Home Nitro Compounds 19983-44-9
19983-44-9,MFCD00173799
Catalog No.:AA002CBE

19983-44-9 | 1,1-Dioxide-6-nitro-benzo[b]thiophene

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
10mg
98%
in stock  
$15.00   $11.00
- +
25mg
98%
in stock  
$24.00   $17.00
- +
50mg
98%
in stock  
$36.00   $25.00
- +
100mg
98%
in stock  
$48.00   $34.00
- +
250mg
95%
in stock  
$83.00   $58.00
- +
500mg
95%
in stock  
$121.00   $85.00
- +
1g
95%
in stock  
$171.00   $120.00
- +
5g
96%
in stock  
$610.00   $427.00
- +
10g
96%
in stock  
$1,009.00   $706.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002CBE
Chemical Name:
1,1-Dioxide-6-nitro-benzo[b]thiophene
CAS Number:
19983-44-9
Molecular Formula:
C8H5NO4S
Molecular Weight:
211.1946
MDL Number:
MFCD00173799
SMILES:
[O-][N+](=O)c1ccc2c(c1)S(=O)(=O)C=C2
Properties
Properties
 
BP:
461.1°C at 760 mmHg  
Form:
Solid  
Solubility:
DMSO: >20mg/mL  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
375  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
XLogP3:
0.7  

Upstream Synthesis Route

[1]BioorganicandMedicinalChemistry,2004,vol.12,#5,p.963-968

[2]JournaloftheChemicalSociety,1955,p.1565,1568

[1]Patent:WO2006/36024,2006,A1,.Locationinpatent:Page/Pagecolumn154-155

[2]Patent:EP2336107,2015,B1,.Locationinpatent:Paragraph0292

[3]JournaloftheChemicalSociety,1948,p.1615,1617

[4]JournaloftheChemicalSociety,1957,p.826,830

[5]BioorganicandMedicinalChemistry,2004,vol.12,#5,p.963-968

[6]Patent:EP1803709,2007,A1,

[1]JournaloftheAmericanChemicalSociety,1955,vol.77,p.5939,5943

[1]JournaloftheAmericanChemicalSociety,1955,vol.77,p.5939,5943

[1]JournaloftheAmericanChemicalSociety,1955,vol.77,p.5939,5943

Downstream Synthesis Route

[1]JournaloftheChemicalSociety,1948,p.1615,1617

19983-44-9   
(+/-)-<i>trans</i>-2,3-dibromo-6-nitro-2,3-dihydro-benzo<i>b</i>thiophene-1,1-dioxide 

[1]JournaloftheChemicalSociety,1948,p.1615,1617

[1]BioorganicandMedicinalChemistry,2004,vol.12,p.963-968

[2]JournaloftheChemicalSociety,1955,p.1565,1568

[1]ArchivderPharmazie,1988,vol.321,p.241-246

[2]Patent:WO2006/36024,2006,A1.Locationinpatent:Page/Pagecolumn155

[3]Patent:EP2336107,2015,B1.Locationinpatent:Paragraph0293

[4]RecueildesTravauxChimiquesdesPays-Bas,1954,vol.73,p.819,829

[5]JournaloftheAmericanChemicalSociety,1955,vol.77,p.5939,5943

[6]JournaloftheChemicalSociety,1955,p.1565,1568

[7]Patent:EP1803709,2007,A1

[8]Patent:WO2005/58867,2005,A1.Locationinpatent:Page/Pagecolumn30

[9]JournalofMedicinalChemistry,2014,vol.57,p.159-170

[1]Patent:WO2006/36024,2006,A1.Locationinpatent:Page/Pagecolumn154-155

[2]Patent:EP2336107,2015,B1.Locationinpatent:Paragraph0292

[3]JournaloftheChemicalSociety,1948,p.1615,1617

[4]Patent:EP1803709,2007,A1

Literature

Title: The ROS-mediated activation of IL-6/STAT3 signaling pathway is involved in the 27-hydroxycholesterol-induced cellular senescence in nerve cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20171201

Title: Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.

Journal: Toxicology and applied pharmacology 20171101

Title: Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.

Journal: Neoplasia (New York, N.Y.) 20150701

Title: Noncanonical STAT3 activation regulates excess TGF-β1 and collagen I expression in muscle of stricturing Crohn's disease.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20150401

Title: Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.

Journal: The FEBS journal 20150301

Title: Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.

Journal: The Journal of biological chemistry 20140502

Title: Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation.

Journal: Cancer letters 20140501

Title: JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic.

Journal: Cell cycle (Georgetown, Tex.) 20130101

Title: Proteinase-activated receptor 2 (PAR(2)) in cholangiocarcinoma (CCA) cells: effects on signaling and cellular level.

Journal: Histochemistry and cell biology 20121201

Title: Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10.

Journal: The Journal of nutritional biochemistry 20121101

Title: HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.

Journal: Cancer biology & therapy 20120701

Title: JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120601

Title: STAT3 does not regulate acute liver injury after ischemia/reperfusion.

Journal: The Journal of surgical research 20111201

Title: STAT3 is necessary for proliferation and survival in colon cancer-initiating cells.

Journal: Cancer research 20111201

Title: Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion.

Journal: Circulation research 20111111

Title: XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells.

Journal: Apoptosis : an international journal on programmed cell death 20110501

Title: STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy?

Journal: International journal of cancer 20110215

Title: Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation - the rat isolated working heart.

Journal: British journal of pharmacology 20110201

Title: Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion.

Journal: Basic research in cardiology 20101101

Title: Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis.

Journal: European journal of immunology 20100901

Title: Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma).

Journal: Biology of the cell 20090923

Title: STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria.

Journal: Molecular immunology 20090501

Title: Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.

Journal: Journal of molecular endocrinology 20090401

Title: Regulating RISK: a role for JAK-STAT signaling in postconditioning?

Journal: American journal of physiology. Heart and circulatory physiology 20081001

Title: Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

Journal: Chemistry & biology 20061101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12.

Title: John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13(11):1123-4.

Title: Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33(2):214-223.

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Tags:19983-44-9 Molecular Formula|19983-44-9 MDL|19983-44-9 SMILES|19983-44-9 1,1-Dioxide-6-nitro-benzo[b]thiophene