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[1]Nucleosides,nucleotidesandnucleicacids,2005,vol.24,p.471-476
[2]Nucleosides,nucleotidesandnucleicacids,2005,vol.24,p.459-464
[1]ProteinScience,2017,vol.26,p.985-996
Title: Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway.
Journal: RNA (New York, N.Y.) 20121001
Title: Synthesis of N²-modified 7-methylguanosine 5'-monophosphates as nematode translation inhibitors.
Journal: Bioorganic & medicinal chemistry 20120801
Title: Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins.
Journal: RNA (New York, N.Y.) 20120701
Title: Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs.
Journal: The Journal of biological chemistry 20120608
Title: Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.
Journal: RNA (New York, N.Y.) 20120601
Title: E2F1-dependent methyl cap formation requires RNA pol II phosphorylation.
Journal: Cell cycle (Georgetown, Tex.) 20120601
Title: Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity.
Journal: PLoS pathogens 20120301
Title: Targeting Mnks for cancer therapy.
Journal: Oncotarget 20120201
Title: Bioinformatics tools and novel challenges in long non-coding RNAs (lncRNAs) functional analysis.
Journal: International journal of molecular sciences 20120101
Title: Chemical approaches for structure and function of RNA in postgenomic era.
Journal: Journal of nucleic acids 20120101
Title: High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis.
Journal: PloS one 20120101
Title: In vitro transcription and capping of Gaussia luciferase mRNA followed by HeLa cell transfection.
Journal: Journal of visualized experiments : JoVE 20120101
Title: Functional and structural analysis of the internal ribosome entry site present in the mRNA of natural variants of the HIV-1.
Journal: PloS one 20120101
Title: Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.
Journal: PloS one 20120101
Title: The eIF4F and eIFiso4F Complexes of Plants: An Evolutionary Perspective.
Journal: Comparative and functional genomics 20120101
Title: Versatility of RNA-Binding Proteins in Cancer.
Journal: Comparative and functional genomics 20120101
Title: ATPase cycle and DNA unwinding kinetics of RecG helicase.
Journal: PloS one 20120101
Title: Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression.
Journal: Frontiers in genetics 20120101
Title: Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.
Journal: Biochemistry 20111213
Title: RAM/Fam103a1 is required for mRNA cap methylation.
Journal: Molecular cell 20111118
Title: Periodic expression of Sm proteins parallels formation of nuclear Cajal bodies and cytoplasmic snRNP-rich bodies.
Journal: Histochemistry and cell biology 20111101
Title: The state-of-the-art determination of urinary nucleosides using chromatographic techniques 'hyphenated' with advanced bioinformatic methods.
Journal: Analytical and bioanalytical chemistry 20111001
Title: Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1.
Journal: PLoS pathogens 20111001
Title: Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.
Journal: Biochimie 20110901
Title: Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis.
Journal: Nature structural & molecular biology 20110901
Title: Synthesis of a new class of ribose functionalized dinucleotide cap analogues for biophysical studies on interaction of cap-binding proteins with the 5' end of mRNA.
Journal: Organic & biomolecular chemistry 20110807
Title: An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.
Journal: PLoS pathogens 20110701
Title: Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.
Journal: Journal of molecular modeling 20110401
Title: A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.
Journal: PLoS biology 20110301
Title: Targeting translation dependence in cancer.
Journal: Oncotarget 20110201
Title: Mutation and selection on the wobble nucleotide in tRNA anticodons in marine bivalve mitochondrial genomes.
Journal: PloS one 20110101
Title: Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden.
Journal: PloS one 20110101
Title: Determinants of translation efficiency and accuracy.
Journal: Molecular systems biology 20110101
Title: Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine.
Journal: Cancer cell international 20110101
Title: Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism.
Journal: PloS one 20110101
Title: Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and HOXD4.
Journal: PloS one 20110101
Title: tRNA Modification and Genetic Code Variations in Animal Mitochondria.
Journal: Journal of nucleic acids 20110101
Title: Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease.
Journal: PloS one 20110101
Title: Identification and analysis of the RNA degrading complexes and machinery of Giardia lamblia using an in silico approach.
Journal: BMC genomics 20110101
Title: Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.
Journal: PloS one 20110101
Title: MicroRNAs in Hepatobiliary and Pancreatic Cancers.
Journal: Frontiers in genetics 20110101
Title: Thousands of Novel Transcripts Identified in Mouse Cerebrum, Testis, and ES Cells Based on ribo-minus RNA Sequencing.
