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177834-92-3,MFCD08141806
Catalog No.:AA0025I9

177834-92-3 | Eletriptan hydrobromide

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100mg
>98%(HPLC)powder
in stock  
$70.00   $49.00
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250mg
98%
in stock  
$120.00   $84.00
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1g
98%
in stock  
$270.00   $189.00
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5g
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$992.00   $695.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0025I9
Chemical Name:
Eletriptan hydrobromide
CAS Number:
177834-92-3
Molecular Formula:
C22H27BrN2O2S
Molecular Weight:
463.4310
MDL Number:
MFCD08141806
SMILES:
CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1.Br
Properties
Computed Properties
 
Complexity:
582  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  

Literature

Title: Quantitative analysis of eletriptan in human plasma by HPLC-MS/MS and its application to pharmacokinetic study.

Journal: Analytical and bioanalytical chemistry 20111101

Title: Efficacy, safety, and tolerability of sertraline on depressive symptoms in women with comorbid migraine: an open-label study.

Journal: Journal of clinical psychopharmacology 20110601

Title: BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study.

Journal: Cephalalgia : an international journal of headache 20110401

Title: Cluster headache following dental treatment: a case report.

Journal: Journal of oral science 20110301

Title: Drug dependence associated with triptans and ergot derivatives: a case/non-case study.

Journal: European journal of clinical pharmacology 20100401

Title: Perimenstrual eletriptan prevents menstrual migraine: an open-label study.

Journal: Headache 20100401

Title: Real-life experiences in migraine therapy.

Journal: Bratislavske lekarske listy 20100101

Title: A case of ocular hypertension complicated by SUNCT syndrome.

Journal: Annals of ophthalmology (Skokie, Ill.) 20100101

Title: Eletriptan.

Journal: Expert opinion on drug metabolism & toxicology 20091201

Title: Study of forced degradation behavior of eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method.

Journal: Journal of pharmaceutical and biomedical analysis 20091101

Title: Large-scale screening and subsequent effects of migraine treatment on the work floor in the Netherlands.

Journal: Cephalalgia : an international journal of headache 20090601

Title: Treatment of sinus headache as migraine: the diagnostic utility of triptans.

Journal: The Laryngoscope 20081201

Title: Halide salts of antimigraine agents eletriptan and naratriptan.

Journal: Acta crystallographica. Section C, Crystal structure communications 20081201

Title: Triptans: actions and reactions.

Journal: Headache 20080401

Title: Predictors of migraine headache recurrence: a pooled analysis from the eletriptan database.

Journal: Headache 20080201

Title: Identification of negative predictors of pain-free response to triptans: analysis of the eletriptan database.

Journal: Cephalalgia : an international journal of headache 20080101

Title: Patient satisfaction with eletriptan in the acute treatment of migraine in primary care.

Journal: International journal of clinical practice 20071001

Title: Efficacy of eletriptan in migraine-related functional impairment: functional and work productivity outcomes.

Journal: Headache 20070501

Title: Eletriptan for the acute treatment of migraine in adolescents: results of a double-blind, placebo-controlled trial.

Journal: Headache 20070401

Title: Comment on eletriptan in migraine patients reporting unsatisfactory response to rizatriptan.

Journal: Headache 20070301

Title: Efficacy of eletriptan in triptan-naïve patients: results of a combined analysis.

Journal: Headache 20070201

Title: Eletriptan: a review and new perspectives.

Journal: Expert review of neurotherapeutics 20061001

Title: Comparative sensitivity of stopwatch methodology and conventional pain assessment measures for detecting early response to triptans in migraine: results of a randomized, open-label pilot study.

Journal: Clinical therapeutics 20060801

Title: [Triptanes in the treatment of migraine. A review based on three Cochrane reviews].

Journal: Ugeskrift for laeger 20060508

Title: Does earlier headache response equate to earlier return to functioning in patients suffering from migraine?

