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188116-07-6,MFCD18450225
Catalog No.:AA002GMH

188116-07-6 | Awd 131-138

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$18.00   $13.00
- +
5mg
97%
in stock  
$45.00   $31.00
- +
10mg
98%
in stock  
$66.00   $47.00
- +
25mg
98%
in stock  
$111.00   $78.00
- +
50mg
98%
in stock  
$188.00   $132.00
- +
100mg
97%
in stock  
$356.00   $249.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002GMH
Chemical Name:
Awd 131-138
CAS Number:
188116-07-6
Molecular Formula:
C13H14ClN3O2
Molecular Weight:
279.7222
MDL Number:
MFCD18450225
SMILES:
O=C1N=C(CN1c1ccc(cc1)Cl)N1CCOCC1
Properties
Properties
 
BP:
421.8±55.0°C at 760 mmHg  
Form:
Solid  
MP:
264℃ (ethanol )  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
374  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
1.2  

Literature

Title: Anticonvulsant activity and tolerance of ELB138 in dogs with epilepsy: a clinical pilot study.

Journal: Veterinary journal (London, England : 1997) 20060701

Title: Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

Journal: Journal of medicinal chemistry 20060323

Title: Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.

Journal: Epilepsia 20041001

Title: Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys.

Journal: European journal of pharmacology 20030404

Title: [Identity and physicochemical properties of 1-(4-chlorophenyl)-4-morpholino-imidazolin-2-one, AWD 131-138].

Journal: Die Pharmazie 20010601

Title: Sigel E, et al. The antiepileptic drug AWD 131-138 stimulates different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site. Neurosci Lett. 1998 Apr 3;245(2):85-8.

Title: Yasar S, et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 4;465(3):257-65.

Title: Loscher W, et al. Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. Epilepsia. 2004 Oct;45(10):1228-39.

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