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191732-72-6,MFCD28168030
Catalog No.:AA002FDI

191732-72-6 | 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
98%
in stock  
$6.00   $4.00
- +
250mg
98%
in stock  
$7.00   $5.00
- +
1g
98%
in stock  
$9.00   $7.00
- +
5g
98%
in stock  
$15.00   $11.00
- +
10g
98%
in stock  
$28.00   $20.00
- +
25g
98%
in stock  
$61.00   $43.00
- +
100g
98%
in stock  
$240.00   $168.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA002FDI
Chemical Name:
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
CAS Number:
191732-72-6
Molecular Formula:
C13H13N3O3
Molecular Weight:
259.2606
MDL Number:
MFCD28168030
SMILES:
O=C1CCC(C(=O)N1)N1Cc2c(C1=O)cccc2N
NSC Number:
747972
Properties
Computed Properties
 
Complexity:
437  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.5  

Downstream Synthesis Route

[1]Patent:CN107337666,2017,A.Locationinpatent:Paragraph0025;0030;0033-0034;0037-0038;0041-0042;0045

[2]Patent:CN110407807,2019,A.Locationinpatent:Paragraph0032;0045-0046

[3]Patent:CN110642834,2020,A.Locationinpatent:Paragraph0024;0026-0027;0029

[4]Patent:CN107033126,2017,A.Locationinpatent:Paragraph0058-0059

[5]Patent:CN109400579,2019,A.Locationinpatent:Paragraph0063;0064;0065;0066

[6]Patent:CN111196800,2020,A.Locationinpatent:Paragraph0085-0090

[7]Patent:CN104710405,2019,B.Locationinpatent:Paragraph0021-0029

[8]Patent:CN108218833,2018,A.Locationinpatent:Paragraph0035;0047;0048;0061;0062;0075;0076

[9]Patent:CN108752313,2018,A.Locationinpatent:Paragraph0025;0026

[10]Patent:CN105440012,2016,A.Locationinpatent:Paragraph0023;0033;0034;0035;0036

[11]Patent:CN110551100,2019,A.Locationinpatent:Paragraph0040-0061

[12]Patent:WO2010/139266,2010,A1.Locationinpatent:Page/Pagecolumn56-57

[13]Patent:CN109776493,2019,A.Locationinpatent:Paragraph0031;0043-0044

[14]Patent:WO2015/57043,2015,A1.Locationinpatent:Paragraph0018

[15]Patent:WO2016/26785,2016,A1.Locationinpatent:Page/Pagecolumn8

[16]Patent:CN109608434,2019,A.Locationinpatent:Paragraph0067;0068;0069;0070;0071;0072-0088

[17]Patent:CN106957299,2017,A.Locationinpatent:Paragraph0014

[18]Patent:CN111217792,2020,A.Locationinpatent:Paragraph0119-0120

[19]Patent:US2012/71509,2012,A1.Locationinpatent:Page/Pagecolumn8

[20]Patent:WO2011/27326,2011,A1.Locationinpatent:Page/Pagecolumn12

[21]Patent:WO2011/27326,2011,A1.Locationinpatent:Page/Pagecolumn12

[22]ChemistryofHeterocyclicCompounds,2015,vol.51,p.133-138    Khim.Geterotsikl.Soedin.,2015,vol.51,p.133-138,6

[23]Patent:WO2011/50962,2011,A1.Locationinpatent:Page/Pagecolumn31-32

[24]BioorganicandMedicinalChemistryLetters,1999,vol.9,p.1625-1630

[25]ChemicalandPharmaceuticalBulletin,2006,vol.54,p.855-860

[26]Patent:US6335/349,2002,B1.Locationinpatent:Example1

[27]Patent:WO2009/114601,2009,A2.Locationinpatent:Page/Pagecolumn22-23

[28]Patent:WO2010/100476,2010,A2.Locationinpatent:Page/Pagecolumn23-24

[29]Patent:WO2011/33468,2011,A1.Locationinpatent:Page/Pagecolumn4

[30]Patent:WO2011/50962,2011,A1

[31]Patent:WO2011/61611,2011,A1.Locationinpatent:Page/Pagecolumn4

[32]Patent:WO2011/111053,2011,A1.Locationinpatent:Page/Pagecolumn16-17

[33]Patent:WO2013/5229,2013,A1.Locationinpatent:Page/Pagecolumn9

[34]Patent:CN105218515,2016,A.Locationinpatent:Paragraph0054

[35]BioorganicandMedicinalChemistryLetters,2017,vol.27,p.4075-4081

[36]Patent:WO2017/197056,2017,A1.Locationinpatent:Page/Pagecolumn251

[37]Patent:US2017/107193,2017,A1.Locationinpatent:Page/Pagecolumn0086;0089-0091;0096