Journal: Cephalalgia : an international journal of headache 20060401

Title: Preference for rizatriptan 10-mg wafer vs. eletriptan 40-mg tablet for acute treatment of migraine.

Journal: Cephalalgia : an international journal of headache 20060301

Title: [Medical treatment of migraine attacks in the child].

Journal: Revue de l'infirmiere 20060101

Title: Safety and efficacy of eletriptan in the treatment of acute migraine.

Journal: Pharmacotherapy 20060101

Title: Eletriptan: a review of its use in the acute treatment of migraine.

Journal: Drugs 20060101

Title: Eletriptan in migraine patients reporting unsatisfactory response to rizatriptan.

Journal: Headache 20060101

Title: Spotlight on eletriptan in migraine.

Journal: CNS drugs 20060101

Title: Effects of sumatriptan and eletriptan on diseased epicardial coronary arteries.

Journal: European journal of clinical pharmacology 20051101

Title: Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.

Journal: Clinical science (London, England : 1979) 20050901

Title: Therapeutic benefit of eletriptan compared to sumatriptan for the acute relief of migraine pain--results of a model-based meta-analysis that accounts for encapsulation.

Journal: Cephalalgia : an international journal of headache 20050901

Title: Eletriptan treatment of migraine in patients switching from barbiturate-containing analgesics: results from a multiple-attack study.

Journal: Cephalalgia : an international journal of headache 20050901

Title: Eletriptan in the early treatment of acute migraine: influence of pain intensity and time of dosing.

Journal: Cephalalgia : an international journal of headache 20050901

Title: Multiple attack study on the available triptans in Italy versus placebo.

Journal: European journal of neurology 20050701

Title: Triptans for migraine therapy: a comparison based on number needed to treat and doses needed to treat.

Journal: Journal of managed care pharmacy : JMCP 20050601

Title: Eletriptan review.

Journal: Expert opinion on pharmacotherapy 20050401

Title: Patient preference for eletriptan 80 mg versus subcutaneous sumatriptan 6 mg: results of a crossover study in patients who have recently used subcutaneous sumatriptan.

Journal: European journal of neurology 20050201

Title: pH-mediated acid stacking with reverse pressure for the analysis of cationic pharmaceuticals in capillary electrophoresis.

Journal: Electrophoresis 20050201

Title: Eletriptan in migraine.

Journal: Expert review of neurotherapeutics 20050101

Title: Which is more elusive, the pot of gold at the end of a rainbow or determining the most cost-effective triptan?

Journal: Journal of managed care pharmacy : JMCP 20050101

Title: [Probabilistic cost-effectiveness analysis of oral eletriptan in the treatment of acute migraine in Portugal].

Journal: Acta medica portuguesa 20050101

Title: No effect of eletriptan administration during the aura phase of migraine.

Journal: European journal of neurology 20041001

Title: [Spanish contribution to the clinical development of eletriptan: an analysis of controlled studies].

Journal: Neurologia (Barcelona, Spain) 20041001

Title: TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management.

Journal: Acta neurologica Scandinavica 20040901

Title: [Triptans in migraine: a comparative review of pharmacology, pharmacokinetics].

Journal: No to shinkei = Brain and nerve 20040901

Title: [Triptans in migraine: from clinical view].

Journal: No to shinkei = Brain and nerve 20040901

Title: [Meta-analysis of triptan treatment in migraine].

Journal: No to shinkei = Brain and nerve 20040901

Title: [Side effects of triptans].

Journal: No to shinkei = Brain and nerve 20040901

Title: Meta-analysis of oral triptans.

Journal: Cephalalgia : an international journal of headache 20040801

Title: Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040701

Title: Cardiovascular safety of triptans.

Journal: Cephalalgia : an international journal of headache 20040701

Title: Effect of high-dose intravenous eletriptan on coronary artery diameter.

Journal: Cephalalgia : an international journal of headache 20040701

Title: Migraine headache.