Journal: Frontiers in genetics 20110101
Title: A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA.
Journal: Scientific reports 20110101
Title: RNA decay and RNA silencing in plants: competition or collaboration?
Journal: Frontiers in plant science 20110101
Title: Myc up-regulates formation of the mRNA methyl cap.
Journal: Biochemical Society transactions 20101201
Title: Regulation of influenza RNA polymerase activity and the switch between replication and transcription by the concentrations of the vRNA 5' end, the cap source, and the polymerase.
Journal: Biochemistry 20101130
Title: Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways.
Journal: Molecular and cellular biology 20101001
Title: Identification of a quality-control mechanism for mRNA 5'-end capping.
Journal: Nature 20100930
Title: The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.
Journal: Molecular cell 20100924
Title: Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies.
Journal: The FEBS journal 20100701
Title: Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles.
Journal: Human molecular genetics 20100201
Title: Regulation of mRNA cap methylation.
Journal: The Biochemical journal 20100115
Title: Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.
Journal: Cell metabolism 20100106
Title: The Arc of synaptic memory.
Journal: Experimental brain research 20100101
Title: Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.
Journal: RNA (New York, N.Y.) 20100101
Title: The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.
Journal: PloS one 20100101
Title: Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.
Journal: Cancer cell international 20100101
Title: Heritability in the efficiency of nonsense-mediated mRNA decay in humans.
Journal: PloS one 20100101
Title: Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana.
Journal: BMC plant biology 20100101
Title: A conserved stem loop motif in the 5'untranslated region regulates transforming growth factor-β(1) translation.
Journal: PloS one 20100101
Title: Expression analysis and knockdown of two antennal odorant-binding protein genes in Aedes aegypti.
Journal: Journal of insect science (Online) 20100101
Title: Proteomic analysis of streptomycin resistant and sensitive clinical isolates of Mycobacterium tuberculosis.
Journal: Proteome science 20100101
Title: A screen for RNA-binding proteins in yeast indicates dual functions for many enzymes.
Journal: PloS one 20100101
Title: The role of molecular biology in the biomonitoring of human exposure to chemicals.
Journal: International journal of molecular sciences 20100101
Title: Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity.
Journal: Gastroenterology research and practice 20100101
Title: Mi-DISCOVERER: A bioinformatics tool for the detection of mi-RNA in human genome.
Journal: Bioinformation 20100101
Title: Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.
Journal: Journal of the American Chemical Society 20091223
Title: Influenza A: understanding the viral life cycle.
Journal: The Yale journal of biology and medicine 20091201
Title: The GTPase activity of Escherichia coli FtsZ determines the magnitude of the FtsZ polymer bundling by ZapA in vitro.
Journal: Biochemistry 20091124
Title: Comparative analysis of an experimental subcellular protein localization assay and in silico prediction methods.
Journal: Journal of molecular histology 20091001
Title: TERRA: telomeric repeat-containing RNA.
Journal: The EMBO journal 20090902
Title: Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma.
Journal: British journal of cancer 20090804
Title: Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils.
Journal: Pflugers Archiv : European journal of physiology 20090801
Title: Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.
Journal: Cell 20090723
Title: PcrA helicase tightly couples ATP hydrolysis to unwinding double-stranded DNA, modulated by the initiator protein for plasmid replication, RepD.
Journal: Biochemistry 20090714
Title: Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation.
Journal: Bioorganic & medicinal chemistry letters 20090401
Title: The RNA polymerase dictates ORF1 requirement and timing of LINE and SINE retrotransposition.
Journal: PLoS genetics 20090401
Title: Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex.
Journal: Journal of molecular biology 20090116
Title: Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer.
Journal: Journal of experimental & clinical cancer research : CR 20090101
Title: The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif.
Journal: Biology direct 20090101
Title: Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome.
Journal: Retrovirology 20090101
Title: Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection.
Journal: BMC cancer 20090101
Title: microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.
Journal: PloS one 20090101
Title: Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.
Journal: PloS one 20090101
Title: MicroRNA profiling and head and neck cancer.
Journal: Comparative and functional genomics 20090101
Title: Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.
Journal: PloS one 20090101
Title: EBNA3C interacts with Gadd34 and counteracts the unfolded protein response.
Journal: Virology journal 20090101
Title: Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase.
Journal: Archives of biochemistry and biophysics 20081215
Title: The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis.
Journal: Molecular microbiology 20081101
Title: snoRNA, a novel precursor of microRNA in Giardia lamblia.