[38]Patent:WO2018/140809,2018,A1.Locationinpatent:Paragraph00392

[39]Patent:US2018/334443,2018,A1.Locationinpatent:Paragraph0063;0064;0065;0066;0067;0068;0069-0078

[40]Patent:WO2019/64222,2019,A1.Locationinpatent:Page/Pagecolumn22;23;25;26

[41]Patent:WO2019/207538,2019,A1.Locationinpatent:Page/Pagecolumn121

[1]Muller,GeorgeW.;Chen,Roger;Huang,Shaei-Yun;Corral,LauraG.;Wong,LuMin;Patterson,RebeccaT.;Chen,Yuxi;Kaplan,Gilla;Stirling,DavidI.[BioorganicandMedicinalChemistryLetters,1999,vol.9,#11,p.1625-1630]

[2]CurrentPatentAssignee:WangYanping;YangYi;ZhangXiaoling;ZhouQinghe;XuCongying-CN108218833,2018,A

[3]CurrentPatentAssignee:SHIJIAZHUANGDUENMEDICALTECH-CN109776493,2019,A

[1]CurrentPatentAssignee:H.LEEMOFFITTCANCERCENTER&RESEARCHINSTITUTE-WO2020/14489,2020,A2Locationinpatent:Page/Pagecolumn171

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2003/96841,2003,A1

[3]Chen,Lijuan;Chen,Yong;Deng,Dexin;Liu,Kongjun;Shi,Mingsong;Tang,Minghai;Yang,Tao;Yuan,Xue[BioorganicChemistry,2022,vol.119]

[4]Chen,Lijuan;Chen,Yong;Deng,Dexin;Liu,Kongjun;Shi,Mingsong;Tang,Minghai;Yang,Tao;Yuan,Xue[BioorganicChemistry,2022,vol.119]

[1]Ruchelman,AlexanderL.;Man,Hon-Wah;Zhang,Weihong;Chen,Roger;Capone,Lori;Kang,Jian;Parton,Anastasia;Corral,Laura;Schafer,PeterH.;Babusis,Darius;Moghaddam,MehranF.;Tang,Yang;Shirley,MichaelA.;Muller,GeorgeW.[BioorganicandMedicinalChemistryLetters,2013,vol.23,#1,p.360-365]

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2008/115516,2008,A2Locationinpatent:Page/Pagecolumn51

[3]CurrentPatentAssignee:EASTCHINANORMALUNIVERSITY-CN107739389,2018,A

[4]CurrentPatentAssignee:GOOGLEINC;ABBVIEINC-WO2021/127586,2021,A1Locationinpatent:Page/Pagecolumn173-174

[5]CurrentPatentAssignee:BEIJINGINNOCAREPHARMATECH;BEIJINGNUOCHENGJIANHUAMEDICINETECH-CN113896711,2022,A

[1]Patent:WO2010/61209,2010,A1.Locationinpatent:Page/Pagecolumn17-18

[2]Patent:US2011/263649,2011,A1.Locationinpatent:Page/Pagecolumn6

Literature

Title: Krönke J, et al. Lenalidomide induces degradation of IKZF1 and IKZF3. Oncoimmunology. 2014 Jul 3;3(7):e941742.

Title: Kotla V, et al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009 Aug 12;2:36.

Title: Lopez-Girona A, et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35.

Title: Rozewski DM, et al. Pharmacokinetics and tissue disposition of lenalidomide in mice. AAPS J. 2012 Dec;14(4):872-82.

Title: Minzel W, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20;175(1):171-185.e25.

Title: Nagashima, Takeyuki, et al. PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND AS ACTIVE INGREDIENT. Patent. 20170360780A1.

