Catalog No.:AA0025DN

17766-28-8 | 1-Cyclohexylpiperazine

Name: Name:1-Cyclohexylpiperazine
Brand: AABLOCKS
SKU: AA0025DN
Availability: InStock
Rating: 90 (10 reviews)

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in stock

$18.00 $13.00

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98%

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$23.00 $16.00

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10g

98%

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$33.00 $23.00

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25g

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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA0025DN

Chemical Name:

1-Cyclohexylpiperazine

CAS Number:

17766-28-8

Molecular Formula:

C10H20N2

Molecular Weight:

168.2792

MDL Number:

MFCD03434391

SMILES:

C1CCC(CC1)N1CCNCC1

Properties

BP:

255.7°C at 760 mmHg

Form:

Solid

MP:

28-32 °C

Refractive Index:

1.6011

Storage:

Inert atmosphere;Room Temperature;

Computed Properties

Complexity:

124

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

1.4

Upstream Synthesis Route

1224935-95-8

17766-28-8

[1]Patent:WO2010/51374,2010,A1,.Locationinpatent:Page/Pagecolumn84;85

110-85-0

108-85-0

17766-28-8

[1]DaltonTransactions,2018,vol.47,#4,p.1233-1242

[2]IndustrieChimiqueBelge,1957,vol.22,p.409,416

159974-46-6

17766-28-8

[1]TetrahedronLetters,1994,vol.35,#40,p.7331-7334

17766-28-8

892242-64-7

[1]Patent:WO2017/27465,2017,A1,.Locationinpatent:Page/Pagecolumn15

[2]Patent:US2015/218132,2015,A1,.Locationinpatent:Paragraph0199;0206

[3]Patent:WO2016/43975,2016,A1,.Locationinpatent:Page/Pagecolumn27

Downstream Synthesis Route

17766-28-8

74-88-4

4-cyclohexyl-1,1-dimethylpiperazinium

[1]JournaloftheAmericanChemicalSociety,2005,vol.127,p.11560-11561

17766-28-8

28657-39-8

3-(4-cyclohexylpiperazin-1-yl)-4-methyl-6-phenylpyridazine

[1]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.414-418

[2]Patent:US2009/325973,2009,A1.Locationinpatent:Page/Pagecolumn40

17766-28-8

5891-45-2

512785-08-9

[1]BioorganicandMedicinalChemistry,2007,vol.15,p.2054-2080

17766-28-8

5-bromo-4-(4-chlorothiophen-2-yl)-2-aminothiazole

2-amino-4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazole

[1]Patent:CN107383000,2017,A.Locationinpatent:Paragraph0047;0048;0060

[2]Patent:EP1466912,2004,A1.Locationinpatent:Page17

17766-28-8

2-chloro-5,6-dihydro-10-methyl-imidazo4,5,1-j,k1,4benzodiazepin-7-(4H)one

2-(4-cyclohexylpiperazin-1-yl)-5,6-dihydro-10-methylimidazo4,5,1-j,k1,4benzodiazepin-7-(4H)one

[1]Patent:US2004/29866,2004,A1.Locationinpatent:Page/Pagecolumn11

Literature

Title: 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity.

Journal: ChemMedChem 20110103

Title: Complete experimental and theoretical proton and carbon nuclear magnetic resonance spectral assignments, molecular structure and conformational study of 1-cyclohexylpiperazine and 1-(4-pyridyl)piperazine.

Journal: Magnetic resonance in chemistry : MRC 20100101

Title: Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

Journal: Journal of medicinal chemistry 20091210

Title: 1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 (sigma1) and sigma-2 (sigma2) receptor ligands: a review.

Journal: Central nervous system agents in medicinal chemistry 20090901

Title: Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors.

Journal: ChemMedChem 20090201

Title: Preparation of 99mTc-nitrido asymmetrical heterocomplex with 4-(cyclohexylpiperazin-1-yl)-dithioformate and its biological evaluation as a potential myocardial imaging agent.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20071001

Title: Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer.

Journal: Molecular cancer therapeutics 20060701

Title: Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET.

Journal: The Journal of pharmacy and pharmacology 20051101

Title: Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors.

Journal: Bioorganic & medicinal chemistry 20050601

Title: New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of 'THIQ'.

Journal: Journal of medicinal chemistry 20040826

Title: 4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.

Journal: Journal of medicinal chemistry 20040422

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