Home Carboxes 202821-81-6
202821-81-6,MFCD00083578
Catalog No.:AA0028DG

202821-81-6 | 1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$129.00   $90.00
- +
10mg
98% by HPLC
in stock  
$206.00   $144.00
- +
25mg
98% by HPLC
in stock  
$364.00   $255.00
- +
50mg
98% by HPLC
in stock  
$575.00   $403.00
- +
100mg
98% by HPLC
in stock  
$949.00   $664.00
- +
500mg
98% by HPLC
in stock  
$2,920.00   $2,044.00
- +
1000mg
98% by HPLC
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0028DG
Chemical Name:
1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-
CAS Number:
202821-81-6
Molecular Formula:
C16H10ClF3N2O3
Molecular Weight:
370.7104
MDL Number:
MFCD00083578
SMILES:
Clc1ccc(c(c1)Cn1nc(oc1=O)c1ccc(cc1)C(F)(F)F)O
Properties
Computed Properties
 
Complexity:
535  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
4.3  

Downstream Synthesis Route

[1]Hewawasam,Piyasena;Ding,Min;Chen,Nathan;King,Dalton;Knipe,Jay;Pajor,Lorraine;Ortiz,Astrid;Gribkoff,ValentinK.;Starrett,John[BioorganicandMedicinalChemistryLetters,2003,vol.13,#10,p.1695-1698]

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US5939405,1999,A

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-EP1056754,2003,B1

[3]Hewawasam,Piyasena;Ding,Min;Chen,Nathan;King,Dalton;Knipe,Jay;Pajor,Lorraine;Ortiz,Astrid;Gribkoff,ValentinK.;Starrett,John[BioorganicandMedicinalChemistryLetters,2003,vol.13,#10,p.1695-1698]

[4]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US6034113,2000,A

[1]Hewawasam,Piyasena;Ding,Min;Chen,Nathan;King,Dalton;Knipe,Jay;Pajor,Lorraine;Ortiz,Astrid;Gribkoff,ValentinK.;Starrett,John[BioorganicandMedicinalChemistryLetters,2003,vol.13,#10,p.1695-1698]

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US5939405,1999,A

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-EP1056754,2003,B1

60853-81-8    202821-81-6   
dimethylamino-aceticacid4-chloro-2-2-oxo-5-(4-trifluoromethyl-phenyl)-1,3,4oxadiazol-3-ylmethyl-phenylester 

[1]BioorganicandMedicinalChemistryLetters,2003,vol.13,p.1695-1698

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US5939405,1999,A

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-EP1056754,2003,B1

[3]Hewawasam,Piyasena;Ding,Min;Chen,Nathan;King,Dalton;Knipe,Jay;Pajor,Lorraine;Ortiz,Astrid;Gribkoff,ValentinK.;Starrett,John[BioorganicandMedicinalChemistryLetters,2003,vol.13,#10,p.1695-1698]

Literature

Title: Vasodilation of retinal arterioles induced by activation of BKCa channels is attenuated in diabetic rats.

Journal: European journal of pharmacology 20111101

Title: Role of calcium-activated potassium channels in acetylcholine-induced vasodilation of rat retinal arterioles in vivo.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110101

Title: BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo.

Journal: Biological & pharmaceutical bulletin 20110101

Title: 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.

Journal: Journal of medicinal chemistry 20070208

Title: Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.

Journal: Bioorganic & medicinal chemistry letters 20030519

Title: Romine JL, et al. 3-[(5-Chloro-2-hydroxyphenyl)methyl-5--(trifluoromethyl)phenyl -1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. J Med Chem. 2007 Feb 8;50(3):528-42.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 202821-81-6
Tags:202821-81-6 Molecular Formula|202821-81-6 MDL|202821-81-6 SMILES|202821-81-6 1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-