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23288-49-5,MFCD00079281
Catalog No.:AA002MPR

23288-49-5 | 2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
98%
in stock  
$6.00   $4.00
- +
100mg
98%
in stock  
$7.00   $5.00
- +
1g
98%
in stock  
$16.00   $11.00
- +
5g
98%
in stock  
$43.00   $30.00
- +
25g
98%
in stock  
$103.00   $73.00
- +
100g
98%
in stock  
$184.00   $129.00
- +
500g
98%
in stock  
$735.00   $514.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002MPR
Chemical Name:
2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol
CAS Number:
23288-49-5
Molecular Formula:
C31H48O2S2
Molecular Weight:
516.8416
MDL Number:
MFCD00079281
SMILES:
CC(Sc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)(Sc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)C
Properties
Properties
 
BP:
546.7°C at 760 mmHg  
Form:
Solid  
MP:
126-128°C  
Refractive Index:
1.5341 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
583  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
11.3  

Upstream Synthesis Route

[1]Patent:EP1849768,2007,A1,.Locationinpatent:Page/Pagecolumn5

[2]JournalofMedicinalChemistry,1970,vol.13,p.722-725

[1]CollectionofCzechoslovakChemicalCommunications,1999,vol.64,#7,p.1100-1110

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Title: Antioxidant interventions as novel preventive strategies for postoperative atrial fibrillation.

Journal: International journal of cardiology 20101105

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Design of more potent squalene synthase inhibitors with multiple activities.

Journal: Bioorganic & medicinal chemistry 20101101

Title: A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.

Journal: Journal of clinical biochemistry and nutrition 20101101

Title: Lipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis.

Journal: Current cardiology reviews 20101101

Title: Probucol and succinobucol in atrial fibrillation: pros and cons.

Journal: International journal of cardiology 20101008

Title: Transglycosylated stevia and hesperidin as pharmaceutical excipients: dramatic improvement in drug dissolution and bioavailability.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101001

Title: Chlorogenic acid attenuates adhesion molecules upregulation in IL-1beta-treated endothelial cells.

Journal: European journal of nutrition 20100801

Title: Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia.

Journal: Journal of atherosclerosis and thrombosis 20100730

Title: AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.

Journal: Molecular and cellular endocrinology 20100729

Title: Effects of atorvastatin versus probucol on low-density lipoprotein subtype distribution and renal function in hyperlipidemic patients with nondiabetic nephropathy.

Journal: Renal failure 20100701

Title: Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.

Journal: Cardiovascular research 20100601

Title: Post-prandial lipid metabolism, lipid-modulating agents and cerebrovascular integrity: implications for dementia risk.

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Title: [Front line of oxidized lipoproteins: role of oxidized lipoproteins in atherogenesis and cardiovascular disease risk].

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Title: ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion.

Journal: The Journal of nutritional biochemistry 20100501

Title: Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro.

Journal: British journal of cancer 20100427

Title: The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100401

Title: Effects of grape pomace on the antioxidant defense system in diet-induced hypercholesterolemic rabbits.

Journal: Nutrition research and practice 20100401

Title: Cross-platform expression microarray performance in a mouse model of mitochondrial disease therapy.

Journal: Molecular genetics and metabolism 20100301

Title: Probucol and antioxidant vitamins rescue ischemia-induced neovascularization in mice exposed to cigarette smoke: potential role of endothelial progenitor cells.

Journal: Atherosclerosis 20100201

Title: Homogeneous nanoparticles to enhance the efficiency of a hydrophobic drug, antihyperlipidemic probucol, characterized by solid-state NMR.

Journal: Molecular pharmaceutics 20100201

Title: Vitamin E prevents steroid-induced osteonecrosis in rabbits.

Journal: Acta orthopaedica 20100201

Title: Antioxidant therapy reverses impaired graft healing in hypercholesterolemic rabbits.

Journal: Journal of vascular surgery 20100101

Title: Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits.

Journal: International journal of molecular sciences 20100101

Title: Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.

Journal: Mediators of inflammation 20100101

Title: Janus kinase 2/signal transducers and activators of transcription signal inhibition regulates protective effects of probucol on mesangial cells treated with high glucose.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes.

Journal: Reproductive biology and endocrinology : RB&E 20100101

Title: Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment.

Journal: Nutrition journal 20100101

Title: Variability of serum oxidative stress biomarkers relative to biochemical data and clinical parameters of glaucoma patients.

Journal: Molecular vision 20100101

Title: Impact of medical therapy on atheroma volume measured by different cardiovascular imaging modalities.

Journal: Cardiology research and practice 20100101

Title: Methylguanidine cytotoxicity on HK-2 cells and protective effect of antioxidants against MG-induced apoptosis in renal proximal tubular cells in vitro.

Journal: Renal failure 20100101

Title: [Immunocorrecting therapy of chronic bacterial prostatitis].

Journal: Urologiia (Moscow, Russia : 1999) 20100101

Title: Effects of fenofibrate on lipid profiles, cholesterol ester transfer activity, and in-stent intimal hyperplasia in patients after elective coronary stenting.

Journal: Lipids in health and disease 20100101

Title: High-density lipoprotein therapeutics and cardiovascular prevention.

Journal: Journal of clinical lipidology 20100101

Title: Analyses of copy number variation of GK rat reveal new putative type 2 diabetes susceptibility loci.

Journal: PloS one 20100101

Title: Low high-density lipoprotein cholesterol: current status and future strategies for management.

Journal: Vascular health and risk management 20100101

Title: Use of hamster as a model to study diet-induced atherosclerosis.

Journal: Nutrition & metabolism 20100101

Title: Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin.

Journal: International journal of molecular sciences 20100101

Title: Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.

Journal: The open cardiovascular medicine journal 20100101

Title: Metabolic clues: novel directives for broad treatment strategies.

Journal: Oxidative medicine and cellular longevity 20100101

Title: Update on the role of candesartan in the optimal management of hypertension and cardiovascular risk reduction.

Journal: Integrated blood pressure control 20100101

Title: Development, characterization and solubility study of solid dispersions of azithromycin dihydrate by solvent evaporation method.

Journal: Journal of advanced pharmaceutical technology & research 20100101

Title: Development, characterization and solubility study of solid dispersions of Cefuroxime Axetil by the solvent evaporation method.

Journal: Journal of advanced pharmaceutical technology & research 20100101

Title: Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E.

Journal: Biochemistry 20091222

Title: Improvement of nephrotic syndrome by intensive lipid-lowering therapy in a patient with lipoprotein glomerulopathy.

Journal: Clinical and experimental nephrology 20091201

Title: Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20091201

Title: Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL).

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091201

Title: Protective effects of lycopene against H2O2-induced oxidative injury and apoptosis in human endothelial cells.

Journal: Cardiovascular drugs and therapy 20091201

Title: Small discoidal pre-beta1 HDL particles are efficient acceptors of cell cholesterol via ABCA1 and ABCG1.

Journal: Biochemistry 20091124

Title: Where are we with probucol: a new life for an old drug?

Journal: Atherosclerosis 20091101

Title: Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis.

Journal: Journal of lipid research 20091101

Title: Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide.

Journal: Cardiovascular research 20091101

Title: Pharmacologic therapy of non-alcoholic steatohepatitis.

Journal: Clinics in liver disease 20091101

Title: Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.

Journal: Diabetes care 20091101

Title: Enhanced bioavailability of probucol following the administration of solid dispersion systems of probucol-polyvinylpyrrolidone in rabbits.

Journal: Biological & pharmaceutical bulletin 20091101

Title: Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome.

Journal: Microcirculation (New York, N.Y. : 1994) 20091101

Title: Pro-atherogenic effects of probucol in apo E-KO mice may be mediated through alterations in immune system: Parallel alterations in gene expression in the aorta and liver.

Journal: Atherosclerosis 20091001

Title: Heme oxygenase-1 increases endothelial progenitor cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20091001

Title: A concise description of cardioprotective strategies in doxorubicin-induced cardiotoxicity.

Journal: Canadian journal of physiology and pharmacology 20091001

Title: Potential interactions between cilostazol and probucol: a two-part, single-dose, open-label study in healthy Korean male volunteers.

Journal: Clinical therapeutics 20091001

Title: [Effects of atorvastatin, alone and in combination with probucol on endothelial function in patients with acute coronary syndrome].

Journal: Zhonghua xin xue guan bing za zhi 20091001

Title: Computer diagnosis in cardiology: oxidative stress hypothesis.

