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199850-67-4,MFCD09038565
Catalog No.:AA002CAY

199850-67-4 | (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$173.00   $121.00
- +
10mg
≥98%
in stock  
$245.00   $171.00
- +
25mg
≥98%
in stock  
$560.00   $392.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA002CAY
Chemical Name:
(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
CAS Number:
199850-67-4
Molecular Formula:
C17H18BrNO4S
Molecular Weight:
412.2981
MDL Number:
MFCD09038565
SMILES:
Brc1ccc(cc1)c1ccc(cc1)S(=O)(=O)N[C@H](C(=O)O)C(C)C
Properties
Computed Properties
 
Complexity:
515  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4.2  

Literature

Title: Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts.

Journal: American journal of physiology. Cell physiology 20121101

Title: Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.

Journal: Bioorganic & medicinal chemistry 20070315

Title: Metalloproteinase inhibitor counters high-energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in subacute heart failure.

Journal: The Journal of pharmacology and experimental therapeutics 20060501

Title: Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.

Journal: Journal of medicinal chemistry 20060209

Title: Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2.

Journal: Cardiovascular research 20020101

Title: O'Brien PM, et, al. Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem. 2000 Jan 27;43(2):156-66.

Title: Kaludercic N, et, al. Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond. Cardiovasc Ther. Spring 2008;26(1):24-37.

Title: Chancey AL, et, al. Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation. 2002 Apr 23;105(16):1983-8.

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SDS
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Tags:199850-67-4 Molecular Formula|199850-67-4 MDL|199850-67-4 SMILES|199850-67-4 (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
Catalog No.: AA002CAY
199850-67-4,MFCD09038565
199850-67-4 | (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
Pack Size： 5mg
Purity： ≥98%
in stock
$173.00 $121.00
Pack Size： 10mg
Purity： ≥98%
in stock
$245.00 $171.00
Pack Size： 25mg
Purity： ≥98%
in stock
$560.00 $392.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA002CAY
Chemical Name: (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
CAS Number: 199850-67-4
Molecular Formula: C17H18BrNO4S
Molecular Weight: 412.2981
MDL Number: MFCD09038565
SMILES: Brc1ccc(cc1)c1ccc(cc1)S(=O)(=O)N[C@H](C(=O)O)C(C)C
Properties
Complexity: 515  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 6  
XLogP3: 4.2  
Literature fold

Title: Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts.

Journal: American journal of physiology. Cell physiology20121101

Title: Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.

Journal: Bioorganic & medicinal chemistry20070315

Title: Metalloproteinase inhibitor counters high-energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in subacute heart failure.

Journal: The Journal of pharmacology and experimental therapeutics20060501

Title: Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.

Journal: Journal of medicinal chemistry20060209

Title: Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2.

Journal: Cardiovascular research20020101

Title: O'Brien PM, et, al. Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem. 2000 Jan 27;43(2):156-66.

Title: Kaludercic N, et, al. Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond. Cardiovasc Ther. Spring 2008;26(1):24-37.

Title: Chancey AL, et, al. Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation. 2002 Apr 23;105(16):1983-8.

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