Home Amines 207679-81-0
207679-81-0,MFCD09264524
Catalog No.:AA002J4H

207679-81-0 | Benzenemethanol, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-

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1mg
≥99%
in stock  
$134.00   $94.00
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100mg
95%
in stock  
$300.00   $210.00
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250mg
95%
in stock  
$546.00   $382.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002J4H
Chemical Name:
Benzenemethanol, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-
CAS Number:
207679-81-0
Molecular Formula:
C22H31NO2
Molecular Weight:
341.4870
MDL Number:
MFCD09264524
SMILES:
OCc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O
Properties
Properties
 
BP:
490.721°C at 760 mmHg  
Form:
Solid  
MP:
68-72 °C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
357  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
4.4  

Literature

Title: Comparison of pharmacokinetic variability of fesoterodine vs. tolterodine extended release in cytochrome P450 2D6 extensive and poor metabolizers.

Journal: British journal of clinical pharmacology 20110801

Title: Pharmacokinetics of tolterodine in Japanese and Koreans: physiological and stochastic assessment of ethnic differences.

Journal: Drug metabolism and pharmacokinetics 20110601

Title: Effects of hepatic dysfunction on the single-dose pharmacokinetics of fesoterodine.

Journal: Journal of clinical pharmacology 20110301

Title: Spinal effects of the fesoterodine metabolite 5-hydroxymethyl tolterodine and/or doxazosin in rats with or without partial urethral obstruction.

Journal: The Journal of urology 20100801

Title: The pharmacokinetic profile of fesoterodine 8 mg with daytime or nighttime dosing.

Journal: European journal of clinical pharmacology 20100201

Title: The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine.

Journal: Current medicinal chemistry 20090101

Title: Pharmacokinetic profile of fesoterodine.

Journal: International journal of clinical pharmacology and therapeutics 20081101

Title: Effect of the proton pump inhibitor omeprazole on the pharmacokinetics of extended-release formulations of oxybutynin and tolterodine.

Journal: Journal of clinical pharmacology 20050801

Title: Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists.

Journal: Pharmacology & toxicology 20020501

Title: The effect of tolterodine on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive containing ethinyl estradiol and levonorgestrel.

Journal: Clinical therapeutics 20011101

Title: Food increases the bioavailability of tolterodine but not effective exposure.

Journal: Journal of clinical pharmacology 20010301

Title: Nilvebrant L, Gillberg PG, Sparf B. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol. 1997 Oct;81(4):169-72.

Title: Fullhase, Claudius; Soler, Roberto; Gratzke, Christian et al. Spinal effects of the fesoterodine metabolite 5-hydroxymethyl tolterodine and/or doxazosin in rats with or without partial urethral obstruction. Journal of Urology (New York, NY, United States) (2010), 184(2), 783-789.

Title: B Malhotra, et al. The Design and Development of Fesoterodine as a Prodrug of 5-hydroxymethyl Tolterodine (5-HMT), the Active Metabolite of Tolterodine. Curr Med Chem. 2009;16(33):4481-9.

Title: Naoki Aizawa, et al. Selective Inhibitory Effect of Imidafenacin and 5-hydroxymethyl Tolterodine on Capsaicin Sensitive C Fibers of the Primary Bladder Mechanosensitive Afferent Nerves in the Rat. J Urol. 2015 Apr;193(4):1423-32.

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SDS
Tags:207679-81-0 Molecular Formula|207679-81-0 MDL|207679-81-0 SMILES|207679-81-0 Benzenemethanol, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-