Journal: North American journal of medical sciences 20091001

Title: Malformed mdx myofibers have normal cytoskeletal architecture yet altered EC coupling and stress-induced Ca2+ signaling.

Journal: American journal of physiology. Cell physiology 20090901

Title: Antiphospholipid antibodies in systemic sclerosis: a double oxidative hit?

Journal: Clinical rheumatology 20090801

Title: Antioxidant probucol attenuates myocardial oxidative stress and collagen expressions in post-myocardial infarction rats.

Journal: Journal of cardiovascular pharmacology 20090801

Title: Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

Journal: Current cardiology reviews 20090801

Title: [Effects of probucol, aspirin and atorvastatin combination therapy upon atherosclerosis].

Journal: Zhonghua yi xue za zhi 20090728

Title: Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture.

Journal: International journal of pharmaceutics 20090706

Title: Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090701

Title: Neurogenic inflammation and cardiac dysfunction due to hypomagnesemia.

Journal: The American journal of the medical sciences 20090701

Title: Influence of T-calcium channel blocker treatment on deterioration of renal function in chronic kidney disease.

Journal: Heart and vessels 20090701

Title: Effects of N-acetyl-cysteine on endothelial function and inflammation in patients with type 2 diabetes mellitus.

Journal: Heart international 20090630

Title: Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats.

Journal: Journal of gastroenterology and hepatology 20090601

Title: Cytotoxicity of 5-fluorouracil: Effect on endothelial differentiation via cell cycle inhibition in mouse embryonic stem cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090601

Title: Molecular mechanisms underlying the antiatherosclerotic and antidiabetic effects of probucol, succinobucol, and other probucol analogues.

Journal: Current opinion in lipidology 20090601

Title: Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress.

Journal: Microbiology and immunology 20090601

Title: Selective thromboxane inhibition after vascular protectant AGI-1067: results of assessment of lipoprotein profiles (ALPS) biomarkers in vitro and in vivo substudy.

Journal: Journal of thrombosis and thrombolysis 20090501

Title: Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review.

Journal: Journal of pediatric gastroenterology and nutrition 20090501

Title: [Role of probucol in preventing contrast induced acute kidney injury after coronary interventional procedure: a randomized trial].

Journal: Zhonghua xin xue guan bing za zhi 20090501

Title: Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs.

Journal: Biochemical and biophysical research communications 20090403

Title: A polymer-free dual drug-eluting stent in patients with coronary artery disease: a randomized trial vs. polymer-based drug-eluting stents.

Journal: European heart journal 20090401

Title: Succinobucol: review of the metabolic, antiplatelet and cardiovascular effects.

Journal: Expert opinion on investigational drugs 20090401

Title: Chemotherapy induced cardiomyopathy: pathogenesis, monitoring and management.

Journal: Journal of clinical medicine research 20090401

Title: Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1.

Journal: Circulation research 20090313

Title: Role of probucol in preventing contrast-induced acute kidney injury after coronary interventional procedure.

Journal: The American journal of cardiology 20090215

Title: The pre-clinical assessment of rapamycin-eluting, durable polymer-free stent coating concepts.

Journal: Biomaterials 20090201

Title: Activation of hepatic lipase expression by oleic acid: possible involvement of USF1.

Journal: Nutrients 20090201

Title: Probucol attenuates atrial autonomic remodeling in a canine model of atrial fibrillation produced by prolonged atrial pacing.

Journal: Chinese medical journal 20090105

Title: Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries.

Journal: European journal of nuclear medicine and molecular imaging 20090101

Title: Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis.

Journal: BMJ (Clinical research ed.) 20090101

Title: Nanoparticle processing in the solid state dramatically increases the cell membrane permeation of a cholesterol-lowering drug, probucol.

Journal: Molecular pharmaceutics 20090101

Title: Alpha-tocopherol: looking beyond an antioxidant.

Journal: Molecular vision 20090101

Title: [Antiviral activity of panavir in experimental Measles virus infection in cell cultures].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: [Preclinical and clinical studies of the efficacy of Panavir in therapy for tick-borne encephalitis].

Journal: Voprosy virusologii 20090101

Title: The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials.

Journal: BMJ (Clinical research ed.) 20090101

Title: [Coronary artery bypass graft in adolescent suffering from homozygous familial hypercholesterolemia resistant to probucol therapy].

Journal: Le Mali medical 20090101

Title: [Effect of Panavir on Herpes simplex virus types 1 and 2 proteins synthesis in cell culture].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: Anti-atherosclerotic molecules targeting oxidative stress and inflammation.

Journal: Current pharmaceutical design 20090101

Title: [Protective activity of panavir in experimental rabies infection].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: [A case of type 2 diabetes mellitus associated with familial hypercholesterolemia confirming the improvement of blood glucose control by colestimide].

Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20090101

Title: Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol.

Journal: European journal of pharmacology 20081228

Title: Risk factors for developing osteonecrosis after prophylaxis in steroid-treated rabbits.

Journal: The Journal of rheumatology 20081201

Title: Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan.

Journal: Journal of atherosclerosis and thrombosis 20081201

Title: A uniqe antilipidemic drug--probucol.

Journal: Journal of atherosclerosis and thrombosis 20081201

Title: [Effect of xiongshao capsule on lipid metabolism and platelet aggregation in experimental atherosclerosis rabbits].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.

Journal: American journal of physiology. Lung cellular and molecular physiology 20081101

Title: Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conversion into alpha-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling.

Journal: Atherosclerosis 20081001

Title: N-acetylcysteine protects against renal injury following bilateral ureteral obstruction.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081001

Title: [Effects of Xiongshao capsule on the proliferation of vascular smooth muscle cells in rabbits with atherosclerosis].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081001

Title: Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy.

Journal: Journal of cancer research and clinical oncology 20080901

Title: Chylomicrons in disease-future challenges Invited keynote address.

Journal: Atherosclerosis. Supplements 20080901

Title: Lipid lowering effect of antioxidant alpha-lipoic Acid in experimental atherosclerosis.

Journal: Journal of clinical biochemistry and nutrition 20080901

Title: Preparation, characterization and optimization of probucol self-emulsified drug delivery system to enhance solubility and dissolution.

Journal: Die Pharmazie 20080901

Title: Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model.

Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20080901

Title: Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.

Journal: Journal of medicinal chemistry 20080814

Title: Liver histology changes in nonalcoholic steatohepatitis after one year of treatment with probucol.

Journal: Digestive diseases and sciences 20080801

Title: In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080801

Title: Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy.

Journal: Pediatric nephrology (Berlin, Germany) 20080801

Title: In situ mouse carotid perfusion model: glucose and cholesterol transport in the eye and brain.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080801

Title: Effects of statins on high-density lipoproteins: a potential contribution to cardiovascular benefit.

Journal: Cardiovascular drugs and therapy 20080801

Title: Synergistic efficacy of concurrent treatment with cilostazol and probucol on the suppression of reactive oxygen species and inflammatory markers in cultured human coronary artery endothelial cells.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20080801

Title: Antiatherogenic effects of cilostazol and probucol alone, and in combination in low density lipoprotein receptor-deficient mice fed with a high fat diet.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20080701

Title: Development of novel antiatherogenic biaryls: design, synthesis, and reactivity.

Journal: Journal of medicinal chemistry 20080612

Title: Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601

Title: Morphology and surface States of colloidal probucol nanoparticles evaluated by atomic force microscopy.

Journal: Chemical & pharmaceutical bulletin 20080601

Title: [Advance in the study of compounds inducing the expression of heme oxygenase-1].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080601

Title: Novel cardiac therapies and innocent by standers.

Journal: Lancet (London, England) 20080524

Title: Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial.

Journal: Lancet (London, England) 20080524

Title: [Influence of oxidative stress on atrial myocardium pathohistological and ultrastructural changes in atrial fibrillation: experiment with dogs].

Journal: Zhonghua yi xue za zhi 20080408

Title: Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture.

Journal: International journal of pharmaceutics 20080320

Title: Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial.

Journal: Atherosclerosis 20080301

Title: Expression and biological activity of ABCA1 in alveolar epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20080301

Title: In vivo assessment of oral administration of probucol nanoparticles in rats.

Journal: Biological & pharmaceutical bulletin 20080201

Title: Effect of the anti-oxidant probucol on soluble thrombomodulin (sTM) in hypercholesterolemic rabbits.

Journal: International journal of cardiology 20080111

Title: Does membrane fatty acid composition modulate mitochondrial functions and their thermal sensitivities?

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20080101

Title: Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.

