Title: Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility.
Journal: Bioorganic & medicinal chemistry letters20130915
Title: Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents.
Journal: Bioorganic & medicinal chemistry letters20121201
Title: Interactions of microbicide nanoparticles with a simulated vaginal fluid.
Journal: Molecular pharmaceutics20121105
Title: Current status of topical antiretroviral chemoprophylaxis.
Journal: Current opinion in HIV and AIDS20121101
Title: Polymeric nanoparticles affect the intracellular delivery, antiretroviral activity and cytotoxicity of the microbicide drug candidate dapivirine.
Journal: Pharmaceutical research20120601
Title: Testing of viscous anti-HIV microbicides using Lactobacillus.
Journal: Journal of microbiological methods20120201
Title: Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs).
Journal: Bioorganic & medicinal chemistry20111015
Title: Synergy against drug-resistant HIV-1 with the microbicide antiretrovirals, dapivirine and tenofovir, in combination.
Journal: AIDS (London, England)20110824
Title: Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level.
Journal: Journal of medicinal chemistry20110428
Title: Complete inactivation of HIV-1 using photo-labeled non-nucleoside reverse transcriptase inhibitors.
Journal: Virus research20110101
Title: Update on microbicide research and development - seeking new HIV prevention tools for women.
Journal: European journal of medical research20110101
Title: Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism-Importance of slow dissociation and relaxation rates for antiviral efficacy.
Journal: Biochemical pharmacology20101015
Title: Pharmacokinetics of 2 dapivirine vaginal microbicide gels and their safety vs. Hydroxyethyl cellulose-based universal placebo gel.
Journal: Journal of acquired immune deficiency syndromes (1999)20101001
Title: Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles.
Journal: Journal of pharmaceutical and biomedical analysis20100605
Title: Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20100219
Title: Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease.
Journal: Retrovirology20100101
Title: Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry letters20090915
Title: Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor.
Journal: Antimicrobial agents and chemotherapy20090201
Title: Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide.
Journal: International journal of pharmaceutics20061115
Title: Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol.
Journal: PLoS pathogens20061101
Title: From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal: Journal of medicinal chemistry20050324
Title: In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
Journal: Journal of medicinal chemistry20050324
Title: TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1.
Journal: Antimicrobial agents and chemotherapy20041201
Title: A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides.
Journal: Antimicrobial agents and chemotherapy20041001
Title: Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
Journal: Journal of medicinal chemistry20040506
Title: In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides.
Journal: Antimicrobial agents and chemotherapy20040101
Title: Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors.
Journal: Current topics in medicinal chemistry20040101
Title: Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.
Journal: Drugs in R&D20040101
Title: Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Journal: Bioorganic & medicinal chemistry letters20010903
