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17791-52-5,MFCD00065576
Catalog No.:AA0025IQ

17791-52-5 | Boc-His-OH

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$7.00   $5.00
- +
10g
98%
in stock  
$13.00   $9.00
- +
25g
98%
in stock  
$27.00   $19.00
- +
500g
98%
in stock  
$462.00   $323.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0025IQ
Chemical Name:
Boc-His-OH
CAS Number:
17791-52-5
Molecular Formula:
C11H17N3O4
Molecular Weight:
255.2704
MDL Number:
MFCD00065576
SMILES:
O=C(OC(C)(C)C)N[C@H](C(=O)O)Cc1nc[nH]c1
Properties
Properties
 
BP:
522.2°C at 760 mmHg  
Form:
Solid  
MP:
195 °C (dec.);(lit.);  
Refractive Index:
26 ° (C=1, MeOH)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
314  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
0.7  

Upstream Synthesis Route

[1]ChemistryofNaturalCompounds,1982,vol.18,#3,p.322-327

[2]KhimiyaPrirodnykhSoedinenii,1982,#3,p.349-354

[1]ChemistryofNaturalCompounds,1982,vol.18,#3,p.322-327

[2]KhimiyaPrirodnykhSoedinenii,1982,#3,p.349-354

[1]TetrahedronLetters,2002,vol.43,#2,p.311-313

[1]TetrahedronLetters,2002,vol.43,#2,p.311-313

[1]BioorganicandMedicinalChemistryLetters,2014,vol.24,#14,p.3150-3154

[2]BioorganicandMedicinalChemistryLetters,2014,vol.24,#14,p.3150-3154

[3]JournalofMedicinalChemistry,2017,vol.60,#15,p.6607-6621

Downstream Synthesis Route

[1]Kawasaki;Miyano;Murakami;Kakimi[ChemicalandPharmaceuticalBulletin,1989,vol.37,#11,p.3112-3113]

[1]JournalofMedicinalChemistry,1993,vol.36,p.2431-2447

[1]ChemistryofNaturalCompounds,1982,vol.18,p.322-327    KhimiyaPrirodnykhSoedinenii,1982,p.349-354

19887-32-2    104882-10-2    17791-52-5   
{(S)-1-(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl-2-phenyl-ethyl}-carbamicacidethylester 

[1]JournalofMedicinalChemistry,1988,vol.31,p.2264-2276

19887-32-2    117248-32-5    17791-52-5   
{(S)-1-(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl-2-phenyl-ethyl}-carbamicacidethylester 

[1]JournalofMedicinalChemistry,1988,vol.31,p.2264-2276

Literature

Title: N-Boc-histidine-capped PLGA-PEG-PLGA as a smart polymer for drug delivery sensitive to tumor extracellular pH.

Journal: Macromolecular bioscience 20101008

Title: Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Journal: Nature chemical biology 20090101

Title: Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelators.

Journal: Cellular and molecular life sciences : CMLS 20070101

Title: Histidine-conjugated poly(amino acid) derivatives for the novel endosomolytic delivery carrier of doxorubicin.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20060810

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SDS
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