Home Other Building Blocks 211096-49-0
211096-49-0,MFCD09971124
Catalog No.:AA002L2O

211096-49-0 | Sb 265610

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%(HPLC)
in stock  
$122.00   $85.00
- +
5mg
≥98%
in stock  
$186.00   $130.00
- +
10mg
≥98%
in stock  
$319.00   $223.00
- +
50mg
≥98%(HPLC)
in stock  
$1,454.00   $1,018.00
- +
100mg
≥98%(HPLC)
in stock  
$2,572.00   $1,800.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002L2O
Chemical Name:
Sb 265610
CAS Number:
211096-49-0
Molecular Formula:
C14H9BrN6O
Molecular Weight:
357.1649
MDL Number:
MFCD09971124
SMILES:
N#Cc1ccc(c2c1nn[nH]2)NC(=O)Nc1ccccc1Br
Properties
Computed Properties
 
Complexity:
466  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
2  

Literature

Title: Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction.

Journal: Circulation 20161101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Identification of a novel allosteric binding site in the CXCR2 chemokine receptor.

Journal: Molecular pharmacology 20111201

Title: The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8.

Journal: Journal of hepatology 20100501

Title: A common intracellular allosteric binding site for antagonists of the CXCR2 receptor.

Journal: British journal of pharmacology 20100401

Title: SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor.

Journal: British journal of pharmacology 20090901

Title: Nicotinanilides as inhibitors of neutrophil chemotaxis.

Journal: Bioorganic & medicinal chemistry letters 20020603

Title: Auten RL, et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5.

Title: Milatovic S, et al. Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Repair Regen. 2003 May-Jun;11(3):213-9.

Title: Li Yang, et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell. 2008 Jan;13(1):23-35.

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SDS
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