174022-42-5,MFCD00954243
Catalog No.:AA001ZBK

174022-42-5 | Bevirimat

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$40.00   $28.00
- +
5mg
≥98%
in stock  
$180.00   $126.00
- +
10mg
95%
in stock  
$287.00   $201.00
- +
50mg
95%
in stock  
$839.00   $588.00
- +
250mg
95%
in stock  
$1,617.00   $1,132.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001ZBK
Chemical Name:
Bevirimat
CAS Number:
174022-42-5
Molecular Formula:
C36H56O6
Molecular Weight:
584.8262
MDL Number:
MFCD00954243
SMILES:
O=C(CC(C(=O)O)(C)C)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC[C@H]2[C@@]1(C)CC[C@@]1([C@@H]2[C@@H](CC1)C(=C)C)C(=O)O)C)C
Properties
Computed Properties
 
Complexity:
1170  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
9.1  

Literature

Title: Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1.

Journal: Journal of medicinal chemistry 20161013

Title: Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.

Journal: Antimicrobial agents and chemotherapy 20160701

Title: Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

Journal: ACS medicinal chemistry letters 20160609

Title: C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

Journal: Bioorganic & medicinal chemistry 20160415

Title: Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.

Journal: Bioorganic & medicinal chemistry letters 20160415

Title: Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.

Journal: Bioorganic & medicinal chemistry letters 20160101

Title: Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina.

Journal: Journal of natural products 20150522

Title: Synthesis and biological evaluation of a new derivative of bevirimat that targets the Gag CA-SP1 cleavage site.

Journal: European journal of medicinal chemistry 20130401

Title: New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.

Journal: Journal of medicinal chemistry 20130314

Title: Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.

Journal: Journal of medicinal chemistry 20120927

Title: Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.

Journal: Bioorganic & medicinal chemistry letters 20120815

Title: New betulinic acid derivatives as potent proteasome inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat.

Journal: Antimicrobial agents and chemotherapy 20110701

Title: Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.

Journal: Retrovirology 20110101

Title: The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles.

Journal: Retrovirology 20110101

Title: A fourth scale sensitive to the magnetic field; intermolecular frequency symmetry in a specific interaction between protein and low-molecular compound.

Journal: Chemical & pharmaceutical bulletin 20101201

Title: Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.

Journal: Antimicrobial agents and chemotherapy 20101001

Title: Conjugates of betulin derivatives with AZT as potent anti-HIV agents.

Journal: Bioorganic & medicinal chemistry 20100901

Title: The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation.

Journal: Virology 20100425

Title: Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

Journal: Journal of medicinal chemistry 20100422

Title: Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Journal: Journal of natural products 20100326

Title: High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates.

Journal: AIDS (London, England) 20100313

Title: Can the further clinical development of bevirimat be justified?

Journal: AIDS (London, England) 20100313

Title: [The role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and the inhibitors].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100201

Title: High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor.

Journal: AIDS (London, England) 20100128

Title: Predicting Bevirimat resistance of HIV-1 from genotype.

Journal: BMC bioinformatics 20100101

Title: Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat.

Journal: Retrovirology 20100101

Title: [Prediction of the efficacy of bevirimat used for the treatment of HIV infection in Russia].

Journal: Voprosy virusologii 20100101

Title: Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.

Journal: Journal of medicinal chemistry 20091210

Title: New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation.

Journal: Antimicrobial agents and chemotherapy 20091201

Title: Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.

Journal: Bioorganic & medicinal chemistry letters 20090701

Title: Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.

Journal: Journal of medicinal chemistry 20090528

Title: An oral human drug absorption study to assess the impact of site of delivery on the bioavailability of bevirimat.

Journal: Journal of clinical pharmacology 20090501

Title: [New antiretroviral drug classes in HIV therapy].

Journal: MMW Fortschritte der Medizin 20090430

Title: Drug interactions with new and investigational antiretrovirals.

Journal: Clinical pharmacokinetics 20090101

Title: Study may point way forward for bevirimat.

Journal: Project Inform perspective 20081201

Title: Report from the 2008 joint ICAAC/IDSA meeting. Bevirimat: predictors of response.

Journal: AIDS clinical care 20081201

Title: The absorption, distribution, metabolism and elimination of bevirimat in rats.

Journal: Biopharmaceutics & drug disposition 20081001

Title: Pharmacokinetic properties and tolerability of bevirimat and atazanavir in healthy volunteers: an open-label, parallel-group study.

Journal: Clinical therapeutics 20081001

Title: New drugs.

Journal: Journal of HIV therapy 20080601

Title: Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection.

Journal: Antiviral chemistry & chemotherapy 20080101

Title: The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain.

Journal: Virology journal 20080101

Title: The maturation inhibitor bevirimat (PA-457) can be active in patients carrying HIV type-1 non-B subtypes and recombinants.

Journal: Antiviral therapy 20080101

Title: Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry letters 20071201

Title: Activation and inhibition of the proteasome by betulinic acid and its derivatives.

