20244-86-4,MFCD16661197
Catalog No.:AA00286E

20244-86-4 | 7-Methylguanosine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
≥98%
in stock  
$46.00   $32.00
- +
50mg
≥98%
in stock  
$88.00   $61.00
- +
100mg
≥98%
in stock  
$125.00   $87.00
- +
250mg
≥98%
in stock  
$285.00   $199.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00286E
Chemical Name:
7-Methylguanosine
CAS Number:
20244-86-4
Molecular Formula:
C11H17N5O5
Molecular Weight:
299.2832
MDL Number:
MFCD16661197
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N1CN(c2c1nc(N)[nH]c2=O)C
Properties
Computed Properties
 
Complexity:
474  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Formal Charge:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
2  
XLogP3:
-1.8  

Downstream Synthesis Route
20244-86-4    623925-45-1    578-76-7   
8-13C-7-15N-6-chloro-9-(β-D-ribofuranosyl)purine 

[1]JournalofOrganicChemistry,2003,vol.68,p.8657-8661

[1]Nucleosides,nucleotidesandnucleicacids,2005,vol.24,p.471-476

[2]Nucleosides,nucleotidesandnucleicacids,2005,vol.24,p.459-464

[1]ProteinScience,2017,vol.26,p.985-996

Literature

Title: Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway.

Journal: RNA (New York, N.Y.) 20121001

Title: Synthesis of N²-modified 7-methylguanosine 5'-monophosphates as nematode translation inhibitors.

Journal: Bioorganic & medicinal chemistry 20120801

Title: Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins.

Journal: RNA (New York, N.Y.) 20120701

Title: Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs.

Journal: The Journal of biological chemistry 20120608

Title: Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.

Journal: RNA (New York, N.Y.) 20120601

Title: E2F1-dependent methyl cap formation requires RNA pol II phosphorylation.

Journal: Cell cycle (Georgetown, Tex.) 20120601

Title: Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity.

Journal: PLoS pathogens 20120301

Title: Targeting Mnks for cancer therapy.

Journal: Oncotarget 20120201

Title: Bioinformatics tools and novel challenges in long non-coding RNAs (lncRNAs) functional analysis.

Journal: International journal of molecular sciences 20120101

Title: Chemical approaches for structure and function of RNA in postgenomic era.

Journal: Journal of nucleic acids 20120101

Title: High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis.

Journal: PloS one 20120101

Title: In vitro transcription and capping of Gaussia luciferase mRNA followed by HeLa cell transfection.

Journal: Journal of visualized experiments : JoVE 20120101

Title: Functional and structural analysis of the internal ribosome entry site present in the mRNA of natural variants of the HIV-1.

Journal: PloS one 20120101

Title: Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.

Journal: PloS one 20120101

Title: The eIF4F and eIFiso4F Complexes of Plants: An Evolutionary Perspective.

Journal: Comparative and functional genomics 20120101

Title: Versatility of RNA-Binding Proteins in Cancer.

Journal: Comparative and functional genomics 20120101

Title: ATPase cycle and DNA unwinding kinetics of RecG helicase.

Journal: PloS one 20120101

Title: Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression.

Journal: Frontiers in genetics 20120101

Title: Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.

Journal: Biochemistry 20111213

Title: RAM/Fam103a1 is required for mRNA cap methylation.

Journal: Molecular cell 20111118

Title: Periodic expression of Sm proteins parallels formation of nuclear Cajal bodies and cytoplasmic snRNP-rich bodies.

Journal: Histochemistry and cell biology 20111101

Title: The state-of-the-art determination of urinary nucleosides using chromatographic techniques 'hyphenated' with advanced bioinformatic methods.

Journal: Analytical and bioanalytical chemistry 20111001

Title: Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1.

Journal: PLoS pathogens 20111001

Title: Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.

Journal: Biochimie 20110901

Title: Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis.

Journal: Nature structural & molecular biology 20110901

Title: Synthesis of a new class of ribose functionalized dinucleotide cap analogues for biophysical studies on interaction of cap-binding proteins with the 5' end of mRNA.

Journal: Organic & biomolecular chemistry 20110807

Title: An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.

Journal: PLoS pathogens 20110701

Title: Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.

Journal: Journal of molecular modeling 20110401

Title: A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.

Journal: PLoS biology 20110301

Title: Targeting translation dependence in cancer.

Journal: Oncotarget 20110201

Title: Mutation and selection on the wobble nucleotide in tRNA anticodons in marine bivalve mitochondrial genomes.

