Home Other Heterocycles 192703-06-3
192703-06-3,MFCD05662316
Catalog No.:AA002G5Q

192703-06-3 | 1H-Pyrazole-3-carboxamide, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-

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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002G5Q
Chemical Name:
1H-Pyrazole-3-carboxamide, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-
CAS Number:
192703-06-3
Molecular Formula:
C29H34ClN3O
Molecular Weight:
476.0528
MDL Number:
MFCD05662316
SMILES:
Cc1ccc(cc1)Cn1nc(cc1c1ccc(c(c1)C)Cl)C(=O)N[C@H]1[C@@]2(C)CC[C@@H](C1(C)C)C2
Properties
Computed Properties
 
Complexity:
750  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
7.4  

Literature

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Title: Δ-Tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: involvement of cannabinoid receptor 2 and p38 MAPK.

Journal: Toxicology 20131215

Title: Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice.

Journal: Behavioural pharmacology 20121001

Title: Effects of palmitoylethanolamide on aqueous humor outflow.

Journal: Investigative ophthalmology & visual science 20120701

Title: The direct profibrotic and indirect immune antifibrotic balance of blocking the cannabinoid 2 receptor.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120615

Title: Cyclooxygenase-2 prostaglandins mediate anandamide-inhibitory action on nitric oxide synthase activity in the receptive rat uterus.

Journal: European journal of pharmacology 20120615

Title: Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.

Journal: European journal of medicinal chemistry 20120601

Title: AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.

Journal: British journal of pharmacology 20120401

Title: Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321

Title: The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats.

Journal: Brain research 20120320

Title: Sex differences in cannabinoid 1 vs. cannabinoid 2 receptor-selective antagonism of antinociception produced by delta9-tetrahydrocannabinol and CP55,940 in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20120301

Title: 3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.

Journal: The Journal of pharmacology and experimental therapeutics 20120201

Title: CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling.

Journal: The Journal of biological chemistry 20120106

Title: Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats.

Journal: European urology 20120101

Title: Cloning and pharmacological characterization of the dog cannabinoid CB₂receptor.

Journal: European journal of pharmacology 20111101

Title: Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.

Journal: Pharmacology, biochemistry, and behavior 20111001

Title: Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice.

Journal: European journal of pharmacology 20111001

Title: Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor.

Journal: International immunopharmacology 20110901

Title: Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice.

Journal: Journal of medicinal chemistry 20110811

Title: Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.

Journal: Nature chemical biology 20110501

Title: The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.

Journal: The Journal of physiology 20110501

Title: Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults.

Journal: Neuroscience 20110331

Title: Effects of cannabinoid agonists on sheep sphincter of oddi in vitro.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20110101

Title: Energetic metabolism and human sperm motility: impact of CB₁ receptor activation.

Journal: Endocrinology 20101201

Title: Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties.

Journal: European journal of immunology 20101201

Title: Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ(9)-tetrahydrocannabinol.

Journal: Drug and alcohol dependence 20101101

Title: Human platelets express authentic CB₁ and CB₂ receptors.

Journal: Current neurovascular research 20101101

Title: Effects of abnormal cannabidiol on oxytocin-induced myometrial contractility.

Journal: Reproduction (Cambridge, England) 20100401

Title: Endocannabinoid regulation of spinal nociceptive processing in a model of neuropathic pain.

Journal: The European journal of neuroscience 20100401

Title: Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.

Journal: European journal of pain (London, England) 20100101

Title: Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors.

Journal: PloS one 20100101

Title: The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways.

Journal: International archives of allergy and immunology 20100101

Title: Echinacea-induced cytosolic Ca2+ elevation in HEK293.

Journal: BMC complementary and alternative medicine 20100101

Title: Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20091201

Title: The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells.

Journal: Journal of immunotoxicology 20091201

Title: Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.

Journal: Drug and alcohol dependence 20091101

Title: The endocannabinoid transport inhibitor AM404 modulates nociception in cholestasis.

Journal: Neuroscience letters 20091025

Title: Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease.

Journal: Glia 20090815

Title: Regulation and possible role of endocannabinoids and related mediators in hypercholesterolemic mice with atherosclerosis.

Journal: Atherosclerosis 20090801

Title: AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors.

Journal: Biochemical and biophysical research communications 20090403

Title: The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction.

Journal: Reproduction (Cambridge, England) 20090301

Title: A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: contributions of spinal and peripheral CB(2) receptors.

Journal: Neuroscience 20090218

Title: Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.

Journal: The Journal of pharmacology and experimental therapeutics 20090101

Title: Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.

Journal: Journal of cellular and molecular medicine 20081201

Title: CB(2) cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB(2) receptor in pain.

Journal: Neurochemistry international 20081201

Title: Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20081101

Title: N-arachidonylethanolamide-induced increase in aqueous humor outflow facility.

Journal: Investigative ophthalmology & visual science 20081001

Title: Aqueous humor outflow effects of 2-arachidonylglycerol.