Journal: Bioorganic & medicinal chemistry letters 20080101

Title: RNAi for treating hepatitis B viral infection.

Journal: Pharmaceutical research 20080101

Title: Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds.

Journal: Redox report : communications in free radical research 20080101

Title: [Effects of Xiongshao capsule on blood vessel collagenase gene expression in experimental rabbits with arterial restenosis].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080101

Title: Viability of developing CETP inhibitors.

Journal: Cardiovascular therapeutics 20080101

Title: Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30.

Journal: Pharmaceutical development and technology 20080101

Title: Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice.

Journal: PloS one 20080101

Title: [Investigation of antiviral properties of new formulations of Panavir in the treatment of experimental herpes virus infection in mice].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101

Title: Pharmacologic induction of heme oxygenase-1.

Journal: Antioxidants & redox signaling 20071201

Title: Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis.

Journal: Free radical biology & medicine 20071201

Title: Clinical trials update from the European Society of Cardiology Congress in Vienna, 2007: PROSPECT, EVEREST, ARISE, ALOFT, FINESSE, Prague-8, CARESS in MI and ACUITY.

Journal: Cardiovascular drugs and therapy 20071201

Title: hERG channel trafficking: novel targets in drug-induced long QT syndrome.

Journal: Biochemical Society transactions 20071101

Title: Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients.

Journal: Bulletin of experimental biology and medicine 20071101

Title: [Adverse effects of lipid-lowering medications].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028

Title: Probucol modulates iron nitrilotriacetate (Fe-NTA)-dependent renal carcinogenesis and hyperproliferative response: diminution of oxidative stress.

Journal: Molecular and cellular biochemistry 20071001

Title: Combined pantethine and probucol therapy for Japanese patients with non-alcoholic steatohepatitis.

Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20071001

Title: Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans.

Journal: Current drug metabolism 20071001

Title: Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents.

Journal: Bioorganic & medicinal chemistry 20070915

Title: Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway.

Journal: European journal of pharmacology 20070910

Title: Pharmacologic approaches to restenosis prevention.

Journal: The American journal of cardiology 20070903

Title: Glucose fluctuation on the progression of diabetic macroangiopathy--new findings from monocyte adhesion to endothelial cells.

Journal: Diabetes research and clinical practice 20070901

Title: Bioassay-guided fractionation of antifertility components of castorbean (Ricinus communis L.) seed extracts.

Journal: Natural product research 20070901

Title: Probucol does not inhibit myeloperoxidase-dependent low-density lipoprotein oxidation as a potent protective effect in atherosclerosis.

Journal: Journal of cardiovascular pharmacology 20070901

Title: Phase II testing of sunitinib: the National Cancer Institute of Canada Clinical Trials Group IND Program Trials IND.182-185.

Journal: Current oncology (Toronto, Ont.) 20070801

Title: Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067.

Journal: Journal of clinical lipidology 20070801

Title: [Probucol].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070728

Title: [Drug-induced hypolipoproteinemia].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070728

Title: Beneficial synergistic effects of concurrent treatment with cilostazol and probucol against focal cerebral ischemic injury in rats.

Journal: Brain research 20070709

Title: Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processes.

Journal: Biochimica et biophysica acta 20070701

Title: Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice.

Journal: Biochimica et biophysica acta 20070701

Title: AGI-1067, a novel vascular protectant, anti-inflammatory drug and mild antiplatelet agent for treatment of atherosclerosis.

Journal: Expert review of cardiovascular therapy 20070701

Title: Serum cardiac markers in patients with acute myocardial infarction: oxidative stress, C-reactive protein and N-terminal probrain natriuretic Peptide.

Journal: Journal of clinical biochemistry and nutrition 20070701

Title: The MeOH extract of Pleurospermum kamtschaticum and its active component buddlejasaponin (IV) inhibits intrinsic and extrinsic hyperlipidemia and hypercholesterolemia in the rat.

Journal: Journal of ethnopharmacology 20070613

Title: Anticancer prodrugs of butyric acid and formaldehyde protect against doxorubicin-induced cardiotoxicity.

Journal: British journal of cancer 20070604

Title: Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: Mechanisms involved in chylomicron remnant lipid uptake by macrophages.

Journal: Biochemical Society transactions 20070601

Title: [Animal models for steroid-induced osteonecrosis].

Journal: Clinical calcium 20070601

Title: Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Follicular development and expression of the messenger ribonucleic acid for the inhibin/activin subunits in two genetic lines of turkey hens that differ in total egg production.

Journal: Poultry science 20070501

Title: Cloning and expression of human haptoglobin subunits in Escherichia coli: delineation of a major antioxidant domain.

Journal: Protein expression and purification 20070401

Title: Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds.

Journal: Journal of pharmaceutical sciences 20070401

Title: Do statins reduce blood pressure?: a meta-analysis of randomized, controlled trials.

Journal: Hypertension (Dallas, Tex. : 1979) 20070401

Title: Effects of acetylcysteine and probucol on contrast medium-induced depression of intrinsic renal glutathione peroxidase activity in diabetic rats.

Journal: Archives of medical research 20070401

Title: Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis?

Journal: International journal of clinical practice 20070401

Title: [Research and developmental strategy of anti-dyslipidemic agents].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070401

Title: Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20070401

Title: Oral treatment with probucol in a pharmacological dose has no beneficial effects on mortality in chronic ischemic heart failure after large myocardial infarction in rats.

Journal: European journal of pharmacology 20070308

Title: Antioxidant nature of bovine milk beta-lactoglobulin.

Journal: Journal of dairy science 20070201

Title: Anti-apoptotic effects of probucol are associated with downregulation of Daxx expression in THP-1 macrophage.

Journal: Cardiovascular drugs and therapy 20070201

Title: Effect of probucol on HDL metabolism and class B type I scavenger receptor (SR-BI) expression in the liver of hypercholesterolemic rabbits.

Journal: International journal of cardiology 20070131

Title: American Heart Association - Scientific Sessions 2006. Cell therapies for ischemic tissues and treatments for lipid metabolism disorders.

Journal: IDrugs : the investigational drugs journal 20070101

Title: Higher circulating 4-hydroxynonenal-protein thioether adducts correlate with more severe diastolic dysfunction in spontaneously hypertensive rats.

Journal: Redox report : communications in free radical research 20070101

Title: Probucol promotes endogenous antioxidant reserve and confers protection against reperfusion injury.

Journal: Canadian journal of physiology and pharmacology 20070101

Title: Inhibition of lipid peroxidation induced by hydroxyprogesterone caproate by some conventional antioxidants in goat liver homogenates.

Journal: Acta poloniae pharmaceutica 20070101

Title: Are HIV positive patients resistant to statin therapy?

Journal: Lipids in health and disease 20070101

Title: Fish-oil esters of plant sterols differ from vegetable-oil sterol esters in triglycerides lowering, carotenoid bioavailability and impact on plasminogen activator inhibitor-1 (PAI-1) concentrations in hypercholesterolemic subjects.

Journal: Lipids in health and disease 20070101

Title: [Panavir, as a broad spectrum antiviral agent].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20070101

Title: Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelialization.

Journal: Atherosclerosis 20061201

Title: Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules.

Journal: Cardiovascular & hematological disorders drug targets 20061201

Title: Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-gamma, and aortic stiffness in hypercholesterolemia.

Journal: American journal of physiology. Heart and circulatory physiology 20061101

Title: Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR.

Journal: Pharmaceutical research 20061101

Title: Role of probucol in inhibiting intimal hyperplasia after coronary stent implantation: a randomized study.

Journal: American heart journal 20061101

Title: Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20061101

Title: Combined effect of probucol and insulin on renal damage in diabetic rats fed a high cholesterol diet.

Journal: European journal of pharmacology 20061024

Title: [Can antioxidants prevent atherosclerosis?].

Journal: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 20061001

Title: Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits.

Journal: Journal of cardiovascular pharmacology 20061001

Title: Human urotensin-II potentiates the mitogenic effect of mildly oxidized low-density lipoprotein on vascular smooth muscle cells: comparison with other vasoactive agents and hydrogen peroxide.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20061001

Title: Dietary phytosterols reduce probucol-induced atherogenesis in apo E-KO mice.

Journal: Atherosclerosis 20060901

Title: The in vitro effects of a novel vascular protectant, AGI-1067, on platelet aggregation and major receptor expression in subjects with multiple risk factors for vascular disease.

Journal: Journal of cardiovascular pharmacology and therapeutics 20060901

Title: Tripterine inhibits the expression of adhesion molecules in activated endothelial cells.