Journal: FEBS letters 20071016

Title: Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection.

Journal: Antimicrobial agents and chemotherapy 20071001

Title: Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301

Title: New developments in natural products-based anti-AIDS research.

Journal: Medicinal research reviews 20070101

Title: Multiple-dose pharmacokinetics and safety of bevirimat, a novel inhibitor of HIV maturation, in healthy volunteers.

Journal: Clinical pharmacokinetics 20070101

Title: Maturation inhibitors: a new therapeutic class targets the virus structure.

Journal: AIDS reviews 20070101

Title: Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

Journal: PloS one 20070101

Title: The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells.

Journal: Antiviral therapy 20070101

Title: Determinants of activity of the HIV-1 maturation inhibitor PA-457.

Journal: Virology 20061201

Title: Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag.

Journal: Journal of virology 20061201

Title: In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).

Journal: Journal of virology 20061101

Title: Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.

Journal: Journal of medicinal chemistry 20060907

Title: Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901

Title: Drug evaluation: bevirimat--HIV Gag protein and viral maturation inhibitor.

Journal: Current opinion in investigational drugs (London, England : 2000) 20060801

Title: A new assault on HIV.

Journal: Scientific American 20060601

Title: 3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro.

Journal: Journal of virology 20060601

Title: Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry 20060401

Title: 3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents.

Journal: Bioorganic & medicinal chemistry letters 20041206

Title: Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.

Journal: Antimicrobial agents and chemotherapy 20040201

Title: Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation.

Journal: Journal of virology 20040101

Title: The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid.

Journal: Retrovirology 20040101

Title: PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20031111

Title: Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation.

Journal: Antimicrobial agents and chemotherapy 20010401

Title: 3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents.

Journal: Bioorganic & medicinal chemistry letters 20010122

Title: Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.

Journal: Journal of natural products 20001201

Title: Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives.

Journal: Chemical & pharmaceutical bulletin 20000901

Title: Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.

Journal: Journal of medicinal chemistry 19981105

Title: Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry 19971201

Title: Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.

Journal: Journal of medicinal chemistry 19960301

Title: Smith PF, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81.

Title: Salzwedel K, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72.

Title: Martin DE, et al. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.

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SDS
Tags:174022-42-5 Molecular Formula|174022-42-5 MDL|174022-42-5 SMILES|174022-42-5 Bevirimat
Catalog No.: AA001ZBK
174022-42-5,MFCD00954243
174022-42-5 | Bevirimat
Pack Size: 1mg
Purity: ≥98%
in stock
$40.00 $28.00
Pack Size: 5mg
Purity: ≥98%
in stock
$180.00 $126.00
Pack Size: 10mg
Purity: 95%
in stock
$287.00 $201.00
Pack Size: 50mg
Purity: 95%
in stock
$839.00 $588.00
Pack Size: 250mg
Purity: 95%
in stock
$1,617.00 $1,132.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001ZBK
Chemical Name: Bevirimat
CAS Number: 174022-42-5
Molecular Formula: C36H56O6
Molecular Weight: 584.8262
MDL Number: MFCD00954243
SMILES: O=C(CC(C(=O)O)(C)C)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC[C@H]2[C@@]1(C)CC[C@@]1([C@@H]2[C@@H](CC1)C(=C)C)C(=O)O)C)C
Properties
Complexity: 1170  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 10  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 42  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 9.1  
Literature fold

Title: Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1.

Journal: Journal of medicinal chemistry20161013

Title: Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.

Journal: Antimicrobial agents and chemotherapy20160701

Title: Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

Journal: ACS medicinal chemistry letters20160609

Title: C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

Journal: Bioorganic & medicinal chemistry20160415

Title: Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.

Journal: Bioorganic & medicinal chemistry letters20160415

Title: Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.

Journal: Bioorganic & medicinal chemistry letters20160101

Title: Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina.

Journal: Journal of natural products20150522

Title: Synthesis and biological evaluation of a new derivative of bevirimat that targets the Gag CA-SP1 cleavage site.

Journal: European journal of medicinal chemistry20130401

Title: New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.

Journal: Journal of medicinal chemistry20130314

Title: Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.

Journal: Journal of medicinal chemistry20120927

Title: Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.

Journal: Bioorganic & medicinal chemistry letters20120815

Title: New betulinic acid derivatives as potent proteasome inhibitors.

Journal: Bioorganic & medicinal chemistry letters20111001

Title: A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat.

Journal: Antimicrobial agents and chemotherapy20110701

Title: Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.

Journal: Bioorganic & medicinal chemistry letters20110101

Title: HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.

Journal: Retrovirology20110101

Title: The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles.

Journal: Retrovirology20110101

Title: A fourth scale sensitive to the magnetic field; intermolecular frequency symmetry in a specific interaction between protein and low-molecular compound.

Journal: Chemical & pharmaceutical bulletin20101201

Title: Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.

