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252025-52-8,MFCD06198883
Catalog No.:AA002QTD

252025-52-8 | 1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, hydrazide

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10mg
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$232.00   $163.00
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25mg
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50mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002QTD
Chemical Name:
1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, hydrazide
CAS Number:
252025-52-8
Molecular Formula:
C15H12Cl2N4O
Molecular Weight:
335.1880
MDL Number:
MFCD06198883
SMILES:
NNC(=O)c1nn(c2c1cccc2)Cc1ccc(cc1Cl)Cl
Properties
Computed Properties
 
Complexity:
411  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.3  

Literature

Title: rpS6 Regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment.

Journal: Endocrinology 20121001

Title: Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility.

Journal: International journal of andrology 20120201

Title: Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis.

Journal: PloS one 20120101

Title: Drug transporters and blood--testis barrier function.

Journal: The Journal of endocrinology 20110601

Title: Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes.

Journal: Reproduction (Cambridge, England) 20110501

Title: Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: novel insights from studies on Eps8 and Arp3.

Journal: The Biochemical journal 20110501

Title: c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes.

Journal: The international journal of biochemistry & cell biology 20110401

Title: Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo.

Journal: The international journal of biochemistry & cell biology 20101101

Title: AF-2364 is a prospective spermicide candidate.

Journal: Asian journal of andrology 20100501

Title: Impact of marine drugs on cytoskeleton-mediated reproductive events.

Journal: Marine drugs 20100101

Title: A novel tissue-specific meta-analysis approach for gene expression predictions, initiated with a mammalian gene expression testis database.

Journal: BMC genomics 20100101

Title: Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier.

Journal: The international journal of biochemistry & cell biology 20091201

Title: An in vivo study on adjudin and blood-testis barrier dynamics.

Journal: Endocrinology 20091001

Title: 14-3-3 Protein regulates cell adhesion in the seminiferous epithelium of rat testes.

Journal: Endocrinology 20091001

Title: Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090801

Title: RAB13 participates in ectoplasmic specialization dynamics in the rat testis.

Journal: Biology of reproduction 20090301

Title: Adjudin-mediated germ cell depletion alters the anti-oxidant status of adult rat testis.

Journal: Molecular reproduction and development 20090101

Title: Adjudin targeting rabbit germ cell adhesion as a male contraceptive: a pharmacokinetics study.

Journal: Journal of andrology 20090101

Title: Testicular cell junction: a novel target for male contraception.

Journal: Current medicinal chemistry 20090101

Title: A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose.

Journal: Biology of reproduction 20080601

Title: New perspectives in non-hormonal male contraception.

Journal: Trends in endocrinology and metabolism: TEM 20080301

Title: Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis.

Journal: Oxidative medicine and cellular longevity 20080101

Title: Cross-talk between tight and anchoring junctions-lesson from the testis.

Journal: Advances in experimental medicine and biology 20080101

Title: Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model.

Journal: The Journal of endocrinology 20070301

Title: Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes.

Journal: The Journal of endocrinology 20070101

Title: Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testis.

Journal: Journal of andrology 20070101

Title: Dynamin II interacts with the cadherin- and occludin-based protein complexes at the blood-testis barrier in adult rat testes.

Journal: The Journal of endocrinology 20061201

Title: A male contraceptive targeting germ cell adhesion.

Journal: Nature medicine 20061101

Title: Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions.

Journal: Journal of cellular physiology 20060701

Title: The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin.

Journal: Journal of andrology 20060101

Title: AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data.

Journal: Contraception 20051001

Title: Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study.

Journal: Biology of reproduction 20050901

Title: TGF-beta3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study.

Journal: Developmental biology 20050415

Title: Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis.

Journal: Journal of cellular physiology 20050201

Title: Interactions of proteases, protease inhibitors, and the beta1 integrin/laminin gamma3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis.

Journal: Biology of reproduction 20040401

Title: Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: is this a potential target for male contraceptive development?

Journal: Human reproduction update 20040101

Title: Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study.

Journal: Biology of reproduction 20030801

Title: Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway.

Journal: Biology of reproduction 20030601

Title: Adhering junction dynamics in the testis are regulated by an interplay of beta 1-integrin and focal adhesion complex-associated proteins.

Journal: Endocrinology 20030501

Title: Rab8B GTPase and junction dynamics in the testis.

Journal: Endocrinology 20030401

Title: Indazole carboxylic acids in male contraception.

Journal: Contraception 20020401

Title: Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis.

Journal: Biology of reproduction 20010801

Title: Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide.

Journal: Biology of reproduction 20010501

Title: Li K, et al. Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans. Hum Reprod. 2013 Jan;28(1):47-59.

Title: Li X, et al. Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells. J Mater Chem B. 2015 Feb 28;3(8):1556-1564.

Title: Xie QR, et al. Male contraceptive Adjudin is a potential anti-cancer drug. Biochem Pharmacol. 2013 Feb 1;85(3):345-55.

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Tags:252025-52-8 Molecular Formula|252025-52-8 MDL|252025-52-8 SMILES|252025-52-8 1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, hydrazide