Title: Omran A, et al. Effects of MRP8, LPS, and lenalidomide on the expressions of TNF-α , brain-enriched, and inflammation-related microRNAs in the primary astrocyte culture. ScientificWorldJournal. 2013 Sep 21;2013:208309.

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Tags:191732-72-6 Molecular Formula|191732-72-6 MDL|191732-72-6 SMILES|191732-72-6 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
Catalog No.: AA002FDI
191732-72-6,MFCD28168030
191732-72-6 | 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
Pack Size： 50mg
Purity： 98%
in stock
$6.00 $4.00
Pack Size： 250mg
Purity： 98%
in stock
$7.00 $5.00
Pack Size： 1g
Purity： 98%
in stock
$9.00 $7.00
Pack Size： 5g
Purity： 98%
in stock
$15.00 $11.00
Pack Size： 10g
Purity： 98%
in stock
$28.00 $20.00
Pack Size： 25g
Purity： 98%
in stock
$61.00 $43.00
Pack Size： 100g
Purity： 98%
in stock
$240.00 $168.00
Quantity
- +
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Technical Information
Catalog Number: AA002FDI
Chemical Name: 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
CAS Number: 191732-72-6
Molecular Formula: C13H13N3O3
Molecular Weight: 259.2606
MDL Number: MFCD28168030
SMILES: O=C1CCC(C(=O)N1)N1Cc2c(C1=O)cccc2N
NSC Number: 747972
Properties
Complexity: 437  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 1  
XLogP3: -0.5  
Downstream Synthesis Route
827026-45-9    879126-98-4 

[1]Patent:CN107337666,2017,A.Locationinpatent:Paragraph0025;0030;0033-0034;0037-0038;0041-0042;0045

[2]Patent:CN110407807,2019,A.Locationinpatent:Paragraph0032;0045-0046

[3]Patent:CN110642834,2020,A.Locationinpatent:Paragraph0024;0026-0027;0029

[4]Patent:CN107033126,2017,A.Locationinpatent:Paragraph0058-0059

[5]Patent:CN109400579,2019,A.Locationinpatent:Paragraph0063;0064;0065;0066

[6]Patent:CN111196800,2020,A.Locationinpatent:Paragraph0085-0090

[7]Patent:CN104710405,2019,B.Locationinpatent:Paragraph0021-0029

[8]Patent:CN108218833,2018,A.Locationinpatent:Paragraph0035;0047;0048;0061;0062;0075;0076

[9]Patent:CN108752313,2018,A.Locationinpatent:Paragraph0025;0026

[10]Patent:CN105440012,2016,A.Locationinpatent:Paragraph0023;0033;0034;0035;0036

[11]Patent:CN110551100,2019,A.Locationinpatent:Paragraph0040-0061

[12]Patent:WO2010/139266,2010,A1.Locationinpatent:Page/Pagecolumn56-57

[13]Patent:CN109776493,2019,A.Locationinpatent:Paragraph0031;0043-0044

[14]Patent:WO2015/57043,2015,A1.Locationinpatent:Paragraph0018

[15]Patent:WO2016/26785,2016,A1.Locationinpatent:Page/Pagecolumn8

[16]Patent:CN109608434,2019,A.Locationinpatent:Paragraph0067;0068;0069;0070;0071;0072-0088

[17]Patent:CN106957299,2017,A.Locationinpatent:Paragraph0014

[18]Patent:CN111217792,2020,A.Locationinpatent:Paragraph0119-0120

[19]Patent:US2012/71509,2012,A1.Locationinpatent:Page/Pagecolumn8

[20]Patent:WO2011/27326,2011,A1.Locationinpatent:Page/Pagecolumn12

[21]Patent:WO2011/27326,2011,A1.Locationinpatent:Page/Pagecolumn12

[22]ChemistryofHeterocyclicCompounds,2015,vol.51,p.133-138    Khim.Geterotsikl.Soedin.,2015,vol.51,p.133-138,6