Journal: PloS one 20110101

Title: Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden.

Journal: PloS one 20110101

Title: Determinants of translation efficiency and accuracy.

Journal: Molecular systems biology 20110101

Title: Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine.

Journal: Cancer cell international 20110101

Title: Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism.

Journal: PloS one 20110101

Title: Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and HOXD4.

Journal: PloS one 20110101

Title: tRNA Modification and Genetic Code Variations in Animal Mitochondria.

Journal: Journal of nucleic acids 20110101

Title: Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease.

Journal: PloS one 20110101

Title: Identification and analysis of the RNA degrading complexes and machinery of Giardia lamblia using an in silico approach.

Journal: BMC genomics 20110101

Title: Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.

Journal: PloS one 20110101

Title: MicroRNAs in Hepatobiliary and Pancreatic Cancers.

Journal: Frontiers in genetics 20110101

Title: Thousands of Novel Transcripts Identified in Mouse Cerebrum, Testis, and ES Cells Based on ribo-minus RNA Sequencing.

Journal: Frontiers in genetics 20110101

Title: A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA.

Journal: Scientific reports 20110101

Title: RNA decay and RNA silencing in plants: competition or collaboration?

Journal: Frontiers in plant science 20110101

Title: Myc up-regulates formation of the mRNA methyl cap.

Journal: Biochemical Society transactions 20101201

Title: Regulation of influenza RNA polymerase activity and the switch between replication and transcription by the concentrations of the vRNA 5' end, the cap source, and the polymerase.

Journal: Biochemistry 20101130

Title: Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways.

Journal: Molecular and cellular biology 20101001

Title: Identification of a quality-control mechanism for mRNA 5'-end capping.

Journal: Nature 20100930

Title: The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.

Journal: Molecular cell 20100924

Title: Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies.

Journal: The FEBS journal 20100701

Title: Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles.

Journal: Human molecular genetics 20100201

Title: Regulation of mRNA cap methylation.

Journal: The Biochemical journal 20100115

Title: Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.

Journal: Cell metabolism 20100106

Title: The Arc of synaptic memory.

Journal: Experimental brain research 20100101

Title: Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

Journal: RNA (New York, N.Y.) 20100101

Title: The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.

Journal: PloS one 20100101

Title: Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.

Journal: Cancer cell international 20100101

Title: Heritability in the efficiency of nonsense-mediated mRNA decay in humans.

Journal: PloS one 20100101

Title: Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana.

Journal: BMC plant biology 20100101

Title: A conserved stem loop motif in the 5'untranslated region regulates transforming growth factor-β(1) translation.

Journal: PloS one 20100101

Title: Expression analysis and knockdown of two antennal odorant-binding protein genes in Aedes aegypti.

Journal: Journal of insect science (Online) 20100101

Title: Proteomic analysis of streptomycin resistant and sensitive clinical isolates of Mycobacterium tuberculosis.

Journal: Proteome science 20100101

Title: A screen for RNA-binding proteins in yeast indicates dual functions for many enzymes.

Journal: PloS one 20100101

Title: The role of molecular biology in the biomonitoring of human exposure to chemicals.

Journal: International journal of molecular sciences 20100101

Title: Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity.

Journal: Gastroenterology research and practice 20100101

Title: Mi-DISCOVERER: A bioinformatics tool for the detection of mi-RNA in human genome.

Journal: Bioinformation 20100101

Title: Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.

Journal: Journal of the American Chemical Society 20091223

Title: Influenza A: understanding the viral life cycle.

Journal: The Yale journal of biology and medicine 20091201

Title: The GTPase activity of Escherichia coli FtsZ determines the magnitude of the FtsZ polymer bundling by ZapA in vitro.

Journal: Biochemistry 20091124

Title: Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods.

Journal: Journal of molecular histology 20091001

Title: TERRA: telomeric repeat-containing RNA.

Journal: The EMBO journal 20090902

Title: Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma.

Journal: British journal of cancer 20090804

Title: Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils.

Journal: Pflugers Archiv : European journal of physiology 20090801

Title: Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.

Journal: Cell 20090723

Title: PcrA helicase tightly couples ATP hydrolysis to unwinding double-stranded DNA, modulated by the initiator protein for plasmid replication, RepD.

Journal: Biochemistry 20090714

Title: Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation.

Journal: Bioorganic & medicinal chemistry letters 20090401

Title: The RNA polymerase dictates ORF1 requirement and timing of LINE and SINE retrotransposition.

Journal: PLoS genetics 20090401

Title: Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex.

