Title: Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035.
Journal: Pharmaceutical research 20061101
Title: A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.
Journal: British journal of pharmacology 20060301
Title: Role of human liver cytochrome P450 2C9 in the metabolism of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035.
Journal: Drug metabolism and pharmacokinetics 20050401
Title: Pharmacokinetics and metabolism of TR-14035, a novel antagonist of a4ss1/a4ss7 integrin mediated cell adhesion, in rat and dog.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050401
Title: 2,3-Diphenylpropionic acids as potent VLA-4 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20050103
Title: Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD.
Journal: Pulmonary pharmacology & therapeutics 20040101
Title: A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.
Journal: The Journal of pharmacology and experimental therapeutics 20030901
Title: Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.
Journal: The Journal of pharmacology and experimental therapeutics 20020701
Title: Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist.
Journal: Bioorganic & medicinal chemistry 20020601
Title: The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20011022
Title: Sircar I, et al. Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist. Bioorg Med Chem. 2002 Jun;10(6):2051-66.
Title: Egger LA, et al. Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow. J Pharmacol Exp Ther. 2002 Jul;302(1):153-62.
Title: Julio Cortijo, et al. A small molecule, orally active, α4β1/α4β7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats. Br J Pharmacol. 2006 Mar; 147(6): 661–670.
Title: M Tsuda-Tsukimoto, et al. Pharmacokinetics and metabolism of TR-14035, a novel antagonist of a4ss1/a4ss7 integrin mediated cell adhesion, in rat and dog. Xenobiotica
