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Title: Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150401
Title: Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
Journal: The Journal of toxicological sciences 20150401
Title: Solid state simulation of tetramer form of 5-aminoorotic acid: the vibrational spectra and molecular structure study by using MP2 and DFT calculations.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101
Title: Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.
Journal: Human molecular genetics 20120915
Title: Ion-exclusion chromatography determination of organic acid in uridine 5'-monophosphate fermentation broth.
Journal: Journal of chromatographic science 20120901
Title: D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis.
Journal: Antiviral chemistry & chemotherapy 20120821
Title: Crystal structure of dihydroorotate dehydrogenase from Leishmania major.
Journal: Biochimie 20120801
Title: Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii.
Journal: Molecular and biochemical parasitology 20120801
Title: Enhanced uridine 5'-monophosphate production by whole cell of Saccharomyces cerevisiae through rational redistribution of metabolic flux.
Journal: Bioprocess and biosystems engineering 20120601
Title: Secondary processes in atmospheric pressure chemical ionization-ion trap mass spectrometry: a case study of orotic acid.
Journal: Journal of mass spectrometry : JMS 20120601
Title: Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid.
Journal: Life sciences 20120409
Title: Sustained correction of OTC deficiency in spf( ash) mice using optimized self-complementary AAV2/8 vectors.
Journal: Gene therapy 20120401
Title: Reference intervals for orotic acid in urine, plasma and dried blood spot using hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120201
Title: Preclinical evaluation of a clinical candidate AAV8 vector for ornithine transcarbamylase (OTC) deficiency reveals functional enzyme from each persisting vector genome.
Journal: Molecular genetics and metabolism 20120201
Title: Conformational studies of hydantoin-5-acetic acid and orotic acid.
Journal: Acta crystallographica. Section C, Crystal structure communications 20120201
Title: [The ileocoecal valve changes in chronic constipation in children].
Journal: Klinichna khirurhiia 20120201
Title: Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats.
Journal: Lipids in health and disease 20120101
Title: [Correction of a connective tissue dysplasia in the treatment of postoperative abdominal hernias].
Journal: Klinichna khirurhiia 20120101
Title: Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells.
Journal: The Journal of toxicological sciences 20120101
Title: Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis.
Journal: PloS one 20120101
Title: Distinct fluctuations in nucleotide metabolism accompany the enhanced in vitro embryogenic capacity of Brassica cells over-expressing SHOOTMERISTEMLESS.
Journal: Planta 20111201
Title: The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved.
Journal: PLoS genetics 20111201
Title: Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension.
Journal: Biochemical and biophysical research communications 20111028
Title: The function of oxalic acid in the human metabolism.
Journal: Clinical chemistry and laboratory medicine 20110901
Title: Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver.
Journal: Journal of lipid research 20110901
Title: Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20110810
Title: Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
Journal: The Plant cell 20110801
Title: Development of pyrF-based gene knockout systems for genome-wide manipulation of the archaea Haloferax mediterranei and Haloarcula hispanica.
Journal: Journal of genetics and genomics = Yi chuan xue bao 20110620
Title: OAT2 catalyses efflux of glutamate and uptake of orotic acid.
Journal: The Biochemical journal 20110601
Title: Study on possible mechanism of orotic acid-induced fatty liver in rats.
Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20110501
Title: Human urate transporter 1 (hURAT1) mediates the transport of orotate.
Journal: The journal of physiological sciences : JPS 20110501
Title: Identification of the UMP synthase gene by establishment of uracil auxotrophic mutants and the phenotypic complementation system in the marine diatom Phaeodactylum tricornutum.
Journal: Plant physiology 20110501
Title: Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20110501
Title: [Analysis of clinical features, biochemical analysis and gene mutations in one Chinese pedigree with neonatal-onset ornithine transcarbamylase deficiency].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20110501
Title: Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase.
Journal: Biochemistry 20110412
Title: A common telomeric gene silencing assay is affected by nucleotide metabolism.
Journal: Molecular cell 20110408
Title: Molecular recognition of melamine by vesicles spontaneously formed from orotic acid derived bolaamphiphiles.