Journal: Journal of molecular biology 20090116

Title: Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer.

Journal: Journal of experimental & clinical cancer research : CR 20090101

Title: The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif.

Journal: Biology direct 20090101

Title: Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome.

Journal: Retrovirology 20090101

Title: Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection.

Journal: BMC cancer 20090101

Title: microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.

Journal: PloS one 20090101

Title: Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.

Journal: PloS one 20090101

Title: MicroRNA profiling and head and neck cancer.

Journal: Comparative and functional genomics 20090101

Title: Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

Journal: PloS one 20090101

Title: EBNA3C interacts with Gadd34 and counteracts the unfolded protein response.

Journal: Virology journal 20090101

Title: Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase.

Journal: Archives of biochemistry and biophysics 20081215

Title: The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis.

Journal: Molecular microbiology 20081101

Title: snoRNA, a novel precursor of microRNA in Giardia lamblia.

Journal: PLoS pathogens 20081101

Title: Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode.

Journal: Journal of molecular biology 20081017

Title: The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon.

Journal: The EMBO journal 20080820

Title: Stacking efficiency and flexibility analysis of aromatic amino acids in cap-binding proteins.

Journal: Proteins 20080601

Title: Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.

Journal: RNA (New York, N.Y.) 20080601

Title: MicroRNA: An emerging therapeutic target and intervention tool.

Journal: International journal of molecular sciences 20080601

Title: Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.

Journal: Genes & development 20080515

Title: Motor step size and ATP coupling efficiency of the dsDNA translocase EcoR124I.

Journal: The EMBO journal 20080507

Title: Detection and localization of small nuclear ribonucleoproteins (snRNPs) in trypanosomatids using anti-m3G antibodies.

Journal: Japanese journal of infectious diseases 20080301

Title: Biochemical characterization of Yin Yang 1-RNA complexes.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20080201

Title: Evolutionary patterns in the sequence and structure of transfer RNA: a window into early translation and the genetic code.

Journal: PloS one 20080101

Title: m7GTP alphaS is a strong and stable inhibitor of cap-dependent translation.

Journal: Nucleic acids symposium series (2004) 20080101

Title: Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader.

Journal: BMC molecular biology 20080101

Title: piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071101

Title: Transcriptional networking cap-tures the 7SK RNA 5'-gamma-methyltransferase.

Journal: Molecular cell 20070817

Title: The major 5' end of HIV type 1 RNA corresponds to G456.

Journal: AIDS research and human retroviruses 20070801

Title: RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.

Journal: The Journal of biological chemistry 20070511

Title: Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.

Journal: Molecular microbiology 20070201

Title: Methylation: a regulator of HIV-1 replication?

Journal: Retrovirology 20070101

Title: Conflict between translation initiation and elongation in vertebrate mitochondrial genomes.

Journal: PloS one 20070101

Title: EcoTILLING for the identification of allelic variants of melon eIF4E, a factor that controls virus susceptibility.

Journal: BMC plant biology 20070101

Title: Identification of modified residues in RNAs by reverse transcription-based methods.

Journal: Methods in enzymology 20070101

Title: MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans.

Journal: BMC bioinformatics 20070101

Title: Systematic identification of non-coding RNA 2,2,7-trimethylguanosine cap structures in Caenorhabditis elegans.

Journal: BMC molecular biology 20070101

Title: Solid-supported synthesis of 5'-mRNA CAP-4 from Trypanosomatids.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: Interactions of calf spleen purine nucleoside phosphorylase with formycin B and its aglycone - spectroscopic and kinetic studies.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: Non-adenine based purines accelerate wound healing.

Journal: Purinergic signalling 20061101

Title: Yeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decay.

Journal: RNA (New York, N.Y.) 20060701

Title: Calcium-stimulated guanosine--inosine nucleosidase from yellow lupin (Lupinus luteus).

Journal: Phytochemistry 20060701

Title: Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control.

Journal: British journal of cancer 20060605

Title: Parallel evolution of the genetic code in arthropod mitochondrial genomes.

Journal: PLoS biology 20060501

Title: An industrial process for selective synthesis of 7-methyl guanosine 5'-diphosphate: versatile synthon for synthesis of mRNA cap analogues.

Journal: Nucleosides, nucleotides & nucleic acids 20060301

Title: VPg of murine norovirus binds translation initiation factors in infected cells.

Journal: Virology journal 20060101

Title: The complete sequence of the mitochondrial genome of Nautilus macromphalus (Mollusca: Cephalopoda).

