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1811-28-5,MFCD00149650
Catalog No.:AA0022LY

1811-28-5 | Proflavine hemisulfate hydrate

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1g
>97%(N)
in stock  
$32.00   $23.00
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5g
>97.0%(N)
in stock  
$50.00   $35.00
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25g
>97.0%(N)
in stock  
$134.00   $94.00
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100g
≥ 99% (Assay on anhydrous basis)
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$352.00   $246.00
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250g
≥ 99% (Assay on anhydrous basis)
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$647.00   $453.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0022LY
Chemical Name:
Proflavine hemisulfate hydrate
CAS Number:
1811-28-5
Molecular Formula:
C26H24N6O4S
Molecular Weight:
516.5716
MDL Number:
MFCD00149650
SMILES:
OS(=O)(=O)O.Nc1ccc2c(c1)nc1c(c2)ccc(c1)N.Nc1ccc2c(c1)nc1c(c2)ccc(c1)N
Properties
Properties
 
BP:
1012.9°C at 760 mmHg  
Form:
Solid  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
313  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
6  

Literature

Title: Molecular mechanism of direct proflavine-DNA intercalation: evidence for drug-induced minimum base-stacking penalty pathway.

Journal: The journal of physical chemistry. B 20121011

Title: Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancer.

Journal: Annals of surgical oncology 20121001

Title: Intermolecular hydrogen bonds in hetero-complexes of biologically active aromatic molecules probed by the methods of vibrational spectroscopy.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901

Title: Visible light-driven NADH regeneration sensitized by proflavine for biocatalysis.

Journal: Chembiochem : a European journal of chemical biology 20120618

Title: Vital-dye enhanced fluorescence imaging of GI mucosa: metaplasia, neoplasia, inflammation.

Journal: Gastrointestinal endoscopy 20120401

Title: A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection.

Journal: Molecular bioSystems 20120301

Title: Existence of a new emitting singlet state of proflavine: femtosecond dynamics of the excited state processes and quantum chemical studies in different solvents.

Journal: The journal of physical chemistry. A 20120112

Title: [Studies by means of 1H NMR spectroscopy of complex formation of aromatic biologically active compounds with antibiotic topotecan].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20120101

Title: Large-scale symmetry-adapted perturbation theory computations via density fitting and Laplace transformation techniques: investigating the fundamental forces of DNA-intercalator interactions.

Journal: The Journal of chemical physics 20111107

Title: Fluorimetric study on the interaction between Norfloxacin and Proflavine hemisulphate.

Journal: Journal of fluorescence 20110701

Title: c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators.

Journal: Chemical communications (Cambridge, England) 20110428

Title: Proflavine derivatives as fluorescent imaging agents of amyloid deposits.

Journal: Bioorganic & medicinal chemistry letters 20110415

Title: DNA binding of a proflavine derivative bearing a platinum hanging residue.

Journal: Journal of inorganic biochemistry 20110401

Title: [Energetics of complex formation of the DNA hairpin structure d(GCGAAGC) with aromatic ligands].

Journal: Biofizika 20110101

Title: [Comparative sensitivity of liver monoamine oxidases of frog and whitefish to some tricyclic compounds].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20110101

Title: Magnetic field effect corroborated with docking study to explore photoinduced electron transfer in drug-protein interaction.

Journal: The journal of physical chemistry. A 20101230

Title: Synthesis, characterization and cytotoxicity studies of palladium(II)-proflavine complexes.

Journal: Journal of inorganic biochemistry 20101101

Title: Change of the binding mode of the DNA/proflavine system induced by ethanol.

Journal: The journal of physical chemistry. B 20100701

Title: The nature of the force-induced conformation transition of dsDNA studied by using single molecule force spectroscopy.

Journal: Langmuir : the ACS journal of surfaces and colloids 20100615

Title: Triple dye plus rubbing alcohol versus triple dye alone for umbilical cord care.

Journal: Clinical pediatrics 20100101

Title: 1H and 13C NMR signal assignments of some new N,N'-diacyl proflavine derivatives.

Journal: Magnetic resonance in chemistry : MRC 20090801

Title: Photo-inducible cytotoxic and clastogenic activities of 3,6-di-substituted acridines obtained by acylation of proflavine.

Journal: European journal of medicinal chemistry 20090601

Title: Solution structure and thermodynamics of 2',5' RNA intercalation.

Journal: Journal of the American Chemical Society 20090429

Title: Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures.

Journal: DNA and cell biology 20090401

Title: [Features of binding of proflavine to DNA at different DNA-ligand concentration ratios].

Journal: Biofizika 20090101

Title: [Experimental study of proflavine acetate phototransformation processes].

Journal: Gigiena i sanitariia 20090101

Title: Fluorophore labeling to monitor tRNA dynamics.

Journal: Methods in enzymology 20090101

Title: Electroanalytical study of proflavine intercalation in 5-methyl or inosine-containing amplicons.

Journal: Analytical and bioanalytical chemistry 20081001

Title: Role of the third strand in the binding of proflavine and pt-proflavine to poly(rA).2poly(rU): a thermodynamic and kinetic study.

Journal: The journal of physical chemistry. B 20080612

Title: Cytotoxic activity of proflavine diureas: synthesis, antitumor, evaluation and DNA binding properties of 1',1''-(acridin-3,6-diyl)-3',3''-dialkyldiureas.

Journal: Bioorganic & medicinal chemistry 20080401

Title: DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

Title: A randomised controlled trial of a double layer of Allevyn compared to Jellonet and proflavin as a tie-over dressing for small skin grafts.

Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20080101

Title: Skipjack tuna (Katsuwonus pelamis) liver monoamine oxidase: substrate-inhibitor analysis.

Journal: Doklady. Biochemistry and biophysics 20080101

Title: Protonation linked equilibria and apparent affinity constants: the thermodynamic profile of the alpha-chymotrypsin-proflavin interaction.

Journal: European biophysics journal : EBJ 20071201

Title: Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay.

Journal: FEBS letters 20071016

Title: Quantifying RNA-peptide interaction by single-quantum dot-based nanosensor: an approach for drug screening.

Journal: Analytical chemistry 20071015

Title: Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine.

Journal: European journal of medicinal chemistry 20071001

Title: Characterization of the multidrug efflux regulator AcrR from Escherichia coli.

Journal: Biochemical and biophysical research communications 20070914

Title: On the origin of the decrease in stability of the DNA hairpin d(GCGAAGC) on complexation with aromatic drugs.

Journal: Biophysical chemistry 20070801

Title: Synthesis, DNA interaction, and cytotoxic activity of a novel proflavine-dithiazolidinone pharmacophore.

Journal: Bioconjugate chemistry 20070101

Title: A rare cause of breast mass that mimics carcinoma: Foreign body reaction to amorphous surgical material.

Journal: Wiener klinische Wochenschrift 20070101

Title: Catalytic properties of monoamine oxidase from mink (Mustela vison) liver.

Journal: Doklady. Biochemistry and biophysics 20070101

Title: [Comparative toxicity of photosensitizers in varying destruction].

Journal: Gigiena i sanitariia 20070101

Title: Ethidium and proflavine binding to a 2',5'-linked RNA duplex.

Journal: Journal of the American Chemical Society 20061206

Title: Determination of the DNA-binding characteristics of ethidium bromide, proflavine, and cisplatin by flow injection analysis: usefulness in studies on antitumor drugs.

Journal: Analytical biochemistry 20060815

Title: Dye-induced aggregation of single stranded RNA: a mechanistic approach.

Journal: Archives of biochemistry and biophysics 20060815

Title: Physical nature of ethidium and proflavine interactions with nucleic acid bases in the intercalation plane.

Journal: The journal of physical chemistry. B 20060518

Title: Electrochemical and spectroscopic studies of the interaction of proflavine with DNA.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060301

Title: Inhibiting protein-amyloid interactions with small molecules: a surface chemistry approach.

Journal: Bioorganic & medicinal chemistry letters 20060215

Title: Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.

Journal: Research in microbiology 20060101

Title: Catalytic properties of monoamine oxidase from the lamprey Lampetrafluviatilis liver.

Journal: Doklady. Biochemistry and biophysics 20060101

Title: Fluorescence of acridinic dyes in anionic surfactant solution.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001

Title: A randomized study of 3 umbilical cord care regimens at home in thai neonates: comparison of time to umbilical cord separation, parental satisfaction and bacterial colonization.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20050701

Title: Relaxation kinetics of the interaction between RNA and metal-intercalators: the Poly(A).Poly(U)/platinum-proflavine system.

Journal: Archives of biochemistry and biophysics 20050515

Title: Dendrimers with both polar and apolar nanocontainer characteristics.

Journal: Journal of the American Chemical Society 20041208

Title: Changes in newborn bathing practices may increase the risk for omphalitis.

Journal: Clinical pediatrics 20041001

Title: Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein.

Journal: The EMBO journal 20040804

Title: Management of ventral hernia after giant exomphalos with external pressure compression using helmet device.

Journal: Journal of pediatric surgery 20040801

Title: Assembly of an antiparallel homo-adenine DNA duplex by small-molecule binding.

Journal: Journal of the American Chemical Society 20040721

Title: Enzymatic behavior by intercalating molecules in a template-directed ligation reaction.

Journal: Angewandte Chemie (International ed. in English) 20040402

Title: Equilibria and kinetics of the intercalation of Pt-proflavine and proflavine into calf thymus DNA.

Journal: Archives of biochemistry and biophysics 20031001

Title: Proflavine acts as a Rev inhibitor by targeting the high-affinity Rev binding site of the Rev responsive element of HIV-1.

Journal: Biochemistry 20030708

Title: A biochemical logic gate using an enzyme and its inhibitor. Part II: The logic gate.

Journal: Bio Systems 20030601

Title: To dye or not to dye: a randomized, clinical trial of a triple dye/alcohol regime versus dry cord care.

Journal: Pediatrics 20030101

Title: Post-surgery vaginal packs.

Journal: Journal of wound care 20021001

Title: Synthesis and DNA interaction of a mixed proflavine-phenanthroline Tröger base.

Journal: European journal of medicinal chemistry 20020401

Title: Randomized trial of alcohol versus triple dye for umbilical cord care.

Journal: Clinical pediatrics 20020101

Title: [NMR study of complex formation of aromatic ligands with heptadeoxynucleotide 5'-d(GCGAAGC) forming stable hairpin structure in aqueous solution].

Journal: Molekuliarnaia biologiia 20020101

Title: Dialysis cells for controlled DNA: drug binding studies.

Journal: The Analyst 20010601

Title: Contact dermatitis complicating pinnaplasty.

Journal: British journal of plastic surgery 20010401

Title: Proflavine-mediated inactivation of Salmonella dublin exposed to visible sunlight in natural fresh water.

Journal: Microbios 20010101

Title: Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity.

Journal: Biochemistry 19940726

Title: Kinetics of alpha-chymotrypsin dimerization.

Journal: The Journal of biological chemistry 19760125

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