Home Carboxes 178167-75-4
178167-75-4,MFCD01321460
Catalog No.:AA0025QH

178167-75-4 | 2H-1-Benzopyran-2-propanoic acid, 3,4-dihydro-6-hydroxy-2,7,8-trimethyl-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$32.00   $22.00
- +
5mg
≥98%
in stock  
$136.00   $95.00
- +
10mg
≥98%
in stock  
$239.00   $167.00
- +
25mg
≥98%
in stock  
$519.00   $363.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0025QH
Chemical Name:
2H-1-Benzopyran-2-propanoic acid, 3,4-dihydro-6-hydroxy-2,7,8-trimethyl-
CAS Number:
178167-75-4
Molecular Formula:
C15H20O4
Molecular Weight:
264.3169
MDL Number:
MFCD01321460
SMILES:
OC(=O)CCC1(C)CCc2c(O1)c(C)c(c(c2)O)C
Properties
Computed Properties
 
Complexity:
343  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.8  

Literature

Title: Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system.

Journal: Surgical neurology international 20120101

Title: Tocotrienamines and tocopheramines: reactions with radicals and metal ions.

Journal: Bioorganic & medicinal chemistry 20111101

Title: Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol.

Journal: Journal of nutritional science and vitaminology 20110101

Title: Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100601

Title: Enantioselective total synthesis of the natural gamma-tocopherol metabolite (S)-gamma-CEHC [(S)-LLU-alpha].

Journal: Organic letters 20100205

Title: In vitro stable isotope labeling for discovery of novel metabolites by liquid chromatography-mass spectrometry: Confirmation of gamma-tocopherol metabolism in human A549 cell.

Journal: Journal of chromatography. A 20100129

Title: Present trends in vitamin E research.

Journal: BioFactors (Oxford, England) 20100101

Title: Vitamin E supplementation and hepatic drug metabolism in humans.

Journal: Journal of cardiovascular pharmacology 20091201

Title: Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation.

Journal: Journal of lipid research 20090501

Title: Coenzyme Q10-Binding/Transfer Protein Saposin B also Binds gamma-Tocopherol.

Journal: Journal of clinical biochemistry and nutrition 20080901

Title: gamma-Tocopherol Accelerated Sodium Excretion in a Dose-Dependent Manner in Rats with a High Sodium Intake.

Journal: Journal of clinical biochemistry and nutrition 20071101

Title: Hydroxymatairesinol and sesaminol act differently on tocopherol concentrations in rats.

Journal: Journal of nutritional science and vitaminology 20071001

Title: Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070901

Title: Dietary sesame seed decreases urinary excretion of alpha- and gamma-tocopherol metabolites in rats.

Journal: Journal of nutritional science and vitaminology 20070801

Title: A new compound-specific pleiotropic effect of statins: modification of plasma gamma-tocopherol levels.

Journal: Atherosclerosis 20070701

Title: Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentrations in rats.

Journal: Lipids 20070701

Title: Measurement of the vitamin E metabolites, carboxyethyl hydroxychromans (CEHCs), in biological samples.

Journal: Current protocols in toxicology 20060901

Title: Nitration of gamma-tocopherol prevents its oxidative metabolism by HepG2 cells.

Journal: Free radical biology & medicine 20050815

Title: The effect of gamma-tocopherol administration on alpha-tocopherol levels and metabolism in humans.

Journal: European journal of clinical nutrition 20050801

Title: Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.

Journal: Free radical biology & medicine 20050315

Title: The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols.

Journal: Annals of the New York Academy of Sciences 20041201

Title: Intravenous administration of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman (gamma-CEHC) to rats and determination of its plasma concentration and urinary sodium excretion.

Journal: Biomedical chromatography : BMC 20041101

Title: A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromans.

Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20040901

Title: Cigarette smokers have decreased lymphocyte and platelet alpha-tocopherol levels and increased excretion of the gamma-tocopherol metabolite gamma-carboxyethyl-hydroxychroman (gamma-CEHC).

Journal: Free radical research 20040801

Title: Gamma-tocopherol enhances sodium excretion as a natriuretic hormone precursor.

Journal: Journal of nutritional science and vitaminology 20040801

Title: Anti-inflammatory effects of tocopherol metabolites.

Journal: Biochemical and biophysical research communications 20040702

Title: The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation.

Journal: Archives of biochemistry and biophysics 20040301

Title: Gamma-tocopherol--an underestimated vitamin?

Journal: Annals of nutrition & metabolism 20040101

Title: gamma-Tocopherol biokinetics and transformation in humans.

Journal: Free radical research 20031101

Title: Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor.

Journal: Journal of lipid research 20030801

Title: Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501

Title: Measurement of vitamin E metabolites by high-performance liquid chromatography during high-dose administration of alpha-tocopherol.

Journal: European journal of clinical nutrition 20030301

Title: Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC.

Journal: Journal of lipid research 20021201

Title: Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E.

Journal: European journal of nutrition 20020601

Title: Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma.

Journal: Free radical biology & medicine 20020215

Title: LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol.

Journal: Toxicology letters 20010706

Title: Alpha-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2 (2'-carboxyethyl)-6-hydroxychroman, gamma-tocopherol metabolite, in rats.

Journal: Lipids 20010501

Title: A fluorimetric, column-switching HPLC and its application to an elimination study of LLU-alpha enantiomers in rat plasma.

Journal: Biomedical chromatography : BMC 20010401

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:178167-75-4 Molecular Formula|178167-75-4 MDL|178167-75-4 SMILES|178167-75-4 2H-1-Benzopyran-2-propanoic acid, 3,4-dihydro-6-hydroxy-2,7,8-trimethyl-