Journal: BMC genomics 20060101

Title: 'Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells'.

Journal: Cancer cell international 20060101

Title: Mechanism and regulation of translation in C. elegans.

Journal: WormBook : the online review of C. elegans biology 20060101

Title: The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro.

Journal: RNA (New York, N.Y.) 20051001

Title: Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2).

Journal: The Journal of biological chemistry 20050916

Title: A new yeast poly(A) polymerase complex involved in RNA quality control.

Journal: PLoS biology 20050601

Title: Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis.

Journal: Proteins 20050515

Title: The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.

Journal: The EMBO journal 20050504

Title: Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.

Journal: Journal of molecular biology 20050408

Title: Yeast-like mRNA capping apparatus in Giardia lamblia.

Journal: The Journal of biological chemistry 20050401

Title: Translation initiation factor (eIF) 4B affects the rates of binding of the mRNA m7G cap analogue to wheat germ eIFiso4F and eIFiso4F.PABP.

Journal: Biochemistry 20050322

Title: A mutant of eukaryotic protein synthesis initiation factor eIF4E(K119A) has an increased binding affinity for both m7G cap analogues and eIF4G peptides.

Journal: Biochemistry 20050322

Title: [Simultaneous determination of 7-methylguanosine and mitomycin C by capillary electrophoresis with amperometric detection].

Journal: Se pu = Chinese journal of chromatography 20050301

Title: A competitive ELISA detecting 7-methylguanosine adduct induced by N-nitrosodimethylamine exposure.

Journal: Human & experimental toxicology 20050201

Title: Phylogenetic analysis of eIF4E-family members.

Journal: BMC evolutionary biology 20050101

Title: Kinetic properties of Cellulomonas sp. purine nucleoside phosphorylase with typical and non-typical substrates: implications for the reaction mechanism.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: Deaggregation of eIF4E induced by mRNA 5' cap binding.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: Synthesis and enzymatic characterization of methylene analogs of adenosine 5'-tetraphosphate (P4A).

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: Thermodynamics of mRNA 5' cap binding by eukaryotic translation initiation factor eIF4E.

Journal: Biochemistry 20041026

Title: Chemical synthesis and binding activity of the trypanosomatid cap-4 structure.

Journal: RNA (New York, N.Y.) 20040901

Title: Determination of the capped site sequence of mRNA based on the detection of cap-dependent nucleotide addition using an anchor ligation method.

Journal: DNA research : an international journal for rapid publication of reports on genes and genomes 20040831

Title: Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus.

Journal: Biochemistry 20040511

Title: Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites.

Journal: Genome biology 20040101

Title: Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.

Journal: Journal of biomolecular NMR 20031101

Title: Macrocyclic amines as catalysts of the hydrolysis of the triphosphate bridge of the mRNA 5'-cap structure.

Journal: Organic & biomolecular chemistry 20031007

Title: Charge distribution in 7-methylguanine regarding cation-pi interaction with protein factor eIF4E.

Journal: Biophysical journal 20030901

Title: Synthesis of novel mRNA 5' cap-analogues: dinucleoside P1, P3-tri-, P1, P4-tetra-, and P1, P5-pentaphosphates.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Dinucleoside monophosphates containing AZT and 1-methyladenosine or 7-methylguanosine.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Thermodynamics of 7-methylguanosine cation stacking with tryptophan upon mRNA 5' cap binding to translation factor eIF4E.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Binding studies of eukaryotic initiation factor eIF4E with novel mRNA dinucleotide cap analogues.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.

Journal: RNA (New York, N.Y.) 20021001

Title: The 'cap-binding slot' of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap.

Journal: Biochemistry 20020618

Title: Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism, hydrolysis of 7-methylguanosine, and oligomeric state in solution.

Journal: Biochimica et biophysica acta 20020429

Title: A procedure for analysis of stopped-flow transients for protein-ligand association.

Journal: Journal of biochemical and biophysical methods 20020418

Title: Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region.

Journal: The Biochemical journal 20020315

Title: Beyond the proteome: non-coding regulatory RNAs.

Journal: Genome biology 20020101

Title: Poly(rC) binding proteins mediate poliovirus mRNA stability.

Journal: RNA (New York, N.Y.) 20010801

Title: Transcriptional regulation of the rat eIF4E gene in cardiac muscle cells: the role of specific elements in the promoter region.

Journal: Gene 20010404

Title: A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements.

Journal: The EMBO journal 20010301

Title: The major transcription initiation site of the p27Kip1 gene is conserved in human and mouse and produces a long 5'-UTR.

