Catalog No.:AA002LKV

2295-31-0 | 2,4-Thiazolidinedione

Name: Name:2,4-Thiazolidinedione
Brand: AABLOCKS
SKU: AA002LKV
Availability: InStock
Rating: 90 (10 reviews)

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Quantity

97%

in stock

$11.00 $8.00

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25g

95%

in stock

$18.00 $13.00

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100g

95%

in stock

$24.00 $17.00

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500g

97%

in stock

$37.00 $26.00

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA002LKV

Chemical Name:

2,4-Thiazolidinedione

CAS Number:

2295-31-0

Molecular Formula:

C3H3NO2S

Molecular Weight:

117.1264

MDL Number:

MFCD00005478

SMILES:

O=C1SCC(=O)N1

NSC Number:

6745

Properties

BP:

305.7°C at 760 mmHg

Form:

Solid

MP:

125-127 °C(lit.);

Refractive Index:

1.5130 (estimate)

Storage:

Keep in dry area;Room Temperature;

Computed Properties

Complexity:

122

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

XLogP3:

0.1

Literature

Title: Establishment of a novel mouse model for pioglitazone-induced skeletal muscle injury.

Journal: Toxicology 20170501

Title: Kinetics of the Absorption, Distribution, Metabolism, and Excretion of Lobeglitazone, a Novel Activator of Peroxisome Proliferator-Activated Receptor Gamma in Rats.

Journal: Journal of pharmaceutical sciences 20150901

Title: Synthesis of kifunensine thioanalogs and their inhibitory activities against HIV-RT and α-mannosidase.

Journal: Carbohydrate research 20130110

Title: Density functional study on the cytochrome-mediated S-oxidation: identification of crucial reactive intermediate on the metabolic path of thiazolidinediones.

Journal: The journal of physical chemistry. A 20121025

Title: Adiponectin and all-cause mortality in elderly people with type 2 diabetes.

Journal: Diabetes care 20120901

Title: Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.

Journal: European journal of medicinal chemistry 20120701

Title: Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats.

Journal: Canadian journal of physiology and pharmacology 20120701

Title: Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.

Journal: British journal of pharmacology 20120601

Title: 5-benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials.

Journal: Bioorganic & medicinal chemistry letters 20120415

Title: Initiation of insulin among veterans with type 2 diabetes and sustained elevation of A1c.

Journal: Primary care diabetes 20120401

Title: Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue.

Journal: Endocrinology 20120301

Title: Effect of structural modifications on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione-induced hepatotoxicity in Fischer 344 rats.

Journal: Journal of applied toxicology : JAT 20120201

Title: Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity.

Journal: Chemistry & biology 20120127

Title: Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry.

Journal: Journal of medicinal chemistry 20120126

Title: PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease.

Journal: Neurobiology of disease 20120101

Title: Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moieties.

Journal: Bioorganic & medicinal chemistry letters 20120101

Title: In vivo adipogenesis in rats measured by cell kinetics in adipocytes and plastic-adherent stroma-vascular cells in response to high-fat diet and thiazolidinedione.

Journal: Diabetes 20120101

Title: New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds.

Journal: Bioorganic & medicinal chemistry 20111215

Title: The role of PPARβ/δ in the management of metabolic syndrome and its associated cardiovascular complications.

Journal: Endocrine, metabolic & immune disorders drug targets 20111201

Title: Comparison of the acute toxicities of novel algicides, thiazolidinedione derivatives TD49 and TD53, to various marine organisms.

Journal: Environmental toxicology and chemistry 20111201

Title: Genetic predisposition and nongenetic risk factors of thiazolidinedione-related edema in patients with type 2 diabetes.

Journal: Pharmacogenetics and genomics 20111201

Title: Effects of plane of nutrition and 2,4-thiazolidinedione on insulin responses and adipose tissue gene expression in dairy cattle during late gestation.

Journal: Journal of dairy science 20111201

Title: Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-α and leptin, and adipose tissue gene expression.

Journal: Journal of dairy science 20111101

Title: Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Journal: Nature 20110922

Title: The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease.

