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Home Carboxes 2004-06-0
2004-06-0,MFCD00005738
Catalog No.:AA002CO6

2004-06-0 | 6-Chloropurine ribonucleoside

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
97%
in stock  
$11.00   $8.00
- +
5g
97%
in stock  
$33.00   $23.00
- +
10g
97%
in stock  
$39.00   $28.00
- +
25g
97%
in stock  
$71.00   $50.00
- +
100g
97%
in stock  
$261.00   $183.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002CO6
Chemical Name:
6-Chloropurine ribonucleoside
CAS Number:
2004-06-0
Molecular Formula:
C10H11ClN4O4
Molecular Weight:
286.6717
MDL Number:
MFCD00005738
SMILES:
OC[C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2Cl
Properties
Computed Properties
 
Complexity:
339  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
0.3  

Upstream Synthesis Route

[1]NucleosidesandNucleotides,1996,vol.15,#1-3,p.619-629

[2]BioorganicandMedicinalChemistry,2008,vol.16,#7,p.3848-3865

[3]ACSMedicinalChemistryLetters,2011,vol.2,#8,p.577-582

[4]Patent:WO2012/82436,2012,A2,.Locationinpatent:Page/Pagecolumn192-193

[5]Patent:WO2012/82436,2012,A2,.Locationinpatent:Page/Pagecolumn256-257

[6]Molecules,2018,vol.23,#5,

[7]JournaloftheAmericanChemicalSociety,1961,vol.83,p.150,154

[8]JournaloftheAmericanChemicalSociety,1996,vol.118,#24,p.5532-5543

[9]JournaloftheAmericanChemicalSociety,1996,vol.118,#29,p.6880-6889

[10]Patent:WO2005/84653,2005,A2,.Locationinpatent:Page/Pagecolumn48

[11]Pr.IV.Congr.Biochem.Wien1958,Bd.15,S.40,

[12]OrganicLetters,2015,vol.17,#6,p.1513-1516

[13]Patent:WO2005/84653,2005,A2,.Locationinpatent:Page/Pagecolumn48

[1]Patent:WO2006/84281,2006,A1,.Locationinpatent:Page/Pagecolumn78-79

[2]JournaloftheAmericanChemicalSociety,2013,vol.135,#45,p.16948-16962

[3]BioorganicandMedicinalChemistry,2017,vol.25,#20,p.5433-5440

[4]Patent:US2017/312284,2017,A1,.Locationinpatent:Paragraph0093;0098

[5]BioorganicandMedicinalChemistryLetters,2007,vol.17,#9,p.2470-2473

[6]Patent:KR2015/10195,2015,A,.Locationinpatent:Paragraph0221-0224

[7]JournalofMedicinalChemistry,1990,vol.33,#9,p.2545-2551

[8]Molecules,2012,vol.17,#11,p.13036-13044

[9]Patent:US2015/376611,2015,A1,.Locationinpatent:Paragraph0474;0475

[10]Patent:US2017/354673,2017,A1,.Locationinpatent:Paragraph0690;0691

[11]ChemMedChem,2011,vol.6,#8,p.1390-1400

[12]Patent:WO2008/111082,2008,A1,.Locationinpatent:Page/Pagecolumn30-31;36

[13]Patent:WO2018/140734,2018,A1,.Locationinpatent:Paragraph00138

[14]BioorganicandMedicinalChemistryLetters,2009,vol.19,#23,p.6736-6739

[15]BioorganicandMedicinalChemistryLetters,1998,vol.8,#6,p.695-698

[16]Patent:EP1589027,2005,A1,.Locationinpatent:Page/Pagecolumn18-19

[17]Patent:US5824657,1998,A,

[18]Patent:EP2511283,2012,A1,.Locationinpatent:Page/Pagecolumn67

[19]Patent:US2013/45942,2013,A1,.Locationinpatent:Paragraph0258;0266

[1]Patent:WO2017/218802,2017,A1,

[1]Chemistry-AEuropeanJournal,2017,vol.23,#59,p.14702-14706

[2]OrganicLetters,2015,vol.17,#6,p.1513-1516

Downstream Synthesis Route

[1]NucleosidesandNucleotides,1996,vol.15,p.619-629

[2]BioorganicandMedicinalChemistry,2008,vol.16,p.3848-3865

[3]ACSMedicinalChemistryLetters,2011,vol.2,p.577-582

[4]Patent:WO2012/82436,2012,A2.Locationinpatent:Page/Pagecolumn192-193

[5]Patent:WO2012/82436,2012,A2.Locationinpatent:Page/Pagecolumn256-257

[6]Molecules,2018,vol.23

[7]JournaloftheAmericanChemicalSociety,1961,vol.83,p.150,154

[8]JournaloftheAmericanChemicalSociety,1996,vol.118,p.5532-5543

[9]JournaloftheAmericanChemicalSociety,1996,vol.118,p.6880-6889

[10]Pr.IV.Congr.Biochem.Wien1958,Bd.15,S.40,

[11]OrganicLetters,2015,vol.17,p.1513-1516

[12]Patent:WO2005/84653,2005,A2.Locationinpatent:Page/Pagecolumn48

[1]JournalofMedicinalChemistry,1986,vol.29,p.989-996

[1]JournalofMedicinalChemistry,1986,vol.29,p.989-996

[1]JournalofMedicinalChemistry,1991,vol.34,p.1043-1049

[1]JournalofMedicinalChemistry,1986,vol.29,p.989-996

Literature

Title: Biosynthesis of anti-HCV compounds using thermophilic microorganisms.

Journal: Bioorganic & medicinal chemistry letters 20121001

Title: Suzuki-miyaura and sonogashira coupling of 6-chloropurines and -nucleosides in water.

Journal: Organic letters 20090618

Title: 5'-O-masked 2'-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents.

Journal: Bioorganic & medicinal chemistry 20071115

Title: Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents.

Journal: Bioorganic & medicinal chemistry letters 20070501

Title: Introduction of a benzyl group onto the 2'-OH of 6-chloropurine 3'-O-benzoylriboside.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Anti-malarial activity of N(6)-substituted adenosine derivatives. Part I.

Journal: Bioorganic & medicinal chemistry 20020301

Title: Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.

Journal: Journal of medicinal chemistry 19841101

Title: Synthesis and antiviral activity of certain carbamoylpyrrolopyrimidine and pyrazolopyrimidine nucleosides.

Journal: Journal of medicinal chemistry 19821101

Title: Synthesis and antiviral activity of certain 9-beta-D-ribofuranosylpurine-6-carboxamides.

Journal: Journal of medicinal chemistry 19810801

Title: Purine analogs as potential anticytomegalovirus agents.

Journal: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19690901

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