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23327-57-3,MFCD00012750
Catalog No.:AA002MT7

23327-57-3 | 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)

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5g
>98.0%(T)(HPLC)
in stock  
$71.00   $50.00
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100g
≥98%
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$1,406.00   $984.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002MT7
Chemical Name:
1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)
CAS Number:
23327-57-3
Molecular Formula:
C17H20ClNO
Molecular Weight:
289.7998
MDL Number:
MFCD00012750
SMILES:
CN1CCOC(c2c(C1)cccc2)c1ccccc1.Cl
Properties
Computed Properties
 
Complexity:
274  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Efficacy and safety of neuromodulators in inflammatory arthritis: a Cochrane systematic review.

Journal: The Journal of rheumatology. Supplement 20120901

Title: Compartmental pharmacokinetics of nefopam during mild hypothermia.

Journal: British journal of anaesthesia 20120501

Title: Neuromodulators for pain management in rheumatoid arthritis.

Journal: The Cochrane database of systematic reviews 20120118

Title: Study of pharmacokinetics and comparative bioavailability of nefopam 30 mg tablets in twelve fasting healthy Pakistani male young subjects: single-dose, randomized, two-period, two-treatment and two-way cross-over design.

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20120101

Title: A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.

Journal: PloS one 20120101

Title: [Comparison between two analgesic protocols on IVF success rates].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20110401

Title: Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients.

Journal: British journal of anaesthesia 20110301

Title: Nefopam enhances the protective activity of antiepileptics against maximal electroshock-induced convulsions in mice.

Journal: Pharmacological reports : PR 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Nefopam pharmacokinetics in patients with end-stage renal disease.

Journal: Anesthesia and analgesia 20101101

Title: The effects of nefopam on the gain and maximum intensity of shivering in healthy volunteers.

Journal: Anesthesia and analgesia 20100801

Title: Prolonged withdrawal delirium in concomitant diphenhydramine and nefopam dependence: A case report.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20100530

Title: Fatal nefopam overdose.

Journal: Emergency medicine journal : EMJ 20100501

Title: [Watch out for headaches at the end of a pregnancy! Do not miss an autoimmune hypositys].

Journal: Gynecologie, obstetrique & fertilite 20100401

Title: Nefopam but not physostigmine affects the thermoregulatory response in mice via alpha(2)-adrenoceptors.

Journal: Neuropharmacology 20100201

Title: Positive interference of the analgesic nefopam in the urine immunoassay for benzodiazepines in a secure setting.

Journal: Journal of psychopharmacology (Oxford, England) 20091101

Title: High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations.

Journal: Organic & biomolecular chemistry 20090907

Title: Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties.

Journal: Anesthesia and analgesia 20090801

Title: Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam.

Journal: European journal of pain (London, England) 20090701

Title: Nefopam and alfentanil additively reduce the shivering threshold in humans whereas nefopam and clonidine do not.

Journal: Anesthesiology 20090701

Title: Nefopam hydrochloride compatibility and stability with selected proton pump inhibitors in bionolyte G5 injection for intravenous infusion.

Journal: Journal of clinical pharmacy and therapeutics 20090201

Title: Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents.

Journal: Pharmacology 20090101

Title: Compatibility and stability of binary mixtures of acetaminophen, nefopam, ketoprofen and ketamine in infusion solutions.

Journal: European journal of anaesthesiology 20090101

Title: Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice.

Journal: Pharmacology 20090101

Title: Single dose oral nefopam for acute postoperative pain in adults.

Journal: The Cochrane database of systematic reviews 20090101

Title: Development and evaluation of nefopam transdermal matrix patch system in human volunteers.

Journal: PDA journal of pharmaceutical science and technology 20090101

Title: Nefopam for the prevention of postoperative pain: quantitative systematic review.

Journal: British journal of anaesthesia 20081101

Title: [Physico-chemical stability and sterility of non-opioid analgesics in solution].

Journal: Annales francaises d'anesthesie et de reanimation 20081001

Title: Nefopam and ketoprofen synergy in rodent models of antinociception.

Journal: European journal of pharmacology 20080428

Title: Cross-reactivity of nefopam and its metabolites with benzodiazepine EMIT immunoassay.

Journal: Journal of analytical toxicology 20080101

Title: Effective dose of nefopam in 80% of patients (ED80): a study using the continual reassessment method.

Journal: British journal of clinical pharmacology 20071101

Title: Hiccup during weaning from mechanical ventilation: the use of nefopam.

Journal: British journal of anaesthesia 20071101

Title: Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia.

Journal: British journal of anaesthesia 20071001

Title: Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database.

Journal: Fundamental & clinical pharmacology 20071001

Title: A review of the literature on post-operative pain in older cancer patients.

Journal: European journal of cancer (Oxford, England : 1990) 20071001

Title: The immunopotentiator effects of nefopam.

Journal: International immunopharmacology 20070201

Title: Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation.

Journal: Amino acids 20070101

Title: [Nefopam by continuous intravenous injection and adverse drug reactions: which causality assessment?].

Journal: Annales francaises d'anesthesie et de reanimation 20070101

Title: Recent advances in the pharmacological management of pain.

Journal: Drugs 20070101

Title: Specific and sensitive analysis of nefopam and its main metabolite desmethyl-nefopam in human plasma by liquid chromatography-ion trap tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20061116

Title: Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception.

Journal: Pharmacological research 20060901

Title: [What are the cardiovascular complications of the analgesics and glucocorticoids?].

Journal: Presse medicale (Paris, France : 1983) 20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Application of polymeric surfactants in micellar electrokinetic chromatography-electrospray ionization mass spectrometry of benzodiazepines and benzoxazocine chiral drugs.

Journal: Electrophoresis 20060301

Title: The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery.