Journal: Biochimica et biophysica acta 20110901

Title: Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.

Journal: Bioorganic & medicinal chemistry letters 20110815

Title: Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.

Journal: Circulation 20110809

Title: Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.

Journal: European journal of medicinal chemistry 20110801

Title: High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Journal: Chemistry & biology 20110729

Title: Efficacy and safety of saxagliptin combination therapy in US patients with type 2 diabetes.

Journal: Postgraduate medicine 20110701

Title: Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis.

Journal: Organic & biomolecular chemistry 20110521

Title: Peroxisome proliferator-activated receptor-γ stimulates 11β-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells.

Journal: Steroids 20110501

Title: Changes and predictors for change to thiazolidinedione prescribing in UK primary care following the rosiglitazone safety warning.

Journal: International journal of clinical practice 20110501

Title: [Effects of drugs for lifestyle-related diseases on bone metabolism].

Journal: Clinical calcium 20110501

Title: [Pharmacotherapy of osteoporosis accompanied by lifestyle-related diseases].

Journal: Clinical calcium 20110501

Title: Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.

Journal: Journal of medicinal chemistry 20110414

Title: Thiazolidinedione use and ulcerative colitis-related flares: an exploratory analysis of administrative data.

Journal: Inflammatory bowel diseases 20110301

Title: Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110215

Title: S-oxidation of thiazolidinedione with hydrogen peroxide, peroxynitrous acid, and C4a-hydroperoxyflavin: a theoretical study.

Journal: The journal of physical chemistry. A 20110210

Title: Convenient synthesis of polyfunctional dihydrothiophenes with tandem reaction of 1,3-thiazolidinedione, aldehyde, arylamine and ethyl cyanoacetate.

Journal: Molecular diversity 20110201

Title: Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201

Title: An arylidene-thiazolidinedione derivative, GPU-4, without PPARγ activation, reduces retinal neovascularization.

Journal: Current neurovascular research 20110201

Title: Concomitant oral antihyperglycemic agent use and associated treatment outcomes after initiation of insulin therapy.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Title: Thiazolidinedione therapy for managing metabolic syndrome.

Journal: American family physician 20101215

Title: Thiazolidinediones as a novel class of algicides against red tide harmful algal species.

Journal: Applied biochemistry and biotechnology 20101201

Title: Safety and tolerability of vildagliptin vs. thiazolidinedione as add-on to metformin in type 2 diabetic patients with and without mild renal impairment: a retrospective analysis of the GALIANT study.

Journal: Diabetes research and clinical practice 20101101

Title: Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma.

Journal: Human molecular genetics 20101015

Title: Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients.

Journal: Diabetes care 20101001

Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Journal: Diabetes care 20101001

Title: Synthesis and primary cytotoxicity evaluation of new 5-benzylidene-2,4-thiazolidinedione derivatives.

Journal: European journal of medicinal chemistry 20101001

Title: Effects of in vitro insulin and 2,4-thiazolidinedione on the function of neutrophils harvested from blood of cows in different physiological states.

Journal: Journal of dairy science 20100901

Title: Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma in humans and mice and contributes to local and systemic carnitine homeostasis.

Journal: The Journal of biological chemistry 20100827

Title: Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

Journal: Chemistry & biology 20100827

Title: MCC-555-induced NAG-1 expression is mediated in part by KLF4.

Journal: European journal of pharmacology 20100710

Title: Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes.

Journal: Diabetes research and clinical practice 20100701

Title: Bone loss and fracture risk associated with thiazolidinedione therapy.

Journal: Pharmacotherapy 20100701

Title: A perspective on the American Heart Association/American College of Cardiology science advisory on thiazolidinedione drugs and cardiovascular risks.

Journal: Circulation. Cardiovascular quality and outcomes 20100501

Title: [Revascularization in patients with type 2 diabetes and coronary artery disease: BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) Study Group].

Journal: Der Internist 20100501

Title: Adherence to a fixed-dose combination of rosiglitazone/glimepiride in subjects switching from monotherapy or dual therapy with a thiazolidinedione and/or a sulfonylurea.