Journal: Journal of leukocyte biology 20060801

Title: Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity.

Journal: Cardiovascular drugs and therapy 20060801

Title: Both hepatitis C virus and Chlamydia pneumoniae infection are related to the progression of carotid atherosclerosis in patients undergoing lipid lowering therapy.

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20060801

Title: Protective effect of calceolarioside on adriamycin-induced cardiomyocyte toxicity.

Journal: European journal of pharmacology 20060710

Title: Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe.

Journal: European journal of pharmacology 20060701

Title: [Beneficial effects of probucol on endothelial function in patients with acute coronary syndrome].

Journal: Zhonghua xin xue guan bing za zhi 20060701

Title: Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies.

Journal: Diabetologia 20060601

Title: CETP levels rather than polymorphisms as markers of coronary risk: healthy athlete with high HDL-C and coronary disease--effectiveness of probucol.

Journal: Atherosclerosis 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Are small biotechs still underselling themselves?

Journal: Nature biotechnology 20060501

Title: [Effects of xuezhikang capsules on vascular endothelial function and redox status in patients with coronary heart disease].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060501

Title: Phenolic compounds from the roots of Lindera fruticosa.

Journal: Journal of natural products 20060501

Title: Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy.

Journal: Journal of cardiovascular pharmacology 20060501

Title: [Effect of probucol and losartan on growth factors after balloon angioplasty in rabbits].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060401

Title: LDL-antioxidant pterocarpans from roots of Glycine max (L.) Merr.

Journal: Journal of agricultural and food chemistry 20060322

Title: Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20060301

Title: Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat.

Journal: Journal of the American Society of Nephrology : JASN 20060301

Title: Determination of DPPH free radical scavenging activity by reversed-phase HPLC: a sensitive screening method for polyherbal formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20060213

Title: Probucol delays progression of diabetic nephropathy.

Journal: Diabetes research and clinical practice 20060201

Title: Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation.

Journal: Natural product research 20060201

Title: Antioxidants: the good, the bad and the ugly.

Journal: The Canadian journal of cardiology 20060201

Title: Probucol and atorvastatin decrease urinary 8-hydroxy-2'-deoxyguanosine in patients with diabetes and hypercholesterolemia.

Journal: Journal of atherosclerosis and thrombosis 20060201

Title: Drug nanoparticle formation from drug/HPMC/SDS ternary ground mixtures.

Journal: Die Pharmazie 20060201

Title: Review article: Drug therapy for non-alcoholic fatty liver disease.

Journal: Alimentary pharmacology & therapeutics 20060115

Title: Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20060101

Title: Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation.

Journal: Natural product research 20060101

Title: Chemical structure-dependent gene expression of proteasome subunits via regulation of the antioxidant response element.

Journal: Free radical research 20060101

Title: AGI-1067: a novel vascular protectant for prevention of restenosis.

Journal: The Annals of pharmacotherapy 20060101

Title: Probucol up-regulates paraoxonase 1 expression in hepatocytes of hypercholesterolemic rabbits.

Journal: Journal of cardiovascular pharmacology 20060101

Title: Evaluation of the rabbit Purkinje fibre assay as an in vitro tool for assessing the risk of drug-induced torsades de pointes in humans.

Journal: Drug safety 20060101

Title: Effect of probucol on elderly hypercholesterolemic patients in the FAST study.

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20060101

Title: Different inflammatory response and oxidative stress in neointimal hyperplasia after balloon angioplasty and stent implantation in cholesterol-fed rabbits.

Journal: Pathology, research and practice 20060101

Title: Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.

Journal: Annual review of nutrition 20060101

Title: Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens.

Journal: BMC neuroscience 20060101

Title: [Interaction between dinitrosyl iron complexes and intermediate products of oxidative stress].

Journal: Biofizika 20060101

Title: Effects of alpha tocopherol and probucol supplements on allergen-induced airway inflammation and hyperresponsiveness in a mouse model of allergic asthma.

Journal: International archives of allergy and immunology 20060101

Title: The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome.

Journal: Lipids in health and disease 20060101

Title: Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats.

Journal: BMC gastroenterology 20060101

Title: Pretreatment with probucol attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion.

Journal: Scandinavian journal of clinical and laboratory investigation 20060101

Title: [The role of epsilon 2/epsilon 3/epsilon 4 polymorphism of the apolipoprotein E gene in the development of dislipoproteinemia and its influence on the efficacy of the hypolipidemic therapy].

Journal: TSitologiia i genetika 20060101

Title: Dietary probucol preserves endothelium-dependent relaxation of arteriovenous fistula in hypercholesterolemic rabbits.

Journal: Chang Gung medical journal 20060101

Title: Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials.

Journal: Chinese medicine 20060101

Title: Inhibition of vascular remodelling in a porcine coronary injury model by herbal extract XS0601.

Journal: Chinese medicine 20060101

Title: [Effect of Panavir on influenza A virus reproduction].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20060101

Title: Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.

Journal: The Journal of biological chemistry 20051230

Title: Design, synthesis, and evaluation of pharmacological properties of cinnamic derivatives as antiatherogenic agents.

Journal: Journal of medicinal chemistry 20051229

Title: [Oxidative stress and cardiovascular diseases].

Journal: Deutsche medizinische Wochenschrift (1946) 20051216

Title: Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051201

Title: Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats.

Journal: Journal of nutritional science and vitaminology 20051201

Title: Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid.

Journal: The Journal of nutritional biochemistry 20051101

Title: Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20051101

Title: In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates.

Journal: Journal of neurosurgery 20051001

Title: Ten-year follow-up of familial hypercholesterolemia patients after intensive cholesterol-lowering therapy.

Journal: International heart journal 20050901

Title: A case of familial hypercholesterolemia; secession from LDL-apheresis by the drug treatment with potent statin and resin.

Journal: The Tokai journal of experimental and clinical medicine 20050901

Title: Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050801

Title: Enzymatic characterization of lipid-based drug delivery systems.

Journal: International journal of pharmaceutics 20050725

Title: Cholesterol levels and statin use in patients with coronary heart disease treated in primary care settings.

Journal: Preventing chronic disease 20050701

Title: [Long QT syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050701

Title: Study of antiparkinsonic activity of panavir on a model of Parkinson syndrome induced by systemic administration of MPTP to outbred rats and C57Bl/6 mice.

Journal: Bulletin of experimental biology and medicine 20050701

Title: Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants.

Journal: Vascular health and risk management 20050601

Title: AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.

Journal: The Journal of pharmacology and experimental therapeutics 20050501

Title: Effort angina in a middle-aged woman with abnormally high levels of serum high-density lipoprotein cholesterol: a case of cholesteryl-ester transfer protein deficiency.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20050501

Title: Reduction of oxidative stress and atherosclerosis in hyperlipidemic rabbits by Dioscorea rhizome.

Journal: Canadian journal of physiology and pharmacology 20050501

Title: Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate.

Journal: The Journal of biological chemistry 20050422

Title: Combined effect of probucol and insulin on cataracts of diabetic rats fed a high cholesterol diet.

Journal: European journal of pharmacology 20050418

Title: Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat.

Journal: Pharmacological research 20050401

Title: Anthocyanins increase low-density lipoprotein and plasma cholesterol and do not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits.

Journal: Molecular nutrition & food research 20050401

Title: Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy.

Journal: American journal of physiology. Heart and circulatory physiology 20050401

Title: Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits.

Journal: Atherosclerosis 20050401

Title: Na+/H+ exchange inhibition and antioxidants lack additive protective effects after reperfusion injury in the working heterotopic rat heart isograft.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050401

Title: Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease.

Journal: Neurobiology of aging 20050301

Title: Antioxidants and atherosclerosis: emerging drug therapies.

Journal: Current atherosclerosis reports 20050201

Title: Low daily dose of antioxidant probucol decreases incidence and severity of restenosis after transluminal coronary balloon angioplasty.

Journal: Bulletin of experimental biology and medicine 20050201

Title: On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathway.

Journal: Journal of lipid research 20050101

Title: Effect of anti-oxidant (carvedilol and probucol) loaded stents in a porcine coronary restenosis model.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20050101

Title: Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release.

Journal: BMC neuroscience 20050101

Title: Protection of cortical cells by equine estrogens against glutamate-induced excitotoxicity is mediated through a calcium independent mechanism.

Journal: BMC neuroscience 20050101

Title: Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo.

Journal: Journal of atherosclerosis and thrombosis 20050101

Title: Oxidative stress and pancreatic beta-cell dysfunction.

