Home Imidazoles 179420-17-8
179420-17-8,MFCD00948114
Catalog No.:AA0026XC

179420-17-8 | 2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-

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1mg
≥98%
in stock  
$63.00   $44.00
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5mg
≥98%
in stock  
$169.00   $118.00
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10mg
≥98%
in stock  
$306.00   $214.00
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25mg
≥98%
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$685.00   $479.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0026XC
Chemical Name:
2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-
CAS Number:
179420-17-8
Molecular Formula:
C22H23N3O2S
Molecular Weight:
393.5019
MDL Number:
MFCD00948114
SMILES:
Cc1nccn1c1ccc(cc1)Sc1cccc(c1)C1(CCOCC1)C(=O)N
Properties
Computed Properties
 
Complexity:
532  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3.2  

Literature

Title: In vitro-in vivo correlation and translation to the clinical outcome for CJ-13,610, a novel inhibitor of 5-lipoxygenase.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701

Title: Pharmacophore modeling and virtual screening for designing potential 5-lipoxygenase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain.

Journal: European journal of pharmacology 20090901

Title: The use of gastrointestinal intubation studies for controlled release development.

Journal: British journal of clinical pharmacology 20090901

Title: A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.

Journal: European journal of pharmacology 20080414

Title: Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics 20071201

Title: Dog colonoscopy model for predicting human colon absorption.

Journal: Pharmaceutical research 20060701

Title: Optimization of imidazole 5-lipoxygenase inhibitors and selection and synthesis of a development candidate.

Journal: Chemical & pharmaceutical bulletin 20050801

Title: 5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues.

Journal: Bioorganic & medicinal chemistry letters 20050516

Title: Molecular pharmacological profile of the nonredox-type 5-lipoxygenase inhibitor CJ-13,610.

Journal: British journal of pharmacology 20040701

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Tags:179420-17-8 Molecular Formula|179420-17-8 MDL|179420-17-8 SMILES|179420-17-8 2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-