Journal: The Annals of pharmacotherapy 20100501

Title: Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents.

Journal: Bioorganic & medicinal chemistry 20100301

Title: Lack of association between thiazolidinediones and macular edema in type 2 diabetes: the ACCORD eye substudy.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20100301

Title: Binding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET.

Journal: Journal of the American Chemical Society 20100217

Title: Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.

Journal: Toxicology letters 20100201

Title: Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: Thiazolidinedione therapy for nonalcoholic steatohepatitis: go, stop, or proceed with caution?

Journal: Hepatology (Baltimore, Md.) 20100201

Title: Thiazolidinedione attenuate proteinuria and glomerulosclerosis in Adriamycin-induced nephropathy rats via slit diaphragm protection.

Journal: Nephrology (Carlton, Vic.) 20100201

Title: Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management.

Journal: Postgraduate medicine 20100101

Title: Biguanide, but not thiazolidinedione, improved insulin resistance in Werner syndrome.

Journal: Journal of the American Geriatrics Society 20100101

Title: Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes.

Journal: Cardiology in review 20100101

Title: Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice.

Journal: PloS one 20100101

Title: Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201

Title: Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis.

Journal: Hepatology (Baltimore, Md.) 20091001

Title: Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives.

Journal: European journal of medicinal chemistry 20090901

Title: A comparison between simplified and intensive dose-titration algorithms using AIR inhaled insulin for insulin-naive patients with type 2 diabetes in a randomized noninferiority trial.

Journal: Diabetes technology & therapeutics 20090901

Title: CoMFA and CoMSIA analysis of 2,4-thiazolidinediones derivatives as aldose reductase inhibitors.

Journal: Journal of molecular modeling 20090701

Title: A randomized trial of therapies for type 2 diabetes and coronary artery disease.

Journal: The New England journal of medicine 20090611

Title: Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090515

Title: Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.

Journal: European journal of medicinal chemistry 20090501

Title: Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials.

Journal: Bioorganic & medicinal chemistry letters 20090501

Title: Translating science into clinical practice: focus on vildagliptin in combination with metformin.

Journal: Diabetes, obesity & metabolism 20090501

Title: Thiazolidinedione use and the risk of fractures.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20090414

Title: Thiazolidinedione use and the risk of fractures.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20090414

Title: Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity.

Journal: Journal of the American Society of Nephrology : JASN 20090401

Title: Quantitative structure-activity relationship models with receptor-dependent descriptors for predicting peroxisome proliferator-activated receptor activities of thiazolidinedione and oxazolidinedione derivatives.

Journal: Chemical biology & drug design 20090401

Title: Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.

Journal: Journal of medicinal chemistry 20090108

Title: Impact of peripheral arterial disease in patients with diabetes--results from PROactive (PROactive 11).

Journal: Atherosclerosis 20090101

Title: Factors associated with results and conclusions of trials of thiazolidinediones.

Journal: PloS one 20090101

Title: Thiazolidinedione therapy is not associated with increased colonic neoplasia risk in patients with diabetes mellitus.

Journal: Gastroenterology 20081201

Title: Thiazolidinedione associated volume overload and pulmonary hypertension.

Journal: Therapeutic advances in cardiovascular disease 20081201

Title: Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones.

Journal: European journal of medicinal chemistry 20081101

Title: An assessment of the effect of thiazolidinedione exposure on the risk of myocardial infarction in type 2 diabetic patients.

Journal: Pharmacoepidemiology and drug safety 20081001

Title: Glycaemic control among patients with type 2 diabetes mellitus in seven European countries: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) study.

Journal: Diabetes, obesity & metabolism 20080601

Title: Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study.

Journal: Diabetes, obesity & metabolism 20080601

Title: Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Thiazolidinedione addition reduces the serum retinol-binding protein 4 in type 2 diabetic patients treated with metformin and sulfonylurea.

Journal: Translational research : the journal of laboratory and clinical medicine 20080601

Title: [Do thiazolidinediones harm skeletal integrity?].