Journal: American journal of therapeutics 20050101

Title: Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet: comparison with probucol.

Journal: Journal of biochemical and molecular toxicology 20050101

Title: Inhibition of lipoprotein lipid oxidation.

Journal: Handbook of experimental pharmacology 20050101

Title: Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Journal: Journal of medicinal chemistry 20041202

Title: Probucol inhibits ABCA1-mediated cellular lipid efflux.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20041201

Title: Effects of probucol versus aspirin and versus brachytherapy on restenosis after femoropopliteal angioplasty: the PAB randomized multicenter trial.

Journal: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 20041201

Title: Antioxidant activities of a new lignan and a neolignan from Saururus chinensis.

Journal: Bioorganic & medicinal chemistry letters 20041115

Title: Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20041101

Title: Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041101

Title: HMG CoA reductase inhibitors (statins) for dialysis patients.

Journal: The Cochrane database of systematic reviews 20041018

Title: 3,4,5,6-Tetrahydroxyxanthone prevents vascular endothelial cell apoptosis induced by high glucose.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041001

Title: Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report.

Journal: Clinical rheumatology 20041001

Title: Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits.

Journal: Arthritis and rheumatism 20041001

Title: Concurrent therapies that protect against doxorubicin-induced cardiomyopathy.

Journal: Clinical journal of oncology nursing 20041001

Title: Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1.

Journal: Circulation 20040928

Title: Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size.

Journal: Bioorganic & medicinal chemistry letters 20040920

Title: [NO and atherosclerosis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040901

Title: [Study of diagnostic criteria of intima-media thickening and effects of drugs on peripheral arteries].

Journal: Zhonghua yi xue za zhi 20040802

Title: Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG.

Journal: Clinical science (London, England : 1979) 20040801

Title: Inhibitory effects of multi-substituted benzylidenethiazolidine-2,4-diones on LDL oxidation.

Journal: Bioorganic & medicinal chemistry 20040801

Title: Antioxidant role of human haptoglobin.

Journal: Proteomics 20040801

Title: Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases.

Journal: Acta pharmacologica Sinica 20040801

Title: Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation.

Journal: The Journal of biological chemistry 20040716

Title: Oligodendrocytes are susceptible to apoptotic cell death induced by prion protein-derived peptides.

Journal: Glia 20040701

Title: Novel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20040607

Title: Probucol and ticlopidine: effect on platelet and monocyte activation markers in hyperlipidemic patients with and without type 2 diabetes.

Journal: Atherosclerosis 20040601

Title: Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs.

Journal: American journal of hypertension 20040601

Title: Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells.

Journal: European journal of biochemistry 20040601

Title: Biodistribution characteristics of galactosylated emulsions and incorporated probucol for hepatocyte-selective targeting of lipophilic drugs in mice.

Journal: Pharmaceutical research 20040601

Title: Acteoside protects endothelial cells against free radical-induced oxidative stress.

Journal: The Journal of pharmacy and pharmacology 20040601

Title: New drugs to improve transplant outcomes.

Journal: Transplantation 20040515

Title: Carvedilol inhibits basal and stimulated ACE production in human endothelial cells.

Journal: Journal of cardiovascular pharmacology 20040501

Title: Effect of probucol on the oral bioavailability of cyclosporine A.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040501

Title: Long-term treatment with probucol improves endothelial function in patients with coronary artery disease.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20040501

Title: Liquid chromatographic method for the simultaneous determination of different lipid-soluble antioxidants in human plasma and low-density lipoproteins.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425

Title: Regulation of mitochondrial transcription factor A expression by high glucose.

Journal: Annals of the New York Academy of Sciences 20040401

Title: [Effect of xiongshao capsule on vascular remodeling in rabbit with experimental atherosclerosis].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040401

Title: Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein.

Journal: The Journal of biological chemistry 20040312

Title: Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent.

Journal: The Journal of pharmacology and experimental therapeutics 20040301

Title: Redox processes underlying the vascular repair reaction.

Journal: World journal of surgery 20040301

Title: Effect of probucol on neointimal thickening in a stent porcine restenosis model.

Journal: Japanese heart journal 20040301

Title: Protective mechanisms against peptide and protein peroxides generated by singlet oxygen.

Journal: Free radical biology & medicine 20040215

Title: Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway.

Journal: The Journal of biological chemistry 20040206

Title: Potent antioxidant properties of 4-hydroxyl-propranolol.

Journal: The Journal of pharmacology and experimental therapeutics 20040101

Title: Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc.

Journal: Journal of pharmacological and toxicological methods 20040101

Title: Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property.

Journal: American journal of physiology. Heart and circulatory physiology 20040101

Title: Alpha-tocopherol preserves endothelial cell migration in the presence of cell-oxidized low-density lipoprotein by inhibiting changes in cell membrane fluidity.

Journal: Journal of vascular surgery 20040101

Title: Effects of probucol on renal function and urinary protein excretion in spontaneously hypercholesterolemic rats fed a normal or high cholesterol diet.

Journal: Kidney & blood pressure research 20040101

Title: Plant sterols: factors affecting their efficacy and safety as functional food ingredients.

Journal: Lipids in health and disease 20040101

Title: Role of antioxidant enzymes and antioxidant compound probucol in antiradical protection of pancreatic beta-cells during alloxan-induced diabetes.

Journal: Bulletin of experimental biology and medicine 20040101

Title: Effect of Lovastatin on lipid peroxidation and total antioxidant concentrations in hemodialysis patients.

Journal: Lipids in health and disease 20040101

Title: Amelioration of the beta-cell dysfunction in diabetic APA hamsters by antioxidants and AGE inhibitor treatments.

Journal: Diabetes/metabolism research and reviews 20040101

Title: Management of hyperlipidaemia associated with heart transplantation.

Journal: Drugs 20040101

Title: Exploring effects of different antioxidants on dexamethasone-induced lipid peroxidation using common laboratory markers.

Journal: Acta poloniae pharmaceutica 20040101

Title: Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study).

Journal: Cardiovascular diabetology 20040101

Title: Probucol as a potent inhibitor of oxygen radical-induced lipid peroxidation and DNA damage: in vitro studies.

Journal: Redox report : communications in free radical research 20040101

Title: Probucol, a hypocholesterolemic agent, prevents the development of uterine adenomyosis induced by pituitary grafting in mice.

Journal: Anticancer research 20040101

Title: Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells.

Journal: American journal of physiology. Heart and circulatory physiology 20031201

Title: Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies.

Journal: Current opinion in lipidology 20031201

Title: Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1.

Journal: Atherosclerosis 20031201

Title: Association of Chlamydia pneumoniae antibody with the cholesterol-lowering effect of statins.

Journal: Atherosclerosis 20031201

Title: Homozygous familial hypercholesterolaemia: development of xanthogranuloma in a boy at puberty under long-term low-density lipoprotein apheresis and drug therapy.

Journal: The British journal of dermatology 20031201

Title: Induction of NAD(P)H:quinone reductase by probucol: a possible mechanism for protection against chemical carcinogenesis and toxicity.

Journal: Pharmacology & toxicology 20031201

Title: Direct vascular effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.

Journal: Clinical and experimental pharmacology & physiology 20031201

Title: Dietary prevention of post-angioplasty restenosis. From illusion and disillusion to pragmatism.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20031201

Title: New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity.

Journal: Cancer chemotherapy and pharmacology 20031101

Title: Experimental and clinical studies show that the probucol derivative AGI-1067 prevents vascular growth.

Journal: Expert opinion on investigational drugs 20031101

Title: Modulation of HDL metabolism by probucol in complete cholesteryl ester transfer protein deficiency.

Journal: Atherosclerosis 20031101

Title: Probucol restores the defective leukocyte-endothelial interaction in experimental diabetes.

Journal: European journal of pharmacology 20031008

Title: Probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver.

Journal: Biological & pharmaceutical bulletin 20031001

Title: Cytochrome P450-mediated oxidative damage of nuclear membrane proteins and its prevention by vitamin C.

Journal: Indian journal of biochemistry & biophysics 20031001

Title: Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030901

Title: Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022.

Journal: The American journal of pathology 20030901

Title: Optimizing probucol administration to preserve left ventricular compliance after reperfusion injury in the heterotopic rat heart isograft.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20030901

Title: Vascular protectants for the treatment of atherosclerosis.

Journal: Expert review of cardiovascular therapy 20030901

Title: Novel 3-O-acyl mesquitol analogues as free-radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship.