Journal: Experimental eye research 20080801

Title: Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.

Journal: Psychopharmacology 20080701

Title: The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20080601

Title: First in vivo evidence for a functional interaction between chemokine and cannabinoid systems in the brain.

Journal: The Journal of pharmacology and experimental therapeutics 20080501

Title: A saturated N-acylethanolamine other than N-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story..

Journal: Journal of neuroendocrinology 20080501

Title: Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20080301

Title: Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor mediated mechanism of action.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080201

Title: Pharmacological evaluation of a novel cannabinoid 2 (CB2) ligand, PF-03550096, in vitro and in vivo by using a rat model of visceral hypersensitivity.

Journal: Journal of pharmacological sciences 20080201

Title: Actions of N-arachidonyl-glycine in a rat neuropathic pain model.

Journal: Neuropharmacology 20080101

Title: [Role of cannabinoid receptors in regulation of cardiac tolerance to ischemia and reperfusion].

Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20080101

Title: Cannabinoid CB(2) receptor activation prevents bronchoconstriction and airway oedema in a model of gastro-oesophageal reflux.

Journal: European journal of pharmacology 20071114

Title: Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.

Journal: British journal of pharmacology 20071101

Title: Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed.

Journal: British journal of pharmacology 20071101

Title: The endogenous cannabinoid anandamide inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation.

Journal: British journal of pharmacology 20071101

Title: Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.

Journal: British journal of pharmacology 20071101

Title: The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor.

Journal: European journal of pharmacology 20070910

Title: Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.

Journal: Journal of neuroimmunology 20070901

Title: The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy.

Journal: British journal of pharmacology 20070801

Title: Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.

Journal: British journal of pharmacology 20070801

Title: 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells.

Journal: Biological & pharmaceutical bulletin 20070701

Title: Attenuation of allergic contact dermatitis through the endocannabinoid system.

Journal: Science (New York, N.Y.) 20070608

Title: Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes.

Journal: Journal of biochemistry 20070501

Title: A novel role of cannabinoids: implication in the fever induced by bacterial lipopolysaccharide.

Journal: The Journal of pharmacology and experimental therapeutics 20070301

Title: Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.

Journal: British journal of pharmacology 20070301

Title: CB2 cannabinoid receptors promote mouse neural stem cell proliferation.

Journal: The European journal of neuroscience 20070201

Title: Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice.

Journal: Life sciences 20070109

Title: CB1 receptor activation in the basolateral amygdala produces antinociception in animal models of acute and tonic nociception.

Journal: Clinical and experimental pharmacology & physiology 20070101

Title: Involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in oxazolone-induced contact dermatitis in mice.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20061215

Title: Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain.

Journal: Journal of neurophysiology 20061201

Title: In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids.

Journal: Journal of neuroimmunology 20061201

Title: Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion.

Journal: Bulletin of experimental biology and medicine 20061101

Title: Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20061001

Title: Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.

Journal: European journal of pharmacology 20060928

Title: Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.

Journal: European journal of pharmacology 20060701

Title: Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.

Journal: Cancer research 20060701

Title: Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.

Journal: Cancer research 20060701

Title: 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts.

Journal: Journal of cardiovascular pharmacology 20060501

Title: [Paticipation of cannabinoid receptors in the regulation of cardiac rhythm and cardiac contractility].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20060401

Title: Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

Journal: Journal of medicinal chemistry 20060323

Title: A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20060201

Title: Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.

Journal: Psychopharmacology 20060101

Title: Cannabinoid receptor agonists inhibit Ca(2+) influx to synaptosomes from rat brain.

Journal: Pharmacology 20060101

Title: Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.

Journal: Methods in molecular medicine 20060101

Title: Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors.

Journal: Brain research 20051214

Title: Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.

Journal: British journal of pharmacology 20051001

Title: Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice.

Journal: European journal of pharmacology 20050927

Title: Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.

Journal: International archives of allergy and immunology 20050901

Title: Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats.

Journal: The European journal of neuroscience 20050701

Title: Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells.

Journal: The Biochemical journal 20050601

Title: Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling.

Journal: British journal of pharmacology 20050601

Title: Peripheral, but not central effects of cannabidiol derivatives: mediation by CB(1) and unidentified receptors.

Journal: Neuropharmacology 20050601

Title: Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear.

Journal: The Journal of biological chemistry 20050506

Title: Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart.

Journal: Bulletin of experimental biology and medicine 20050501

Title: Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis.

Journal: Journal of neurochemistry 20050301

Title: The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro.

Journal: Journal of neuroimmunology 20050201

Title: Endogenous cannabinoid receptor ligand induces the migration of human natural killer cells.

Journal: Journal of biochemistry 20050201

Title: Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes.

Journal: Glia 20050115

Title: Cannabinoids depress excitatory neurotransmission between the subthalamic nucleus and the globus pallidus.

Journal: Neuroscience 20050101

Title: Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors.

Journal: Brain research. Molecular brain research 20041206

Title: Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation.

