Name: Name:β-D-Glucopyranosiduronic acid, 4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl
Brand: AABLOCKS
SKU: AA002EI5
Rating: 90 (10 reviews)

Catalog No.: AA002EI5

190448-57-8 | β-D-Glucopyranosiduronic acid, 4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl

Pack Size： 1mg

Purity： 99%

1 week

$463.00 $324.00

Pack Size： 5mg

Purity： 99%

1 week

$1,320.00 $924.00

Quantity

- +

Add to Card

Order Now

bulk Quotation Request

Technical Information

Catalog Number: AA002EI5

Chemical Name: β-D-Glucopyranosiduronic acid, 4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl

CAS Number: 190448-57-8

Molecular Formula: C30H29F2NO9

Molecular Weight: 585.5494

MDL Number: MFCD08063721

SMILES: OC(=O)[C@H]1O[C@@H](Oc2ccc(cc2)[C@@H]2[C@@H](CC[C@@H](c3ccc(cc3)F)O)C(=O)N2c2ccc(cc2)F)[C@@H]([C@H]([C@@H]1O)O)O

Properties

Form: Solid

MP: 137-140°C

Storage: -20 ℃;Keep in dry area;

Complexity: 921

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 8

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 42

Hydrogen Bond Acceptor Count: 11

Hydrogen Bond Donor Count: 5

Isotope Atom Count: 0

Rotatable Bond Count: 9

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 2.4

Literature fold

Title: Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis.

Journal: Drug metabolism and disposition: the biological fate of chemicals20120301

Title: Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption.

Journal: Bioorganic & medicinal chemistry letters20080115

Title: Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects.

Journal: Drug metabolism and disposition: the biological fate of chemicals20020401

Title: Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.

Journal: Bioorganic & medicinal chemistry letters20020211

Title: Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11.

Title: Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.