Journal: BMC molecular biology 20010101

Title: Kozarski M, et al. 7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase. Bioorg Med Chem. 2018 Jan 1;26(1):191-199.

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Tags:20244-86-4 Molecular Formula|20244-86-4 MDL|20244-86-4 SMILES|20244-86-4 7-Methylguanosine
Catalog No.: AA00286E
20244-86-4,MFCD16661197
20244-86-4 | 7-Methylguanosine
Pack Size: 25mg
Purity: ≥98%
in stock
$46.00 $32.00
Pack Size: 50mg
Purity: ≥98%
in stock
$88.00 $61.00
Pack Size: 100mg
Purity: ≥98%
in stock
$125.00 $87.00
Pack Size: 250mg
Purity: ≥98%
in stock
$285.00 $199.00
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Technical Information
Catalog Number: AA00286E
Chemical Name: 7-Methylguanosine
CAS Number: 20244-86-4
Molecular Formula: C11H17N5O5
Molecular Weight: 299.2832
MDL Number: MFCD16661197
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N1CN(c2c1nc(N)[nH]c2=O)C
Properties
Complexity: 474  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 4  
Formal Charge: 1  
Heavy Atom Count: 21  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 5  
Rotatable Bond Count: 2  
XLogP3: -1.8  
Downstream Synthesis Route
20244-86-4    623925-45-1    578-76-7   
8-13C-7-15N-6-chloro-9-(β-D-ribofuranosyl)purine 

[1]JournalofOrganicChemistry,2003,vol.68,p.8657-8661

20244-86-4    578-76-7    18646-11-2 

[1]Nucleosides,nucleotidesandnucleicacids,2005,vol.24,p.471-476

[2]Nucleosides,nucleotidesandnucleicacids,2005,vol.24,p.459-464

20244-86-4    578-76-7    532-20-7 

[1]ProteinScience,2017,vol.26,p.985-996

Literature fold

Title: Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway.

Journal: RNA (New York, N.Y.)20121001

Title: Synthesis of N²-modified 7-methylguanosine 5'-monophosphates as nematode translation inhibitors.

Journal: Bioorganic & medicinal chemistry20120801

Title: Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins.

Journal: RNA (New York, N.Y.)20120701

Title: Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs.

Journal: The Journal of biological chemistry20120608

Title: Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.

Journal: RNA (New York, N.Y.)20120601

Title: E2F1-dependent methyl cap formation requires RNA pol II phosphorylation.

Journal: Cell cycle (Georgetown, Tex.)20120601

Title: Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity.

Journal: PLoS pathogens20120301

Title: Targeting Mnks for cancer therapy.

Journal: Oncotarget20120201

Title: Bioinformatics tools and novel challenges in long non-coding RNAs (lncRNAs) functional analysis.

Journal: International journal of molecular sciences20120101

Title: Chemical approaches for structure and function of RNA in postgenomic era.

Journal: Journal of nucleic acids20120101

Title: High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis.

Journal: PloS one20120101

Title: In vitro transcription and capping of Gaussia luciferase mRNA followed by HeLa cell transfection.

Journal: Journal of visualized experiments : JoVE20120101

Title: Functional and structural analysis of the internal ribosome entry site present in the mRNA of natural variants of the HIV-1.

Journal: PloS one20120101

Title: Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.

Journal: PloS one20120101

Title: The eIF4F and eIFiso4F Complexes of Plants: An Evolutionary Perspective.

Journal: Comparative and functional genomics20120101

Title: Versatility of RNA-Binding Proteins in Cancer.

Journal: Comparative and functional genomics20120101

Title: ATPase cycle and DNA unwinding kinetics of RecG helicase.

Journal: PloS one20120101

Title: Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression.

Journal: Frontiers in genetics20120101

Title: Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.

Journal: Biochemistry20111213

Title: RAM/Fam103a1 is required for mRNA cap methylation.

Journal: Molecular cell20111118

Title: Periodic expression of Sm proteins parallels formation of nuclear Cajal bodies and cytoplasmic snRNP-rich bodies.

Journal: Histochemistry and cell biology20111101

Title: The state-of-the-art determination of urinary nucleosides using chromatographic techniques 'hyphenated' with advanced bioinformatic methods.

Journal: Analytical and bioanalytical chemistry20111001

Title: Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1.

Journal: PLoS pathogens20111001

Title: Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.

Journal: Biochimie20110901

Title: Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis.