Journal: Clinical calcium 20080501

Title: [Relationship between lipid and glucose metabolism and bone mineral metabolism : pleiotropic effects of therapeutic agents for diabetes and hyperlipidemia].

Journal: Clinical calcium 20080501

Title: Differing pharmacological activities of thiazolidinone analogs at the FSH receptor.

Journal: Biochemical and biophysical research communications 20080411

Title: T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties.

Journal: The Journal of biological chemistry 20080404

Title: Effect of gender, dose, and time on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT)-induced hepatotoxicity in Fischer 344 rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080401

Title: Electrophilic alpha-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: Sitagliptin: a novel agent for the management of type 2 diabetes mellitus.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080315

Title: Antiproteinuric and anti-inflammatory effects of thiazolidinedione.

Journal: Nephrology (Carlton, Vic.) 20080201

Title: Oral antidiabetic medication adherence and glycemic control in managed care.

Journal: The American journal of managed care 20080201

Title: Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study.

Journal: Diabetes, obesity & metabolism 20080101

Title: Fat and beyond: the diverse biology of PPARgamma.

Journal: Annual review of biochemistry 20080101

Title: Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis.

Journal: American journal of nephrology 20080101

Title: Performing meta-analysis with incomplete statistical information in clinical trials.

Journal: BMC medical research methodology 20080101

Title: Outcomes of adding second hypoglycemic drug after metformin monotherapy failure among type 2 diabetes in Hungary.

Journal: Health and quality of life outcomes 20080101

Title: Thiazolidinedione use and post-operative atrial fibrillation: a US nested case-control study.

Journal: Current medical research and opinion 20071101

Title: Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma.

Journal: The Journal of biological chemistry 20071012

Title: Synthesis and three-dimensional qualitative structure selectivity relationship of 3,5-disubstituted-2,4-thiazolidinedione derivatives as COX2 inhibitors.

Journal: Archives of pharmacal research 20071001

Title: Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione.

Journal: The Journal of biological chemistry 20070810

Title: Prepartum 2,4-thiazolidinedione alters metabolic dynamics and dry matter intake of dairy cows.

Journal: Journal of dairy science 20070801

Title: Secondary failure of glycemic control for patients adding thiazolidinedione or sulfonylurea therapy to a metformin regimen.

Journal: The American journal of managed care 20070801

Title: Pharmacogenetics of thiazolidinedione therapy.

Journal: Pharmacogenomics 20070801

Title: Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration.

Journal: The Journal of biological chemistry 20070706

Title: The impact of thiazolidinedione use on outcomes in ambulatory patients with diabetes mellitus and heart failure.

Journal: Journal of the American College of Cardiology 20070703

Title: Effect of thiazolidinedione therapy on restenosis after coronary stent implantation: a meta-analysis of randomized controlled trials.

Journal: American heart journal 20070701

Title: Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.

Journal: Molecular pharmacology 20070601

Title: Thiazolidinedione treatment decreases bone mineral density in type 2 diabetic men.

Journal: Diabetes care 20070601

Title: Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase.

Journal: Molecular pharmacology 20070601

Title: Thiazolidinedione therapy gets complicated: is bone loss the price of improved insulin resistance?

Journal: Diabetes care 20070601

Title: Inhaled insulin for diabetes mellitus.

Journal: The New England journal of medicine 20070517

Title: Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton.

Journal: Bioorganic & medicinal chemistry 20070501

Title: Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway.

Journal: The Journal of biological chemistry 20070406

Title: Summaries for patients. Exenatide therapy for type 2 diabetes.

Journal: Annals of internal medicine 20070403

Title: The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial.

Journal: Annals of internal medicine 20070403

Title: Exenatide in combination therapy: small study, big market, and many unanswered questions.

Journal: Annals of internal medicine 20070403

Title: Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation.

Journal: American journal of physiology. Renal physiology 20070401

Title: Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study.

Journal: Diabetes, obesity & metabolism 20070301

Title: Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.

Journal: Nature medicine 20070301

Title: Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation.