Journal: The journal of physical chemistry. B 20110303
Title: New insights into galactose metabolism by Schizosaccharomyces pombe: isolation and characterization of a galactose-assimilating mutant.
Journal: Journal of bioscience and bioengineering 20110201
Title: Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.
Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20110201
Title: [Adrenoreactivity in patients with arrhythmic syndrome associated with connective tissue dysplasia at the background of intake of the magnezium orotate].
Journal: Kardiologiia 20110101
Title: Arginase I deficiency: severe infantile presentation with hyperammonemia: more common than reported?
Journal: Molecular genetics and metabolism 20110101
Title: Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides.
Journal: Bioscience, biotechnology, and biochemistry 20110101
Title: [Fifteen years experience of the use of magnesium preparations in patients with mitral valve prolapse].
Journal: Kardiologiia 20110101
Title: Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase.
Journal: Journal of the American Chemical Society 20101201
Title: Use of the pyrG gene as a food-grade selection marker in Monascus.
Journal: Biotechnology letters 20101101
Title: Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry.
Journal: Analytical biochemistry 20100401
Title: New classes of PDE7 inhibitors identified by a fission yeast-based HTS.
Journal: Journal of biomolecular screening 20100401
Title: The mechanisms of citrate on regulating the distribution of carbon flux in the biosynthesis of uridine 5'-monophosphate by Saccharomyces cerevisiae.
Journal: Applied microbiology and biotechnology 20100301
Title: A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function.
Journal: The FEBS journal 20100301
Title: Orotic acid quantification in dried blood spots and biological fluids by hydrophilic interaction liquid chromatography tandem mass spectrometry.
Journal: Journal of separation science 20100301
Title: A trial of minimization of chromosome 7 in Aspergillus oryzae by multiple chromosomal deletions.
Journal: Molecular genetics and genomics : MGG 20100101
Title: Quantitation of orotic acid in urine using isotope dilution-selected ion gas chromatography-mass spectrometry.
Journal: Methods in molecular biology (Clifton, N.J.) 20100101
Title: Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling.
Journal: Lipids in health and disease 20100101
Title: Early detection of steatohepatitis in fatty rat liver by using MR elastography.
Journal: Radiology 20091001
Title: Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats.
Journal: Brain research 20090929
Title: Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase.
Journal: Biochemistry 20090915
Title: [Development of anti-trypanosome drugs targeting nucleotides biosynthesis and red-ox regulatory pathway].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090901
Title: Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli.
Journal: Biochemistry 20090804
Title: AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20090801
Title: Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
Journal: Cardiovascular drugs and therapy 20090801
Title: Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090601
Title: In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver.
Journal: Gene therapy 20090601
Title: Marker-disruptive gene integration and URA3 recycling for multiple gene manipulation in Saccharomyces cerevisiae.
Journal: Applied microbiology and biotechnology 20090601
Title: Changes in noninfarcted myocardium explain benefits of on-pump beating-heart coronary artery bypass grafting for acute myocardial infarction.
Journal: The Journal of thoracic and cardiovascular surgery 20090601
Title: Magnesium orotate in severe congestive heart failure (MACH).
Journal: International journal of cardiology 20090501
Title: Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model.
Journal: Experimental parasitology 20090401
Title: Babesia bovis: effect of Albumax II and orotic acid in a low-serum in vitro culture.
Journal: Experimental parasitology 20090301
Title: Regulation of pyrimidine formation in Pseudomonas lundensis.
Journal: Canadian journal of microbiology 20090301
Title: Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.
Journal: Biochemistry 20090203
Title: Efficient generation of recessive traits in diploid sake yeast by targeted gene disruption and loss of heterozygosity.
Journal: Applied microbiology and biotechnology 20090201
Title: Magnesium orotate in severe congestive heart failure (MACH).
Journal: International journal of cardiology 20090109
Title: Mapping the landscape of potentially primordial informational oligomers: oligo-dipeptides tagged with orotic acid derivatives as recognition elements.