Journal: Journal of neurophysiology 20041201

Title: New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation.

Journal: Journal of pharmacological sciences 20041201

Title: Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways.

Journal: American journal of respiratory and critical care medicine 20041101

Title: 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils.

Journal: Journal of leukocyte biology 20041101

Title: Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain.

Journal: The European journal of neuroscience 20041101

Title: Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.

Journal: Circulation 20041005

Title: Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.

Journal: The Journal of pharmacology and experimental therapeutics 20041001

Title: The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2.

Journal: Journal of leukocyte biology 20041001

Title: Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.

Journal: British journal of pharmacology 20040901

Title: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas.

Journal: Cancer research 20040815

Title: Presynaptic cannabinoid CB(1) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats.

Journal: British journal of pharmacology 20040601

Title: Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells.

Journal: Journal of leukocyte biology 20040501

Title: 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells.

Journal: Journal of biochemistry 20040401

Title: Cannabinoid receptors and T helper cells.

Journal: Journal of neuroimmunology 20040201

Title: Cannabinoids and the human uterus during pregnancy.

Journal: American journal of obstetrics and gynecology 20040101

Title: Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat.

Journal: Life sciences 20030919

Title: Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.

Journal: Cellular signalling 20030901

Title: Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.

Journal: British journal of pharmacology 20030901

Title: Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030723

Title: Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor.

Journal: British journal of pharmacology 20030601

Title: Endocannabinoids protect the rat isolated heart against ischaemia.

Journal: British journal of pharmacology 20030601

Title: A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.

Journal: Pain 20030501

Title: Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery.

Journal: British journal of pharmacology 20030401

Title: Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells.

Journal: European journal of pharmacology 20030319

Title: Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line.

Journal: International journal of cancer 20030310

Title: Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart.

Journal: Life sciences 20030307

Title: Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide.

Journal: Glia 20030115

Title: Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids.

Journal: European journal of pharmacology 20030101

Title: A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.

Journal: Neuroscience 20030101

Title: Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.

Journal: Neuroscience 20030101

Title: The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation.

Journal: The Journal of biological chemistry 20021227

Title: Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells.

Journal: Journal of neuroimmunology 20021201

Title: Anandamide induces cough in conscious guinea-pigs through VR1 receptors.

Journal: British journal of pharmacology 20021101

Title: Paradoxical pharmacological effects of deoxy-tetrahydrocannabinol analogs lacking high CB1 receptor affinity.

Journal: Pharmacology 20021001

Title: Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: SR144528 as inverse agonist of CB2 cannabinoid receptor.

Journal: Journal of veterinary science 20020901

Title: Effects of anandamide on embryo implantation in the mouse.

Journal: Life sciences 20020823

Title: Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts.

Journal: Cardiovascular research 20020815

Title: Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20020801

Title: Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors.

Journal: Pain 20020501

Title: [Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020501

Title: CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain.

Journal: Pain 20020401

Title: Down-regulation by cannabinoids of the immunological activation of human basophils and guinea pig mast cells.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

Title: Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.

Journal: European journal of pharmacology 20020329

Title: Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.

Journal: Journal of neuroscience research 20020315

Title: Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF-alpha production by human mononuclear cells.

Journal: International immunopharmacology 20020301

Title: Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity.

Journal: Molecular pharmacology 20020201

Title: Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta.

Journal: Biochemical and biophysical research communications 20020111

Title: Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat.

Journal: British journal of pharmacology 20020101

Title: Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice.

Journal: British journal of pharmacology 20011101

Title: Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages.

Journal: Veterinary immunology and immunopathology 20011001

Title: Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors.

Journal: British journal of pharmacology 20010901

Title: Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells.

Journal: The Biochemical journal 20010815

Title: Modulation of cytokine responses in Corynebacterium parvum-primed endotoxemic mice by centrally administered cannabinoid ligands.

Journal: European journal of pharmacology 20010803

Title: Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.

Journal: Cancer research 20010801

Title: Cannabinoid activation of recombinant and endogenous vanilloid receptors.

Journal: European journal of pharmacology 20010727

Title: Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.

Journal: European journal of pharmacology 20010511

Title: Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed.

Journal: European journal of pharmacology 20010420

Title: Inhibitory effects of SR141716A on G-protein activation in rat brain.

Journal: European journal of pharmacology 20010302

Title: Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors.

Journal: Bulletin of experimental biology and medicine 20010301

Title: Cannabinoids and pain.

Journal: Current opinion in investigational drugs (London, England : 2000) 20010301

Title: In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20010201

Title: Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor.

Journal: European journal of biochemistry 20010201

Title: Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide.

Journal: British journal of pharmacology 20010201

Title: Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010201

Title: Delta-9-tetrahydrocannabinol differentially suppresses cisplatin-induced emesis and indices of motor function via cannabinoid CB(1) receptors in the least shrew.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation.

Journal: The Journal of biological chemistry 20000526

Title: Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20000301

Title: Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.

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