Journal: The Journal of clinical endocrinology and metabolism 20070201

Title: The ASP receptor C5L2 is regulated by metabolic hormones associated with insulin resistance.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20070201

Title: Effect of thiazolidinedione on the proliferation of bovine retinal endothelial cells stimulated by vascular endothelial cell growth factor.

Journal: Japanese journal of ophthalmology 20070101

Title: Thiazolidinedione induced thyroid associated orbitopathy.

Journal: BMC ophthalmology 20070101

Title: The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment.

Journal: Journal of lipid research 20061101

Title: Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice.

Journal: Bone 20061001

Title: Thiazolidinedione use and bone loss in older diabetic adults.

Journal: The Journal of clinical endocrinology and metabolism 20060901

Title: Plasma concentrations of vascular endothelial growth factor are associated with peripheral oedema in patients treated with thiazolidinedione.

Journal: Diabetologia 20060901

Title: Endothelial dysfunction and its role in diabetic vascular disease.

Journal: Endocrinology and metabolism clinics of North America 20060901

Title: Thailand diabetes registry project: glycemic control in Thai type 2 diabetes and its relation to hypoglycemic agent usage.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801

Title: Amelioration of age-related inflammation and oxidative stress by PPARgamma activator: suppression of NF-kappaB by 2,4-thiazolidinedione.

Journal: Experimental gerontology 20060601

Title: Can thiazolidinediones delay disease progression in type 2 diabetes?

Journal: Current medical research and opinion 20060601

Title: Etiology of insulin resistance.

Journal: The American journal of medicine 20060501

Title: Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus.

Journal: The American journal of cardiology 20060301

Title: Outcomes associated with introduction of thiazolidinedione therapy in Medicaid enrolled patients with type 2 diabetes: an updated and expanded retrospective analysis.

Journal: Current medical research and opinion 20060301

Title: Quantitative structure-activity analysis of 5-arylidene-2,4-thiazolidinediones as aldose reductase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20060201

Title: Attenuation of experimental colonic injury by thiazolidinedione agents.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060101

Title: Treatment of type 2 diabetes. Use of fixed-dose oral combinations.

Journal: Postgraduate medicine 20060101

Title: Synthesis and antidiabetic activity of novel 2,4-thiazolidinedione derivatives containing a thiazole ring.

Journal: Arzneimittel-Forschung 20060101

Title: Oral agents in managing diabetes mellitus in children and adolescents.

Journal: Pediatric clinics of North America 20051201

Title: SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.

Journal: Journal of medicinal chemistry 20051117

Title: [Insulin resistance: the adipose tissue in the focus].

Journal: Orvosi hetilap 20051023

Title: [The effects of thiazolidinedione from the cardiologic viewpoint].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20051001

Title: Impact of thiazolidinedione therapy on atherogenesis.

Journal: Current atherosclerosis reports 20050901

Title: Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis.

Journal: World journal of gastroenterology 20050828

Title: Peroxisome proliferator-activated receptor gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines.

Journal: Acta pharmacologica Sinica 20050601

Title: The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells.

Journal: The Journal of pharmacology and experimental therapeutics 20050501

Title: Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone.

Journal: The Journal of nutrition 20050501

Title: [Polycystic ovary syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050401

Title: Thiazolidinedione treatment attenuates diffuse neointimal hyperplasia in restenotic lesions after coronary stent implantation in type 2 diabetic patients: an intravascular ultrasound study.

Journal: Journal of cardiology 20050401

Title: Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.

Journal: The Journal of biological chemistry 20050318

Title: PPAR-gamma activation fails to provide myocardial protection in ischemia and reperfusion in pigs.

Journal: American journal of physiology. Heart and circulatory physiology 20050301

Title: Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.

Journal: The Journal of biological chemistry 20050225

Title: Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.

Journal: Genes & development 20050215

Title: [Selection of oral antidiabetic drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050201

Title: The utility of oral diabetes medications in type 2 diabetes of the young.

Journal: Current diabetes reviews 20050201

Title: Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide.

