Title: Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Journal: Journal of medicinal chemistry 20120823
Title: Functional observational battery and motor activity in rats after single administration of two NHE 1 inhibitors.
Journal: Toxicology and applied pharmacology 20051101
Title: Population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction.
Journal: Journal of clinical pharmacology 20050601
Title: Myocardial protection at a crossroads: the need for translation into clinical therapy.
Journal: Circulation research 20040723
Title: Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest.
Journal: The Annals of thoracic surgery 20040201
Title: Mice with a null mutation in the NHE1 Na+-H+ exchanger are resistant to cardiac ischemia-reperfusion injury.
Journal: Circulation research 20031017
Title: Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide.
Journal: Molecular and cellular biochemistry 20030801
Title: An overview of inhibitors of Na(+)/H(+) exchanger.
Journal: European journal of medicinal chemistry 20030601
Title: Na+/H+ exchange inhibition with cardioplegia reduces cytosolic [Ca2+] and myocardial damage after cold ischemia.
Journal: Journal of cardiovascular pharmacology 20030501
Title: Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.
Journal: European journal of pharmacology 20020906
Title: Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass: an experimental study.
Journal: The Journal of thoracic and cardiovascular surgery 20020501
Title: In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559.
Journal: British journal of pharmacology 20020401
Title: Clinical trials update: highlights of the scientific sessions of the XXIII Congress of the European Society of Cardiology--WARIS II, ESCAMI, PAFAC, RITZ-1 and TIME.
Journal: European journal of heart failure 20011201
Title: The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial.
Journal: Journal of the American College of Cardiology 20011115
Title: Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.
Journal: Journal of medicinal chemistry 20010927
Title: Na(+)/H(+) exchange inhibition prevents endothelial dysfunction after I/R injury.
Journal: American journal of physiology. Heart and circulatory physiology 20010901
Title: Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559.
Journal: European journal of pharmacology 20010518
Title: Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.
Journal: Bioorganic & medicinal chemistry letters 20010326
Title: The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure.
Journal: Drugs 20010101