Journal: Nature structural & molecular biology20110901

Title: Synthesis of a new class of ribose functionalized dinucleotide cap analogues for biophysical studies on interaction of cap-binding proteins with the 5' end of mRNA.

Journal: Organic & biomolecular chemistry20110807

Title: An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.

Journal: PLoS pathogens20110701

Title: Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.

Journal: Journal of molecular modeling20110401

Title: A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.

Journal: PLoS biology20110301

Title: Targeting translation dependence in cancer.

Journal: Oncotarget20110201

Title: Mutation and selection on the wobble nucleotide in tRNA anticodons in marine bivalve mitochondrial genomes.

Journal: PloS one20110101

Title: Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden.

Journal: PloS one20110101

Title: Determinants of translation efficiency and accuracy.

Journal: Molecular systems biology20110101

Title: Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine.

Journal: Cancer cell international20110101

Title: Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism.

Journal: PloS one20110101

Title: Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and HOXD4.

Journal: PloS one20110101

Title: tRNA Modification and Genetic Code Variations in Animal Mitochondria.

Journal: Journal of nucleic acids20110101

Title: Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease.

Journal: PloS one20110101

Title: Identification and analysis of the RNA degrading complexes and machinery of Giardia lamblia using an in silico approach.

Journal: BMC genomics20110101

Title: Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.

Journal: PloS one20110101

Title: MicroRNAs in Hepatobiliary and Pancreatic Cancers.

Journal: Frontiers in genetics20110101

Title: Thousands of Novel Transcripts Identified in Mouse Cerebrum, Testis, and ES Cells Based on ribo-minus RNA Sequencing.

Journal: Frontiers in genetics20110101

Title: A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA.

Journal: Scientific reports20110101

Title: RNA decay and RNA silencing in plants: competition or collaboration?

Journal: Frontiers in plant science20110101

Title: Myc up-regulates formation of the mRNA methyl cap.

Journal: Biochemical Society transactions20101201

Title: Regulation of influenza RNA polymerase activity and the switch between replication and transcription by the concentrations of the vRNA 5' end, the cap source, and the polymerase.

Journal: Biochemistry20101130

Title: Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways.

Journal: Molecular and cellular biology20101001

Title: Identification of a quality-control mechanism for mRNA 5'-end capping.

Journal: Nature20100930

Title: The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.

Journal: Molecular cell20100924

Title: Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies.

Journal: The FEBS journal20100701

Title: Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles.

Journal: Human molecular genetics20100201

Title: Regulation of mRNA cap methylation.

Journal: The Biochemical journal20100115

Title: Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.

Journal: Cell metabolism20100106

Title: The Arc of synaptic memory.

Journal: Experimental brain research20100101

Title: Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

Journal: RNA (New York, N.Y.)20100101

Title: The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.

Journal: PloS one20100101

Title: Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.

Journal: Cancer cell international20100101

Title: Heritability in the efficiency of nonsense-mediated mRNA decay in humans.

Journal: PloS one20100101

Title: Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana.

Journal: BMC plant biology20100101

Title: A conserved stem loop motif in the 5'untranslated region regulates transforming growth factor-β(1) translation.

Journal: PloS one20100101

Title: Expression analysis and knockdown of two antennal odorant-binding protein genes in Aedes aegypti.

Journal: Journal of insect science (Online)20100101

Title: Proteomic analysis of streptomycin resistant and sensitive clinical isolates of Mycobacterium tuberculosis.

Journal: Proteome science20100101

Title: A screen for RNA-binding proteins in yeast indicates dual functions for many enzymes.

Journal: PloS one20100101

Title: The role of molecular biology in the biomonitoring of human exposure to chemicals.

Journal: International journal of molecular sciences20100101

Title: Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity.

Journal: Gastroenterology research and practice20100101

Title: Mi-DISCOVERER: A bioinformatics tool for the detection of mi-RNA in human genome.

Journal: Bioinformation20100101

Title: Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.

Journal: Journal of the American Chemical Society20091223

Title: Influenza A: understanding the viral life cycle.

Journal: The Yale journal of biology and medicine20091201

Title: The GTPase activity of Escherichia coli FtsZ determines the magnitude of the FtsZ polymer bundling by ZapA in vitro.

Journal: Biochemistry20091124

Title: Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods.

Journal: Journal of molecular histology20091001

Title: TERRA: telomeric repeat-containing RNA.

Journal: The EMBO journal20090902

Title: Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma.

Journal: British journal of cancer20090804

Title: Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils.