Journal: Angewandte Chemie (International ed. in English) 20090101
Title: New amides of 5-(4-chlorobenzoyl)aminoorotic acid: their synthesis and biological activity.
Journal: Archiv der Pharmazie 20081101
Title: Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction.
Journal: Biochemistry 20081014
Title: The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080901
Title: Clinical applications of urinary organic acids. Part I: Detoxification markers.
Journal: Alternative medicine review : a journal of clinical therapeutic 20080901
Title: The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.
Journal: Biochemistry 20080826
Title: Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors.
Journal: The journal of gene medicine 20080801
Title: Surprisingly low aqueous acidity at the alpha-positions of pyridiniums and pyrimidinium: the role of solvation.
Journal: Organic letters 20080703
Title: Ghrelin and orotic acid increased in subclinical mastitis.
Journal: Archives of physiology and biochemistry 20080701
Title: New lanthanide complexes with antioxidant activity.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701
Title: Postchemotherapy hyperammonemic encephalopathy emulating ornithine transcarbamoylase (OTC) deficiency.
Journal: Southern medical journal 20080501
Title: Fenofibrate prevents orotic acid--induced hepatic steatosis in rats.
Journal: Life sciences 20080409
Title: Stochastic switching as a survival strategy in fluctuating environments.
Journal: Nature genetics 20080401
Title: Control of 5-FOA and 5-FU resistance by Saccharomyces cerevisiae YJL055W.
Journal: Yeast (Chichester, England) 20080201
Title: Gene tagging and gene replacement using recombinase-mediated cassette exchange in Schizosaccharomyces pombe.
Journal: Gene 20080115
Title: Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy.
Journal: Acta biochimica Polonica 20080101
Title: Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids.
Journal: Molecular pharmaceutics 20080101
Title: Differentiation of 2-alkylthioorotic acids, methyl and ethyl 2-alkylthioorotates and hydrazides of 2-alkylthioorotic acids by using electron ionization mass spectra.
Journal: European journal of mass spectrometry (Chichester, England) 20080101
Title: QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis.
Journal: The journal of physical chemistry. B 20071101
Title: The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker.
Journal: Microbiology (Reading, England) 20071101
Title: Transformation by complementation of a uracil auxotroph of the hyper lignin-degrading basidiomycete Phanerochaete sordida YK-624.
Journal: Applied microbiology and biotechnology 20071001
Title: Diversity of crystal structure with different lanthanide ions involving in situ oxidation-hydrolysis reaction.
Journal: Dalton transactions (Cambridge, England : 2003) 20070928
Title: The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites.
Journal: Molecular and biochemical parasitology 20070901
Title: Carbanions from decarboxylation of orotate analogs: stability and mechanistic implications.
Journal: Bioorganic chemistry 20070801
Title: Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process.
Journal: Applied microbiology and biotechnology 20070801
Title: Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.
Journal: The Journal of pharmacology and experimental therapeutics 20070801
Title: Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium.
Journal: Microbiology (Reading, England) 20070801
Title: Structures of ligand-free and inhibitor complexes of dihydroorotase from Escherichia coli: implications for loop movement in inhibitor design.
Journal: Journal of molecular biology 20070727
Title: The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.
Journal: FEMS microbiology letters 20070501
Title: Comparative studies on pyrimidine metabolism in excised cotyledons of Pinus radiata during shoot formation in vitro.
Journal: Journal of plant physiology 20070401
Title: Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.
Journal: FEMS microbiology letters 20070301
Title: Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form.
Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20070301
Title: Japanese black cattle with orotic aciduria detected by gas-chromatography/mass-spectrometry.
Journal: The Journal of veterinary medical science 20070301
Title: Two step derivatization for the analyses of organic, amino acids and glycines on filter paper plasma by GC-MS/SIM.
Journal: Archives of pharmacal research 20070301
Title: The clinical application of metabolic therapy for cardiovascular disease.
Journal: Heart, lung & circulation 20070101
Title: Classical genetics.
Journal: Methods in molecular biology (Clifton, N.J.) 20070101
Title: Improved protocols for functional analysis in the pathogenic fungus Aspergillus flavus.
