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17388-39-5,MFCD07783984
Catalog No.:AA001Z6G

17388-39-5 | Swertiamarin

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1mg
97%
in stock  
$6.00   $4.00
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5mg
97%
in stock  
$7.00   $5.00
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100mg
95%
in stock  
$89.00   $62.00
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250mg
95%
in stock  
$209.00   $147.00
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1g
95%
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$481.00   $337.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001Z6G
Chemical Name:
Swertiamarin
CAS Number:
17388-39-5
Molecular Formula:
C16H22O10
Molecular Weight:
374.3399
MDL Number:
MFCD07783984
SMILES:
C=C[C@H]1[C@@H](OC=C2[C@@]1(O)CCOC2=O)O[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
592  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
4  
XLogP3:
-2  

Downstream Synthesis Route
2'-(2'',3''-dihydroxybenzoyl)swertiamarin 
  2411-83-8    17388-39-5 

[1]Fitoterapia,2013,vol.91,p.166-172

17388-39-5   
sweritranslactoneA 
 
sweritranslactoneB 
 
sweritranslactoneC 

[1]JournalofOrganicChemistry,2017,vol.82,p.13263-13267

17388-39-5   
gentianineN-oxide 

[1]TetrahedronLetters,2019,vol.60,p.721-725

17388-39-5   
C16H21N3O9 

[1]FEBSJournal,2020,vol.287,p.1816-1829

17388-39-5   
CASUnavailable 

[1]Kumar,Satyender;Niguram,Prakash;Bhat,Vedika;Jinagal,Seema;Jairaj,Vinod;Chauhan,Neelam[NaturalProductResearch,2022,vol.36,#9,p.2197-2207]

Literature

Title: The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats.

Journal: Toxicology letters 20170104

Title: Beneficial effects of swertiamarin on dyslipidaemia in streptozotocin-induced type 2 diabetic rats.

Journal: Phytotherapy research : PTR 20120801

Title: Determination of the plasma pharmacokinetic and tissue distributions of swertiamarin in rats by liquid chromatography with tandem mass spectrometry.

Journal: Arzneimittel-Forschung 20120301

Title: Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils.

Journal: Phytotherapy research : PTR 20120201

Title: Determination of novel nitrogen-containing metabolite after oral administration of swertiamarin to rats.

Journal: Journal of Asian natural products research 20120101

Title: Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice.

Journal: Fitoterapia 20110901

Title: Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110601

Title: Hypoglycemic activity of C-glycosyl flavonoid from Enicostemma hyssopifolium.

Journal: Pharmaceutical biology 20110401

Title: Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC-MS and RP-HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20110220

Title: A new HPTLC densitometric method for analysis of swertiamarin in Enicostemma littorale and commercial formulations.

Journal: Natural product research 20110101

Title: Introgression of Swertia mussotii gene into Bupleurum scorzonerifolium via somatic hybridization.

Journal: BMC plant biology 20110101

Title: Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against D-galactosamine induced acute liver damage in rats.

Journal: Journal of ethnopharmacology 20100706

Title: Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats.

Journal: Molecular and cellular biochemistry 20100701

Title: Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats.

Journal: Journal of natural medicines 20091001

Title: Swertiamarin: a lead from Enicostemma littorale Blume. for anti-hyperlipidaemic effect.

Journal: European journal of pharmacology 20090901

Title: [Determination of six active components in three species of genus Swertia by HPLC multiwavelength with detection].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090601

Title: Antinociceptive activity of swertiamarin isolated from Enicostemma axillare.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090301

Title: Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare.

Journal: Planta medica 20090101

Title: Fagraldehyde, a secoiridoid isolated from Fagraea fragrans.

Journal: Journal of natural products 20081201

Title: [Chemical constituents from herbs of Swertia delavayi].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801

Title: Simultaneous determination of swertiamarin and its metabolites (5Z)-5-ethylidene-8-hydroxy-3,4,5,6,7,8-hexahydro-1H-pyrano[3,4-c]pyridin-1-one and erythrocentaurin in broth of Aspergillus niger by HPLC.

Journal: Biomedical chromatography : BMC 20080201

Title: [Determination of iridoids and triterpenes in herb of Swertia pseudochinesis by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201

Title: Simultaneous estimation of mangiferin and four secoiridoid glycosides in rat plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study of herbal preparation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

Title: [Simultaneous determination of six main constituents in Swertia of Qinghai Province and Sichuan Province by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [HPLC fingerprinting of total glycosides of Swertia franchetiana].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050501

Title: Variation of active constituents of an important Tibet folk medicine Swertia mussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed.

Journal: Journal of ethnopharmacology 20050408

Title: Separation and determination of gentiopicroside and swertiamarin in Tibetan medicines by micellar electrokinetic electrophoresis.

Journal: Biomedical chromatography : BMC 20040101

Title: Bioactivity of secoiridoid glycosides from Centaurium erythraea.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20030501

Title: Patel N, et al. Curr Drug Targets. 2018;19(16):1958-1967. doi: 10.2174/1389450119666180406113428.

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