Journal: Pflugers Archiv : European journal of physiology20090801

Title: Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.

Journal: Cell20090723

Title: PcrA helicase tightly couples ATP hydrolysis to unwinding double-stranded DNA, modulated by the initiator protein for plasmid replication, RepD.

Journal: Biochemistry20090714

Title: Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation.

Journal: Bioorganic & medicinal chemistry letters20090401

Title: The RNA polymerase dictates ORF1 requirement and timing of LINE and SINE retrotransposition.

Journal: PLoS genetics20090401

Title: Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex.

Journal: Journal of molecular biology20090116

Title: Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer.

Journal: Journal of experimental & clinical cancer research : CR20090101

Title: The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif.

Journal: Biology direct20090101

Title: Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome.

Journal: Retrovirology20090101

Title: Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection.

Journal: BMC cancer20090101

Title: microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.

Journal: PloS one20090101

Title: Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.

Journal: PloS one20090101

Title: MicroRNA profiling and head and neck cancer.

Journal: Comparative and functional genomics20090101

Title: Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

Journal: PloS one20090101

Title: EBNA3C interacts with Gadd34 and counteracts the unfolded protein response.

Journal: Virology journal20090101

Title: Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase.

Journal: Archives of biochemistry and biophysics20081215

Title: The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis.

Journal: Molecular microbiology20081101

Title: snoRNA, a novel precursor of microRNA in Giardia lamblia.

Journal: PLoS pathogens20081101

Title: Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode.

Journal: Journal of molecular biology20081017

Title: The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon.

Journal: The EMBO journal20080820

Title: Stacking efficiency and flexibility analysis of aromatic amino acids in cap-binding proteins.

Journal: Proteins20080601

Title: Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.

Journal: RNA (New York, N.Y.)20080601

Title: MicroRNA: An emerging therapeutic target and intervention tool.

Journal: International journal of molecular sciences20080601

Title: Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.

Journal: Genes & development20080515

Title: Motor step size and ATP coupling efficiency of the dsDNA translocase EcoR124I.

Journal: The EMBO journal20080507

Title: Detection and localization of small nuclear ribonucleoproteins (snRNPs) in trypanosomatids using anti-m3G antibodies.

Journal: Japanese journal of infectious diseases20080301

Title: Biochemical characterization of Yin Yang 1-RNA complexes.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire20080201

Title: Evolutionary patterns in the sequence and structure of transfer RNA: a window into early translation and the genetic code.

Journal: PloS one20080101

Title: m7GTP alphaS is a strong and stable inhibitor of cap-dependent translation.

Journal: Nucleic acids symposium series (2004)20080101

Title: Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader.

Journal: BMC molecular biology20080101

Title: piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20071101

Title: Transcriptional networking cap-tures the 7SK RNA 5'-gamma-methyltransferase.

Journal: Molecular cell20070817

Title: The major 5' end of HIV type 1 RNA corresponds to G456.

Journal: AIDS research and human retroviruses20070801

Title: RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.

Journal: The Journal of biological chemistry20070511

Title: Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.

Journal: Molecular microbiology20070201

Title: Methylation: a regulator of HIV-1 replication?

Journal: Retrovirology20070101

Title: Conflict between translation initiation and elongation in vertebrate mitochondrial genomes.

Journal: PloS one20070101

Title: EcoTILLING for the identification of allelic variants of melon eIF4E, a factor that controls virus susceptibility.

Journal: BMC plant biology20070101

Title: Identification of modified residues in RNAs by reverse transcription-based methods.

Journal: Methods in enzymology20070101

Title: MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans.

Journal: BMC bioinformatics20070101

Title: Systematic identification of non-coding RNA 2,2,7-trimethylguanosine cap structures in Caenorhabditis elegans.

Journal: BMC molecular biology20070101

Title: Solid-supported synthesis of 5'-mRNA CAP-4 from Trypanosomatids.

Journal: Nucleosides, nucleotides & nucleic acids20070101

Title: Interactions of calf spleen purine nucleoside phosphorylase with formycin B and its aglycone - spectroscopic and kinetic studies.

Journal: Nucleosides, nucleotides & nucleic acids20070101

Title: Non-adenine based purines accelerate wound healing.

Journal: Purinergic signalling20061101

Title: Yeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decay.

Journal: RNA (New York, N.Y.)20060701

Title: Calcium-stimulated guanosine--inosine nucleosidase from yellow lupin (Lupinus luteus).

Journal: Phytochemistry20060701

Title: Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control.