Journal: The Journal of pharmacology and experimental therapeutics 20050101

Title: Potential role of oral thiazolidinedione therapy in preserving beta-cell function in type 2 diabetes mellitus.

Journal: Drugs 20050101

Title: Efficacy and safety of ezetimibe co-administered with simvastatin in thiazolidinedione-treated type 2 diabetic patients.

Journal: Diabetes, obesity & metabolism 20050101

Title: Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes.

Journal: Diabetologia 20041201

Title: Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability.

Journal: Diabetes technology & therapeutics 20041201

Title: Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes.

Journal: Bioinformatics (Oxford, England) 20041122

Title: Peroxisome proliferator-activated receptor gamma-dependent and -independent growth inhibition of gastrointestinal tumour cells.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20041101

Title: Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.

Journal: Gastroenterology 20041101

Title: Synthesis and biological activity of benzoxazole containing thiazolidinedione derivatives.

Journal: Archives of pharmacal research 20041101

Title: Application of liquid chromatography/mass spectrometry and nuclear magnetic resonance to the identification of degradates of a novel insulin sensitizer in aqueous solutions.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041025

Title: Integrated genomic and proteomic analyses of gene expression in Mammalian cells.

Journal: Molecular & cellular proteomics : MCP 20041001

Title: Healthcare costs and prescription adherence with introduction of thiazolidinedione therapy in Medicaid type 2 diabetic patients: a retrospective data analysis.

Journal: Current medical research and opinion 20041001

Title: Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects.

Journal: International journal of oncology 20040901

Title: Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment.

Journal: Molecular cancer therapeutics 20040801

Title: Continuation of thiazolidinedione therapy in patients without left ventricular dysfunction who developed edema and congestive-heart-failure symptoms.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040801

Title: Limited tumor growth (HT29) in vivo under RO205-2349 is due to increased apoptosis and reduced cell volume but not to decreased proliferation rate.

Journal: Cancer letters 20040708

Title: Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells.

Journal: The Journal of nutrition 20040701

Title: Increased adipose tissue expression of Grb14 in several models of insulin resistance.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040601

Title: Quantitative determination of a novel insulin sensitizer and its para-hydroxylated metabolite in human plasma by LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20040528

Title: Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer.

Journal: Cancer research 20040515

Title: Coronary vasomotor abnormalities in insulin-resistant individuals.

Journal: Annals of internal medicine 20040504

Title: Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity.

Journal: Endocrinology 20040501

Title: Thiazolidinedione-induced congestive heart failure.

Journal: The Annals of pharmacotherapy 20040501

Title: Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans.

Journal: Diabetologia 20040501

Title: Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione.

Journal: European journal of medicinal chemistry 20040501

Title: Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity.

Journal: Journal of molecular endocrinology 20040401

Title: [Achieving better control of blood sugar--understanding of oral hypoglycemic agents according to their characteristics in pharmacological action mechanism (discussion)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040401

Title: Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.

Journal: The Journal of biological chemistry 20040326

Title: Type 2 diabetes mellitus: what is the optimal treatment regimen?

Journal: The American journal of medicine 20040308

Title: Increased CD36 protein as a response to defective insulin signaling in macrophages.

Journal: The Journal of clinical investigation 20040301

Title: Prevalence of edema in patients receiving combination therapy with insulin and thiazolidinedione.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040215

Title: Antiproliferative effect of fluvastatin and thiazolidinedione in mesangial cells of diabetic rats.

Journal: Pediatric nephrology (Berlin, Germany) 20040101

Title: Antitumor effects of peroxisome proliferator activate receptor gamma ligands on anaplastic thyroid carcinoma.

Journal: International journal of oncology 20040101

Title: Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association.

Journal: Diabetes care 20040101

Title: Cardiovascular implications of thiazolidinedione therapy.

Journal: Progress in cardiovascular nursing 20040101

Title: Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes.

Journal: Biochemistry 20031209

Title: The roles of insulin resistance, hyperinsulinemia, and thiazolidinediones in cardiovascular disease.