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2113-05-5,MFCD00053019
Catalog No.:AA002L7B

2113-05-5 | 1-(3-Chlorophenyl)biguanide HCl

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1g
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$32.00   $23.00
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5g
97%
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$95.00   $67.00
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25g
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$261.00   $183.00
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100g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002L7B
Chemical Name:
1-(3-Chlorophenyl)biguanide HCl
CAS Number:
2113-05-5
Molecular Formula:
C8H11Cl2N5
Molecular Weight:
248.1124
MDL Number:
MFCD00053019
SMILES:
NC(=N)NC(=N)Nc1cccc(c1)Cl.Cl
NSC Number:
210906
Properties
Properties
 
BP:
434.1°C at 760 mmHg  
Form:
Solid  
MP:
190-194 °C(lit.)  
Solubility:
H2O: soluble  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
246  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  

Literature

Title: A coupled array of noncovalent interactions impacts the function of the 5-HT3A serotonin receptor in an agonist-specific way.

Journal: ACS chemical neuroscience 20121017

Title: Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT(3) receptor in the posterior and anterior insular cortex.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20121003

Title: Inhibitory effect of ramosetron on corticotropin releasing factor- and soybean oil-induced delays in gastric emptying in rats.

Journal: Journal of gastroenterology and hepatology 20120901

Title: 5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide.

Journal: Epilepsy research 20120901

Title: Effect of chronic activation of 5-HT3 receptors on 5-HT3, 5-HT(1A) and 5-HT(2A) receptors functional activity and expression of key genes of the brain serotonin system.

Journal: Neuroscience letters 20120726

Title: Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons.

Journal: BMC neuroscience 20120101

Title: Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08).

Journal: Neurochemical research 20111101

Title: Central 5-HT3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss.

Journal: Neuroscience letters 20111031

Title: Blockade of the NMDA and AMPA/kainate receptors in the dorsal raphe nucleus prevents the 5-HT₃ receptor agonist m-chlorophenylbiguanide-induced suppression of REM sleep in the rat.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20110701

Title: Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation.

Journal: Neuropeptides 20110601

Title: The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice.

Journal: Epilepsy & behavior : E&B 20110601

Title: Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.

Journal: Brain research 20110525

Title: 5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems.

Journal: Respiratory physiology & neurobiology 20100630

Title: Granisetron ameliorates acetic acid-induced colitis in rats.

Journal: Human & experimental toxicology 20100401

Title: Activation of 5-HT3 receptors leads to altered responses 6 months after MDMA treatment.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20100301

Title: Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor.

Journal: Neuroscience letters 20091106

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn.

Journal: Journal of neurophysiology 20090901

Title: Cross-regulation between colocalized nicotinic acetylcholine and 5-HT3 serotonin receptors on presynaptic nerve terminals.

Journal: Acta pharmacologica Sinica 20090601

Title: Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus.

Journal: Hearing research 20090501

Title: Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission.

Journal: Behavioural pharmacology 20090501

Title: Activation of the serotonin 5-HT3 receptor in the dorsal raphe nucleus suppresses REM sleep in the rat.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080515

Title: The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor.

Journal: Journal of neurophysiology 20061201

Title: Activation of serotonin-3 receptors increases dopamine release within the ventral tegmental area of Wistar and alcohol-preferring (P) rats.

Journal: Alcohol (Fayetteville, N.Y.) 20061101

Title: Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats.

Journal: Brain research 20060712

Title: Effects of repeated daily treatments with a 5-HT3 receptor antagonist on dopamine neurotransmission and functional activity of 5-HT3 receptors within the nucleus accumbens of Wistar rats.

Journal: Pharmacology, biochemistry, and behavior 20060601

Title: Molecular cloning and pharmacological characterization of serotonin 5-HT(3A) receptor subtype in dog.

Journal: European journal of pharmacology 20060524

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord.

Journal: Pharmacology 20060101

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on temporal differentiation: evidence for the involvement of 5-HT2A but not 5-HT3 receptors in interval timing behaviour.

Journal: Psychopharmacology 20050901

Title: The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide.

Journal: Biochemistry 20050628

Title: The serotonin type 3A receptor facilitates luteinizing hormone release and LHbeta promoter activity in immortalized pituitary gonadotropes.

Journal: Endocrine 20050601

Title: Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release.

Journal: European journal of pharmacology 20050221

Title: Effects of quipazine and m-chlorophenylbiguanide (m-CPBG) on the discrimination of durations: evidence for the involvement of 5-HT2A but not 5-HT3 receptors.

Journal: Behavioural pharmacology 20050201

Title: Serotonin type 3 receptors stimulate offensive aggression in Syrian hamsters.

Journal: Behavioural brain research 20050106

Title: Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats.

Journal: Brain research 20041126

Title: Acetaminophen: a central analgesic drug that involves a spinal tropisetron-sensitive, non-5-HT(3) receptor-mediated effect.

Journal: Molecular pharmacology 20040901

Title: The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury.

Journal: Pain 20040701

Title: Excitatory action of prostanoids on the ferret isolated vagus nerve preparation.

Journal: European journal of pharmacology 20040426

Title: Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: in vitro slice and synaptosome studies.

Journal: Neuroscience 20040101

Title: Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats.

Journal: Brain research 20030815

Title: Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG).

Journal: Bioorganic & medicinal chemistry letters 20030324

Title: Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.

Journal: Neuropharmacology 20030201

Title: Effect of pharmacologically induced smooth muscle activation on permeability in murine colitis.

Journal: Mediators of inflammation 20030201

Title: Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes.

Journal: Synapse (New York, N.Y.) 20021201

Title: Central 5-HT(3) receptors and water intake in rats.

Journal: Physiology & behavior 20021101

Title: Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020801

Title: Glutamate and NO mediation of the pressor response to 5-HT3 receptor stimulation in the nucleus tractus solitarii.

Journal: Neuroreport 20020507

Title: Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020201

Title: 5-HT3 receptors in selective animal models of cognition.

Journal: Indian journal of experimental biology 20020201

Title: Serotonin(3) receptor stimulation in the nucleus tractus solitarii activates non-catecholaminergic neurons in the rat ventrolateral medulla.

Journal: Neuroscience 20020101

Title: Hypoglossal nerve response to 5-HT3 drugs injected into the XII nucleus and vena cava in the rat.

Journal: Sleep 20011215

Title: Serotonin increases the incidence of primary afferent-evoked long-term depression in rat deep dorsal horn neurons.

Journal: Journal of neurophysiology 20010501

Title: The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism.

Journal: Pharmacology, biochemistry, and behavior 20010401

Title: Postsynaptic target regulates functional responses induced by 5-HT3 serotonin receptors on axonal varicosities of NG108-15 hybrid neuroblastoma cells.

Journal: Neuroscience 20010101

Title: Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.

Journal: European journal of pharmacology 20001208

Title: Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.

Journal: European journal of pharmacology 20000707

Title: The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit.

Journal: The Journal of biological chemistry 19991022

Title: Identification of a domain affecting agonist potency of meta-chlorophenylbiguanide in 5-HT3 receptors.

Journal: European journal of pharmacology 19990312

Title: Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment.

Journal: British journal of pharmacology 19980201

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