenin.

Journal: The Journal of organic chemistry 20050624

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SDS
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