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2292-16-2,MFCD01707128
Catalog No.:AA002LG6

2292-16-2 | Neferine

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5mg
≥98%
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$89.00   $62.00
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10mg
≥98%
in stock  
$156.00   $109.00
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25mg
≥98%
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$363.00   $254.00
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50mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002LG6
Chemical Name:
Neferine
CAS Number:
2292-16-2
Molecular Formula:
C38H44N2O6
Molecular Weight:
624.7658
MDL Number:
MFCD01707128
SMILES:
COc1ccc(cc1)C[C@H]1N(C)CCc2c1cc(Oc1cc(ccc1O)C[C@@H]1N(C)CCc3c1cc(OC)c(c3)OC)c(c2)OC
Properties
Computed Properties
 
Complexity:
933  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
6.7  

Literature

Title: Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.

Journal: Chemico-biological interactions 20141205

Title: Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells.

Journal: Food chemistry 20130115

Title: The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.

Journal: Phytotherapy research : PTR 20120201

Title: Comparative effects of liensinine and neferine on the human ether-a-go-go-related gene potassium channel and pharmacological activity analysis.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Effect of neferine on liver ischemia-reperfusion injury in rats.

Journal: Transplantation proceedings 20110901

Title: Effects of neferine on the pharmacokinetics of amiodarone in rats.

Journal: Biomedical chromatography : BMC 20110801

Title: Synergistic effect of hyperthermia and neferine on reverse multidrug resistance in adriamycin-resistant SGC7901/ADM gastric cancer cells.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110801

Title: Neferine increases STI571 chemosensitivity via inhibition of P-gp expression in STI571-resistant K562 cells.

Journal: Leukemia & lymphoma 20110401

Title: Protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the DDAH-ADMA pathway.

Journal: Canadian journal of physiology and pharmacology 20110401

Title: [Effect of different heating methods combined with neferine on the expressions of γH2AX and mdr-1/P-gp in MCF-7/Adr breast cancer cells].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20110401

Title: Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study.

Journal: Arzneimittel-Forschung 20110101

Title: Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1.

Journal: Life sciences 20100925

Title: Neferine inhibits angiotensin II-stimulated proliferation in vascular smooth muscle cells through heme oxygenase-1.

Journal: Acta pharmacologica Sinica 20100601

Title: Antidepressant-like effects of neferine in the forced swimming test involve the serotonin1A (5-HT1A) receptor in mice.

Journal: European journal of pharmacology 20100525

Title: Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis.

Journal: European journal of pharmacology 20100210

Title: Blockade of HERG K+ channel by isoquinoline alkaloid neferine in the stable transfected HEK293 cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090801

Title: Neferine enhances insulin sensitivity in insulin resistant rats.

Journal: Journal of ethnopharmacology 20090706

Title: Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN using high-speed counter-current chromatography.

Journal: Journal of separation science 20090701

Title: Effects of extracts and neferine from the embryo of Nelumbo nucifera seeds on the central nervous system.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20081201

Title: [Neferine protects endothelial cells against damages induced by LPC and relationship with asymmetric dimethylarginine].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: Effects of plant extract neferine on cyclic adenosine monophosphate and cyclic guanosine monophosphate levels in rabbit corpus cavernosum in vitro.

Journal: Asian journal of andrology 20080301

Title: Relaxation mechanisms of neferine on the rabbit corpus cavernosum tissue in vitro.

Journal: Asian journal of andrology 20071101

Title: Improved RP-HPLC method to determine neferine in dog plasma and its application to pharmacokinetics.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

Title: [Metabolic products and pathway of neferine in rat liver].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071001

Title: [Determination of three alkaloids in total alkaloids exfracts from Lotus plumule by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

Title: Effects of neferine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbits.

Journal: Andrologia 20070801

Title: [Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. by liquid chromatography coupled to diode array detector and tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: [Effect of neferine on the chemotherapic sensitivity of STI 571 to K562/A02 cells].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20051001

Title: [Influence of neferine and erythromycin on cellular GSH concentration in K562/A02 cell line].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20040601

Title: Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives.

Journal: Acta pharmacologica Sinica 20021201

Title: [Poteintation of vincristine-induced apoptosis by tetrandrine, neferine and dauricine in the human mammary MCF-7 multidrug-resistant cells].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010201

Title: Baskaran R, et al. Neferine prevents NF-κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia. Biofactors. 2016 Jul 8;42(4):407-17.

Title: Liu X, et al. Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice. Oncotarget. 2016 Sep 20;7(38):61703-61715.

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