Journal: BMC microbiology 20070101
Title: Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases.
Journal: Biochemistry 20061219
Title: New lanthanum (III) complex--synthesis, characterization, and cytotoxic activity.
Journal: Archiv der Pharmazie 20061101
Title: Effects of arginine treatment on nutrition, growth and urea cycle function in seven Japanese boys with late-onset ornithine transcarbamylase deficiency.
Journal: European journal of pediatrics 20060901
Title: Control of ribosome turnover during growth of the haloalkaliphilic archaeon Natronococcus occultus.
Journal: Research in microbiology 20060901
Title: Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction.
Journal: Biochemistry 20060711
Title: Long-term correction of ammonia metabolism and prolonged survival in ornithine transcarbamylase-deficient mice following liver-directed treatment with adeno-associated viral vectors.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20060701
Title: Vector-related tumorigenesis not found in ornithine transcarbamylase-deficient mice.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20060701
Title: Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.
Journal: The Journal of biological chemistry 20060630
Title: 13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus.
Journal: Biochemistry 20060613
Title: PCR-mediated seamless gene deletion and marker recycling in Saccharomyces cerevisiae.
Journal: Yeast (Chichester, England) 20060415
Title: Stability of large segmental duplications in the yeast genome.
Journal: Genetics 20060401
Title: Accelerated decarboxylation of 1,3-dimethylorotic acid in ionic liquid.
Journal: Bioorganic chemistry 20060401
Title: Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Journal: Bioorganic & medicinal chemistry letters 20060315
Title: Electronic structure of orotic acid III geometric feature and thermal properties of some transition metal orotic acid complexes.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060301
Title: Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms.
Journal: Parasitology international 20060301
Title: A new type of migrating zone boundary in electrophoresis: 3. The hybrid boundary and stacking criteria.
Journal: Electrophoresis 20060301
Title: Pulsed electrochemical detection of orotic acid by an activated potential waveform at a gold working electrode following anion-exchange chromatography.
Journal: Journal of chromatography. A 20060224
Title: Hazards associated with pregnancies and deliveries in lysinuric protein intolerance.
Journal: Metabolism: clinical and experimental 20060201
Title: Influence of calcium and phosphorus, lactose, and salt-to-moisture ratio on Cheddar cheese quality: changes in residual sugars and water-soluble organic acids during ripening.
Journal: Journal of dairy science 20060201
Title: Counter-selectable marker for bacterial-based interaction trap systems.
Journal: BioTechniques 20060201
Title: An unusual clinical and biochemical presentation of ornithine transcarbamylase deficiency in a male patient.
Journal: Journal of inherited metabolic disease 20060201
Title: An engineered nonsense URA3 allele provides a versatile system to detect the presence, absence and appearance of the [PSI+] prion in Saccharomyces cerevisiae.
Journal: Yeast (Chichester, England) 20060130
Title: Integration of genomic and metabonomic data in systems biology--are we 'there' yet?
Journal: Current opinion in drug discovery & development 20060101
Title: Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.
Journal: Arzneimittel-Forschung 20060101
Title: A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.
Journal: Journal of experimental botany 20060101
Title: 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.
Journal: Mycologia 20060101
Title: Genomic reconstruction by serial mitotic recombination of yeast artificial chromosomes.
Journal: Methods in molecular biology (Clifton, N.J.) 20060101
Title: [Use of orotic acid and orotates].
Journal: Journal de pharmacie de Belgique 20060101
Title: [The results of application of magnesium-bearing medications and different load doses of vitamins B1 and B2 in volunteers].
Journal: Voprosy pitaniia 20060101
Title: Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate.
Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20051001
Title: A high-efficiency method to replace essential genes with mutant alleles in yeast.
Journal: Yeast (Chichester, England) 20050730
Title: The influence of metals on the electronic system of biologically important ligands. Spectroscopic study of benzoates, salicylates, nicotinates and isoorotates. Review.
Journal: Journal of inorganic biochemistry 20050701
Title: Inhibition of de novo pyrimidine synthesis in growing potato tubers leads to a compensatory stimulation of the pyrimidine salvage pathway and a subsequent increase in biosynthetic performance.