Journal: PLoS pathogens 20081101
Title: Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode.
Journal: Journal of molecular biology 20081017
Title: The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon.
Journal: The EMBO journal 20080820
Title: Stacking efficiency and flexibility analysis of aromatic amino acids in cap-binding proteins.
Journal: Proteins 20080601
Title: Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.
Journal: RNA (New York, N.Y.) 20080601
Title: MicroRNA: An emerging therapeutic target and intervention tool.
Journal: International journal of molecular sciences 20080601
Title: Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
Journal: Genes & development 20080515
Title: Motor step size and ATP coupling efficiency of the dsDNA translocase EcoR124I.
Journal: The EMBO journal 20080507
Title: Detection and localization of small nuclear ribonucleoproteins (snRNPs) in trypanosomatids using anti-m3G antibodies.
Journal: Japanese journal of infectious diseases 20080301
Title: Biochemical characterization of Yin Yang 1-RNA complexes.
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20080201
Title: Evolutionary patterns in the sequence and structure of transfer RNA: a window into early translation and the genetic code.
Journal: PloS one 20080101
Title: m7GTP alphaS is a strong and stable inhibitor of cap-dependent translation.
Journal: Nucleic acids symposium series (2004) 20080101
Title: Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader.
Journal: BMC molecular biology 20080101
Title: piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071101
Title: Transcriptional networking cap-tures the 7SK RNA 5'-gamma-methyltransferase.
Journal: Molecular cell 20070817
Title: The major 5' end of HIV type 1 RNA corresponds to G456.
Journal: AIDS research and human retroviruses 20070801
Title: RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.
Journal: The Journal of biological chemistry 20070511
Title: Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.
Journal: Molecular microbiology 20070201
Title: Methylation: a regulator of HIV-1 replication?
Journal: Retrovirology 20070101
Title: Conflict between translation initiation and elongation in vertebrate mitochondrial genomes.
Journal: PloS one 20070101
Title: EcoTILLING for the identification of allelic variants of melon eIF4E, a factor that controls virus susceptibility.
Journal: BMC plant biology 20070101
Title: Identification of modified residues in RNAs by reverse transcription-based methods.
Journal: Methods in enzymology 20070101
Title: MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans.
Journal: BMC bioinformatics 20070101
Title: Systematic identification of non-coding RNA 2,2,7-trimethylguanosine cap structures in Caenorhabditis elegans.
Journal: BMC molecular biology 20070101
Title: Solid-supported synthesis of 5'-mRNA CAP-4 from Trypanosomatids.
Journal: Nucleosides, nucleotides & nucleic acids 20070101
Title: Interactions of calf spleen purine nucleoside phosphorylase with formycin B and its aglycone - spectroscopic and kinetic studies.
Journal: Nucleosides, nucleotides & nucleic acids 20070101
Title: Non-adenine based purines accelerate wound healing.
Journal: Purinergic signalling 20061101
Title: Yeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decay.
Journal: RNA (New York, N.Y.) 20060701
Title: Calcium-stimulated guanosine--inosine nucleosidase from yellow lupin (Lupinus luteus).
Journal: Phytochemistry 20060701
Title: Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control.
Journal: British journal of cancer 20060605
Title: Parallel evolution of the genetic code in arthropod mitochondrial genomes.
Journal: PLoS biology 20060501
Title: An industrial process for selective synthesis of 7-methyl guanosine 5'-diphosphate: versatile synthon for synthesis of mRNA cap analogues.
Journal: Nucleosides, nucleotides & nucleic acids 20060301
Title: VPg of murine norovirus binds translation initiation factors in infected cells.
Journal: Virology journal 20060101
Title: The complete sequence of the mitochondrial genome of Nautilus macromphalus (Mollusca: Cephalopoda).
Journal: BMC genomics 20060101
Title: 'Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells'.
Journal: Cancer cell international 20060101
Title: Mechanism and regulation of translation in C. elegans.
Journal: WormBook : the online review of C. elegans biology 20060101
Title: The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro.
Journal: RNA (New York, N.Y.) 20051001
Title: Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2).
Journal: The Journal of biological chemistry 20050916
Title: A new yeast poly(A) polymerase complex involved in RNA quality control.
Journal: PLoS biology 20050601
Title: Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis.
Journal: Proteins 20050515
Title: The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.
Journal: The EMBO journal 20050504
Title: Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
Journal: Journal of molecular biology 20050408
Title: Yeast-like mRNA capping apparatus in Giardia lamblia.