Journal: Bioorganic & medicinal chemistry letters 20030818

Title: Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats.

Journal: Journal of the American Society of Nephrology : JASN 20030801

Title: Effect of antioxidant probucol on cell-mediated LDL oxidation in vitro and in vivo.

Journal: Bulletin of experimental biology and medicine 20030801

Title: Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus.

Journal: Bulletin of experimental biology and medicine 20030801

Title: Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.

Journal: Journal of medicinal chemistry 20030703

Title: NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy.

Journal: Journal of molecular and cellular cardiology 20030701

Title: Mechanisms of glomerular immune injury: effects of antioxidant treatment.

Journal: Journal of the American Society of Nephrology : JASN 20030701

Title: Signal jammer. An academic experiment leads to a new class of drug for attacking heart disease.

Journal: Scientific American 20030701

Title: Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins.

Journal: Molecular and cellular biochemistry 20030701

Title: Protective effects of probucol treatment on pancreatic beta-cell function of SZ-induced diabetic APA hamsters.

Journal: Experimental animals 20030701

Title: AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Oxidized low-density lipoprotein inhibits endothelium-dependent vasodilation by an antioxidant-sensitive, lysophosphatidylcholine-independent mechanism.

Journal: Journal of cardiovascular pharmacology 20030601

Title: Effects of candesartan and probucol on restenosis after coronary stenting: results of insight of stent intimal hyperplasia inhibition by new angiotensin II receptor antagonist (ISHIN) trial.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20030601

Title: A water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterol-fed rabbits.

Journal: International immunopharmacology 20030501

Title: Probucol promotes functional reendothelialization in balloon-injured rabbit aortas.

Journal: Circulation 20030422

Title: Antioxidants, statins, and atherosclerosis.

Journal: Journal of the American College of Cardiology 20030402

Title: Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study.

Journal: Journal of hepatology 20030401

Title: [Prevention of restenosis after PTCA and patient's QOL].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030401

Title: [Prevention of postangioplasty restenosis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030401

Title: [Treatment of high blood cholesterol in patients with coronary heart disease].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030401

Title: Tumor necrosis factor-alpha in low doses preactivates and activates macrophages by increasing their ability to produce reactive oxygen species and oxidize low-density lipoproteins: protective effect of antioxidants.

Journal: Bulletin of experimental biology and medicine 20030401

Title: NF-kappa B activation in endothelial cells treated with oxidized high-density lipoprotein.

Journal: Biochemical and biophysical research communications 20030328

Title: Amlodipine inhibits doxorubicin-induced apoptosis in neonatal rat cardiac myocytes.

Journal: Journal of the American College of Cardiology 20030305

Title: Optimal management of nonalcoholic fatty liver/steatohepatitis.

Journal: Journal of clinical gastroenterology 20030301

Title: Probucol in the treatment of nonalcoholic steatohepatitis: an open-labeled study.

Journal: Journal of clinical gastroenterology 20030301

Title: Differential effects of catalase on apoptosis induction in human promonocytic cells. Relationships with heat-shock protein expression.

Journal: Molecular pharmacology 20030301

Title: Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease.

Journal: Trends in molecular medicine 20030301

Title: Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease.

Journal: The American journal of cardiology 20030206

Title: Clinical results with AGI-1067: a novel antioxidant vascular protectant.

Journal: The American journal of cardiology 20030206

Title: Effects of AGI-1067 and probucol after percutaneous coronary interventions.

Journal: Circulation 20030204

Title: Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation.

Journal: The Journal of biological chemistry 20030131

Title: Hypercholesterolemia is a prerequisite for puromycin inducible damage in mouse kidney.

Journal: Kidney international 20030101

Title: Resolution of typical lipoprotein glomerulopathy by intensive lipid-lowering therapy.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20030101

Title: Oxidized low-density lipoprotein and high-density lipoprotein cholesterol modulate coronary arterial remodeling: an intravascular ultrasound study.

Journal: Clinical cardiology 20030101

Title: Interactions between cyclosporin and lipid-lowering drugs: implications for organ transplant recipients.

Journal: Drugs 20030101

Title: Ascorbic acid augments cytotoxicity induced by oxidized low-density lipoprotein.

Journal: Journal of atherosclerosis and thrombosis 20030101

Title: Alpha-tocopherol modulates the low density lipoprotein receptor of human HepG2 cells.

Journal: Nutrition journal 20030101

Title: The antiatherogenic effect of DiNAC: experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases.

Journal: Cardiovascular drug reviews 20030101

Title: Potential role of the interaction between equine estrogens, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in the prevention of coronary heart and neurodegenerative diseases in postmenopausal women.

Journal: Lipids in health and disease 20030101

Title: Effects of probucol on endothelial damage by 5-fluorouracil.

Journal: Acta oncologica (Stockholm, Sweden) 20030101

Title: The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease.

Journal: Neuroscience 20030101

Title: Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-alpha expression.

Journal: BMC pharmacology 20030101

Title: Equine estrogens differentially inhibit DNA fragmentation induced by glutamate in neuronal cells by modulation of regulatory proteins involved in programmed cell death.

Journal: BMC neuroscience 20030101

Title: [The history of experimental diabetes in Iaşi ].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20030101

Title: [The use of antioxidants and antihypoxants for decreasing of LDL oxidation by macrophages and endothelial cells in ischemia and reperfusion of vascular wall].

Journal: Biomeditsinskaia khimiia 20030101

Title: Effect of antioxidant probucol for preventing stent restenosis.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20021201

Title: [Effect of probucol on the blood concentration of cyclosporin A in patients with nephrotic syndrome: a case study with a microemulsion formulation (Neoral)].

Journal: Nihon Jinzo Gakkai shi 20021201

Title: Nitric oxide releasing morpholine derivatives as hypolipidemic and antioxidant agents.

Journal: Journal of medicinal chemistry 20021121

Title: Application of quantitative competitive polymerase chain reaction for measurements of mRNA from antioxidative enzymes in the diabetic rat retina and kidney.

Journal: Metabolism: clinical and experimental 20021001

Title: Antioxidative effects of fluvastatin and its metabolites against DNA damage in streptozotocin-treated mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021001

Title: The effect of probucol on atherosclerosis in streptozotocin-induced diabetic-hyperlipidemic APA hamsters in different stages of atherosclerosis.

Journal: Experimental animals 20021001

Title: Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification.

Journal: Endocrinology 20020901

Title: Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells.

Journal: Hypertension (Dallas, Tex. : 1979) 20020901

Title: Japanese familial hypercholesterolaemia with a 327insC mutation in the LDL receptor gene.

Journal: Annals of clinical biochemistry 20020901

Title: Evaluation of pharmacokinetic interaction between cyclosporin A and probucol in rats.

Journal: Pharmaceutical research 20020901

Title: Gateways to Clinical Trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020901

Title: Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits.

Journal: Atherosclerosis 20020801

Title: Effect of probucol on cytochrome P450 activities in human liver microsomes.

Journal: Biological & pharmaceutical bulletin 20020801

Title: Effects of probucol in hyperlipidemic rabbit liver: a preliminary ultrastructural study.

Journal: Okajimas folia anatomica Japonica 20020801

Title: Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: roles of oxidative stress and inflammation.

Journal: Circulation 20020716

Title: Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes.

Journal: Diabetes research and clinical practice 20020701

Title: DNA damage and the effect of antioxidants in streptozotocin-treated mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020701

Title: Potential emerging therapeutic strategies to prevent restenosis in the peripheral vasculature.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20020701

Title: Intensification of free radical oxidation of low-density lipoproteins in the plasma of patients with ischemic heart disease receiving beta-hydroxy-beta-methylglutaryl-coenzyme A reductase inhibitor cerivastatin and inhibition of low-density lipoprotein peroxidation with antioxidant probucol.

Journal: Bulletin of experimental biology and medicine 20020701

Title: Antioxidative activity of green tea polyphenol in cholesterol-fed rats.

Journal: Journal of agricultural and food chemistry 20020605

Title: Probucol inhibits oxidized-low density lipoprotein-induced adhesion of monocytes to endothelial cells in vitro.

Journal: Acta pharmacologica Sinica 20020601

Title: Antioxidative and hypolipidemic effects of barley leaf essence in a rabbit model of atherosclerosis.

Journal: Japanese journal of pharmacology 20020601

Title: Policosanol: a new treatment for cardiovascular disease?

Journal: Alternative medicine review : a journal of clinical therapeutic 20020601

Title: Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat.