Journal: British journal of cancer20060605

Title: Parallel evolution of the genetic code in arthropod mitochondrial genomes.

Journal: PLoS biology20060501

Title: An industrial process for selective synthesis of 7-methyl guanosine 5'-diphosphate: versatile synthon for synthesis of mRNA cap analogues.

Journal: Nucleosides, nucleotides & nucleic acids20060301

Title: VPg of murine norovirus binds translation initiation factors in infected cells.

Journal: Virology journal20060101

Title: The complete sequence of the mitochondrial genome of Nautilus macromphalus (Mollusca: Cephalopoda).

Journal: BMC genomics20060101

Title: 'Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells'.

Journal: Cancer cell international20060101

Title: Mechanism and regulation of translation in C. elegans.

Journal: WormBook : the online review of C. elegans biology20060101

Title: The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro.

Journal: RNA (New York, N.Y.)20051001

Title: Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2).

Journal: The Journal of biological chemistry20050916

Title: A new yeast poly(A) polymerase complex involved in RNA quality control.

Journal: PLoS biology20050601

Title: Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis.

Journal: Proteins20050515

Title: The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.

Journal: The EMBO journal20050504

Title: Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.

Journal: Journal of molecular biology20050408

Title: Yeast-like mRNA capping apparatus in Giardia lamblia.

Journal: The Journal of biological chemistry20050401

Title: Translation initiation factor (eIF) 4B affects the rates of binding of the mRNA m7G cap analogue to wheat germ eIFiso4F and eIFiso4F.PABP.

Journal: Biochemistry20050322

Title: A mutant of eukaryotic protein synthesis initiation factor eIF4E(K119A) has an increased binding affinity for both m7G cap analogues and eIF4G peptides.

Journal: Biochemistry20050322

Title: [Simultaneous determination of 7-methylguanosine and mitomycin C by capillary electrophoresis with amperometric detection].

Journal: Se pu = Chinese journal of chromatography20050301

Title: A competitive ELISA detecting 7-methylguanosine adduct induced by N-nitrosodimethylamine exposure.

Journal: Human & experimental toxicology20050201

Title: Phylogenetic analysis of eIF4E-family members.

Journal: BMC evolutionary biology20050101

Title: Kinetic properties of Cellulomonas sp. purine nucleoside phosphorylase with typical and non-typical substrates: implications for the reaction mechanism.

Journal: Nucleosides, nucleotides & nucleic acids20050101

Title: Deaggregation of eIF4E induced by mRNA 5' cap binding.

Journal: Nucleosides, nucleotides & nucleic acids20050101

Title: Synthesis and enzymatic characterization of methylene analogs of adenosine 5'-tetraphosphate (P4A).

Journal: Nucleosides, nucleotides & nucleic acids20050101

Title: Thermodynamics of mRNA 5' cap binding by eukaryotic translation initiation factor eIF4E.

Journal: Biochemistry20041026

Title: Chemical synthesis and binding activity of the trypanosomatid cap-4 structure.

Journal: RNA (New York, N.Y.)20040901

Title: Determination of the capped site sequence of mRNA based on the detection of cap-dependent nucleotide addition using an anchor ligation method.

Journal: DNA research : an international journal for rapid publication of reports on genes and genomes20040831

Title: Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus.

Journal: Biochemistry20040511

Title: Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites.

Journal: Genome biology20040101

Title: Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.

Journal: Journal of biomolecular NMR20031101

Title: Macrocyclic amines as catalysts of the hydrolysis of the triphosphate bridge of the mRNA 5'-cap structure.

Journal: Organic & biomolecular chemistry20031007

Title: Charge distribution in 7-methylguanine regarding cation-pi interaction with protein factor eIF4E.

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Title: Synthesis of novel mRNA 5' cap-analogues: dinucleoside P1, P3-tri-, P1, P4-tetra-, and P1, P5-pentaphosphates.

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Title: Dinucleoside monophosphates containing AZT and 1-methyladenosine or 7-methylguanosine.

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Title: Thermodynamics of 7-methylguanosine cation stacking with tryptophan upon mRNA 5' cap binding to translation factor eIF4E.

Journal: Nucleosides, nucleotides & nucleic acids20030101

Title: Binding studies of eukaryotic initiation factor eIF4E with novel mRNA dinucleotide cap analogues.

Journal: Nucleosides, nucleotides & nucleic acids20030101

Title: Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.

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Title: The 'cap-binding slot' of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap.

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Title: Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism, hydrolysis of 7-methylguanosine, and oligomeric state in solution.

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