Journal: The Journal of biological chemistry 20050401
Title: Translation initiation factor (eIF) 4B affects the rates of binding of the mRNA m7G cap analogue to wheat germ eIFiso4F and eIFiso4F.PABP.
Journal: Biochemistry 20050322
Title: A mutant of eukaryotic protein synthesis initiation factor eIF4E(K119A) has an increased binding affinity for both m7G cap analogues and eIF4G peptides.
Journal: Biochemistry 20050322
Title: [Simultaneous determination of 7-methylguanosine and mitomycin C by capillary electrophoresis with amperometric detection].
Journal: Se pu = Chinese journal of chromatography 20050301
Title: A competitive ELISA detecting 7-methylguanosine adduct induced by N-nitrosodimethylamine exposure.
Journal: Human & experimental toxicology 20050201
Title: Phylogenetic analysis of eIF4E-family members.
Journal: BMC evolutionary biology 20050101
Title: Kinetic properties of Cellulomonas sp. purine nucleoside phosphorylase with typical and non-typical substrates: implications for the reaction mechanism.
Journal: Nucleosides, nucleotides & nucleic acids 20050101
Title: Deaggregation of eIF4E induced by mRNA 5' cap binding.
Journal: Nucleosides, nucleotides & nucleic acids 20050101
Title: Synthesis and enzymatic characterization of methylene analogs of adenosine 5'-tetraphosphate (P4A).
Journal: Nucleosides, nucleotides & nucleic acids 20050101
Title: Thermodynamics of mRNA 5' cap binding by eukaryotic translation initiation factor eIF4E.
Journal: Biochemistry 20041026
Title: Chemical synthesis and binding activity of the trypanosomatid cap-4 structure.
Journal: RNA (New York, N.Y.) 20040901
Title: Determination of the capped site sequence of mRNA based on the detection of cap-dependent nucleotide addition using an anchor ligation method.
Journal: DNA research : an international journal for rapid publication of reports on genes and genomes 20040831
Title: Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus.
Journal: Biochemistry 20040511
Title: Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites.
Journal: Genome biology 20040101
Title: Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.
Journal: Journal of biomolecular NMR 20031101
Title: Macrocyclic amines as catalysts of the hydrolysis of the triphosphate bridge of the mRNA 5'-cap structure.
Journal: Organic & biomolecular chemistry 20031007
Title: Charge distribution in 7-methylguanine regarding cation-pi interaction with protein factor eIF4E.
Journal: Biophysical journal 20030901
Title: Synthesis of novel mRNA 5' cap-analogues: dinucleoside P1, P3-tri-, P1, P4-tetra-, and P1, P5-pentaphosphates.
Journal: Nucleosides, nucleotides & nucleic acids 20030101
Title: Dinucleoside monophosphates containing AZT and 1-methyladenosine or 7-methylguanosine.
Journal: Nucleosides, nucleotides & nucleic acids 20030101
Title: Thermodynamics of 7-methylguanosine cation stacking with tryptophan upon mRNA 5' cap binding to translation factor eIF4E.
Journal: Nucleosides, nucleotides & nucleic acids 20030101
Title: Binding studies of eukaryotic initiation factor eIF4E with novel mRNA dinucleotide cap analogues.
Journal: Nucleosides, nucleotides & nucleic acids 20030101
Title: Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.
Journal: RNA (New York, N.Y.) 20021001
Title: The 'cap-binding slot' of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap.
Journal: Biochemistry 20020618
Title: Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism, hydrolysis of 7-methylguanosine, and oligomeric state in solution.
Journal: Biochimica et biophysica acta 20020429
Title: A procedure for analysis of stopped-flow transients for protein-ligand association.
Journal: Journal of biochemical and biophysical methods 20020418
Title: Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region.
Journal: The Biochemical journal 20020315
Title: Beyond the proteome: non-coding regulatory RNAs.
Journal: Genome biology 20020101
Title: Poly(rC) binding proteins mediate poliovirus mRNA stability.
Journal: RNA (New York, N.Y.) 20010801
Title: Transcriptional regulation of the rat eIF4E gene in cardiac muscle cells: the role of specific elements in the promoter region.
Journal: Gene 20010404
Title: A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements.
Journal: The EMBO journal 20010301
Title: The major transcription initiation site of the p27Kip1 gene is conserved in human and mouse and produces a long 5'-UTR.
Journal: BMC molecular biology 20010101
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