Journal: Circulation 20020528

Title: Importance of NAD(P)H oxidase-mediated oxidative stress and contractile type smooth muscle myosin heavy chain SM2 at the early stage of atherosclerosis.

Journal: Circulation 20020514

Title: Inhibitory effect of a novel water-soluble vitamin E derivative on atherosclerosis in rabbits.

Journal: Atherosclerosis 20020501

Title: Stilbazulenyl nitrone (STAZN): a nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants.

Journal: Journal of the American Chemical Society 20020501

Title: Immunomodulation with DiNAC-- a new approach to the treatment of atherosclerosis?

Journal: Expert opinion on investigational drugs 20020501

Title: 2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5.

Journal: Journal of natural products 20020501

Title: Anti-lipid-peroxidative principles from Tournefortia sarmentosa.

Journal: Journal of natural products 20020501

Title: [Anti-hyperlipidemic agents].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020501

Title: Effects of antioxidants on kidney disease.

Journal: Mechanisms of ageing and development 20020430

Title: The effect of antioxidants on glycated albumin-induced cytotoxicity in bovine retinal pericytes.

Journal: Biochemical and biophysical research communications 20020412

Title: Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits.

Journal: Atherosclerosis 20020401

Title: Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits.

Journal: Clinica chimica acta; international journal of clinical chemistry 20020301

Title: Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.

Journal: British journal of pharmacology 20020301

Title: Effects of plaque composition on vascular remodelling after angioplasty in the MultiVitamins and Probucol (MVP) trial.

Journal: The Canadian journal of cardiology 20020301

Title: [Pharmacokinetics and relative bioavailability of probucol inclusion complex capsule in healthy dogs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020301

Title: Antioxidant treatment of therapy-resistant idiopathic membranous nephropathy with probucol: a pilot study.

Journal: Wiener klinische Wochenschrift 20020227

Title: Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST).

Journal: Journal of the American College of Cardiology 20020220

Title: Improved post-myocardial infarction survival with probucol in rats: effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression.

Journal: Journal of the American College of Cardiology 20020102

Title: Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: An investigation on the role of natural chylomicrons in atherosclerosis.

Journal: Journal of cellular biochemistry 20020101

Title: Drug reverses coronary atherosclerosis.

Journal: Drug discovery today 20020101

Title: Esophageal cancer and the esophagus: challenges and potential strategies for selective cytoprotection of the tumor-bearing organ during cancer treatment.

Journal: Seminars in radiation oncology 20020101

Title: Effects of Ginkgo biloba extract on the proliferation of vascular smooth muscle cells in vitro and on intimal thickening and interleukin-1beta expression after balloon injury in cholesterol-fed rabbits in vivo.

Journal: Journal of cellular biochemistry 20020101

Title: Effects of pravastatin on exercise electrocardiography test performance and cardiovascular mortality and morbidity in patients with hypercholesterolemia: Lipid Intervention Study in Kyoto.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20020101

Title: Probucol and liver efficiency during chemically-induced hepatocarcinogenesis.

Journal: Anticancer research 20020101

Title: Evaluation of probucol as suppressor of ceftizoxime induced lipid peroxidation.

Journal: Acta poloniae pharmaceutica 20020101

Title: The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits.

Journal: Journal of atherosclerosis and thrombosis 20020101

Title: Effects of inhibition of glycation and oxidative stress on the development of diabetic nephropathy in rats.

Journal: Journal of diabetes and its complications 20020101

Title: [Invasive cardiology: focus on restenosis. Part II].

Journal: Kardiologiia 20020101

Title: Prevention of restenosis with antioxidants: mechanisms and implications.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101

Title: Relationship between free radicals produced by entamoeba histolytica and its proteases complex activity.

Journal: Revista latinoamericana de microbiologia 20020101

Title: Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic rats.

Journal: Diabetes 20011201

Title: Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice.

Journal: The Journal of clinical investigation 20011201

Title: Low-density lipoprotein-antioxidant constituents of Saururus chinensis.

Journal: Journal of natural products 20011201

Title: [Lipid-lowering drugs].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011201

Title: Antioxidative effects of fluvastatin and its metabolites against oxidative DNA damage in mammalian cultured cells.

Journal: Free radical research 20011201

Title: Fluvastatin depresses the enhanced lipid peroxidation in vitamin E-deficient hamsters.

Journal: Free radical research 20011201

Title: Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease.

Journal: Life sciences 20011130

Title: A novel series of 2,6,7-substituted 2,3-dihydro-1,4-benzodioxin and 2,6,7-substituted 1,4-benzodioxin derivatives as lipid peroxidation inhibitors. Structure-activity relationships for high inhibition of human low-density lipoprotein peroxidation.

Journal: Journal of medicinal chemistry 20011108

Title: Anti-atherogenic antioxidants regulate the expression and function of proteasome alpha-type subunits in human endothelial cells.

Journal: The Journal of biological chemistry 20011102

Title: Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression.

Journal: Atherosclerosis 20011101

Title: Allergic reactions at repeat femoral angiography with ioxaglate.

Journal: Acta radiologica (Stockholm, Sweden : 1987) 20011101

Title: N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

Title: A dynamic in vitro lipolysis model. II: Evaluation of the model.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20011001

Title: Antioxidant compounds and Ca(2+) pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity.

Journal: Journal of neuroscience research 20011001

Title: [Effect of probucol on the concentration of cyclosporin A in patients with nephrotic syndrome].

Journal: Nihon Jinzo Gakkai shi 20011001

Title: Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes.

Journal: Current eye research 20011001

Title: Alpha-tocopherol and probucol reduce autoantibody titer to MDA-LDL in hypercholesterolemic rabbits.

Journal: Free radical biology & medicine 20010915

Title: Endothelin-1 synthesis and endothelin B receptor expression in human coronary artery smooth muscle cells and monocyte-derived macrophages is up-regulated by low density lipoproteins.

Journal: Journal of molecular and cellular cardiology 20010901

Title: Restenosis drug discovery--a formidable task.

Journal: Current opinion in investigational drugs (London, England : 2000) 20010901

Title: Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species.

Journal: Life sciences 20010810

Title: Action of the novel antioxidants 4GBE43 and 2BBE43 against lipid peroxidation.

Journal: Biochemical pharmacology 20010801

Title: Oxidants and antioxidants in atherosclerosis.

Journal: Current opinion in lipidology 20010801

Title: Antioxidative properties of probucol estimated by the reactivity with superoxide and by electrochemical oxidation.

Journal: Chemical & pharmaceutical bulletin 20010801

Title: Angiotensin-converting enzyme inhibitors and probucol suppress the time-dependent increase in urinary Type IV collagen excretion of Type II diabetes mellitus patients with early diabetic nephropathy.

Journal: Clinical nephrology 20010801

Title: Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C.

Journal: Microcirculation (New York, N.Y. : 1994) 20010801

Title: Effects of probucol on atherosclerosis of apoE-deficient or LDL receptor-deficient mice.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010801

Title: Apheresis technology for prevention and regression of atherosclerosis.

Journal: Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis 20010801

Title: A comparison of alternative polymer excipients and processing methods for making solid dispersions of a poorly water soluble drug.

Journal: International journal of pharmaceutics 20010703

Title: Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells.

Journal: Hypertension (Dallas, Tex. : 1979) 20010701

Title: Hepatic cholesterol and bile acid synthesis, low-density lipoprotein receptor function, and plasma and fecal sterol levels in mice: effects of apolipoprotein E deficiency and probucol or phytosterol treatment.

Journal: Metabolism: clinical and experimental 20010601

Title: Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.

Journal: Journal of hypertension 20010601

Title: Characterization of simple and reproducible vascular stenosis model in hypercholesterolemic hamsters.

Journal: Lipids 20010501

Title: Inhibition of purified pig and human liver retinyl ester hydrolase by pharmacologic agents.

Journal: Lipids 20010501

Title: The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide.

Journal: The Journal of biological chemistry 20010427

Title: Structure, function and regulation of the ABC1 gene product.

Journal: Current opinion in lipidology 20010401

Title: Treatment of hyperlipidemia in HIV-infected patients.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20010401

Title: Specific antioxidant activity of caffeoyl derivatives and other natural phenolic compounds: LDL protection against oxidation and decrease in the proinflammatory lysophosphatidylcholine production.

Journal: Journal of natural products 20010401

Title: Selective inhibition by probucol of vascular cell adhesion molecule-1 (VCAM-1) expression in human vascular endothelial cells.