Journal: Clinical evidence 20040601

Title: Double-blind clinical trials of oral triptans vs other classes of acute migraine medication - a review.

Journal: Cephalalgia : an international journal of headache 20040501

Title: Eletriptan for the short-term prophylaxis of cluster headache.

Journal: Headache 20040401

Title: Effectiveness of eletriptan in acute migraine: primary care for Excedrin nonresponders.

Journal: Headache 20040301

Title: Eletriptan for the acute treatment of migraine: results of bridging a Japanese study to Western clinical trials.

Journal: Current medical research and opinion 20040301

Title: The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat.

Journal: Brain research 20040213

Title: [Use of triptanes according to indications. Risk of infarct is not increased].

Journal: MMW Fortschritte der Medizin 20040212

Title: [Recent progress in therapy for migraine headache].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040210

Title: The 40-mg dose of eletriptan: comparative efficacy and tolerability versus sumatriptan 100 mg.

Journal: European journal of neurology 20040201

Title: New drugs 04, part 1.

Journal: Nursing 20040201

Title: Comparative efficacy of eletriptan and zolmitriptan in the acute treatment of migraine.

Journal: Cephalalgia : an international journal of headache 20031201

Title: Migraine headache.

Journal: Clinical evidence 20031201

Title: Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine.

Journal: Cephalalgia : an international journal of headache 20031101

Title: Tolerability and safety of eletriptan in the treatment of migraine: a comprehensive review.

Journal: Headache 20031001

Title: Efficacy of eletriptan in migraineurs with persistent poor response to nonsteroidal anti-inflammatory drugs.

Journal: Headache 20031001

Title: Unilateral time-delayed encapsulation does not make for a fair race.

Journal: Headache 20030901

Title: Encapsulated sumatriptan is not bioequivalent to commercial sumatriptan.

Journal: Headache 20030901

Title: Musing on Mathew et al.

Journal: Headache 20030901

Title: [Strong and sustained-acting triptan. Therewith migraine does not return soon].

Journal: MMW Fortschritte der Medizin 20030807

Title: Eletriptan for the treatment of migraine in patients with previous poor response or tolerance to oral sumatriptan.

Journal: Cephalalgia : an international journal of headache 20030701

Title: Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030701

Title: [Pharmacological, pharmacokinetic and clinical profile of eletriptan (Relpax), a new triptan for migraine].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030701

Title: The evolving management of migraine.

Journal: Current opinion in neurology 20030601

Title: [Improved pharmacokinetics. Fast tryptan with sustained response].

Journal: MMW Fortschritte der Medizin 20030526

Title: [Highly selective beginning. Associated symptoms and side effects in retrospect].

Journal: MMW Fortschritte der Medizin 20030526

Title: Eletriptan (relpax) for migraine.

Journal: The Medical letter on drugs and therapeutics 20030428

Title: Eletriptan vs sumatriptan: a double-blind, placebo-controlled, multiple migraine attack study.

Journal: Neurology 20030408

Title: Efficacy, safety, and tolerability of oral eletriptan for treatment of acute migraine: a multicenter, double-blind, placebo-controlled study conducted in the United States.

Journal: Headache 20030301

Title: Comparative efficacy of eletriptan 40 mg versus sumatriptan 100 mg.

Journal: Headache 20030301

Title: Cost-effectiveness of migraine treatment: a commentary.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20030101

Title: A cost-effectiveness analysis of eletriptan 40 and 80 mg versus sumatriptan 50 and 100 mg in the acute treatment of migraine.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20030101

Title: Eletriptan issues.

Journal: Headache 20030101

Title: Sumatriptan versus eletriptan: which is best?

Journal: The Lancet. Neurology 20021201

Title: Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate.

Journal: Brain research 20021025

Title: Eletriptan vs sumatriptan: a double-blind, placebo-controlled, multiple migraine attack study.

Journal: Neurology 20021022

Title: New medications show promise for migraine sufferers.

