176977-56-3,MFCD00945878
Catalog No.:AA0024YS

176977-56-3 | Benzonitrile, 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$42.00   $29.00
- +
5mg
≥98%
in stock  
$143.00   $100.00
- +
10mg
≥98%
in stock  
$266.00   $186.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0024YS
Chemical Name:
Benzonitrile, 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]-
CAS Number:
176977-56-3
Molecular Formula:
C24H17NO4
Molecular Weight:
383.3961
MDL Number:
MFCD00945878
SMILES:
COc1ccc2c(c1)oc(c2C(=O)c1ccc(cc1)C#N)c1ccc(cc1)OC
Properties
Computed Properties
 
Complexity:
612  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.

Journal: British journal of pharmacology 20120401

Title: Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.

Journal: European journal of medicinal chemistry 20110201

Title: Modulation of N-type calcium currents by presynaptic imidazoline receptor activation in rat superior cervical ganglion neurons.

Journal: Experimental physiology 20101001

Title: Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization.

Journal: Molecular pharmacology 20091001

Title: Functional CB2 type cannabinoid receptors at CNS synapses.

Journal: Neuropharmacology 20090901

Title: Cannabinoids and hamster circadian activity rhythms.

Journal: Brain research 20080730

Title: Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.

Journal: Journal of medicinal chemistry 20080424

Title: Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex.

Journal: Neural plasticity 20080101

Title: Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed.

Journal: British journal of pharmacology 20071101

Title: Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: Inverse agonism and neutral antagonism at cannabinoid CB1 receptors.

Journal: Life sciences 20050204

Title: Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.

Journal: The Journal of pharmacology and experimental therapeutics 20041001

Title: Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia.

Journal: Neuroscience 20040101

Title: Cannabinoid activation of recombinant and endogenous vanilloid receptors.

Journal: European journal of pharmacology 20010727

Title: Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed.

Journal: European journal of pharmacology 20010420

Title: Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens.

Journal: British journal of pharmacology 20010301

Title: LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.

Journal: The Journal of pharmacology and experimental therapeutics 19980101

Title: Felder CC, et, al. LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan; 284(1):291-7.

Title: Landucci E, et, al. CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices. Neuropharmacology. 2011 Mar; 60(4):674-82.

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Tags:176977-56-3 Molecular Formula|176977-56-3 MDL|176977-56-3 SMILES|176977-56-3 Benzonitrile, 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]-
Catalog No.: AA0024YS
176977-56-3,MFCD00945878
176977-56-3 | Benzonitrile, 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]-
Pack Size: 1mg
Purity: ≥98%
in stock
$42.00 $29.00
Pack Size: 5mg
Purity: ≥98%
in stock
$143.00 $100.00
Pack Size: 10mg
Purity: ≥98%
in stock
$266.00 $186.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA0024YS
Chemical Name: Benzonitrile, 4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]-
CAS Number: 176977-56-3
Molecular Formula: C24H17NO4
Molecular Weight: 383.3961
MDL Number: MFCD00945878
SMILES: COc1ccc2c(c1)oc(c2C(=O)c1ccc(cc1)C#N)c1ccc(cc1)OC
Properties
Complexity: 612  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5  
Literature fold

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.

Journal: British journal of pharmacology20120401

Title: Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.

Journal: European journal of medicinal chemistry20110201

Title: Modulation of N-type calcium currents by presynaptic imidazoline receptor activation in rat superior cervical ganglion neurons.

Journal: Experimental physiology20101001

Title: Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization.

Journal: Molecular pharmacology20091001

Title: Functional CB2 type cannabinoid receptors at CNS synapses.

Journal: Neuropharmacology20090901

Title: Cannabinoids and hamster circadian activity rhythms.

Journal: Brain research20080730

Title: Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.

Journal: Journal of medicinal chemistry20080424

Title: Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex.

Journal: Neural plasticity20080101

Title: Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed.

Journal: British journal of pharmacology20071101

Title: Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics20070601

Title: Inverse agonism and neutral antagonism at cannabinoid CB1 receptors.

Journal: Life sciences20050204

Title: Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.

Journal: The Journal of pharmacology and experimental therapeutics20041001

Title: Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia.

Journal: Neuroscience20040101

Title: Cannabinoid activation of recombinant and endogenous vanilloid receptors.

Journal: European journal of pharmacology20010727

Title: Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed.

Journal: European journal of pharmacology20010420

Title: Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens.

Journal: British journal of pharmacology20010301

Title: LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.

Journal: The Journal of pharmacology and experimental therapeutics19980101

Title: Felder CC, et, al. LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan; 284(1):291-7.

Title: Landucci E, et, al. CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices. Neuropharmacology. 2011 Mar; 60(4):674-82.

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