Name: Name:4-Isothiazolecarboxamide, 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-
Brand: AABLOCKS
SKU: AA002QST
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA002QST

Chemical Name: 4-Isothiazolecarboxamide, 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-

CAS Number: 252003-65-9

Molecular Formula: C20H24BrF2N5O3S

Molecular Weight: 532.4021

MDL Number: MFCD07772279

SMILES: O=C(Nc1snc(c1C(=O)N)OCc1c(F)cc(cc1F)Br)NCCCCN1CCCC1

Properties

BP: 548.601°C at 760 mmHg

Storage: Keep in dry area;2-8℃;

Complexity: 622

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 32

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 3

Rotatable Bond Count: 10

XLogP3: 3.7

Literature fold

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.

Journal: Journal of medicinal chemistry20121227

Title: Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.

Journal: Bioorganic & medicinal chemistry letters20080815

Title: Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases.

Journal: Bioorganic & medicinal chemistry letters20080315

Title: A phase I/randomized phase II, non-comparative, multicenter, open label trial of CP-547,632 in combination with paclitaxel and carboplatin or paclitaxel and carboplatin alone as first-line treatment for advanced non-small cell lung cancer (NSCLC).

Journal: Cancer chemotherapy and pharmacology20070601

Title: Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy.

Journal: Cancer research20031101

252003-65-9 | 4-Isothiazolecarboxamide, 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-