Journal: Anesthesia and analgesia 20060101

Title: Cyclodextrin inclusion complexes of the central analgesic drug nefopam.

Journal: Drug development and industrial pharmacy 20060101

Title: Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients: a study of interaction using sequential analysis and isobolographic analysis.

Journal: Anesthesiology 20050601

Title: Physostigmine for the prevention of postanaesthetic shivering following general anaesthesia - a placebo-controlled comparison with nefopam.

Journal: Anaesthesia 20050501

Title: Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels.

Journal: Amino acids 20050301

Title: Nefopam or clonidine in the pharmacologic prevention of shivering in patients undergoing conscious sedation for interventional neuroradiology.

Journal: Anaesthesia 20050201

Title: Nefopam and ketamine comparably enhance postoperative analgesia.

Journal: Anesthesia and analgesia 20050101

Title: [Analgesic effect of continuous intravenous nefopam after urological surgery].

Journal: Annales francaises d'anesthesie et de reanimation 20050101

Title: Role of the histamine system in nefopam-induced antinociception in mice.

Journal: European journal of pharmacology 20041025

Title: Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering: a quantitative systematic review of randomized controlled trials.

Journal: Anesthesia and analgesia 20040901

Title: Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.

Journal: Brain research 20040709

Title: Spectrophotometric microdetermination of nefopam, mebevrine and phenylpropanolamine hydrochloride in pharmaceutical formulations using alizarins.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040701

Title: A comparison of nefopam and clonidine for the prevention of postanaesthetic shivering: a comparative, double-blind and placebo-controlled dose-ranging study.

Journal: Anaesthesia 20040601

Title: Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat.

Journal: Pharmacology, biochemistry, and behavior 20040401

Title: [The management of acute pain in ambulatory patients. The place of nefopam].

Journal: Presse medicale (Paris, France : 1983) 20040227

Title: The median effective dose of nefopam and morphine administered intravenously for postoperative pain after minor surgery: a prospective randomized double-blinded isobolographic study of their analgesic action.

Journal: Anesthesia and analgesia 20040201

Title: Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects.

Journal: Anesthesiology 20040101

Title: Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery.

Journal: British journal of anaesthesia 20031201

Title: Morphine-sparing effect of nefopam by continuous intravenous injection after abdominal surgery by laparotomy.

Journal: European journal of anaesthesiology 20031201

Title: Comparative pharmacokinetics and pharmacodynamics of intravenous and oral nefopam in healthy volunteers.

Journal: Pharmacology & toxicology 20030601

Title: Effect of route of administration on the pharmacokinetic behavior of enantiomers of nefopam and desmethylnefopam.

Journal: Therapeutic drug monitoring 20030401

Title: Sensitive determination of nefopam and its metabolite desmethyl-nefopam in human biological fluids by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20021107

Title: Nefopam abuse.

Journal: The Annals of pharmacotherapy 20021001

Title: Pharmacological prevention of postanesthetic shivering.

Journal: Anesthesia and analgesia 20021001

Title: [A new cause of postoperative confusion syndrome: nefopam].

Journal: Annales francaises d'anesthesie et de reanimation 20020601

Title: Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat.

Journal: European journal of pharmacology 20020419

Title: Fatal overdosage with nefopam (Acupan).

Journal: Journal of analytical toxicology 20020101

Title: Nefopam and tramadol for the prevention of shivering during neuraxial anesthesia.

Journal: Regional anesthesia and pain medicine 20020101

Title: Nefopam, an analogue of orphenadrine, protects against both NMDA receptor-dependent and independent veratridine-induced neurotoxicity.

Journal: Amino acids 20020101

Title: Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat.

Journal: Pharmacological research 20011201

Title: Novel effect of nefopam preventing cGMP increase, oxygen radical formation and neuronal death induced by veratridine.

Journal: Neuropharmacology 20011201

Title: Nefopam for refractory postoperative hiccups.

Journal: Anesthesia and analgesia 20011101

Title: Managing postoperative pain.

Journal: Hospital medicine (London, England : 1998) 20010901

Title: Effects of shivering prevention on haemodynamic and metabolic demands in hypothermic postoperative neurosurgical patients.

Journal: Anaesthesia 20010601

Title: Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection.

Journal: Anaesthesia 20010601

Title: Nefopam analgesia as a substitute of neurolept analgesia for extracorporeal shock wave lithotripsy.

Journal: Anesthesia and analgesia 20010201

Title: [Pharmacologic dependence on nefopam (Acupan): a case report].

Journal: Therapie 20010101

Title: Postanaesthetic shivering: epidemiology, pathophysiology, and approaches to prevention and management.

Journal: Drugs 20010101

Title: Effect of a non-opiate analgesic, nefopam hydrochloride, on stress gastric ulcer in rats.

Journal: Proceedings of the Western Pharmacology Society 20010101

Title: Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease.

Journal: Antimicrobial agents and chemotherapy 19960201

Title: Molecular properties and inhibition kinetics of acetylcholinesterase obtained from rat brain and cockroach ganglion.

Journal: Toxicology and industrial health 19901201

Title: [Analgesic and respiratory effects of nalbuphine during the immediate postoperative period in thoracotomy].

Journal: Annales francaises d'anesthesie et de reanimation 19900101

Title: Nefopam and propoxyphene in episiotomy pain.

Journal: Clinical pharmacology and therapeutics 19800401

Title: Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27(2):103-11.

Title: Baht GS, et al. Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair. Bone. 2017 May;98:31-36.

Title: Poon R, et al. A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders. PLoS One. 2012;7(5):e37940.

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SDS
Tags:23327-57-3 Molecular Formula|23327-57-3 MDL|23327-57-3 SMILES|23327-57-3 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)