Home Amines 178616-26-7
178616-26-7,MFCD01321072
Catalog No.:AA002644

178616-26-7 | 1-(4-Aminophenyl)-7,8-dimethoxy-3H-benzo[d][1,2]diazepin-4(5H)-one

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10mg
≥98%
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$365.00   $255.00
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50mg
≥98%
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$1,170.00   $819.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002644
Chemical Name:
1-(4-Aminophenyl)-7,8-dimethoxy-3H-benzo[d][1,2]diazepin-4(5H)-one
CAS Number:
178616-26-7
Molecular Formula:
C17H17N3O3
Molecular Weight:
311.3352
MDL Number:
MFCD01321072
SMILES:
COc1cc2c(cc1OC)CC(=O)NN=C2c1ccc(cc1)N
Properties
Computed Properties
 
Complexity:
460  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
1  

Literature

Title: Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain.

Journal: Molecular pain 20080101

Title: AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth.

Journal: Cancer biology & therapy 20071201

Title: An alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate glutamate-receptor antagonist can inhibit premicturition contractions in rats with bladder outlet obstruction.

Journal: BJU international 20070701

Title: Effects of non-competitive AMPA receptor antagonists injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.

Journal: Neuropharmacology 20061101

Title: Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton.

Journal: Journal of medicinal chemistry 20060907

Title: Glutamate receptor agonist kainate enhances primary dendrite number and length from immature mouse cortical neurons in vitro.

Journal: Journal of neuroscience research 20060501

Title: Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro.

Journal: European journal of pharmacology 20060327

Title: Glutamate receptors on human melanocytes regulate the expression of MiTF.

Journal: Pigment cell research 20060201

Title: Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives.

Journal: Farmaco (Societa chimica italiana : 1989) 20040101

Title: Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.

Journal: Journal of medicinal chemistry 20030814

Title: Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist.

Journal: Journal of medicinal chemistry 20030102

Title: Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block.

Journal: European journal of pharmacology 20020906

Title: Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats.

Journal: European journal of pharmacology 19990305

Title: De Sarro G, et al. Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur J Pharmacol. 1999 Mar 5;368(2-3):149-59.

Title: Rizzo M, et al. Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 1999 Aug 20;731(2):207-15.

Title: Stepulak A, et al. AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth. Cancer Biol Ther. 2007 Dec;6(12):1908-15.

Title: Park JS, et al. Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain. 2008 Dec 30;4:67.

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Tags:178616-26-7 Molecular Formula|178616-26-7 MDL|178616-26-7 SMILES|178616-26-7 1-(4-Aminophenyl)-7,8-dimethoxy-3H-benzo[d][1,2]diazepin-4(5H)-one