Journal: Antimicrobial agents and chemotherapy20101001

Title: Conjugates of betulin derivatives with AZT as potent anti-HIV agents.

Journal: Bioorganic & medicinal chemistry20100901

Title: The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation.

Journal: Virology20100425

Title: Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

Journal: Journal of medicinal chemistry20100422

Title: Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Journal: Journal of natural products20100326

Title: High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates.

Journal: AIDS (London, England)20100313

Title: Can the further clinical development of bevirimat be justified?

Journal: AIDS (London, England)20100313

Title: [The role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and the inhibitors].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100201

Title: High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor.

Journal: AIDS (London, England)20100128

Title: Predicting Bevirimat resistance of HIV-1 from genotype.

Journal: BMC bioinformatics20100101

Title: Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat.

Journal: Retrovirology20100101

Title: [Prediction of the efficacy of bevirimat used for the treatment of HIV infection in Russia].

Journal: Voprosy virusologii20100101

Title: Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.

Journal: Journal of medicinal chemistry20091210

Title: New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation.

Journal: Antimicrobial agents and chemotherapy20091201

Title: Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.

Journal: Bioorganic & medicinal chemistry letters20090701

Title: Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.

Journal: Journal of medicinal chemistry20090528

Title: An oral human drug absorption study to assess the impact of site of delivery on the bioavailability of bevirimat.

Journal: Journal of clinical pharmacology20090501

Title: [New antiretroviral drug classes in HIV therapy].

Journal: MMW Fortschritte der Medizin20090430

Title: Drug interactions with new and investigational antiretrovirals.

Journal: Clinical pharmacokinetics20090101

Title: Study may point way forward for bevirimat.

Journal: Project Inform perspective20081201

Title: Report from the 2008 joint ICAAC/IDSA meeting. Bevirimat: predictors of response.

Journal: AIDS clinical care20081201

Title: The absorption, distribution, metabolism and elimination of bevirimat in rats.

Journal: Biopharmaceutics & drug disposition20081001

Title: Pharmacokinetic properties and tolerability of bevirimat and atazanavir in healthy volunteers: an open-label, parallel-group study.

Journal: Clinical therapeutics20081001

Title: New drugs.

Journal: Journal of HIV therapy20080601

Title: Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection.

Journal: Antiviral chemistry & chemotherapy20080101

Title: The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain.

Journal: Virology journal20080101

Title: The maturation inhibitor bevirimat (PA-457) can be active in patients carrying HIV type-1 non-B subtypes and recombinants.

Journal: Antiviral therapy20080101

Title: Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry letters20071201

Title: Activation and inhibition of the proteasome by betulinic acid and its derivatives.

Journal: FEBS letters20071016

Title: Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection.

Journal: Antimicrobial agents and chemotherapy20071001

Title: Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences.

Journal: Drug metabolism and disposition: the biological fate of chemicals20070301

Title: New developments in natural products-based anti-AIDS research.

Journal: Medicinal research reviews20070101

Title: Multiple-dose pharmacokinetics and safety of bevirimat, a novel inhibitor of HIV maturation, in healthy volunteers.

Journal: Clinical pharmacokinetics20070101

Title: Maturation inhibitors: a new therapeutic class targets the virus structure.

Journal: AIDS reviews20070101

Title: Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

Journal: PloS one20070101

Title: The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells.

Journal: Antiviral therapy20070101

Title: Determinants of activity of the HIV-1 maturation inhibitor PA-457.

Journal: Virology20061201

Title: Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag.

Journal: Journal of virology20061201

Title: In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).

Journal: Journal of virology20061101

Title: Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.

Journal: Journal of medicinal chemistry20060907

Title: Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma.

Journal: Drug metabolism and disposition: the biological fate of chemicals20060901

Title: Drug evaluation: bevirimat--HIV Gag protein and viral maturation inhibitor.

Journal: Current opinion in investigational drugs (London, England : 2000)20060801

Title: A new assault on HIV.

Journal: Scientific American20060601

Title: 3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro.

Journal: Journal of virology20060601

Title: Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry20060401

Title: 3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents.

Journal: Bioorganic & medicinal chemistry letters20041206

Title: Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.

Journal: Antimicrobial agents and chemotherapy20040201

Title: Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation.

Journal: Journal of virology20040101

Title: The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid.

Journal: Retrovirology20040101

Title: PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.

Journal: Proceedings of the National Academy of Sciences of the United States of America20031111

Title: Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation.

Journal: Antimicrobial agents and chemotherapy20010401

Title: 3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents.

Journal: Bioorganic & medicinal chemistry letters20010122

Title: Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.

Journal: Journal of natural products20001201

Title: Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives.

Journal: Chemical & pharmaceutical bulletin20000901

Title: Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.

Journal: Journal of medicinal chemistry19981105

Title: Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry19971201

Title: Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.

Journal: Journal of medicinal chemistry19960301

Title: Smith PF, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81.

Title: Salzwedel K, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72.

Title: Martin DE, et al. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.

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