Journal: The Plant cell 20050701
Title: Urinary uracil in female patients with ornithine transcarbamylase deficiency.
Journal: Pediatrics international : official journal of the Japan Pediatric Society 20050601
Title: Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits.
Journal: Journal of molecular biology 20050506
Title: Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid.
Journal: Biochemical pharmacology 20050215
Title: 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans.
Journal: Yeast (Chichester, England) 20050115
Title: Regulation of pyrimidine biosynthesis in Acidovorax delafieldii.
Journal: Journal of basic microbiology 20050101
Title: [Clinical value of the use of magnesium orotate in adolescents with syndrome of cardiac connective tissue dysplasia].
Journal: Kardiologiia 20050101
Title: Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid.
Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20050101
Title: Dietary supplementation with orotate and uracil increases adaptive growth of jejunal mucosa after massive small bowel resection in rats.
Journal: JPEN. Journal of parenteral and enteral nutrition 20050101
Title: Ornithine aminotransferase deficiency: diagnostic difficulties in neonatal presentation.
Journal: Journal of inherited metabolic disease 20050101
Title: Synthesis and properties of PNA oligomers containing orotic acid derivatives.
Journal: Nucleosides, nucleotides & nucleic acids 20050101
Title: Mechanism of the dihydroorotase reaction.
Journal: Biochemistry 20041228
Title: Alterations in pyrimidine nucleotide metabolism as an early signal during the execution of programmed cell death in tobacco BY-2 cells.
Journal: Journal of experimental botany 20041201
Title: Adsorption of bile acid by chitosan-orotic acid salt and its application as an oral preparation.
Journal: Chemical & pharmaceutical bulletin 20041001
Title: Alleviation of fatty liver by alpha-linolenic acid.
Journal: Journal of nutritional science and vitaminology 20040801
Title: Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy.
Journal: Biochemistry 20040601
Title: Improvement of culture conditions and evidence for nuclear transformation by homologous recombination in a red alga, Cyanidioschyzon merolae 10D.
Journal: Plant & cell physiology 20040601
Title: A suspected case of ornithine transcarbamylase deficiency in a cat.
Journal: The Journal of veterinary medical science 20040601
Title: Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.
Journal: Annals of the New York Academy of Sciences 20040601
Title: An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.
Journal: Physiological genomics 20040413
Title: Modest catalysis of the decarboxylation of orotate by hydrogen bonding: a theoretical model for orotidine- 5' -monophosphate decarboxylase.
Journal: Bioorganic chemistry 20040401
Title: Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.
Journal: Protein science : a publication of the Protein Society 20040401
Title: pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.
Journal: Eukaryotic cell 20040401
Title: Analytical derivatization-a tool for determination of orotic acid.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040125
Title: Alanine : glyoxylate aminotransferase of Saccharomyces cerevisiae-encoding gene AGX1 and metabolic significance.
Journal: Yeast (Chichester, England) 20040115
Title: Regulation of pyrimidine nucleotide formation in Pseudomonas reptilivora.
Journal: Letters in applied microbiology 20040101
Title: Determination of orotic acid, uric acid, and creatinine in milk by liquid chromatography.
Journal: Journal of AOAC International 20040101
Title: Orotic aciduria and plasma urea cycle-related amino acid alterations in short bowel syndrome, evoked by an arginine-free diet.
Journal: JPEN. Journal of parenteral and enteral nutrition 20040101
Title: Acetate-mediated production of orotic acid by ura3 mutants of Candida albicans.
Journal: Microbiology and immunology 20040101
Title: Magnesium orotate--experimental and clinical evidence.
Journal: Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101
Title: Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.
Journal: Carcinogenesis 20031201
Title: High-resolution diffusion and relaxation-edited magic angle spinning 1H NMR spectroscopy of intact liver tissue.
Journal: Magnetic resonance in medicine 20031101
Title: Cloning and disruption of the PpURA5 gene and construction of a set of integration vectors for the stable genetic modification of Pichia pastoris.
Journal: Yeast (Chichester, England) 20031101
Title: Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function.
Journal: The Journal of biological chemistry 20030801
Title: Concentration and purification of orotic acid directly from whey with an expanded bed adsorption system.
Journal: Journal of chromatography. A 20030718
Title: Quantification of non-protein nitrogen components of infant formulae and follow-up milks: comparison with cows' and human milk.
Journal: The British journal of nutrition 20030701
Title: Comprehensive study of the luminescent properties and lifetimes of Eu(3+) and Tb(3+) chelated with various ligands in aqueous solutions: influence of the synergic agent, the surfactant and the energy level of the ligand triplet.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030601
Title: Influence of dietary arginine on sexual dimorphism of arginine metabolism in mice.
Journal: The Journal of nutritional biochemistry 20030601
Title: Magnesium-orotate supplementation for idiopathic infertile male patients: a randomized, placebo-controlled clinical pilot study.
Journal: Magnesium research 20030601
Title: Functions of a chitosan-orotic acid salt in the gastrointestinal tract.
Journal: Biological & pharmaceutical bulletin 20030501
Title: Determination of orotic acid in urine by capillary zone electrophoresis in tandem-coupled columns with diode array detection.
Journal: Journal of chromatography. A 20030321
Title: Rapid determination of orotic acid in urine by liquid chromatography-electrospray tandem mass spectrometry.
Journal: Clinical chemistry 20030301
Title: Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet.
Journal: Clinical nutrition (Edinburgh, Scotland) 20030201
Title: Rapid determination of orotic acid in urine by a fast liquid chromatography/tandem mass spectrometric method.
Journal: Rapid communications in mass spectrometry : RCM 20030101
Title: [Mechanism of action of a novel antitumor preparation of chlofiden. Effect on RNA synthesis].
Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101
Title: Diagnostic value of urinary orotic acid levels: applicable separation methods.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021205
Title: The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers.
Journal: Protein science : a publication of the Protein Society 20021101
Title: Urine amino and organic acids analysis in developmental delay or intellectual disability.
Journal: Journal of paediatrics and child health 20021001
Title: An investigation of orotic acid levels in the breastmilk of smoking and non-smoking mothers.
Journal: European journal of clinical nutrition 20021001
Title: Elevated incidence of loss of heterozygosity (LOH) in an sgs1 mutant of Saccharomyces cerevisiae: roles of yeast RecQ helicase in suppression of aneuploidy, interchromosomal rearrangement, and the simultaneous incidence of both events during mitotic growth.
Journal: Mutation research 20020725
Title: Unexpected toxicity induced by magnesium orotate treatment in congenital hypomagnesemia.
Journal: Journal of internal medicine 20020701
Title: Variation in organic acids content during ripening of pickled white cheese.
Journal: Journal of dairy science 20020701
Title: Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.
Journal: Bioscience, biotechnology, and biochemistry 20020601
Title: Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.
Journal: Journal of hepatology 20020501
Title: The interaction of 5-fluoroorotic acid with transition metals: synthesis and characterisation of Ni(II), Cu(II) and Zn(II) complexes.
Journal: Journal of inorganic biochemistry 20020428
Title: Transfer RNA gene-targeted retrotransposition of Dictyostelium TRE5-A into a chromosomal UMP synthase gene trap.
Journal: Journal of molecular biology 20020426
Title: Development of a CE method to analyze organic acids in dairy products: application to study the metabolism of heat-shocked spores.
Journal: Journal of agricultural and food chemistry 20020327
Title: Behavior of alginate gel beads containing chitosan salt prepared with water-soluble vitamins.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020301
Title: Transcriptional cosuppression of yeast Ty1 retrotransposons.
Journal: Genes & development 20020215
Title: The oral anti-volatile sulphur compound effects of zinc salts and their stability constants.
Journal: European journal of oral sciences 20020201
Title: Dietary orotic acid increases 1 ,2-diacylglycerol level and lowers superoxide dismutase activity in rat liver.
Journal: Journal of nutritional science and vitaminology 20020201
Title: Fluorescence sensing of ionic analytes in water: from transition metal ions to vitamin B13.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20020104
Title: A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency.
Journal: Human gene therapy 20020101
Title: [Orotic acid as a metabolic agent].
Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20020101
Title: Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism.
Journal: BMC pediatrics 20020101
Title: Theoretical studies of mechanisms and kinetic isotope effects on the decarboxylation of orotic acid and derivatives.
Journal: Journal of the American Chemical Society 20011205
Title: Evolution: constantly avoiding mutation.
Journal: Current biology : CB 20011113
Title: Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase.
Journal: The Journal of pharmacology and experimental therapeutics 20011101
Title: Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration.
Journal: Parasitology international 20011101
Title: Orotic acid added to casein, but not to egg protein, soy protein, or wheat gluten diets increases 1,2-diacylglycerol levels and lowers superoxide dismutase activities in rat liver.
Journal: Bioscience, biotechnology, and biochemistry 20011001
Title: Pitfalls in the detection of heterozygosity by allopurinol in a variant form of ornithine carbamoyltransferase deficiency.
Journal: Journal of inherited metabolic disease 20010801
Title: Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis.
Journal: Archives of biochemistry and biophysics 20010715
Title: Contribution of the bacterial endosymbiont to the biosynthesis of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila.
Journal: The Journal of biological chemistry 20010629
Title: Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.
Journal: Biochemistry 20010619
Title: Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.
Journal: Nature structural biology 20010601
Title: Intra-day variations in urinary pyrimidines in ornithine carbamoyltransferase deficiency and healthy individuals.
Journal: Clinica chimica acta; international journal of clinical chemistry 20010601
Title: Capillary zone electrophoresis of orotic acid in urine with on-line isotachophoresis sample pretreatment and diode array detection.
Journal: Journal of chromatography. A 20010504
Title: Rapid selection against truncation mutants in yeast reverse two-hybrid screens.
Journal: BioTechniques 20010501
Title: Extremely short small bowel induces focal tubulointerstitial fibrosis.
Journal: Journal of pediatric gastroenterology and nutrition 20010501
Title: Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies.
Journal: Biochemistry 20010410
Title: Successful living-donor liver transplantation from an asymptomatic carrier mother in ornithine transcarbamylase deficiency.
Journal: The Journal of pediatrics 20010301
Title: Large-scale production of the carbohydrate portion of the sialyl-Tn epitope, alpha-Neup5Ac-(2-->6)-D-GalpNAc, through bacterial coupling.
Journal: Carbohydrate research 20010227
Title: Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.
Journal: Biochemistry 20010220
Title: Ornithine carbamoyltransferase deficiency: improved sensitivity of testing for protein tolerance in the diagnosis of heterozygotes.
Journal: Journal of inherited metabolic disease 20010201
Title: Laboratory evaluation of urea cycle disorders.
Journal: The Journal of pediatrics 20010101
Title: [Passive orthostatic test in evaluation of efficiency of medical rehabilitation of flying personnel].
Journal: Voenno-meditsinskii zhurnal 20010101
Title: [Effectiveness of treating periodontitis in patients with thyroid dysfunction].
Journal: Stomatologiia 20010101
Title: Media formulations for various two-hybrid systems.
Journal: Methods in molecular biology (Clifton, N.J.) 20010101
Title: [Psychophysiological effects of combined administration of pantogam and potassium orotate in patients with neurotic disorders].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101
Title: Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.
Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20010101
Title: Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from Toxoplasma gondii.
Journal: Biochemical pharmacology 19991101
Title: Effects of C-terminal deletion on the activity and thermostability of orotate phosphoribosyltransferase from Thermus thermophilus.
Journal: Journal of biochemistry 19990101
Title: Magnesium orotate in myocardial and neuronal protection.
Journal: Romanian journal of internal medicine = Revue roumaine de medecine interne 19990101
Title: Metabolic supplementation with orotic acid and magnesium orotate.
Journal: Cardiovascular drugs and therapy 19980901
Title: In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
Journal: Carcinogenesis 19940901
Title: Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase.
Journal: Biochimica et biophysica acta 19530101
