1745-07-9,MFCD00777849
Catalog No.:AA001ZMY

1745-07-9 | 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$11.00   $8.00
- +
5g
95%
in stock  
$49.00   $34.00
- +
10g
95%
in stock  
$76.00   $53.00
- +
25g
95%
in stock  
$178.00   $125.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001ZMY
Chemical Name:
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS Number:
1745-07-9
Molecular Formula:
C11H15NO2
Molecular Weight:
193.2423
MDL Number:
MFCD00777849
SMILES:
COc1cc2CNCCc2cc1OC
Properties
Computed Properties
 
Complexity:
186  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.3  

Literature

Title: Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures.

Journal: Journal of molecular neuroscience : MN 20120101

Title: Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111012

Title: Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers.

Journal: European journal of medicinal chemistry 20110901

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.

Journal: The European journal of neuroscience 20090801

Title: Relationship between exposure of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a 'funny' if current channel inhibitor, and heart rate reduction in tachycardia-induced beagle dogs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090701

Title: Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors.

Journal: ChemMedChem 20090201

Title: 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.

Journal: Journal of medicinal chemistry 20081211

Title: 4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.

Journal: Bioorganic & medicinal chemistry 20080401

Title: Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.

Journal: Bioorganic & medicinal chemistry 20080101

Title: In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450.

Journal: Bioorganic & medicinal chemistry 20061201

Title: 3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents.

Journal: Archiv der Pharmazie 20060701

Title: In vivo bioconversion of tetrahydroisoquinoline by recombinant coclaurine N-methyltransferase.

Journal: Bioscience, biotechnology, and biochemistry 20040401

Title: The chromatographic data in QSAR assay of TIQs derivatives with beta2-adrenergic activity.

Journal: Acta poloniae pharmaceutica 20040101

Title: N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.

Journal: Bioorganic & medicinal chemistry letters 20031215

Title: Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica.

Journal: The Journal of biological chemistry 20020104

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SDS
Tags:1745-07-9 Molecular Formula|1745-07-9 MDL|1745-07-9 SMILES|1745-07-9 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
Catalog No.: AA001ZMY
1745-07-9,MFCD00777849
1745-07-9 | 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
Pack Size: 1g
Purity: 95%
in stock
$11.00 $8.00
Pack Size: 5g
Purity: 95%
in stock
$49.00 $34.00
Pack Size: 10g
Purity: 95%
in stock
$76.00 $53.00
Pack Size: 25g
Purity: 95%
in stock
$178.00 $125.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA001ZMY
Chemical Name: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS Number: 1745-07-9
Molecular Formula: C11H15NO2
Molecular Weight: 193.2423
MDL Number: MFCD00777849
SMILES: COc1cc2CNCCc2cc1OC
Properties
Complexity: 186  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 14  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.3  
Literature fold

Title: Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures.

Journal: Journal of molecular neuroscience : MN20120101

Title: Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20111012

Title: Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers.

Journal: European journal of medicinal chemistry20110901

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.

Journal: The European journal of neuroscience20090801

Title: Relationship between exposure of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a 'funny' if current channel inhibitor, and heart rate reduction in tachycardia-induced beagle dogs.

Journal: Drug metabolism and disposition: the biological fate of chemicals20090701

Title: Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors.

Journal: ChemMedChem20090201

Title: 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.

Journal: Journal of medicinal chemistry20081211

Title: 4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.

Journal: Bioorganic & medicinal chemistry20080401

Title: Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.

Journal: Bioorganic & medicinal chemistry20080101

Title: In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450.

Journal: Bioorganic & medicinal chemistry20061201

Title: 3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents.

Journal: Archiv der Pharmazie20060701

Title: In vivo bioconversion of tetrahydroisoquinoline by recombinant coclaurine N-methyltransferase.

Journal: Bioscience, biotechnology, and biochemistry20040401

Title: The chromatographic data in QSAR assay of TIQs derivatives with beta2-adrenergic activity.

Journal: Acta poloniae pharmaceutica20040101

Title: N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.

Journal: Bioorganic & medicinal chemistry letters20031215

Title: Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica.

Journal: The Journal of biological chemistry20020104

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