Journal: Atherosclerosis 20010301

Title: Effect of probucol in lecithin-cholesterol acyltransferase-deficient mice: inhibition of 2 independent cellular cholesterol-releasing pathways in vivo.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010301

Title: Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes.

Journal: Free radical research 20010301

Title: Lipids and atherosclerosis: clinical management of hypercholesterolaemia.

Journal: Expert opinion on pharmacotherapy 20010301

Title: [Pathogenesis of hypolipidemia].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010301

Title: [Probucol].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010301

Title: [Nicotinic acid and the derivative].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010301

Title: [Antioxidants].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010301

Title: [Treatments for dyslipidemia associated with kidney disease].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010301

Title: The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons.

Journal: The Journal of biological chemistry 20010216

Title: Oxygen radicals mediate the final exacerbation of endothelin-1-induced gastric ulcer in rat.

Journal: European journal of pharmacology 20010209

Title: The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits.

Journal: Atherosclerosis 20010201

Title: Effects of probucol on rat carotid artery responses to balloon catheter injury.

Journal: Atherosclerosis 20010201

Title: Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes.

Journal: The Journal of pharmacy and pharmacology 20010201

Title: Apoptosis in adriamycin cardiomyopathy and its modulation by probucol.

Journal: Antioxidants & redox signaling 20010201

Title: [Hyperlipidemia and cerebrovascular disease].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010201

Title: Antioxidant therapy attenuates JNK activation and apoptosis in the remote noninfarcted myocardium after large myocardial infarction.

Journal: Biochemical and biophysical research communications 20010112

Title: Impact of residual plaque burden after balloon angioplasty in the MultiVitamins and Probucol (MVP) trial.

Journal: The Canadian journal of cardiology 20010101

Title: A salvianolic acid B-rich fraction of Salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model.

Journal: Histology and histopathology 20010101

Title: [Antioxidative effects of fluvastatin, and its major metabolites [II]].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101

Title: Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus.

Journal: BMC medical genetics 20010101

Title: Effect of nilvadipine in weak acidic medium by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

Journal: Arzneimittel-Forschung 20010101

Title: Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-alpha-treated human aortic endothelial cells.

Journal: Journal of cellular biochemistry 20010101

Title: Probucol decreases total body fat loss in VX2-carcinoma-induced cachectic rabbits.

Journal: Oncology reports 20010101

Title: Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women.

Journal: Menopause (New York, N.Y.) 20010101

Title: [Antioxidant effect of novel probucol analogs and their combinations with alpha-tocopherol].

Journal: Voprosy meditsinskoi khimii 20010101

Title: Evaluation of alpha-tocopherol, probucol and ascorbic acid as suppressors of digoxin induced lipid peroxidation.

Journal: Acta poloniae pharmaceutica 20010101

Title: Oxidative stress and functional deficit in diabetic cardiomyopathy.

Journal: Advances in experimental medicine and biology 20010101

Title: Type 2 diabetes: pharmacological intervention in an animal model.

Journal: Advances in experimental medicine and biology 20010101

Title: [A 50-year history of new drugs in Japan: the developments and trends of antihyperlipidemic drugs].

Journal: Yakushigaku zasshi 20010101

Title: Structure-activity relationship of antioxidants for inhibitors of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells.

Journal: Cytotechnology 20010101

Title: Effects of probucol on cholesterol metabolism in mouse peritoneal macrophages: inhibition of HDL-mediated cholesterol efflux.

Journal: Atherosclerosis 20001001

Title: Nephrin in experimental glomerular disease.

Journal: Kidney international 20001001

Title: Effect of probucol on repeat revascularization rate after percutaneous transluminal coronary angioplasty (from the Probucol Angioplasty Restenosis Trial [PART]).

Journal: The American journal of cardiology 20000901

Title: Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats.

Journal: Cardiovascular research 20000601

Title: Adriamycin-induced heart failure: mechanism and modulation.

Journal: Molecular and cellular biochemistry 20000401

Title: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.

Journal: Kidney international 19991201

Title: Attenuation of reperfusion injury with probucol in the heterotopic rat cardiac isograft.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 19990801

Title: Combined effects of probucol and benzafibrate on lipoprotein metabolism and liver cholesteryl ester transfer protein mRNA in cholesterol-fed rabbits.

Journal: Japanese circulation journal 19990601

Title: Zinc accumulation in adriamycin-induced cardiomyopathy in rats: effects of melatonin, a cardioprotective antioxidant.

Journal: Journal of pineal research 19990501

Title: Effect of probucol on serum lipids, atherosclerosis and toxicology in fat-fed LDL receptor deficient mice.

Journal: Atherosclerosis 19981201

Title: Some natural and synthetic antioxidants as stabilizers of beta-carotene conversion into vitamin A.

Journal: Biochemistry. Biokhimiia 19980201

Title: Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.

Journal: Journal of the American Society of Nephrology : JASN 19980201

Title: Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats.

Journal: Life sciences 19980101

Title: Effectiveness of an antioxidant in preventing restenosis after percutaneous transluminal coronary angioplasty: the Probucol Angioplasty Restenosis Trial.

Journal: Journal of the American College of Cardiology 19971001

Title: Inhibition of progression of chronic puromycin aminonucleoside nephrosis by probucol, an antioxidant.

Journal: Journal of the American Society of Nephrology : JASN 19961101

Title: The mitogenic effect of H2O2 for vascular smooth muscle cells is mediated by an increase of the affinity of basic fibroblast growth factor for its receptor.

Journal: FEBS letters 19961014

Title: Probucol-associated tachyarrhythmic events and QT prolongation: importance of gender.

Journal: American heart journal 19960601

Title: The protective effect of probucol on adriamycin nephrosis in the rat.

Journal: Nihon Jinzo Gakkai shi 19951101

Title: Currently available hypolipidaemic drugs and future therapeutic developments.

Journal: Bailliere's clinical endocrinology and metabolism 19951001

Title: Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants.

Journal: Circulation 19950715

Title: [The ameliorative effect of probucol on adriamycin (ADR) induced nephrotic rats].

Journal: Nihon Jinzo Gakkai shi 19950301

Title: 3,5-Di-t-butyl-4-hydroxytoluene (BHT) and probucol stimulate selectively the reaction of mammalian 15-lipoxygenase with biomembranes.

Journal: Biochimica et biophysica acta 19950103

Title: Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect.

Journal: Circulation 19950101

Title: Antihyperlipidaemic agents. Drug interactions of clinical significance.

Journal: Drug safety 19941101

Title: Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats.

Journal: Circulation 19940601

Title: Probucol-induced QT prolongation and syncope.

Journal: Japanese circulation journal 19940501

Title: Propranolol for probucol-induced QT prolongation with polymorphic ventricular tachycardia.

Journal: Lancet (London, England) 19930109

Title: Polymorphic ventricular tachycardia (Torsade de Pointes) associated with the use of probucol.

Journal: The New England journal of medicine 19920521

Title: Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.

Journal: Journal of medicinal chemistry 19911001

Title: Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19900401

Title: Lipid-lowering agents in proteinuric diseases.

Journal: American journal of nephrology 19900101

Title: Structural changes in oxidised low-density lipoproteins and of the effect of the anti-atherosclerotic drug probucol observed by synchrotron X-ray and neutron solution scattering.

Journal: European journal of biochemistry 19890801

Title: Treatment of heterozygous familial hypercholesterolemia with lipid-lowering drugs.

Journal: Arteriosclerosis (Dallas, Tex.) 19890101

Title: Probucol-induced QT prolongation and torsades de pointes.

Journal: Japanese journal of medicine 19890101

Title: Effects of some hypolipidemic agents on biochemical values and hepatic peroxisomal enzymes in rats: comparison of probucol, CGA, KCD-232, MLM-160, AL-369 and clinofibrate with clofibrate.

Journal: Journal of pharmacobio-dynamics 19870301

Title: Effect of probucol on plasma lipids and lipoproteins in type IIb hyperlipoproteinemia.

Journal: Atherosclerosis 19801101

Title: Adrenergaically mediated ventricular fibrillation in probucol-treated dogs: roles of alpha and beta adrenergic receptors.

Journal: Pacing and clinical electrophysiology : PACE 19790701

Title: Sensitization to epinephrine-induced ventricular fibrillation produced by probucol in dogs.

Journal: Toxicology and applied pharmacology 19730401

Title: Probucol

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Tags:23288-49-5 Molecular Formula|23288-49-5 MDL|23288-49-5 SMILES|23288-49-5 2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol