Home Other Building Blocks 19728-88-2
19728-88-2,MFCD00209930
Catalog No.:AA002AMO

19728-88-2 | Methiothepin maleate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
≥98%
in stock  
$46.00   $32.00
- +
25mg
≥98%
in stock  
$100.00   $70.00
- +
50mg
≥98%
in stock  
$143.00   $100.00
- +
100mg
≥98%
in stock  
$263.00   $184.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002AMO
Chemical Name:
Methiothepin maleate
CAS Number:
19728-88-2
Molecular Formula:
C24H28N2O4S2
Molecular Weight:
472.6201
MDL Number:
MFCD00209930
SMILES:
OC(=O)/C=C\C(=O)O.CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
529  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route
Literature

Title: Mechanisms of amnesia induced by impairment of long-term memory reconsolidation in edible snail.

Journal: Bulletin of experimental biology and medicine 20120901

Title: μ1- and 5-HT1-dependent mechanisms in the anterior pretectal nucleus mediate the antinociceptive effects of retrosplenial cortex stimulation in rats.

Journal: Life sciences 20120614

Title: Characterization of 5-hydroxytryptamine-induced contraction and acetylcholine-induced relaxation in isolated chicken basilar artery.

Journal: Poultry science 20120501

Title: Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test.

Journal: Neuroscience letters 20111024

Title: 5-HT receptors mediate lineage-dependent effects of serotonin on adult neurogenesis in Procambarus clarkii.

Journal: Neural development 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.

Journal: Molecular pain 20100101

Title: Presynaptic inhibition selectively weakens peptidergic cotransmission in a small motor system.

Journal: Journal of neurophysiology 20091201

Title: Neurochemical mechanisms of consolidation of associative aversive training to food in the common snail.

Journal: Neuroscience and behavioral physiology 20091101

Title: Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis?

Journal: The Journal of experimental biology 20091101

Title: Neurochemical mechanisms of consolidation of associative aversive learning to food in the common snail.

Journal: Neuroscience and behavioral physiology 20090901

Title: Behavioral adaptation in C. elegans produced by antipsychotic drugs requires serotonin and is associated with calcium signaling and calcineurin inhibition.

Journal: Neuroscience research 20090701

Title: 5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: role of dorsal raphe nucleus.

Journal: Experimental neurology 20090501

Title: Altered response of human umbilical artery to 5-HT in gestational diabetic pregnancy.

Journal: Pharmacological reports : PR 20090101

Title: Combined blockade of serotonergic and muscarinic transmission disrupts the anterior thalamic head direction signal.

Journal: Behavioral neuroscience 20081201

Title: [Neurochemical mechanisms of food aversion conditioning consolidation in snail Helix lucorum].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20081101

Title: Serotonin and NMDA glutamate receptor antagonists selectively impair the reactivation of associative memory in the common snail.

Journal: Neuroscience and behavioral physiology 20080901

Title: The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists.

Journal: Journal of molecular graphics & modelling 20080801

Title: Effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on sneeze-induced urethral continence reflex in rats.

Journal: American journal of physiology. Renal physiology 20080701

Title: Spatial-specific action of serotonin within the leech midbody ganglion.

Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20080601

Title: Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans.

Journal: PloS one 20080101

Title: An antidepressant that extends lifespan in adult Caenorhabditis elegans.

Journal: Nature 20071122

Title: Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart.

Journal: Clinical and experimental pharmacology & physiology 20071101

Title: [Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20071001

Title: Effects of medullary Raphé stimulation on fictive lung ventilation during development in Rana catesbeiana.

Journal: The Journal of experimental biology 20070601

Title: A61603-induced contractions of the porcine meningeal artery are mediated by alpha1- and alpha2-adrenoceptors.

Journal: Basic & clinical pharmacology & toxicology 20070401

Title: Amphetamine depresses excitatory synaptic transmission at prefrontal cortical layer V synapses.

Journal: Neuropharmacology 20070101

Title: Evaluation of the serotonin receptor blocker methiothepin in broilers injected intravenously with lipopolysaccharide and microparticles.

Journal: Poultry science 20061201

Title: Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera).

Journal: Journal of neurochemistry 20060901

Title: Methiothepin-sensitive serotonin receptors are involved in the postsynaptic mechanism of sensitization of the defensive response in the common snail.

Journal: Neuroscience and behavioral physiology 20060701

Title: Serotonin receptor antagonists discriminate between PKA- and PKC-mediated plasticity in aplysia sensory neurons.

Journal: Journal of neurophysiology 20060401

Title: Evaluation of the serotonin receptor blockers ketanserin and methiothepin on the pulmonary hypertensive responses of broilers to intravenously infused serotonin.

Journal: Poultry science 20060401

Title: Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.

Journal: European journal of pharmacology 20060327

Title: Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT(7) serotonin receptor.