Journal: Dentistry today 20021001

Title: Eletriptan Pfizer.

Journal: Current opinion in investigational drugs (London, England : 2000) 20020901

Title: Mechanisms of action of the 5-HT1B/1D receptor agonists.

Journal: Archives of neurology 20020701

Title: Efficacy and safety of eletriptan 20 mg, 40 mg and 80 mg in Japanese migraineurs.

Journal: Cephalalgia : an international journal of headache 20020701

Title: The pharmacokinetics and safety of single escalating oral doses of eletriptan.

Journal: Journal of clinical pharmacology 20020501

Title: Pharmacokinetics, pharmacodynamics, and safety of the 5-HT(1B/1D) agonist eletriptan following intravenous and oral administration.

Journal: Journal of clinical pharmacology 20020501

Title: [Migraine has to be treated. Otherwise a stroke threatens].

Journal: MMW Fortschritte der Medizin 20020214

Title: Efficacy, safety and tolerability of oral eletriptan in the acute treatment of migraine: results of a phase III, multicentre, placebo-controlled study across three attacks.

Journal: Cephalalgia : an international journal of headache 20020201

Title: [New triptanes in control of migraine attacks. More rapid onset of action--more efficient reduction of pain].

Journal: MMW Fortschritte der Medizin 20020124

Title: Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison.

Journal: European neurology 20020101

Title: Pharmacokinetics and safety of oral eletriptan during different phases of the menstrual cycle in healthy volunteers.

Journal: Journal of clinical pharmacology 20011201

Title: Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials.

Journal: Lancet (London, England) 20011117

Title: Eletriptan.

Journal: Expert opinion on investigational drugs 20011001

Title: Triptans are all different.

Journal: Archives of neurology 20010901

Title: Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain.

Journal: European journal of pharmacology 20010817

Title: Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels.

Journal: Neurology 20010710

Title: [New potent serotonin receptor agonist. Helps migraine patients even when other triptans fail].

Journal: MMW Fortschritte der Medizin 20010705

Title: Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans).

Journal: Archives of neurology 20010701

Title: Pharmacology and efficacy of eletriptan for the treatment of migraine attacks.

Journal: International journal of clinical practice 20010601

Title: [Eletriptan shortly before drug approval. Fewer problems in migraine therapy].

Journal: MMW Fortschritte der Medizin 20010528

Title: Functional immunohistochemistry of neuropeptides and nitric oxide synthase in the nerve fibers of the supratentorial dura mater in an experimental migraine model.

Journal: Microscopy research and technique 20010501

Title: [Current topics: expectation for new triptans].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20010410

Title: Acute treatment of migraine and the role of triptans.

Journal: Current neurology and neuroscience reports 20010301

Title: pH-mediated field-amplified sample stacking of pharmaceutical cations in high-ionic strength samples.

Journal: Electrophoresis 20010101

Title: Eletriptan for acute migraine.

Journal: The Cochrane database of systematic reviews 20010101

Title: Eletriptan: pharmacological differences and clinical results.

Journal: Current medical research and opinion 20010101

Title: Comparative aspects of triptans in treating migraine.

Journal: Clinical cornerstone 20010101

Title: Profiles of 5-HT 1B/1D agonists in acute migraine with special reference to second generation agents.

Journal: Acta neurologica Belgica 19990601

Title: Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.

Journal: European journal of pharmacology 19990305

Title: Napier C, et al. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of Heletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol, 1999, 368(2-3), 259-268.

Title: MaassenVanDenBrink A, et al. Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels. Neurology, 2000, 55(10), 1524-1530.

Title: Gupta P, et al. The in vivo pharmacological profile of eletriptan (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur J Pharmacol, 2000, 398(1), 73-81.

Title: Hoskin KL, et al. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Brain Res, 2004, 998(1), 91-99.

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Tags:177834-92-3 Molecular Formula|177834-92-3 MDL|177834-92-3 SMILES|177834-92-3 Eletriptan hydrobromide