Home Amines 199864-86-3
199864-86-3,MFCD11112196
Catalog No.:AA002CBK

199864-86-3 | 2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, hydrochloride (1:1)

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1mg
≥98%
in stock  
$46.00   $32.00
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5mg
≥98%
in stock  
$156.00   $109.00
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10mg
≥98%
in stock  
$285.00   $199.00
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  • Technical Information
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Technical Information
Catalog Number:
AA002CBK
Chemical Name:
2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, hydrochloride (1:1)
CAS Number:
199864-86-3
Molecular Formula:
C17H17ClFN3
Molecular Weight:
317.7884
MDL Number:
MFCD11112196
SMILES:
Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C.Cl
Properties
Properties
 
Form:
Solid  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
349  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  

Literature

Title: Role of peripheral and spinal 5-HT2B receptors in formalin-induced nociception.

Journal: Pharmacology, biochemistry, and behavior 20120701

Title: Implication of 5-HT(2B) receptors in the serotonin syndrome.

Journal: Neuropharmacology 20110901

Title: Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110101

Title: 5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100501

Title: A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100201

Title: Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology.

Journal: British journal of pharmacology 20090901

Title: Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach.

Journal: Biological & pharmaceutical bulletin 20070301

Title: Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist.

Journal: European journal of pharmacology 20040101

Title: Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension.

Journal: Nature medicine 20021001

Title: MT-500 (POZEN).

Journal: Current opinion in investigational drugs (London, England : 2000) 20010301

Title: RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist.

Journal: British journal of pharmacology 19990701

Title: Bonhaus DW, et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol. 1999 Jul;127(5):1075-82.

Title: Bassil AK, et al. Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol. 2009 Sep;158(1):252-8

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SDS
Tags:199864-86-3 Molecular Formula|199864-86-3 MDL|199864-86-3 SMILES|199864-86-3 2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, hydrochloride (1:1)