[23]Patent:WO2011/50962,2011,A1.Locationinpatent:Page/Pagecolumn31-32

[24]BioorganicandMedicinalChemistryLetters,1999,vol.9,p.1625-1630

[25]ChemicalandPharmaceuticalBulletin,2006,vol.54,p.855-860

[26]Patent:US6335/349,2002,B1.Locationinpatent:Example1

[27]Patent:WO2009/114601,2009,A2.Locationinpatent:Page/Pagecolumn22-23

[28]Patent:WO2010/100476,2010,A2.Locationinpatent:Page/Pagecolumn23-24

[29]Patent:WO2011/33468,2011,A1.Locationinpatent:Page/Pagecolumn4

[30]Patent:WO2011/50962,2011,A1

[31]Patent:WO2011/61611,2011,A1.Locationinpatent:Page/Pagecolumn4

[32]Patent:WO2011/111053,2011,A1.Locationinpatent:Page/Pagecolumn16-17

[33]Patent:WO2013/5229,2013,A1.Locationinpatent:Page/Pagecolumn9

[34]Patent:CN105218515,2016,A.Locationinpatent:Paragraph0054

[35]BioorganicandMedicinalChemistryLetters,2017,vol.27,p.4075-4081

[36]Patent:WO2017/197056,2017,A1.Locationinpatent:Page/Pagecolumn251

[37]Patent:US2017/107193,2017,A1.Locationinpatent:Page/Pagecolumn0086;0089-0091;0096

[38]Patent:WO2018/140809,2018,A1.Locationinpatent:Paragraph00392

[39]Patent:US2018/334443,2018,A1.Locationinpatent:Paragraph0063;0064;0065;0066;0067;0068;0069-0078

[40]Patent:WO2019/64222,2019,A1.Locationinpatent:Page/Pagecolumn22;23;25;26

[41]Patent:WO2019/207538,2019,A1.Locationinpatent:Page/Pagecolumn121

24666-55-5    191732-72-6 

[1]Muller,GeorgeW.;Chen,Roger;Huang,Shaei-Yun;Corral,LauraG.;Wong,LuMin;Patterson,RebeccaT.;Chen,Yuxi;Kaplan,Gilla;Stirling,DavidI.[BioorganicandMedicinalChemistryLetters,1999,vol.9,#11,p.1625-1630]

[2]CurrentPatentAssignee:WangYanping;YangYi;ZhangXiaoling;ZhouQinghe;XuCongying-CN108218833,2018,A

[3]CurrentPatentAssignee:SHIJIAZHUANGDUENMEDICALTECH-CN109776493,2019,A

79-04-9    191732-72-6    444287-87-0 

[1]CurrentPatentAssignee:H.LEEMOFFITTCANCERCENTER&RESEARCHINSTITUTE-WO2020/14489,2020,A2Locationinpatent:Page/Pagecolumn171

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2003/96841,2003,A1

[3]Chen,Lijuan;Chen,Yong;Deng,Dexin;Liu,Kongjun;Shi,Mingsong;Tang,Minghai;Yang,Tao;Yuan,Xue[BioorganicChemistry,2022,vol.119]

[4]Chen,Lijuan;Chen,Yong;Deng,Dexin;Liu,Kongjun;Shi,Mingsong;Tang,Minghai;Yang,Tao;Yuan,Xue[BioorganicChemistry,2022,vol.119]

191732-72-6    1061604-41-8 

[1]Ruchelman,AlexanderL.;Man,Hon-Wah;Zhang,Weihong;Chen,Roger;Capone,Lori;Kang,Jian;Parton,Anastasia;Corral,Laura;Schafer,PeterH.;Babusis,Darius;Moghaddam,MehranF.;Tang,Yang;Shirley,MichaelA.;Muller,GeorgeW.[BioorganicandMedicinalChemistryLetters,2013,vol.23,#1,p.360-365]

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2008/115516,2008,A2Locationinpatent:Page/Pagecolumn51

[3]CurrentPatentAssignee:EASTCHINANORMALUNIVERSITY-CN107739389,2018,A

[4]CurrentPatentAssignee:GOOGLEINC;ABBVIEINC-WO2021/127586,2021,A1Locationinpatent:Page/Pagecolumn173-174

[5]CurrentPatentAssignee:BEIJINGINNOCAREPHARMATECH;BEIJINGNUOCHENGJIANHUAMEDICINETECH-CN113896711,2022,A

19171-18-7    879126-98-4 

[1]Patent:WO2010/61209,2010,A1.Locationinpatent:Page/Pagecolumn17-18

[2]Patent:US2011/263649,2011,A1.Locationinpatent:Page/Pagecolumn6

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