Journal: European journal of pharmacology 20060217

Title: Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells.

Journal: European journal of pharmacology 20051219

Title: Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.

Journal: Clinical and experimental pharmacology & physiology 20051001

Title: alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.

Journal: European journal of pharmacology 20050704

Title: Involvement of pre- and post-synaptic serotonergic receptors of dorsal raphe nucleus neural network in the control of the sweet-substance-induced analgesia in adult Rattus norvegicus (Rodentia, Muridae).

Journal: Neuroscience letters 20050513

Title: In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking.

Journal: Brain research 20050510

Title: Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.

Journal: European journal of pharmacology 20050418

Title: m-CPP, a 5-HT2C receptor agonist that modifies the perfusion pressure of the hindquarter vascular bed of anesthetized rat.

Journal: Pharmacology 20050201

Title: Clozapine directly relaxes bovine retinal arteries.

Journal: Current eye research 20050201

Title: [Methiothepin-sensitive serotonin receptors are involved in postsynaptic mechanism of sensitization of Helix lucorum escape reaction].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20050101

Title: Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors.

Journal: European journal of pharmacology 20040714

Title: Mechanism of action of A-85380 in an animal model of depression.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20040701

Title: Cloning and pharmacological characterisation of the guinea pig 5-ht5A receptor.

Journal: European journal of pharmacology 20040628

Title: Involvement of serotonin 5HT1 and 5HT2 receptors and nitric oxide synthase in the medial preoptic area on gonadotropin secretion.

Journal: Brain research bulletin 20040430

Title: Neocortical activation by electrical and chemical stimulation of the rat inferior colliculus: intra-collicular mapping and neuropharmacological characterization.

Journal: Experimental brain research 20040201

Title: SER-7b, a constitutively active Galphas coupled 5-HT7-like receptor expressed in the Caenorhabditis elegans M4 pharyngeal motorneuron.

Journal: Journal of neurochemistry 20031001

Title: Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.

Journal: Brain research bulletin 20030515

Title: 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons.

Journal: Anesthesia and analgesia 20030401

Title: Pharmacological characterization of an adenylyl cyclase-coupled 5-HT receptor in aplysia: comparison with mammalian 5-HT receptors.

Journal: Journal of neurophysiology 20030301

Title: Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030301

Title: h5-HT(1B) receptor-mediated constitutive Galphai3-protein activation in stably transfected Chinese hamster ovary cells: an antibody capture assay reveals protean efficacy of 5-HT.

Journal: British journal of pharmacology 20030301

Title: Changes in brain serotonin turnover, body and head shakes in kainic acid-treated rats.

Journal: Pharmacology & toxicology 20030301

Title: 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal slices.

Journal: The European journal of neuroscience 20021101

Title: 5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons.

Journal: Life sciences 20020927

Title: Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats.

Journal: Life sciences 20020802

Title: Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.

Journal: Brain research 20020301

Title: Methiothepin attenuates gastric secretion and motility effects of vagal stimulants at the dorsal vagal complex.

Journal: European journal of pharmacology 20020201

Title: Mechanisms of analgesic action of B vitamins in formalin-induced inflammatory pain.

Journal: Proceedings of the Western Pharmacology Society 20020101

Title: Nad-299 antagonises 5-HT-stimulated and spiperone-inhibited [35S]GTPgammaS binding in cloned 5-HT1A receptors.

Journal: Journal of receptor and signal transduction research 20020101

Title: Cell proliferation in carcinoid valve disease: a mechanism for serotonin effects.

Journal: The Journal of heart valve disease 20011101

Title: No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats.

Journal: European journal of pharmacology 20010914

Title: Rate-independent inhibition by norepinephrine of 5-HT release from the somadendritic region of serotonergic neurons.

Journal: Brain research bulletin 20010801

Title: Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat.

Journal: British journal of pharmacology 20010601

Title: Intrathecal methiothepin and thyrotropin-releasing hormone effects on penile erection.

Journal: Physiology & behavior 20010501

Title: S 14506: novel receptor coupling at 5-HT(1A) receptors.

Journal: Neuropharmacology 20010301

Title: Effects of the serotonin receptor ligand methiothepin on reproductive behavior of the freshwater snail Biomphalaria glabrata: reduction of egg laying and induction of penile erection.

Journal: The Journal of experimental zoology 20010215

Title: Intrarenal serotonin, dopamine, and phosphate handling in remnant kidneys.

Journal: Kidney international 20010201

Title: Constitutive activity at serotonin 5-HT(1D) receptors: detection by homologous GTPgammaS versus [(35)S]-GTPgammaS binding isotherms.

Journal: Neuropharmacology 20010101

Title: Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor.

Journal: European journal of pharmacology 19990910

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:19728-88-2 Molecular Formula|19728-88-2 MDL|19728-88-2 SMILES|19728-88-2 Methiothepin maleate